The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Enhancing Cell Nucleus Accumulation and DNA Cleavage Activity of Anti-Cancer Drug via Graphene Quantum Dots
Open accessAbstract
Graphene quantum dots (GQDs) maintain the intrinsic layered structural motif of graphene but with smaller lateral size and abundant periphery carboxylic groups, and are more compatible with biological system, thus are promising nanomaterials for therapeutic applications. Here we show that GQDs have a superb ability in drug delivery and anti-cancer activity boost without any pre-modification due to their unique structural properties. They could efficiently deliver doxorubicin (DOX) to the nucleus through DOX/GQD conjugates, because the conjugates assume different cellular and nuclear internalization pathways comparing to free DOX. Also, the conjugates could enhance DNA cleavage activity of DOX markedly. This enhancement combining with efficient nuclear delivery improved cytotoxicity of DOX dramatically. Furthermore, the DOX/GQD conjugates could also increase the nuclear uptake and cytotoxicity of DOX to drug-resistant cancer cells indicating that the conjugates may be capable to increase chemotherapy efficacy of anti-cancer drugs that are suboptimal due to the drug resistance.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Cited by
Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications
Zheng, X. T., Ananthanarayanan, A., Luo, K. Q., & Chen, P. (2015) · Small · doi:10.1002/smll.201402648 · Cited by 2,190
Graphene quantum dots for cancer targeted drug delivery
Iannazzo, D., Pistone, A., Salamò, M., Galvagno, S., Romeo, R., Giofré, S. V., Branca, C., Visalli, G., & Di Pietro, A. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.12.060 · Cited by 365
Black Phosphorus and its Biomedical Applications
Choi, J. R., Yong, K. W., Choi, J. Y., Nilghaz, A., Lin, Y., Xu, J., & Lu, X. (2018) · Theranostics · doi:10.7150/thno.22573 · Cited by 353
Carbon-based quantum particles: an electroanalytical and biomedical perspective
Nekoueian, K., Amiri, M., Sillanpää, M., Marken, F., Boukherroub, R., & Szunerits, S. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00445e · Cited by 294
Metadata
- Authors
- Wang, C., Wu, C., Zhou, X., Han, T., Xin, X., Wu, J., Zhang, J., & Guo, S.
- Venue
- Scientific Reports
- Published
- 2013-10-04
- Volume
- 3
- Issue
- 1
- Pages
- 2852-2852
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2046700476
- Cited by
- 206
- References
- 3
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, C., Wu, C., Zhou, X., Han, T., Xin, X., Wu, J., Zhang, J., & Guo, S. (2013). Enhancing Cell Nucleus Accumulation and DNA Cleavage Activity of Anti-Cancer Drug via Graphene Quantum Dots. Scientific Reports. https://doi.org/10.1038/srep02852
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