Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice
Open accessAbstract
Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate in the inflammatory process, including oxidative stress. Xanthine oxidase (XO) is a major source of reactive oxygen species (ROS) and has been linked to the pathogenesis of atherosclerosis, but the underlying mechanisms remain unclear. Here, we show enhanced XO expression in macrophages in the atherosclerotic plaque and in aortic endothelial cells in ApoE−/− mice and that febuxostat, a highly potent XO inhibitor, suppressed plaque formation, reduced arterial ROS levels and improved endothelial dysfunction in ApoE−/− mice without affecting plasma cholesterol levels. In vitro, febuxostat inhibited cholesterol crystal-induced ROS formation and inflammatory cytokine release in murine macrophages. These results demonstrate that in the atherosclerotic plaque, XO-mediated ROS formation is pro-inflammatory and XO-inhibition by febuxostat is a potential therapy for atherosclerosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mice partially or conditionally lacking MnSOD showed dilated cardiomyopathy characterized by left ventricle dilation, decreased wall thickness, and hypertrophy.
“Further, mice partially or conditionally lacking MnSOD showed dilated cardiomyopathy characterized by left ventricle dilation, decreased wall thickness, and hypertrophy (584, 696).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [696]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
The immune system in atherosclerosis
Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,331 · see citing works
Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039 · see citing works
Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2639 · Cited by 935 · see citing works
The inflammasome: an integrated view
Gross, O., Thomas, C. J., Guarda, G., & Tschopp, J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01046.x · Cited by 778 · see citing works
Endothelial dysfunction : the early predictor of atherosclerosis
Mudau, M., Genis, A., Lochner, A., & Strijdom, H. (2012) · Cardiovascular Journal of Africa · doi:10.5830/cvja-2011-068 · Cited by 521 · see citing works
Is oxidative stress a therapeutic target in cardiovascular disease?
Münzel, T., Gori, T., Bruno, R. M., & Taddei, S. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq396 · Cited by 470 · see citing works
Nishino, T., Okamoto, K., Eger, B. T., PAI, E. F., & Nishino, T. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06489.x · Cited by 387 · see citing works
Freigang, S., Ampenberger, F., Weiss, A., Kanneganti, T., Iwakura, Y., Hersberger, M., & Köpf, M. (2013) · Nature Immunology · doi:10.1038/ni.2704 · Cited by 304 · see citing works
Freigang, S., Ampenberger, F., Spohn, G., Heer, S., Shamshiev, A. T., Kisielow, J., Hersberger, M., Yamamoto, M., Bachmann, M. F., & Kopf, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041316 · Cited by 300 · see citing works
Inoue, S., Egashira, K., Ni, W., Kitamoto, S., Usui, M., Otani, K., Ishibashi, M., Hiasa, K., Nishida, K.-I., & Takeshita, A. (2002) · Circulation · doi:10.1161/01.cir.0000038140.80105.ad · Cited by 256 · see citing works
Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
Menu, P., Pellegrin, M., Aubert, J.-F., Bouzourène, K., Tardivel, A., Mazzolai, L., & Tschopp, J. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.18 · Cited by 249 · see citing works
A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues
Beckman, J. S., Parks, D. A., Pearson, J. D., Marshall, P. A., & Freeman, B. Α. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90068-3 · Cited by 233 · see citing works
Usui, F., Shirasuna, K., Kimura, H. J., Tatsumi, K., Kawashima, A., Karasawa, T., Hida, S., Sagara, J., Taniguchi, S., & Takahashi, M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.058 · Cited by 183 · see citing works
Uric Acid Levels Are Relevant in Patients With Stroke Treated With Thrombolysis
Amaro, S., Urra, X., Gómez-Choco, M. J., Obach, V., Cervera, Á., Vargas, M., Torres, F., Ríos, J., Planas, A. M., & Chamorro, Á. (2010) · Stroke · doi:10.1161/strokeaha.110.596528 · Cited by 144 · see citing works
Patetsios, P., Song, M., Shutze, W. P., Pappas, C., Rodino, W., Ramirez, J. A., & Panetta, T. F. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01621-6 · Cited by 143 · see citing works
Inflammasomes: sensors of metabolic stresses for vascular inflammation
Yang, X.-F. (2013) · Frontiers in Bioscience · doi:10.2741/4127 · Cited by 134 · see citing works
Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation
Yang, Z., & Ming, X. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00149 · Cited by 133 · see citing works
Kushiyama, A., Okubo, H., Sakoda, H., Kikuchi, T., Fujishiro, M., Sato, H., Kushiyama, S., Iwashita, M., Nishimura, F., Fukushima, T., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.234559 · Cited by 128 · see citing works
Febuxostat inhibition of endothelial-bound XO: Implications for targeting vascular ROS production
Malik, U. Z., Hundley, N. J., Romero, G., Radi, R., Freeman, B. A., Tarpey, M. M., & Kelley, E. E. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.004 · Cited by 126 · see citing works
Actions of “antioxidants” in the protection against atherosclerosis
Lönn, M. E., Dennis, J. M., & Stocker, R. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.027 · Cited by 124 · see citing works
Sezai, A., Soma, M., Nakata, K., Hata, M., Yoshitake, I., Wakui, S., Hata, H., & Shiono, M. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0082 · Cited by 117 · see citing works
Schröder, K., Vecchione, C., Jung, O., Schreiber, J. G., Shiri‐Sverdlov, R., van Gorp, P. J., Busse, R., & Brandes, R. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.026 · Cited by 86 · see citing works
Nomura, J., Busso, N., Ives, A., Tsujimoto, S., Tamura, M., So, A. K.-L., & Yamanaka, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075527 · Cited by 82 · see citing works
Self-citationLin, J., Shou, X., Mao, X., Dong, J., Mohabeer, N., Kushwaha, K. K., Wang, L., Su, Y., Fang, H., & Li, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062148 · Cited by 79 · see citing works
AkifumiKushiyama, HirofumiOkubo, HideyukiSakoda, TakakoKikuchi, MidoriFujishiro, HirokazuSato, SakuraKushiyama, MisakiIwashita, FusanoriNishimura, ToshiakiFukushima, et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · Cited by 79 · see citing works
Park, J., Ryu, S. Y., Jung, I., Lee, Y.-H., Kang, K. J., Lee, M., Lee, M.-N., Sonn, S. K., Lee, J. H., Lee, H., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.11.029 · Cited by 77 · see citing works
Atherosclerosis: from biology to pharmacological treatment
Riccioni, G., & Sblendorio, V. (2012) · Journal of Geriatric Cardiology · doi:10.3724/sp.j.1263.2012.02132 · Cited by 66 · see citing works
Ye, P., Yang, S., Zhang, W., Lv, Q., Cheng, Q., Mei, M., Luo, T., Liu, L., Chen, S., & Li, Q. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.12.011 · Cited by 55 · see citing works
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction
Madigan, M. C., & Zuckerbraun, B. S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00174 · Cited by 51 · see citing works
Lack of association between serum uric acid levels and outcome in acute ischemic stroke
Miedema, I., Uyttenboogaart, M., Koch, M. W., Kremer, B. P. H., Keyser, J. D., & Luijckx, G. J. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.019 · Cited by 43 · see citing works
Efficacy and safety of febuxostat in patients with hyperuricemia and gout
García-Valladares, I., Khan, T. A., & Espinoza, L. R. (2011) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x11416405 · Cited by 37 · see citing works
Shimada, K., Murayama, T., Yokode, M., Kita, T., Uzui, H., Ueda, T., Lee, J.-D., & Kishimoto, C. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1148 · Cited by 34 · see citing works
Kinoshita, H., Matsumura, T., Ishii, N., Fukuda, K., Senokuchi, T., Motoshima, H., Kondo, T., Taketa, K., Kawasaki, S., Hanatani, S., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.01.014 · Cited by 32 · see citing works
Serum uric acid levels and neuromyelitis optica
Peng, F., Zhong, X., Deng, X., Qiu, W., Wu, A., Long, Y., Hu, X., Li, Q., Jiang, Y., & Dai, Y. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5455-1 · Cited by 18 · see citing works
Okabe, T.-A., Kishimoto, C., Shimada, K., Murayama, T., Yokode, M., & Kita, T. (2006) · Circulation Journal · doi:10.1253/circj.70.1216 · Cited by 15 · see citing works
Liu, C., Xu, Y., Cui, L., Wang, J., Peng, B., Zhong, L.-Z., & Chen, X. (2012) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2012.02.042 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081 · see citing works
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519 · see citing works
Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works
Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Marchio, P., Guerra‐Ojeda, S., Vila, J. M., Aldasoro, M., Víctor, V. M., & Mauricio, M. D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8563845 · Cited by 628 · see citing works
Yanai, H., Adachi, H., Hakoshima, M., & Katsuyama, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179221 · Cited by 608 · see citing works
The Role of Oxidative Stress in Atherosclerosis
Batty, M., Bennett, M. R., & Yu, E. (2022) · Cells · doi:10.3390/cells11233843 · Cited by 569 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies
Yang, X., Li, Y., Li, Y., Ren, X., Zhang, X., Hu, D., Gao, Y., Xing, Y., & Shang, H. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00600 · Cited by 410 · see citing works
Vascular Oxidative Stress: Impact and Therapeutic Approaches
Sena, C. M., Leandro, A., Azul, L., Seiça, R. M. F., & Perry, G. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01668 · Cited by 260 · see citing works
The role of xanthine oxidoreductase and uric acid in metabolic syndrome
Battelli, M. G., Bortolotti, M., Polito, L., & Bolognesi, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.05.003 · Cited by 210 · see citing works
NLRP3 inflammasome pathways in atherosclerosis
Baldrighi, M., Mallat, Z., & Li, X. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.027 · Cited by 202 · see citing works
Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress
Mauricio, M. D., Guerra‐Ojeda, S., Marchio, P., Vallés, S. L., Aldasoro, M., Escribano‐López, I., Herance, J. R., Rocha, M., Vila, J. M., & Víctor, V. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6231482 · Cited by 201 · see citing works
Oxidative Stress and Inflammation in Renal and Cardiovascular Complications of Diabetes
Charlton, A., Garzarella, J., Jandeleit-Dahm, K. A. M., & Jha, J. C. (2020) · Biology · doi:10.3390/biology10010018 · Cited by 200 · see citing works
Reactive Oxygen Species Generation and Atherosclerosis
Nowak, W. N., Deng, J., Ruan, X. Z., & Xu, Q. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309228 · Cited by 179 · see citing works
Kushiyama, A., Nakatsu, Y., Matsunaga, Y., Yamamotoya, T., Mori, K., Ueda, K., Inoue, Y., Sakoda, H., Fujishiro, M., Ono, H., et al. (2016) · Mediators of Inflammation · doi:10.1155/2016/8603164 · Cited by 183 · see citing works
Vascular Macrophages in Atherosclerosis
Xu, H., Jiang, J., Chen, W., Li, W., & Chen, Z. (2019) · Journal of Immunology Research · doi:10.1155/2019/4354786 · Cited by 173 · see citing works
Oxidative Stress and Antioxidants in Atherosclerosis Development and Treatment
Poznyak, A. V., Grechko, A. V., Orekhova, V. A., Chegodaev, Y. S., Wu, W., & Orekhov, A. N. (2020) · Biology · doi:10.3390/biology9030060 · Cited by 152 · see citing works
Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase
Battelli, M. G., Bortolotti, M., Polito, L., & Bolognesi, A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101070 · Cited by 127 · see citing works
Prasad, M., Matteson, E. L., Herrmann, J., Gulati, R., Rihal, C. S., Lerman, L. O., & Lerman, A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08436 · Cited by 110 · see citing works
Oh, T. R., Choi, H. S., Kim, C. S., Bae, E. H., Kwon, S., Sung, S.-A., Kim, Y., Oh, K., Ahn, C., & Kim, S. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-43241-3 · Cited by 109 · see citing works
Impact of hyperuricemia on chronic kidney disease and atherosclerotic cardiovascular disease
Nishizawa, H., Maeda, N., & Shimomura, I. (2022) · Hypertension Research · doi:10.1038/s41440-021-00840-w · Cited by 112 · see citing works
Choi, H. K., Neogi, T., Stamp, L. K., Dalbeth, N., & Terkeltaub, R. A. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40583 · Cited by 105 · see citing works
Marahatha, R., Basnet, S., Bhattarai, B. R., Budhathoki, P., Aryal, B., Adhikari, B., Lamichhane, G., Poudel, D. K., & Parajuli, N. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-03162-5 · Cited by 105 · see citing works
NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
Kim, J., & Keum, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2746457 · Cited by 100 · see citing works
Role of reactive oxygen species in atherosclerosis: Lessons from murine genetic models
Nègre‐Salvayre, A., Guerby, P., Gayral, S., Laffargue, M., & Salvayre, R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.011 · Cited by 98 · see citing works
Reactive Oxygen Species in Pathogenesis of Atherosclerosis
Goncharov, N. V., Avdonin, P. V., Nadeev, A. D., Zharkikh, I. L., & Jenkins, R. O. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141014142557 · Cited by 97 · see citing works
Tanaka, A., Taguchi, I., Teragawa, H., Ishizaka, N., Kanzaki, Y., Tomiyama, H., Sata, M., Sezai, A., Eguchi, K., Kato, T., et al. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003095 · Cited by 93 · see citing works
Xanthine oxidoreductase: A leading actor in cardiovascular disease drama
Polito, L., Bortolotti, M., Battelli, M. G., & Bolognesi, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102195 · Cited by 92 · see citing works
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations
Herb, M., Gluschko, A., & Schramm, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716406 · Cited by 88 · see citing works
Linking uric acid metabolism to diabetic complications
Kushiyama, A. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i6.787 · Cited by 87 · see citing works
Chou, H., Chiu, H.-T., Tsai, C.-W., Ting, I., Yeh, H., Huang, H.-C., & Kuo, C. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx313 · Cited by 83 · see citing works
Roy, B. (2025) · Medical Sciences · doi:10.3390/medsci13030087 · Cited by 89 · see citing works
Sun, H., Zhu, X., Cai, W., & Qiu, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040844 · Cited by 80 · see citing works
Eating the dead to keep atherosclerosis at bay
Brophy, M. L., Dong, Y., Wu, H., Rahman, H. N. A., Song, K., & Chen, H. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00002 · Cited by 68 · see citing works
Yisireyili, M., Hayashi, M., Wu, H., Uchida, Y., Yamamoto, K., Kikuchi, R., Hamrah, M. S., Nakayama, T., Cheng, X. W., Matsushita, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01366-3 · Cited by 68 · see citing works
Role of pyroptosis in atherosclerosis and its therapeutic implications
He, B., Nie, Q., Wang, F., Han, Y., Yang, B., Sun, M., Fan, X., Ye, Z., Liu, P., & Wen, J. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30366 · Cited by 65 · see citing works
Miyamoto, H., Sakumoto, C., Takekoshi, E., Maeda, Y., Hiramoto, N., Itoh, T., & Kato, Y. (2015) · Organic Process Research & Development · doi:10.1021/acs.oprd.5b00161 · Cited by 64 · see citing works
Role of Oxidative Stress in the Pathogenesis of Atherothrombotic Diseases
Petrucci, G., Rizzi, A., Hatem, D., Tosti, G., Rocca, B., & Pitocco, D. (2022) · Antioxidants · doi:10.3390/antiox11071408 · Cited by 67 · see citing works
Hussain, A. (2025) · Cardiovascular Diabetology – Endocrinology Reports · doi:10.1186/s40842-025-00247-3 · Cited by 62 · see citing works
Aroor, A. R., Jia, G., Habibi, J., Sun, Z., Ramirez‐Perez, F. I., Brady, B., Chen, D., Martinez‐Lemus, L. A., Manrique, C. M., Nistala, R., et al. (2017) · Metabolism · doi:10.1016/j.metabol.2017.06.006 · Cited by 61 · see citing works
Zhao, J., Shyue, S., Kou, Y. R., Lu, T., & Lee, T. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.15229 · Cited by 60 · see citing works
Devarajan, A. (2018) · Clinical Science · doi:10.1042/cs20171574 · Cited by 59 · see citing works
The role of endothelial dysfunction and oxidative stress in cerebrovascular diseases
Scicchitano, P., Cortese, F., Gesualdo, M., Palo, M. D., Massari, F., Giordano, P., & Ciccone, M. M. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1620939 · Cited by 59 · see citing works
Fahmi, A. N. A., Shehatou, G. S. G., Shebl, A. M., & Salem, H. A. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1202-6 · Cited by 51 · see citing works
Andreadou, I., Daiber, A., Baxter, G. F., Brizzi, M. F., Lisa, F. D., Kaludercic, N., Lazou, A., Varga, Z. V., Zuurbier, C. J., Schulz, R., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.012 · Cited by 52 · see citing works
Uric Acid and Arterial Stiffness
Albu, A., Para, I., & Porojan, M. D. (2020) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s232033 · Cited by 50 · see citing works
Vitamin C as Scavenger of Reactive Oxygen Species during Healing after Myocardial Infarction
Zheng, H., Xu, Y., Liehn, E. A., & Rusu, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063114 · Cited by 58 · see citing works
Xanthine Oxidase Induces Foam Cell Formation through LOX-1 and NLRP3 Activation
Dai, Y., Cao, Y., Zhang, Z., Vallurupalli, S., & Mehta, J. L. (2017) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6706-x · Cited by 49 · see citing works
Fujii, K., Kubo, A., Miyashita, K., Sato, M., Hagiwara, A., Inoue, H., Ryuzaki, M., Tamaki, M., Hishiki, T., Hayakawa, N., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124816 · Cited by 49 · see citing works
Arauna, D., Furrianca, M. C., Espinosa‐Parrilla, Y., Eduardo Fuentes, Q., Alarcón, M. A., & Palomo, I. F. (2019) · Molecules · doi:10.3390/molecules24234259 · Cited by 48 · see citing works
Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications
Hirawat, R., Saifi, M. A., & Godugu, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118923 · Cited by 47 · see citing works
The Impact of Uric Acid and Hyperuricemia on Cardiovascular and Renal Systems
Agnoletti, D., Cicero, A. F. G., & Borghi, C. (2021) · Cardiology Clinics · doi:10.1016/j.ccl.2021.04.009 · Cited by 47 · see citing works
Ando, K., Takahashi, H., Watanabe, T., Daidoji, H., Otaki, Y., Nishiyama, S., Arimoto, T., Shishido, T., Miyashita, T., Miyamoto, T., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.33951 · Cited by 45 · see citing works
Myszko, M., Bychowski, J., Skrzydlewska, E., & Łuczaj, W. (2025) · Antioxidants · doi:10.3390/antiox14030275 · Cited by 49 · see citing works
Kusano, T., Ehirchiou, D., Matsumura, T., Chobaz, V., Nasi, S., Castelblanco, M., So, A. K.-L., Lavanchy, C., Acha‐Orbea, H., Nishino, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12565-z · Cited by 46 · see citing works
Self-citationHoney as an apitherapic product: its inhibitory effect on urease and xanthine oxidase
Şahin, H. (2015) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2015.1039532 · Cited by 43 · see citing works
Sfyri, P., & Matsakas, A. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0346-8 · Cited by 43 · see citing works
Mizuno, Y., Yamamotoya, T., Nakatsu, Y., Ueda, K., Matsunaga, Y., Inoue, M., Sakoda, H., Fujishiro, M., Ono, H., Kikuchi, T., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194680 · Cited by 42 · see citing works
Kataoka, H., Mochizuki, T., Ohara, M., Tsuruta, Y., Iwasa, N., Yoshida, R. Y., Tsuchiya, K., Nitta, K., Kimura, K., Hosoya, T., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-07737-9 · Cited by 40 · see citing works
Song, C. Y., Ghafoor, K., Ghafoor, H. U., Khan, N. S., Thirunavukkarasu, S., Jennings, B. L., Estes, A. M., Zaidi, S., Bridges, D., Tso, P., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06427 · Cited by 39 · see citing works
On behalf of the PRIZE Study Investigators, Oyama, J., Tanaka, A., Sato, Y., Tomiyama, H., Sata, M., Ishizu, T., Taguchi, I., Kuroyanagi, T., Teragawa, H., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0409-2 · Cited by 39 · see citing works
Odake, K., Tsujii, M., Iino, T., Chiba, K., Kataoka, T., & Sudo, A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.10.033 · Cited by 38 · see citing works
Vitamin D(3) contribution to the regulation of oxidative metabolism in the liver of diabetic mice
Labudzynskyi, D. О. (2015) · The Ukrainian Biochemical Journal · doi:10.15407/ubj87.03.075 · Cited by 38 · see citing works
Oh, S., Choi, S.-Y., Choi, H., Ryu, H., Kim, Y.-J., Jung, H., Cho, J., Kim, C., Park, S.-H., Kwon, T., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802415rr · Cited by 36 · see citing works
Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus
Akoumianakis, I., & Antoniades, C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7421 · Cited by 37 · see citing works
Yamaguchi, M., Okamoto, K., Kusano, T., Matsuda, Y., Suzuki, G., Fuse, A., & Yokota, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133980 · Cited by 37 · see citing works
Zhang, X., Zhang, Y., Liu, Y., Wang, J., Xu, Q., Yu, X., Yang, X., Liu, Z., & Xue, C. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.06.004 · Cited by 33 · see citing works
Engineered Nanoparticles for Effective Redox Signaling During Angiogenic and Antiangiogenic Therapy
Nethi, S. K., Barui, A. K., Mukherjee, S., & Patra, C. R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7383 · Cited by 32 · see citing works
Milosevic, K., Stevanović, I. D., Bozic, I. D., Milosevic, A., Janjic, M. M., Laketa, D., Bjelobaba, I. M., Lavrnja, I. C., & Savić, D. Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073561 · Cited by 31 · see citing works
Xu, X., Guo, Y., Zhao, J., Wang, N., Ding, J., & Liu, Q. (2016) · Mediators of Inflammation · doi:10.1155/2016/8172706 · Cited by 32 · see citing works
Ganji, M., Nardi, V., Prasad, M., Jordan, K. L., Bois, M. C., Franchi, F., Zhu, X. Y., Tang, H. J., Young, M. D., Lerman, L. O., et al. (2021) · Stroke · doi:10.1161/strokeaha.120.032964 · Cited by 30 · see citing works
Kawachi, Y., Fujishima, Y., Nishizawa, H., Nakamura, T., Akari, S., Murase, T., Saito, T., Miyazaki, Y., Nagao, H., Fukuda, S., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.144762 · Cited by 30 · see citing works
Chen, Q., Xu, Q., Zhang, W., Zhang, Y., Bi, Y., Meng, Q., Bian, H., & Yu, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.655081 · Cited by 28 · see citing works
Febuxostat exerts dose-dependent renoprotection in rats with cisplatin-induced acute renal injury
Fahmi, A. N. A., Shehatou, G. S. G., Shebl, A. M., & Salem, H. A. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1258-y · Cited by 27 · see citing works
Sayed, A. M., Sherif, N. H., EL-Gendy, A. O., Shamikh, Y. I., Ali, A. T., Attia, E. Z., El-Katatny, M. H., Khalifa, B. A., Hassan, H. M., & Abdelmohsen, U. R. (2020) · Natural Product Research · doi:10.1080/14786419.2020.1831495 · Cited by 27 · see citing works
The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia
Kim, Y.-J., Oh, S.-H., Ahn, J., Yook, J.-M., Kim, C., Park, S.-H., Park, S.-H., & Kim, Y.-L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207444 · Cited by 27 · see citing works
Significance and amplification methods of the purine salvage pathway in human brain cells
Sekine, M., Fujiwara, M., Okamoto, K., Ichida, K., Nagata, K., Hille, R., & Nishino, T. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107524 · Cited by 26 · see citing works
Role of ROS and autophagy in the pathological process of atherosclerosis
Zhu, L., Liao, Y., & Jiang, B. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01039-6 · Cited by 26 · see citing works
Samimi, F., Namiranian, N., Sharifi-Rigi, A., Siri, M., Abazari, O., & Dastghaib, S. (2024) · International Journal of Endocrinology · doi:10.1155/2024/2247748 · Cited by 25 · see citing works
Abo‐Youssef, A. M., Afify, H., Azouz, A. A., Abdel-Rahman, H. M., Abdel‐Naim, A. B., & Allam, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118414 · Cited by 24 · see citing works
Gumá, M., Dadpey, B., Coras, R., Mikuls, T. R., Hamilton, B. C., Quehenberger, O., Thorisdottir, H., Bittleman, D., Lauro, K., Reilly, S. M., et al. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02852-4 · Cited by 23 · see citing works
Oxidative Stress-Associated Pathology: A Review
Palipoch, S., & Koomhin, P. (2015) · Sains Malaysiana · doi:10.17576/jsm-2015-4410-09 · Cited by 23 · see citing works
Hao, W., Sung, L., Chen, C., Chen, P., Cheng, T., Chao, H., Liu, J., & Chen, J.-J. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7861518 · Cited by 23 · see citing works
Kondo, M., Imanishi, M., Fukushima, K., Ikuto, R., Murai, Y., Horinouchi, Y., Izawa‐Ishizawa, Y., Goda, M., Zamami, Y., Takechi, K., et al. (2018) · American Journal of Hypertension · doi:10.1093/ajh/hpy157 · Cited by 23 · see citing works
Comorbidity in gout and hyperuricemia: prevalence, causes, prospects of urate lowering therapy
Елисеев, М. С., & Novikova, A. M. (2019) · Terapevticheskii arkhiv · doi:10.26442/00403660.2019.05.000232 · Cited by 22 · see citing works
Mayers, J., Hofman, B., Sobiech, I., & Kwesiga, M. P. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1457553 · Cited by 21 · see citing works
Heikal, M. M., Shaaban, A. A., Elkashef, W. F., & Ibrahim, T. M. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0731 · Cited by 21 · see citing works
Wu, J., Zhang, Y., Qu, Y., Jie, L., Deng, J., & Yu, Q. (2019) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13652 · Cited by 21 · see citing works
HDL functionality and crystal-based sterile inflammation in atherosclerosis
Eren, E., Elli̇dağ, H. Y., Aydın, Ö., & Yılmaz, N. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.09.024 · Cited by 20 · see citing works
Febuxostat Attenuates the Progression of Periodontitis in Rats
Nessa, N., Kobara, M., Toba, H., Adachi, T., Yamamoto, T., Kanamura, N., Pezzotti, G., & Nakata, T. (2021) · Pharmacology · doi:10.1159/000513034 · Cited by 20 · see citing works
Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds
Zahid, M. K., Sufian, H. B., Choudhury, M., Yamasaki, M., Al‐Harrasi, A., Moustaïd‐Moussa, N., & Rahman, S. M. (2021) · Biochemical Journal · doi:10.1042/bcj20200894 · Cited by 20 · see citing works
Sakuma, M., Toyoda, S., Arikawa, T., Koyabu, Y., Kato, T., Adachi, T., Suwa, H., Narita, J.-I., Anraku, K., Ishimura, K., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0261445 · Cited by 20 · see citing works
Inoue, M., Yamamotoya, T., Nakatsu, Y., Ueda, K., Inoue, Y., Matsunaga, Y., Sakoda, H., Fujishiro, M., Ono, H., Morii, K., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123967 · Cited by 19 · see citing works
Han, M., Lee, J. P., Park, S., Kim, Y., Kim, Y. C., Ahn, C., Han, D. J., Ha, J., Jung, I. M., Lim, C. S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176786 · Cited by 18 · see citing works
For Excited UA study Investigators, Sakuma, M., Toyoda, S., Arikawa, T., Koyabu, Y., Kato, T., Adachi, T., Suwa, H., Narita, J.-I., Anraku, K., et al. (2018) · Clinical and Experimental Nephrology · doi:10.1007/s10157-018-1599-6 · Cited by 18 · see citing works
Ngarashi, D., Fujikawa, K., Ferdaus, M. Z., Zahid, H. M., Ohara, H., & Nabika, T. (2019) · Hypertension Research · doi:10.1038/s41440-019-0246-2 · Cited by 19 · see citing works
Richette, P., Frazier, A., & Bardin, T. (2015) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000149 · Cited by 18 · see citing works
Focal induction of ROS-release to trigger local vascular degeneration
Minol, J., Reinsch, I., Luik, M., Leferink, A., Barth, M., Assmann, A., Lichtenberg, A., & Akhyari, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179342 · Cited by 17 · see citing works
Fujishima, Y., Kita, S., Nishizawa, H., Maeda, N., & Shimomura, I. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej23-0160 · Cited by 18 · see citing works
Sedik, A. A., Hassan, S. A., Shafey, H. I., Khalil, W. K. B., & Mowaad, N. A. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-28182-9 · Cited by 16 · see citing works
- Authors
- Nomura, J., Busso, N., Ives, A., Matsui, C., Tsujimoto, S., Shirakura, T., Tamura, M., Kobayashi, T., So, A., & Yamanaka, Y.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Teijin Pharma Limited (Japan) (JP)
- Corresponding author
- Nomura, Johji
- Venue
- Scientific Reports
- Published
- 2014-04-01
- Volume
- 4
- Issue
- 1
- Pages
- 4554-4554
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC3971401
- OpenAlex
- W2013963410
- Cited by
- 181
- References
- 39
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 14 · 2023: 8 · 2022: 19 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 16 · 2017: 20 · 2016: 14 · 2015: 10 · 2014: 3
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030)
- Centre Hospitalier Universitaire Vaudois
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- xanthine oxidase inhibition, febuxostat, atherosclerosis, reactive oxygen species, oxidative stress, macrophages, atherosclerotic plaque, endothelial dysfunction, ApoE-deficient mice, cholesterol crystals, inflammatory cytokines, endothelial cells
- MeSH terms
- Febuxostat, Animals, Aorta, Apolipoproteins E, Body Weight, Cholesterol, Disease Models, Animal, Gout Suppressants, Inflammation, L-Lactate Dehydrogenase, Macrophages, Male, Mice, Inbred C57BL, Thiazoles, Xanthine Oxidase, Cytokines, Reactive Oxygen Species, Mice, Knockout, Oxidative Stress, Endothelial Cells, Atherosclerosis, Mice, Plaque, Atherosclerotic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
