The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation
Open accessAbstract
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that the three helical bundles R1-R3 in this region unfold in three distinct steps consistent with the domains unfolding independently. Mechanical stretching of talin R1-R3 enhances its binding to vinculin and vinculin binding inhibits talin refolding after force is released. Mutations that stabilize R3 identify it as the initial mechano-sensing domain in talin, unfolding at ∼5 pN, suggesting that 5 pN is the force threshold for vinculin binding and adhesion progression.
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Citations
Cites
Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin
Margadant, F., Chew, L. L., Hu, X., Yu, H., Bate, N., Zhang, X., & Sheetz, M. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001223 · Cited by 215
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Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Targeting integrin pathways: mechanisms and advances in therapy
Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275
Integrin-mediated mechanotransduction
Sun, Z., Guo, S. S., & Fässler, R. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201609037 · Cited by 1,079
Elosegui-Artola, A., Oria, R., Chen, Y., Kosmalska, A., Pérez-González, C., Castro, N., Zhu, C., Trepat, X., & Roca-Cusachs, P. (2016) · Nature Cell Biology · doi:10.1038/ncb3336 · Cited by 858
Integrin activation by talin, kindlin and mechanical forces
Sun, Z., Costell, M., & Fässler, R. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0234-9 · Cited by 543
Metadata
- Authors
- Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P., & Yan, J.
- Venue
- Scientific Reports
- Published
- 2014-04-09
- Volume
- 4
- Issue
- 1
- Pages
- 4610-4610
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2085117752
- Cited by
- 352
- References
- 1
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P., & Yan, J. (2014). Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation. Scientific Reports. https://doi.org/10.1038/srep04610
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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