Efficacy analysis of tyrosine kinase inhibitors on rare non-small cell lung cancer patients harboring complex EGFR mutations
Open accessAbstract
The efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) in patients with non-small cell lung cancer (NSCLC) is related to EGFR mutations. Although the p.L858R point mutation in exon 21 and the in-frame deletion mutation in exon 19 are well known, efficacy of EGFR-TKI in patients with more than one EGFR mutation is not well understood. 799 NSCLC patients were screened for EGFR mutations. Of the 799 patients, 443 (55.4%) had mutations, out of which 22 (2.75%) had multiple complex mutations. Most multiple mutations (20/22) harbored common mutations such as the p.L858R point mutation in exon 21 and the in-frame deletion mutation in exon 19. 11 out of 22 patients who had multiple EGFR mutations underwent TKI therapy and primary end-points of progression free and overall survival were determined. Our analysis revealed that cases with multiple mutations had similar end-point outcomes as single mutation to TKI therapy. Report of these cases will be helpful in decision making for treatment of NSCLC patients harboring multiple EGFR mutations.
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The coexistence of multiple EGFR mutations has a reported frequency of 4-14% of all EGFR mutations.
“However, the true incidence of these genetic events is unknown, with a reported frequency of 4–14% of all EGFR mutations [21,36,46,47].”
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- Authors
- Peng, L., Song, Z.-G., & Jiao, S.-C.
- Affiliations
- Chinese PLA General Hospital (CN)
- ORCID
- Peng, Liang
- Venue
- Scientific Reports
- Published
- 2014-08-18
- Volume
- 4
- Issue
- 1
- Pages
- 6104-6104
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4135336
- OpenAlex
- W2078054268
- Cited by
- 48
- References
- 18
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 8 · 2015: 6
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- non-small cell lung cancer, EGFR mutation, tyrosine kinase inhibitors, exon 19 deletion, progression-free survival, overall survival
- MeSH terms
- Erlotinib Hydrochloride, Gefitinib, Antineoplastic Agents, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Female, Humans, Lung Neoplasms, Male, Quinazolines, Retrospective Studies, Protein Kinase Inhibitors, ErbB Receptors
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