Uncertainty of Prebiotic Scenarios: The Case of the Non-Enzymatic Reverse Tricarboxylic Acid Cycle
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We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rTCA cycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investigations of the origin of the common metabolic core should be significantly extended.
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Every reported case of non-enzymatic covalent catalysis points to a potential lipid catalyst for the same reaction.
“Beyond the concrete published examples, it should be underscored that every reported case of non-enzymatic covalent catalysis [181,196–198] points to a potential lipid catalyst for the same reaction.”
From Systems protobiology: origin of life in lipid catalytic networks (2018) · cites this paper as [197]
The Abstract discusses chemical catalysts in prebiotic reaction networks, and the Discussion describes hypothetical non-selective catalysts, but neither addresses lipid catalysts or a link between every case of non-enzymatic covalent catalysis and a lipid catalyst. Searches for “non-enzymatic covalent catalysis lipid catalyst” and “lipid catalysts catalysis covalent reactions” found no passage making that point. Page numbers were not available in our copy. (LLM, conf=0.76)
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- Authors
- Zubarev, D. Y., Rappoport, D., & Aspuru-Guzik, A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Zubarev, Dmitry Yu
- Venue
- Scientific Reports
- Published
- 2015-01-26
- Volume
- 5
- Issue
- 1
- Pages
- 8009-8009
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4306138
- OpenAlex
- W2052588218
- Cited by
- 63
- References
- 24
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 3 · 2015: 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Science Foundation (1125087)
- Simons Foundation (SCOL 291937)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- origin of life, prebiotic chemistry, reverse tricarboxylic acid cycle, non-enzymatic catalysis, metabolic network evolution, uncertainty quantification
- MeSH terms
- Origin of Life, Citric Acid Cycle, Biological Evolution, Models, Theoretical, Quantum Theory, Metabolic Networks and Pathways
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