Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis
Open accessAbstract
Pulmonary fibrosis is a serious lung disorder that can lead to respiratory failure. Here we show that transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary fibrosis leading to impaired pulmonary function. Histological analyses revealed a marked increase in extracellular matrix (ECM) deposition and decrease in alveolar size in the lungs of RenTgMK mice compared to wild-type (WT) littermates, accompanied with increased expression of ECM proteins and fibrogenic factors. The increase in lung fibrosis led to a substantial decrease in respiratory system compliance. Two-week treatment with aliskiren (renin inhibitor) or losartan (AT1 antagonist) ameliorated pulmonary ECM deposition, blocked the induction of ECM proteins and fibrogenic factors and improved respiratory compliance in RenTgMK mice, confirming a critical role of the renin-Ang II-AT1 cascade in promoting pulmonary fibrogenesis. However, when RenTgMK mice were treated with hydralazine (a smooth muscle relaxant), the blood pressure was normalized but the lung fibrotic abnormalities, fibrogenic gene induction and pulmonary elasticity were not corrected. Moreover, intratracheal instillation of lipopolysaccharide induced more severe lung injury in RenTgMK mice compared to WT littermates. These observations demonstrate that the renin-angiotensin system is a key mediator of lung fibrosis and its pro-fibrotic effect is independent of blood pressure.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RAAS mediates key events of COVID-19, including viral entry in the cell, inflammation, and lung fibrosis.
“RAAS mediates key events of the disease, including viral entry in the cell [112, 113], inflammation, and lung fibrosis [114].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [114]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The American Journal of Physiology
(1899) · The American Naturalist · doi:10.1086/277182 · Cited by 5,680 · see citing works
Animal models of acute lung injury
Matute‐Bello, G., Frevert, C. W., & Martin, T. R. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00010.2008 · Cited by 1,744 · see citing works
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625 · see citing works
Self-citationFibrosis–a common pathway to organ injury and failure
Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428 · see citing works
Gross, T. J., & Hunninghake, G. W. (2001) · New England Journal of Medicine · doi:10.1056/nejmra003200 · Cited by 970 · see citing works
Pulmonary fibrosis: pathogenesis, etiology and regulation
Wilson, M. S., & Wynn, T. A. (2009) · Mucosal Immunology · doi:10.1038/mi.2008.85 · Cited by 821 · see citing works
Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.
Ignotz, R. A., Endo, T., & Massagué, J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48258-0 · Cited by 722 · see citing works
Structure-based design of aliskiren, a novel orally effective renin inhibitor
Wood, J. M., Maibaum, J., Rahuel, J., Grütter, M. G., Cohen, N.-C., Rasetti, V., Rüeger, H., Göschke, R., Stutz, S., Fuhrer, W., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01451-7 · Cited by 504 · see citing works
Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury
Peng, X., Hassoun, P. M., Sammani, S., McVerry, B. J., Burne, M. J., Rabb, H., Pearse, D. B., Tuder, R. M., & Garcia, J. G. N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200309-1258oc · Cited by 493 · see citing works
Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis
Selman, M., Pardo, A., Barrera, L., Estrada, A., Watson, S. R., Wilson, K., Aziz, N. A., Kaminski, N., & Zlotnik, A. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-644oc · Cited by 455 · see citing works
New Mechanisms of Pulmonary Fibrosis
Strieter, R. M., & Mehrad, B. (2009) · CHEST Journal · doi:10.1378/chest.09-0510 · Cited by 287 · see citing works
Knudsen, L., Weibel, E. R., Gundersen, H. J. G., Weinstein, F. V., & Ochs, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2009 · Cited by 281 · see citing works
Angiotensin II and the fibroproliferative response to acute lung injury
Marshall, R. P., Gohlke, P., Chambers, R. C., Howell, D. C. J., Bottoms, S., Unger, T., McAnulty, R. J., & Laurent, G. J. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00313.2002 · Cited by 268 · see citing works
Wang, R., Ibarra-Sunga, O., Verlinski, L., Pick, R. L., & Uhal, B. D. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.1.l143 · Cited by 245 · see citing works
Angiotensin II Is Mitogenic for Human Lung Fibroblasts via Activation of the Type 1 Receptor
Marshall, R. P., McAnulty, R. J., & Laurent, G. J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.6.9907004 · Cited by 208 · see citing works
Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism
Li, Y. C., Bolt, M. J. G., Cao, L., & Sitrin, M. D. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.3.e558 · Cited by 161 · see citing works
Uhal, B. D., Kim, J. K., Li, X., & Molina‐Molina, M. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780618885 · Cited by 147 · see citing works
Angiotensin signalling in pulmonary fibrosis
Uhal, B. D., Li, X., Piasecki, C. C., & Molina‐Molina, M. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.11.019 · Cited by 128 · see citing works
Inagami, T. (1981) · Annals of Internal Medicine · doi:10.7326/0003-4819-94-1-143_5 · Cited by 121 · see citing works
Finckenberg, P., Inkinen, K. A., Ahonen, J. P., Merasto, S., Louhelainen, M., Vapaatalo, H., Müller, D. N., Ganten, D., Luft, F. C., & Mervaala, E. M. A. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63659-0 · Cited by 109 · see citing works
Vitamin D Receptor Signaling Inhibits Atherosclerosis in Mice
Szeto, F. L., Reardon, C. A., Yoon, D., Wang, Y., Wong, K. E., Chen, Y., Kong, J., Liu, S. Q., Thadhani, R., Getz, G. S., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1329 · Cited by 102 · see citing works
Self-citationMolteni, A., Wolfe, L. F., Ward, W. F., Ts'ao, C.-H., Brizio-Molteni, L., Veno, P. A., Fish, B. L., Taylor, J. M., Quintanilla, N., Herndon, B., et al. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780618777 · Cited by 102 · see citing works
The Angiotensin II Receptor 2 Is Expressed and Mediates Angiotensin II Signaling in Lung Fibrosis
Königshoff, M., Wilhelm, A., Jahn, A., Sedding, D., Amarie, O. V., Eul, B. G., Seeger, W., Fink, L., Günther, A., Eickelberg, O., et al. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0379tr · Cited by 92 · see citing works
Bronchoalveolar Lavage Fluid Angiotensin-converting Enzyme in Interstitial Lung Diseases
Specks, U., Wj, M., & Rohrbach, M. S. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.117 · Cited by 82 · see citing works
Losartan Attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats
Yao, H. W., Zhu, J. P., Zhao, M. H., & Lu, Y. (2005) · Respiration · doi:10.1159/000090140 · Cited by 82 · see citing works
Extravascular sources of lung angiotensin peptide synthesis in idiopathic pulmonary fibrosis
Li, X., Molina‐Molina, M., Abdul‐Hafez, A., Ramírez, J., Serrano‐Mollar, A., Xaubet, A., & Uhal, B. D. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00432.2005 · Cited by 77 · see citing works
Liu, L., Qiu, H., Yang, Y., Wang, L., Ding, H.-M., & Li, H.-P. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.09.019 · Cited by 68 · see citing works
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
Caron, K. M., James, L. R., Kim, H., Knowles, J. W., Uhlir, R., Mao, L., Hagaman, J. R., Cascio, W. E., Rockman, H. A., & Smithies, O. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307333101 · Cited by 50 · see citing works
Renin is an angiotensin-independent profibrotic mediator: role in pulmonary fibrosis
Montes, E., Ruiz, V., Checa, M., Maldonado, V., Meléndez-Zajgla, J., Montaño, M., Ordóñez‐Razo, R. M., Cisneros, J., de Alba, C. G., Pardo, A., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00130310 · Cited by 37 · see citing works
Angiotensin II type-1 receptor antagonist attenuates LPS-induced acute lung injury
Wang, F., Xia, Z., Chen, X., Jia, Y., Wang, Y., & Ma, B. (2009) · Cytokine · doi:10.1016/j.cyto.2009.08.001 · Cited by 36 · see citing works
Alterations in structure of elastic laminae of rat pulmonary arteries in hypoxic hypertension
Liu, S. Q. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.5.2147 · Cited by 28 · see citing works
Self-citationThe RenTg Mice: A Powerful Tool to Study Renin-Dependent Chronic Kidney Disease
Huby, A.-C., Kavvadas, P., Alfieri, C., Abed, A., Toubas, J., Rastaldi, M.-P., Dussaule, J., Chatziantoniou, C., & Chadjichristos, C. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052362 · Cited by 19 · see citing works
Kavvadas, P., Weis, L., Abed, A., Feldman, D. L., Dussaule, J., & Chatziantoniou, C. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00639 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The impact of ethnicity on clinical outcomes in COVID-19: A systematic review
Pan, D., Sze, S., Minhas, J. S., Bangash, M. N., Pareek, N., Divall, P., Williams, C., Oggioni, M. R., Squire, I. B., Nellums, L. B., et al. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100404 · Cited by 520 · see citing works
Nicotine and the renin-angiotensin system
Oakes, J. M., Fuchs, R. M., Gardner, J. D., Lazartigues, E. D., & Yue, X. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00099.2018 · Cited by 318 · see citing works
Targeting the renin–angiotensin system as novel therapeutic strategy for pulmonary diseases
Tan, W. S. D., Liao, W., Zhou, S., Mei, D. F., & Wong, W. S. F. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.12.002 · Cited by 182 · see citing works
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
Quesada‐Gómez, J. M., Castillo, M. E., & Bouillon, R. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105719 · Cited by 145 · see citing works
Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19
Heialy, S. A., Hachim, M. Y., Senok, A. C., Gaudet, M., Tayoun, A. N. A., Hamoudi, R., Alsheikh-Ali, A. A. A., & Hamid, Q. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.555039 · Cited by 134 · see citing works
Shi, Y., Liu, T., Li, Y., Xing, Y., Zhao, X., Fu, J., & Xue, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-03474-6 · Cited by 113 · see citing works
Self-citationLiu, P., Wysocki, J. A., Souma, T., Ye, M., Ramirez, V., Zhou, B., Wilsbacher, L. D., Quaggin, S. E., BATLLE, D. C., & Jin, J. (2018) · Kidney International · doi:10.1016/j.kint.2018.01.029 · Cited by 106 · see citing works
The Impact of Vitamin D in the Treatment of Essential Hypertension
Legarth, C., Grimm, D. G., Wehland, M., Bauer, J. W., & Krüger, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020455 · Cited by 102 · see citing works
Queiroz‐Junior, C. M., dos Santos, A. C. P. M., Galvão, I., Souto, G. R., Mesquita, R. A., de Sá, M. A., & Ferreira, A. J. (2019) · Bone · doi:10.1016/j.bone.2019.115041 · Cited by 82 · see citing works
Shah, H., Khan, M. S. H., Dhurandhar, N. V., & Hegde, V. (2021) · Acta Diabetologica · doi:10.1007/s00592-020-01636-z · Cited by 80 · see citing works
Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin
Hosseinzadeh, A., Javad-Moosavi, S. A., Reiter, R. J., Hemati, K., Ghaznavi, H., & Mehrzadi, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.03.032 · Cited by 75 · see citing works
The renin‐angiotensin system in cutaneous hypertrophic scar and keloid formation
Hedayatyanfard, K., Haddadi, N., Ziai, S. A., Karim, H., Niazi, F., Steckelings, U. M., Habibi, B., Modarressi, A., & Dehpour, A. R. (2020) · Experimental Dermatology · doi:10.1111/exd.14154 · Cited by 60 · see citing works
Sun, N.-N., Yu, C., Pan, M., Zhang, Y., Zheng, B., Yang, Q., Zheng, Z., & Meng, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-13305-3 · Cited by 58 · see citing works
Sarangarajan, R., Winn, R. A., Kiebish, M. A., Bountra, C., Granger, E., & Narain, N. R. (2020) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-020-00853-0 · Cited by 53 · see citing works
Chang, J., Nie, H., Ge, X., Du, J., Liu, W., Li, X., Sun, Y., Wei, X., Xun, Z., & Li, Y. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-96152-7 · Cited by 46 · see citing works
Nejat, R., & Sadr, A. S. (2020) · In Silico Pharmacology · doi:10.1007/s40203-020-00058-7 · Cited by 45 · see citing works
Silva, A. C. S. E., Lanza, K., Palmeira, V. A., Costa, L. B., & Flynn, J. T. (2020) · Pediatric Nephrology · doi:10.1007/s00467-020-04759-1 · Cited by 44 · see citing works
Candesartan could ameliorate the COVID-19 cytokine storm
ELKAHLOUN, A. G., & Saavedra, J. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110653 · Cited by 40 · see citing works
EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice
García‐Martín, A., Navarrete, C. M., Garrido‐Rodríguez, M., Prados, M. E., Caprioglio, D., Appendino, G., & Muñóz, E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112007 · Cited by 39 · see citing works
Gupta, D., Kumar, A., Mandloi, A. S., & Shenoy, V. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105924 · Cited by 39 · see citing works
Angiotensin Receptor Blockers Are Not Just for Hypertension Anymore
Saavedra, J. M. (2021) · Physiology · doi:10.1152/physiol.00036.2020 · Cited by 37 · see citing works
Cheng, X., Jiang, S., Pan, B., Xie, W., & Meng, J. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01964-3 · Cited by 39 · see citing works
He, L., Sun, F., Wang, Y., Zhu, J., Fang, J., Zhang, S., Yu, Q., Gong, Q., Ren, B., Xiang, X., et al. (2016) · PubMed Central · Cited by 34 · see citing works
ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica
Li, S., Li, Y., Xu, H., Wei, Z., Yang, Y., Jin, F., Zhang, M., Wang, C., Song, W., Huo, J., et al. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s252351 · Cited by 25 · see citing works
Xu, X., Shi, L., Ma, X., Su, H., Ma, G., Wu, X., Ying, K., & Zhang, R. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.02.016 · Cited by 24 · see citing works
AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations
Darrah, R. J., Jacono, F. J., Joshi, N., Mitchell, A. L., Sattar, A., Campanaro, C., Litman, P., Frey, J., Nethery, D. E., Barbato, E. S., et al. (2018) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2018.05.013 · Cited by 24 · see citing works
Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease
Monteonofrio, L., Florio, M. C., AlGhatrif, M., Lakatta, E. G., & Capogrossi, M. C. (2020) · Vascular Biology · doi:10.1530/vb-20-0014 · Cited by 20 · see citing works
Dysbalance of ACE2 levels – a possible cause for severe COVID ‐19 outcome in COPD
Fließer, E., Birnhuber, A., Marsh, L. M., Gschwandtner, E., Klepetko, W., Olschewski, H., & Kwapiszewska, G. (2021) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.224 · Cited by 19 · see citing works
Li, S., Li, Y., Zhang, Y., Li, S., Zhang, M., Jin, F., Wei, Z., Yang, Y., Gao, X., Mao, N., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115255 · Cited by 18 · see citing works
Association between the renin–angiotensin system and chronic lung allograft dysfunction
Berra, G., Farkona, S., Mohammed‐Ali, Z., Kotlyar, M., Levy, L., Clotet‐Freixas, S., Ly, P., Renaud-Picard, B., Zehong, G., Daigneault, T., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.02975-2020 · Cited by 17 · see citing works
Vitamin D Endocrine System and COVID‐19
Bouillon, R., & Quesada‐Gómez, J. M. (2021) · JBMR Plus · doi:10.1002/jbm4.10576 · Cited by 17 · see citing works
Vitamin D and pulmonary fibrosis: a review of molecular mechanisms.
Ma, D., & Peng, L. (2019) · PubMed Central · Cited by 17 · see citing works
Dynamic Variation of RAS on Silicotic Fibrosis Pathogenesis in Rats
Zhang, B., Zhang, X., Xu, H., Gao, X., Zhang, G., Zhang, H., & Yang, F. (2019) · Current Medical Science · doi:10.1007/s11596-019-2073-8 · Cited by 15 · see citing works
The use of aliskiren as an antifibrotic drug in experimental models: A systematic review
Marin, T. A., Bertassoli, B. M., Carvalho, A. A. D. S., & Feder, D. (2019) · Drug Development Research · doi:10.1002/ddr.21610 · Cited by 15 · see citing works
Shamloo, K., Weng, J., Ross, C. A., Lee, J., Alfuraih, S., Totonchy, J. E., & Sharma, A. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.13.10 · Cited by 15 · see citing works
Olkowicz, M., Ramadan, K. Z., Rosales-Solano, H., Yu, M., Wang, A., Cypel, M., & Pawliszyn, J. B. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.08.001 · Cited by 14 · see citing works
Humphries, H., Brasch, H. D., van Schaijik, B., Tan, S. T., & Itinteang, T. (2019) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000005867 · Cited by 14 · see citing works
Raupp, D., Fernandes, R. S., Antunes, K. H., Perin, F. A., & Rigatto, K. (2020) · Peptides · doi:10.1016/j.peptides.2020.170384 · Cited by 14 · see citing works
Gautam, R. K., Laltanpuia, Singh, N., & Kushwaha, S. (2025) · Inhalation Toxicology · doi:10.1080/08958378.2025.2461048 · Cited by 13 · see citing works
Radiation-induced pulmonary fibrosis: roles of therapy-induced senescence and microRNAs
Prasanna, P. G. S., Aryankalayil, M. J., Citrin, D. E., & Coleman, C. N. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2177768 · Cited by 13 · see citing works
A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury
Cassatt, D. R., Gorovets, A., Karimi-Shah, B. A., Roberts, R., Price, P. W., Satyamitra, M. M., Todd, N. F., Wang, S., & Marzella, L. (2021) · Radiation Research · doi:10.1667/rade-21-00127.1 · Cited by 12 · see citing works
Gurzu, I. L., Handra, C. M., Ghiţă, I., & Oțelea, M. R. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1506846 · Cited by 12 · see citing works
Abid, A., Khan, M. A., Lee, B. W. H., White, A. J. R., Carnt, N. A., Arshad, S., & Samarawickrama, C. (2022) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1155/2022/9970922 · Cited by 12 · see citing works
Hussien, N. I., El-kerdasy, H. I., Sorour, S. M., & Shoman, A. A. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1676262 · Cited by 11 · see citing works
Role of melatonin in respiratory diseases (Review)
Li, L., Gang, X., Wang, J., & Gong, X. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11197 · Cited by 11 · see citing works
Self-citationPotential use of angiotensin receptor blockers in skin pathologies.
Hedayatyanfard, K., Khalili, A., Karim, H., Nooraei, S., Khosravi, E., Haddadi, N., Dehpour, A. R., & Bayat, G. (2023) · PubMed Central · doi:10.22038/ijbms.2023.66563.14606 · Cited by 10 · see citing works
Protective Effect of Angiotensin (1-7) on Silicotic Fibrosis in Rats.
Zhang, B. N., Xu, H., Gao, X. M., Zhang, G. Z., Zhang, X., & Yang, F. (2019) · PubMed · doi:10.3967/bes2019.057 · Cited by 10 · see citing works
Targeting the renin angiotensin system for respiratory diseases
Gan, P. X. L., Liao, W., Linke, K. M., Mei, D., Wu, X. D., & Wong, W. S. F. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.02.002 · Cited by 9 · see citing works
Lang, C., Huang, B., Chen, Y., & He, Z. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1615991 · Cited by 8 · see citing works
Vitamin D and the Renin-Angiotensin System
Li, Y. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809965-0.00045-8 · Cited by 8 · see citing works
AL-Eitan, L. N., & Alahmad, S. Z. (2023) · Journal of Biosafety and Biosecurity · doi:10.1016/j.jobb.2023.07.005 · Cited by 8 · see citing works
Vitamin D and the renin–angiotensin system
Li, Y. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91386-7.00015-5 · Cited by 7 · see citing works
Zhang, Y., Yang, F., Liu, Y., Peng, H., Geng, Y., Li, S., Xu, H., Zhu, L., Yang, X., & Brann, D. W. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8824 · Cited by 6 · see citing works
Angiotensin II as a Vasopressor for Perioperative Hypotension in Solid Organ Transplant
Benken, S. T., Thomas, R., Fraidenburg, D. R., & Benken, J. J. (2024) · Biomedicines · doi:10.3390/biomedicines12081817 · Cited by 5 · see citing works
Liang, L., Chung, S. I., Guon, T., Park, K. H., Lee, J., & Park, J. (2024) · Respiratory Research · doi:10.1186/s12931-024-02842-x · Cited by 5 · see citing works
Silveira, A. T., Sagrillo‐Fagundes, L., Flôr, J. D. S., Martins, I. A., Otero, L. B., da Silva, L. T. M., Maciel, L. S., Eller, S. C. W. D. S., Guimarães, G. R., Perin, F. A., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13092312 · Cited by 4 · see citing works
Svobodová, B., Löfdahl, A., Nybom, A., Wigén, J., Hirdman, G., Olm, F., Brunnström, H., Lindstedt, S., Westergren‐Thorsson, G., & Elowsson, L. (2024) · Biomedicines · doi:10.3390/biomedicines12122893 · Cited by 4 · see citing works
Özdemir, M., Guirao-Abad, J. P., Kasprovic, D. A., Jaggers, R. M., & Kanisicak, O. (2025) · Cells · doi:10.3390/cells14201584 · Cited by 3 · see citing works
Lehman, M., Domenig, O., Ames, M. K., & Morgan, J. M. (2024) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.17208 · Cited by 3 · see citing works
Lindberg, L. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1504180 · Cited by 2 · see citing works
Infection and obesity: Two sides of the same coin
Nateqi, M., Baliga, V., & Hegde, V. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85730-7.00001-1 · Cited by 1 · see citing works
Park, C. M., Jeon, S., Yang, M., & Kim, M. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116838 · Cited by 1 · see citing works
Villela, D. C., Namsolleck, P., Reichetzeder, C., & Moll, G. N. (2023) · Peptides · doi:10.1016/j.peptides.2023.171106 · Cited by 1 · see citing works
Pathophysiology of Cardiovascular Disease in Chronic Lung Disease
Parekh, T. M., & Dransfield, M. T. (2020) · Respiratory medicine · doi:10.1007/978-3-030-43435-9_4
Is ACE2 a friend or foe in the fight against the COVID19 pandemic?
Hossain, N. (2020) · University of Western Ontario Medical Journal · doi:10.5206/uwomj.v89is.10575
Long-term effects of radiation therapy in outpatient practice
Karseladze, N. D., Tiganova, O. A., Ilyenko, L. I., Nv, O., & Danelyan, S. Z. (2024) · Medical alphabet · doi:10.33667/2078-5631-2024-13-34-41
Cellular response in the pathogenesis of COVID-19
Sharma, L., Kim, J., & Cruz, C. S. D. (2024) · European Respiratory Society eBooks · doi:10.1183/2312508x.10019823
Martins, I. A., Silveira, A. T., Flor, J., Blanco, A., Guimarães, G. R., Vizuete, A. F. K., & Rigatto, K. (2026) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-026-10863-x
- Authors
- Wang, J., Chen, L., Chen, B., Meliton, A., Liu, S. Q., Shi, Y., Liu, T., Deb, D. K., Solway, J., & Chun Li, Y.
- Affiliations
- University of Chicago (US)
- Sheng Jing Hospital (CN)
- Northwestern University (US)
- Venue
- Scientific Reports
- Published
- 2015-10-23
- Volume
- 5
- Issue
- 1
- Pages
- 15561-15561
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4616037
- OpenAlex
- W2410545784
- Cited by
- 70
- References
- 34
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 11 · 2020: 15 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 1
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health (UL1TR000430)
- National Cancer Institute (R01CA180087)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- pulmonary fibrosis, renin-angiotensin system, angiotensin II, angiotensin II type 1 receptor, aliskiren, losartan, hydralazine, extracellular matrix deposition, fibrogenic factors, respiratory compliance, lipopolysaccharide-induced lung injury, transgenic mice, renin overexpression
- MeSH terms
- Angiotensin II, Animals, Hypertension, Mice, Transgenic, Pulmonary Fibrosis, Renin-Angiotensin System, Disease Progression, Receptor, Angiotensin, Type 2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
