Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma
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Magnetic Resonance Imaging (MRI) has been routinely used for the diagnosis and treatment of breast cancer. However, the relationship between the MRI tumor phenotypes and the underlying genetic mechanisms remains under-explored. We integrated multi-omics molecular data from The Cancer Genome Atlas (TCGA) with MRI data from The Cancer Imaging Archive (TCIA) for 91 breast invasive carcinomas. Quantitative MRI phenotypes of tumors (such as tumor size, shape, margin and blood flow kinetics) were associated with their corresponding molecular profiles (including DNA mutation, miRNA expression, protein expression, pathway gene expression and copy number variation). We found that transcriptional activities of various genetic pathways were positively associated with tumor size, blurred tumor margin and irregular tumor shape and that miRNA expressions were associated with the tumor size and enhancement texture, but not with other types of radiomic phenotypes. We provide all the association findings as a resource for the research community (available at http://compgenome.org/Radiogenomics/). These findings pave potential paths for the discovery of genetic mechanisms regulating specific tumor phenotypes and for improving MRI techniques as potential non-invasive approaches to probe the cancer molecular status.
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- Authors
- Zhu, Y., Li, H., Guo, W., Drukker, K., Lan, L., Giger, M. L., & Ji, Y.
- Affiliations
- Endeavor Health (US)
- University of Chicago (US)
- Fudan University (CN)
- Corresponding author
- Giger, Maryellen L.
- Ji, Yuan
- Venue
- Scientific Reports
- Published
- 2015-12-07
- Volume
- 5
- Issue
- 1
- Pages
- 17787-17787
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4671006
- OpenAlex
- W2191672666
- Cited by
- 165
- References
- 45
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 23 · 2021: 18 · 2020: 29 · 2019: 16 · 2018: 22 · 2017: 21 · 2016: 4
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (U01CA195564, R01CA132897)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- invasive breast cancer, radiogenomics, quantitative MRI, tumor size, tumor shape, tumor margin, microRNA expression, DNA mutations, copy number variation, multi-omics integration, tumor molecular profiles
- MeSH terms
- Breast Neoplasms, Female, Humans, Magnetic Resonance Imaging, Mutation, Neoplasm Invasiveness, Phenotype, Radiography, Transcription, Genetic, Genome, Human, MicroRNAs, Genetic Association Studies
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