Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro
Open accessAbstract
Madecassoside (MA), a triterpenoid saponin isolated from C. asitica, exerts various pharmacological activity including antioxidative and antinflammatory. Doxorubicin (DOX), a common chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal-toxicity. We hypothesized that MA administration may decrease renal-toxicity caused by DOX. In this study, we investigated this hypothesis by introducing MA and DOX into the culture of Human Proximal Tubule Cells HK-2 and mice model. Our in vivo study demonstrated that MA (12 mg/kg), treatment for two weeks attenuated DOX-induced renal injury via protecting renal function, recovering antioxidant enzyme activity, inhibiting Bax, p-ERK1/2, NF-κB p65, iNOS expression and increasing Bcl-2 expression. Similar findings were obtained in our in vitro studies with treatment of DOX and/or MA. Further studies with application of iNOS inhibitor and ERK1/2 kinase inhibitor indicated that the inhibitory effects of MA on DOX-induced apoptosis and inflammation might be mediated by the suppression of the activation of cleaved caspase-3, ERK1/2 pathways, NF-κB p65 and NO production. These results suggest that MA is a promising protective agent for DOX-induced renal toxicity and can be a potential candidate to protect against renal toxicity in DOX-treated cancer patients.
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Madecassoside exhibits nephroprotective properties by protecting against nephrotoxicity.
“Madecassoside exhibits nephroprotective properties by protecting against nephrotoxicity”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [124]
DOX-induced cytotoxicity can be suppressed by treating with madecassoside, as it inhibits DOX-associated apoptosis and inflammation in HK-2 cells.
“This DOX‐induced cytotoxicity can be suppressed by treating with madecassoside, as it inhibits DOX‐associated apoptosis and inflammation in HK‐2 cells”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [124]
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
Tan, S. C., Bhattamisra, S. K., Chellappan, D. K., & Candasamy, M. (2021) · Applied Sciences · doi:10.3390/app11188475 · Cited by 72 · see citing works
- Authors
- Su, Z., Ye, J., Qin, Z., & Ding, X.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Corresponding author
- Qin, Zhenxia
- Ding, Xianting
- Venue
- Scientific Reports
- Published
- 2015-12-14
- Volume
- 5
- Issue
- 1
- Pages
- 18314-18314
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4677317
- OpenAlex
- W2258638262
- Cited by
- 83
- References
- 2
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 13 · 2022: 13 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 12 · 2017: 5 · 2016: 2
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81301293, 51375444)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
- Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
- Keywords
- madecassoside, doxorubicin, nephrotoxicity, renal protection, triterpenoid saponins, apoptosis, ERK signaling, NF-κB p65, inducible nitric oxide synthase, nitric oxide, oxidative stress, inflammation, Bcl-2, Bax, caspase-3, chemotherapy-induced kidney injury
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Antioxidants, Body Weight, Cell Line, Cell Survival, Doxorubicin, Kidney, Kidney Function Tests, Male, Nephritis, Nitric Oxide, Triterpenes, NF-kappa B, Apoptosis, Protective Agents, MAP Kinase Signaling System, Mice
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