The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF
Open accessAbstract
The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n = 115) from women experiencing RIF and healthy controls. Using a signature discovery set (n = 81) we identify a signature containing 303 genes predictive of RIF. Independent validation in 34 samples shows that the gene signature predicts RIF with 100% positive predictive value (PPV). The strength of the RIF associated expression signature also stratifies RIF patients into distinct groups with different subsequent implantation success rates. Exploration of the expression changes suggests that RIF is primarily associated with reduced cellular proliferation. The gene signature will be of value in counselling and guiding further treatment of women who fail to conceive upon IVF and suggests new avenues for developing intervention.
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pROC: an open-source package for R and S+ to analyze and compare ROC curves
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Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways
van Wageningen, S., Kemmeren, P., Lijnzaad, P., Margaritis, T., Benschop, J. J., de Castro, I. J., van Leenen, D., Groot Koerkamp, M. J. A., Ko, C. W., Miles, A. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.021 · Cited by 133
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Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids
Rawlings, T. M., Makwana, K., Taylor, D. M., Molè, M. A., Fishwick, K. J., Tryfonos, M., Odendaal, J., Hawkes, A., Zernicka-Goetz, M., Hartshorne, G. M., et al. (2021) · eLife · doi:10.7554/elife.69603 · Cited by 269
Pirtea, P., De Ziegler, D., Tao, X., Sun, L., Zhan, Y., Ayoubi, J. M., Seli, E., Franasiak, J. M., & Scott, R. T. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.07.002 · Cited by 206
Gibson, D. A., Foster, P. A., Simitsidellis, I., Critchley, H. O. D., Kelepouri, O., Collins, F., & Saunders, P. T. K. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0037 · Cited by 10
Metadata
- Authors
- Koot, Y. E. M., van Hooff, S. R., Boomsma, C. M., van Leenen, D., Groot Koerkamp, M. J. A., Goddijn, M., Eijkemans, M. J. C., Fauser, B. C. J. M., Holstege, F. C. P., & Macklon, N. S.
- Venue
- Scientific Reports
- Published
- 2016-01-22
- Volume
- 6
- Issue
- 1
- Pages
- 19411-19411
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2400783197
- Cited by
- 178
- References
- 6
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF. https://app.cochat.ai/papers/10.1038/srep19411
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- Koot, Y. E. M., van Hooff, S. R., Boomsma, C. M., van Leenen, D., Groot Koerkamp, M. J. A., Goddijn, M., Eijkemans, M. J. C., Fauser, B. C. J. M., Holstege, F. C. P., & Macklon, N. S. (2016). An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF. Scientific Reports. https://doi.org/10.1038/srep19411
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
