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Cited by 146Tea Polyphenols and EffectsNanoparticles: synthesis and applicationsPhytochemicals and Antioxidant Activities

Bactericidal activity of green tea extracts: the importance of catechin containing nano particles

Open access
Gopal, Judy, Muthu, Manikandan, Paul, Diby, Kim, Doo-Hwan, Chun, Sechul·2016·Scientific Reports
DOI 10.1038/srep19710PMC PMC4730195
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Abstract

When we drink green tea infusion, we believe we are drinking the extract of the green tea leaves. While practically each tea bag infused in 300 mL water contains about 50 mg of suspended green tea leaf particles. What is the role of these particles in the green tea effect is the objective of this study. These particles (three different size ranges) were isolated via varying speed centrifugation and their respective inputs evaluated. Live oral bacterial samples from human volunteers have been screened against green tea extracts and macro, micro and nano sized green tea particles. The results showed that the presence/absence of the macro and mico sized tea particles in the green tea extract did not contribute much. However, the nano sized particles were characterized to be nature's nano stores of the bioactive catechins. Eradication of these nano tea particles resulted in decrease in the bactericidal property of the green tea extracts. This is a curtain raiser investigation, busting the nano as well as green tea leaf particle contribution in green tea extracts.

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Crossref · 10.1038/srep19710

Cites

46 of 46 references verified0 citation errors · 0 not checkable

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  • The subcellular size allows penetration of nanoparticles or nanoemulsion droplets into microbial cells, leading to enhanced activity.

    “This allows the penetration of the nanoparticles or nanoemulsion droplets to the microbial cells leading to enhanced activity (265, 266).”

    From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [265]

    The Discussion reports that catechin-containing near-nano and nano-sized green tea particles contribute to enhanced antimicrobial activity, and the Results report reduced antibacterial activity when smaller particles are removed. The paper does not say that the particles penetrate microbial cells or that penetration explains the activity; it also does not study nanoemulsion droplets. No page numbers are available in our copy. (LLM, conf=0.87)

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  • Nanoparticles of plant extracts and essential oils have shown higher antioxidant and antimicrobial activities compared with their crude extracts or essential oils.

    “Moreover, nanoparticles of plant extracts and EO have shown higher antioxidant and antimicrobial activities as compared with their crude extracts or EO (265).”

    From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [265]

    The Discussion reports enhanced antioxidant and antimicrobial activity for near-nano green tea particles and a loss of antibacterial activity when those particles were removed from the extract. But the Results (Bioactivity Testing–Anti-Streptococcal activity; page unavailable) explicitly say the particles alone were not more antibacterial than the extracts. The study concerns green tea, not essential oils, so it does not support the broader comparison claimed. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • The higher antimicrobial activity of nanoparticles or nanoemulsions of phytochemicals is related to their size, which is in the subcellular size range.

    “The higher antimicrobial activity of the nanoparticles or nanoemulsion of phytochemicals is related to the size of the nanoparticles or nanoemulsion droplets, which is in the subcellular size range.”

    From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [265]

    The Conclusion (page unavailable) says green-tea particle size affected the extract’s antibacterial activity, and the Discussion reports greater activity when catechin-containing near-nano particles were retained. The paper does not establish that subcellular size is the reason for that activity, nor does it study nanoemulsion droplets or phytochemicals generally. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 2

  1. Juneja L. R., Chu D.-C. & Kim M. (Eds) General chemical composition of green tea and its infusion Chemistry and Applications of Green Tea. 13– 22 (CRC Press Boca Raton, 1997).
  2. Pytkowska K. & Herbata – działanie kosmetyczne. Wiadomości PTK. 5, 23 (2002).

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Authors
Gopal, J., Muthu, M., Paul, D., Kim, D.-H., & Chun, S.
Affiliations
Konkuk University (KR)
Corresponding author
Chun, Sechul
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-01-28
Volume
6
Issue
1
Pages
19710-19710
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep19710
PMC
PMC4730195
OpenAlex
W2426201233
Cited by
146
References
46
Citations by year
2026: 11 · 2025: 19 · 2024: 20 · 2023: 23 · 2022: 26 · 2021: 14 · 2020: 11 · 2019: 11 · 2018: 5 · 2017: 4 · 2016: 2
FWCI
6.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Konkuk University
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
green tea extract, catechins, bactericidal activity, oral bacteria, particle size, bioactive compounds
MeSH terms
Anti-Bacterial Agents, Catechin, Female, Humans, Male, Mouth, Plant Extracts, Tea, Nanoparticles

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