The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Intestinal Microbiota Distinguish Gout Patients from Healthy Humans
Open accessAbstract
Current blood-based approach for gout diagnosis can be of low sensitivity and hysteretic. Here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that the intestinal microbiota of gout patients are highly distinct from healthy individuals in both organismal and functional structures. In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched yet Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted. The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients. In an additional 15-member validation-group, a diagnosis model via 17 gout-associated bacteria reached 88.9% accuracy, higher than the blood-uric-acid based approach. Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes. Thus the Microbial Index of Gout was proposed as a novel, sensitive and non-invasive strategy for diagnosing gout via fecal microbiota.
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Cites
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Cited by
Hill‐Burns, E. M., Debelius, J. W., Morton, J. T., Wissemann, W. T., Lewis, M. R., Wallen, Z. D., Peddada, S. D., Factor, S. A., Molho, E., Zabetian, C. P., et al. (2017) · Movement Disorders · doi:10.1002/mds.26942 · Cited by 874
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Self-citationRevisit gut microbiota and its impact on human health and disease
Ding, R.-X., Goh, W.-R., Wu, R.-N., Yue, X.-Q., Luo, X., Khine, W. W. T., Wu, J.-R., & Lee, Y.-K. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.12.012 · Cited by 268
Self-citationWallen, Z. D., Appah, M., Dean, M. N., Sesler, C. L., Factor, S. A., Molho, E., Zabetian, C. P., Standaert, D. G., & Payami, H. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-020-0112-6 · Cited by 252
Metadata
- Authors
- Guo, Z., Zhang, J., Wang, Z., Ang, K. Y., Huang, S., Hou, Q., Su, X., Qiao, J., Zheng, Y., Wang, L., Koh, E., Danliang, H., Xu, J., Lee, Y. K., & Zhang, H.
- Venue
- Scientific Reports
- Published
- 2016-02-08
- Volume
- 6
- Issue
- 1
- Pages
- 20602-20602
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2259791095
- Cited by
- 382
- References
- 36
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guo, Z., Zhang, J., Wang, Z., Ang, K. Y., Huang, S., Hou, Q., Su, X., Qiao, J., Zheng, Y., Wang, L., Koh, E., Danliang, H., Xu, J., Lee, Y. K., & Zhang, H. (2016). Intestinal Microbiota Distinguish Gout Patients from Healthy Humans. Scientific Reports. https://doi.org/10.1038/srep20602
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