P2X7 Receptor Suppression Preserves Blood-Brain Barrier through Inhibiting RhoA Activation after Experimental Intracerebral Hemorrhage in Rats

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P2X7 Receptor Antagonism Inhibits p38 Mitogen-Activated Protein Kinase Activation and Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

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Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice

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17β-Estradiol Attenuates Hematoma Expansion Through Estrogen Receptor α/Silent Information Regulator 1/Nuclear Factor-kappa B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice

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Receptor for Advanced Glycation End-Product Antagonist Reduces Blood–Brain Barrier Damage After Intracerebral Hemorrhage

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Treatment with Thyroxine Restores Myelination and Clinical Recovery after Intraventricular Hemorrhage

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ATP release due to Thy-1–integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation

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Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats

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P2X7 Receptor Inhibition Increases CNTF in the Subventricular Zone, But Not Neurogenesis or Neuroprotection After Stroke in Adult Mice

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P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage

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Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood–Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway

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Taurine supplementation reduces neuroinflammation and protects against white matter injury after intracerebral hemorrhage in rats

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CD44 mediates shear stress mechanotransduction in an in vitro blood‐brain barrier model through small GTPases RhoA and Rac1

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TRPV4 Blockade Preserves the Blood–Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage

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Adenosine Triphosphate Accumulated Following Cerebral Ischemia Induces Neutrophil Extracellular Trap Formation

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Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Against Neuronal Apoptosis via Activation of Akt/MDM2/p53 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage

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Purinergic signaling: A gatekeeper of blood-brain barrier permeation

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Administration of an antagonist of P2X7 receptor to EAE rats prevents a decrease of expression of claudin-5 in cerebral capillaries

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l-lysine confers neuroprotection by suppressing inflammatory response via microRNA-575/PTEN signaling after mouse intracerebral hemorrhage injury

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Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways

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P2X7 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via MAPKs Signaling Pathways

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PPAR-γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage

Wang, G., Li, T., Duan, S.-N., Dong, L., Sun, X., & Xue, F. (2018) · Behavioural Neurology · doi:10.1155/2018/7646104 · Cited by 29 · see citing works

The P2X7 Receptor as a Mechanistic Biomarker for Epilepsy

Engel, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065410 · Cited by 28 · see citing works

Leveraging the ATP‐P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications

Yin, Y., Wei, L., Caseley, E. A., Lopez‐Charcas, O., Wei, Y., Li, D., Muench, S. P., Roger, S., Wang, L., & Jiang, L. (2023) · Medicinal Research Reviews · doi:10.1002/med.21952 · Cited by 25 · see citing works

Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N., Bhoj, P., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03230-4 · Cited by 23 · see citing works

The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases

Ou, A., Gu, B. J., & Wiley, J. S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.012 · Cited by 26 · see citing works

A fast and reproducible cell- and 96-well plate-based method for the evaluation of P2X7 receptor activation using YO-PRO-1 fluorescent dye

Rat, P., Olivier, E., Tanter, C., Wakx, A., & Dutot, M. (2017) · Journal of Biological Methods · doi:10.14440/jbm.2017.136 · Cited by 25 · see citing works

Cofilin Knockdown Attenuates Hemorrhagic Brain Injury-induced Oxidative Stress and Microglial Activation in Mice

Alhadidi, Q., Nash, K. M., Alaqel, S. I., Sayeed, M. S. B., & Shah, Z. A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.036 · Cited by 25 · see citing works

Methylene blue offers neuroprotection after intracerebral hemorrhage in rats through the PI3K/Akt/GSK3β signaling pathway

Chen, C., Zhou, F., Zeng, L., Jiang, Z., & Hu, Z. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27339 · Cited by 25 · see citing works

Blocking of P2X7r Reduces Mitochondrial Stress Induced by Alcohol and Electronic Cigarette Exposure in Brain Microvascular Endothelial Cells

Mekala, N. K., Gheewala, N., Rom, S., Sriram, U., & Persidsky, Y. (2022) · Antioxidants · doi:10.3390/antiox11071328 · Cited by 24 · see citing works

Ion channels in capillary endothelium

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Glycine confers neuroprotection through PTEN/AKT signal pathway in experimental intracerebral hemorrhage

Zhao, D., Chen, J., Zhang, Y., Liao, H., Zhang, Z., Zhuang, Y., Pan, M., Tang, J., Liu, R., Lei, Y., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.171 · Cited by 20 · see citing works

The Therapeutic Value of Bone Marrow-Derived Endothelial Progenitor Cell Transplantation after Intracerebral Hemorrhage in Rats

Zhang, R., Yang, J., Yuan, J., Song, B., Wang, Y., & Xu, Y. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00174 · Cited by 17 · see citing works

Tolvaptan attenuated brain edema in experimental intracerebral hemorrhage

Tan, Q., Li, Y., Guo, P., Zhou, J., Jiang, Z., Liu, X., Chen, Z., & Feng, H. (2019) · Brain Research · doi:10.1016/j.brainres.2019.01.033 · Cited by 15 · see citing works

Ion Channel Dysregulation Following Intracerebral Hemorrhage

Zhang, X., Zhang, Y., Su, Q., Liu, Y., Li, Z., Yong, V. W., & Xue, M. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01118-6 · Cited by 14 · see citing works

Systematic comparison of basic animal models of cerebral hypoperfusion

Chrishtop, V. V., Nikonorova, V. G., Gutsalova, A., Rumyantseva, T. А., Сергеевна, Д. М., & Salmina, A. B. (2021) · Tissue and Cell · doi:10.1016/j.tice.2021.101715 · Cited by 12 · see citing works

Insight into microRNAs-Mediated Communication between Liver and Brain: A Possible Approach for Understanding Acute Liver Failure?

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Urolithin A alleviates early brain injury after subarachnoid hemorrhage by regulating the AMPK/mTOR pathway-mediated autophagy

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Photoacoustic detecting of brain lymphatic dysfunction in inflammatory models

Wang, M., Wang, D., Wang, Z., Shi, W., & Wang, Z. (2025) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545825500154 · Cited by 8 · see citing works

Micro RNA ‐135a‐5p reduces P2X7‐dependent rise in intracellular calcium and protects against excitotoxicity

Reigada, D., Calderón‐García, A. Á., Soto‐Catalán, M., Nieto‐Díaz, M., Muñoz‐Galdeano, T., del Águila, Á., & Maza, R. M. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14700 · Cited by 7 · see citing works

The NLRP3 Inflammasome: A Possible Therapeutic Target for Treatment of Stroke

Ishrat, T., & Nasoohi, S. (2017) · Springer series in translational stroke research · doi:10.1007/978-3-319-66679-2_22 · Cited by 6 · see citing works

Cleavage of semaphorin 4 C interferes with the neuroprotective effect of the semaphorin 4 C/Plexin B2 pathway on experimental intracerebral hemorrhage in rats

Li, D., Li, X., Wang, J., Li, H., Shen, H., Xu, X. M., & Chen, G. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102318 · Cited by 5 · see citing works

P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives

Mithaiwala, A., Thakur, J., & Godad, A. P. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05330-5 · Cited by 4 · see citing works

Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential

Hu, Z., Xie, S., Chen, C., Luo, Z.-H., Deng, X., & Xiao, R. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1713748 · Cited by 3 · see citing works

Gene expression changes implicate specific peripheral immune responses to Deep and Lobar Intracerebral Hemorrhages in humans

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Fluid shear stress on astrocytes and microglia promotes neuronal toxicity in vitro via purinergic signalingPreprint

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Role of P2 X7 receptor during focused ultrasound induced blood brain barrier modulation

Park, J., Na, Y. C., Lee, J., Seo, Y., Kim, H., Han, S., Song, B.-W., & Chang, W. S. (2025) · Scientific Reports · doi:10.1038/s41598-024-83913-3 · Cited by 1 · see citing works

Serum P2X7 as a prognostic biomarker in acute supratentorial intracerebral hemorrhage: a two-center observational study

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Pathophysiology of Hemorrhagic Stroke

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Increased serum IgG antibody response to Merkel cell polyomavirus oncoproteins in patients with autoimmune rheumatic diseases

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Effect of Valproic Acid on NLR Family Pyrin Domain Containing 1/3 (NLRP1/3) Inflammasome in Rats with Acute Spinal Cord Injury

Feng, S., Huang, T., Shi, J., Wei, T., & Zhang, H. (2022) · Journal of Biomaterials and Tissue Engineering · doi:10.1166/jbt.2022.3008

Cleavage of semaphorin 4C interferes the neuroprotective effect of semaphorin 4C/Plexin B2 pathway on experimental intracerebral hemorrhage in ratsPreprint

Xu, X. M., Li, X., Li, H., Shen, H., You, W., & Chen, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1869123/v1

Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in ratsPreprint

Sun, J., Yang, X., Carmichael, A., Kim, T. J., Kim, Y. J., Wei, Z., Han, L., Stanciu, N., Ko, S., Nan, G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.22.558889

Control of Neuroinflammation and Protecting the Integrity of the Blood-Brain Barrier

Rom, S., & Persidsky, Y. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_42

Role of P2X7 receptor during low-intensity focused ultrasound-induced blood-brain barrier modulation

Park, J., Na, Y. C., Le, J., Kim, H., Han, S., Song, B.-W., & Chang, W. S. (2025) · Brain Stimulation · doi:10.1016/j.brs.2024.12.1026

Additional file 11 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129360

Additional file 12 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129366

Additional file 10 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129357

Additional file 5 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129342

Additional file 6 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129345

Additional file 3 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129336

Additional file 7 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129348

Additional file 9 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129354

Additional file 1 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129330

Additional file 8 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129351

Additional file 4 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129339

Additional file 2 of Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Togre, N. S., Mekala, N. K., Bhoj, P. S., Mogadala, N., Winfield, M., Trivedi, J., Grove, D., Kotnala, S., Rom, S., Sriram, U., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129333

Downregulating ROCK2 by human umbilical cord mesenchymal stem cells promotes pro-resolving microglial polarization and alleviates cerebral injury in germinal matrix hemorrhage

Yang, M., Wu, S., Xu, J., Zhu, X., & Chen, M. (2026) · Cell Transplantation · doi:10.1177/09636897261443446

Rare Variants in Purinergic P2X Receptor Genes (P2RX4, P2RX5, P2RX7) in Individuals With Autism Spectrum Disorder: An Exploratory Study

Ünsel‐Bolat, G., & Bolat, H. (2026) · Human Mutation · doi:10.1155/humu/5522396

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Feng, L., Chen, Y., Ding, R., Fu, Z., Yang, S., Deng, X., & Zeng, J. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0409-2 · Cited by 170 · see citing works

[Protective effects of P2X7 receptor inhibition in cerebral ischemia/reperfusion injury in rats].

Chen, Y., Tang, Y., Tong, X., Wu, J., Li, Y., & Dong, S. (2018) · PubMed · doi:10.11817/j.issn.1672-7347.2018.11.001 · Cited by 3 · see citing works

P2X7 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via MAPKs Signaling Pathways

Wen, Z., Mei, B., Li, H., Dou, Y., Tian, X., Shen, M., & Chen, G. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2257-1 · Cited by 30 · see citing works

P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage

Deng, H., Zhang, Y., Li, G.-G., Yu, H., Bai, S., Guo, G.-Y., Guo, W.-L., Ma, Y., Wang, J.-H., Liu, N., et al. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.303036 · Cited by 47 · see citing works

Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus

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