The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

Receptors for Purines and Pyrimidines

Burnstock, G., & Verkhratsky, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28863-0_5 · Cited by 3,973 · see citing works

Receptors for Purines and Pyrimidines

Ralevic, V., & Burnstock, G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01373-5 · Cited by 2,005 · see citing works

Physiology and Pathophysiology of Purinergic Neurotransmission

Burnstock, G. (2007) · Physiological Reviews · doi:10.1152/physrev.00043.2006 · Cited by 1,579 · see citing works

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267 · see citing works

A P2X purinoceptor expressed by a subset of sensory neurons

Chen, C., Akopian, A. N., Sivilotti, L. G., Colquhoun, D., Burnstock, G., & Wood, J. N. (1995) · Nature · doi:10.1038/377428a0 · Cited by 1,016 · see citing works

Pathophysiology and Therapeutic Potential of Purinergic Signaling

Burnstock, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.5 · Cited by 609 · see citing works

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

Yang, D., He, Y., Muñoz-Planillo, R., Liu, Q., & Núñez, G. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.009 · Cited by 604 · see citing works

Extracellular purines, purinergic receptors and tumor growth

Virgilio, F. D., & Adinolfi, E. (2016) · Oncogene · doi:10.1038/onc.2016.206 · Cited by 555 · see citing works

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

Loi, S., Pommey, S., Haibe‐Kains, B., Beavis, P. A., Darcy, P. K., Smyth, M. J., & Stagg, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222251110 · Cited by 497 · see citing works

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

Abdulqawi, R., Dockry, R., Holt, K. J., Layton, G. R., McCarthy, B. G., Ford, A. P. D. W., & Smith, J. A. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61255-1 · Cited by 488 · see citing works

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Karmakar, M., Katsnelson, M. A., Dubyak, G. R., & Pearlman, E. (2016) · Nature Communications · doi:10.1038/ncomms10555 · Cited by 450 · see citing works

The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 395 · see citing works

P2X7 receptor: an emerging target in central nervous system diseases

Sperlágh, B., & Illes, P. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.08.002 · Cited by 390 · see citing works

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

Iwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

Sorge, R. E., Trang, T., Dorfman, R., Smith, S. B., Beggs, S., Ritchie, J., Austin, J., Zaykin, D. V., Meulen, H. V., Costigan, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2710 · Cited by 360 · see citing works

Expression of P2X7 Receptor Increases In Vivo Tumor Growth

Adinolfi, E., Raffaghello, L., Giuliani, A. L., Cavazzini, L., Capece, M., Chiozzi, P., Bianchi, G., Kroemer, G., Pistoia, V., & Virgilio, F. D. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-1947 · Cited by 348 · see citing works

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works

Purinergic signalling and cancer

Burnstock, G., & Virgilio, F. D. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9372-5 · Cited by 319 · see citing works

Purinergic signalling and immune cells

Burnstock, G., & Boeynaems, J. M. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9427-2 · Cited by 310 · see citing works

Structural basis for subtype-specific inhibition of the P2X7 receptor

Karasawa, A., & Kawate, T. (2016) · eLife · doi:10.7554/elife.22153 · Cited by 308 · see citing works

P2X7 Receptors: Channels, Pores and More

Volonté, C., Apolloni, S., Skaper, S. D., & Burnstock, G. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712803581137 · Cited by 254 · see citing works

Purinergic signaling in the immune system

Virgilio, F. D., & Vuerich, M. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.04.011 · Cited by 231 · see citing works

Altered P2X7‐receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration

Dı́az-Hernández, M., Diez-Zaera, M., Sánchez‐Nogueiro, J., Gómez‐Villafuertes, R., Canals, J. M., Alberch, J., Miras‐Portugal, M. T., & Lucas, J. J. (2009) · The FASEB Journal · doi:10.1096/fj.08-122275 · Cited by 224 · see citing works

The microglial ATP‐gated ion channel P2X7 as a CNS drug target

Bhattacharya, A., & Biber, K. (2016) · Glia · doi:10.1002/glia.23001 · Cited by 221 · see citing works

P2X ion channel receptors and inflammation

Burnstock, G. (2016) · Purinergic Signalling · doi:10.1007/s11302-015-9493-0 · Cited by 215 · see citing works

Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity

Weber, F. C., Esser, P. R., Müller, T., Ganesan, J., Pellegatti, P., Simon, M. M., Zeiser, R., Idzko, M., Jakob, T., & Martin, S. F. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092489 · Cited by 209 · see citing works

P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

Zhao, J., Wang, H., Dai, C., Wang, H., Zhang, H., Huang, Y., Wang, S., Gaskin, F., Yang, N., & Fu, S. M. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38174 · Cited by 192 · see citing works

The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma

Amoroso, F., Capece, M., Rotondò, A., Cangelosi, D., Ferracin, M., Franceschini, A., Raffaghello, L., Pistoia, V., Varesio, L., & Adinolfi, E. (2015) · Oncogene · doi:10.1038/onc.2014.444 · Cited by 187 · see citing works

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation

Danquah, W., Meyer‐Schwesinger, C., Rissiek, B., Pinto, C., Prat, A. S., Amadi, M., Iacenda, D., Knop, J., Hammel, A., Bergmann, P., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8463 · Cited by 182 · see citing works

Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7

Adinolfi, E., Capece, M., Franceschini, A., Falzoni, S., Giuliani, A. L., Rotondo, A., Sarti, A. C., Bonora, M., Syberg, S., Corigliano, D. M., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1259 · Cited by 177 · see citing works

A Thr357 to Ser Polymorphism in Homozygous and Compound Heterozygous Subjects Causes Absent or Reduced P2X7 Function and Impairs ATP-induced Mycobacterial Killing by Macrophages

Shemon, A. N., Sluyter, R., Fernando, S. L., Clarke, A. L., Dao‐Ung, L., Skarratt, K. K., Saunders, B. M., Tan, K. S., Gu, B. J., Fuller, S. J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507816200 · Cited by 173 · see citing works

Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB

Tafani, M., Schito, L., Pellegrini, L., Villanova, L., Marfè, G., Anwar, T., Rosa, R., Indelicato, M., Fini, M., Pucci, B., et al. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr101 · Cited by 172 · see citing works

The P2X7 Receptor-Interleukin-1 Liaison

Giuliani, A. L., Sarti, A. C., Falzoni, S., & Di Virgilio, F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00123 · Cited by 166 · see citing works

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Jimenez‐Pacheco, A., Dı́az-Hernández, M., Arribas-Blázquez, M., Sanz‐Rodriguez, A., Olivos-Oré, L. A., Artalejo, A. R., Alves, M., Letavic, M. A., Miras‐Portugal, M. T., Conroy, R. M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4009-15.2016 · Cited by 161 · see citing works

P2X7 Receptor Signaling in the Pathogenesis of Smoke-Induced Lung Inflammation and Emphysema

Lucattelli, M., Cicko, S., Müller, T., Lommatzsch, M., Cunto, G. D., Cardini, S., Sundas, W., Grimm, M., Zeiser, R., Dürk, T., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0038oc · Cited by 146 · see citing works

Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

Csóka, B., Németh, Z. H., Törő, G., Idzko, M., Zech, A., Koscsó, B., Spolarics, Z., Antonioli, L., Cseri, K., Erdélyi, K., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-272450 · Cited by 139 · see citing works

Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohnʼs Disease

Eser, A., Colombel, J., Rutgeerts, P. J., Vermeire, S., Vogelsang, H., Braddock, M., Persson, T., & Reinisch, W. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000514 · Cited by 138 · see citing works

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

Hoque, R., Sohail, M. A., Salhanick, S. D., Malik, A. F., Ghani, A., Robson, S. C., & Mehal, W. Z. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00352.2011 · Cited by 138 · see citing works

Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation

Territo, P. R., Meyer, J. A., Peters, J. S., Riley, A. K., McCarthy, B. P., Gao, M., Wang, M., Green, M. A., Zheng, Q., & Hutchins, G. D. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.181354 · Cited by 138 · see citing works

Efficacy and Safety of Diquafosol Ophthalmic Solution in Patients with Dry Eye Syndrome: A Japanese Phase 2 Clinical Trial

Matsumoto, Y., Ohashi, Y., Watanabe, H., & Tsubota, K. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.04.010 · Cited by 137 · see citing works

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

Jelassi, B., Anchelin, M., Chamouton, J., Cayuela, M. L., Clarysse, L., Li, J., Goré, J., Jiang, L., & Roger, S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt099 · Cited by 136 · see citing works

AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

Gever, J. R., Soto, R., Henningsen, R. A., Martin, R. S., Hackos, D. H., Panicker, S., Rubas, W., Oglesby, I. B., Dillon, M. P., Milla, M. E., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00796.x · Cited by 132 · see citing works

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

do Carmo, M. R. S., Menezes, A. P. F., Nunes, A. C. L., Pliássova, A., Rolo, A. P., Palmeira, C. M., Cunha, R. A., Canas, P. M., & de Andrade, G. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.045 · Cited by 129 · see citing works

Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore

Monif, M., Reid, C. A., Powell, K. L., Drummond, K., O’Brien, T. J., & Williams, D. A. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0621-8 · Cited by 129 · see citing works

The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice

Gonçalves, R. G., Gabrich, L., Rosário, A., Takiya, C. M., Ferreira, M. L. L., Chiarini, L. B., Persechini, P. M., Coutinho‐Silva, R., & Leite, M. (2006) · Kidney International · doi:10.1038/sj.ki.5001804 · Cited by 126 · see citing works

LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia

Liu, S., Zou, L., Xie, J., Xie, W., Wen, S., Xie, Q., Gao, Y., Li, G., Zhang, C., Xu, C., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0226-2 · Cited by 126 · see citing works

Genetics of the P2X7 receptor and human disease

Fuller, S. J., Stokes, L., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9136-4 · Cited by 125 · see citing works

Purinergic mechanisms and pain—An update

Burnstock, G. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.078 · Cited by 124 · see citing works

Purinergic Signalling and Neurological Diseases: An Update

Burnstock, G. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160922104848 · Cited by 119 · cited 1× · see citing works

Spinal cord pathology is ameliorated by P2X7 antagonism in SOD1-G93A mouse model of amyotrophic lateral sclerosis

Apolloni, S., Amadio, S., Parisi, C., Matteucci, A., Potenza, R. L., Armida, M., Popoli, P., D’Ambrosi, N., & Volonté, C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.017038 · Cited by 118 · see citing works

P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway

Xia, J., Yu, X., Tang, L. P., LI, G., & He, T. (2015) · Oncology Reports · doi:10.3892/or.2015.3979 · Cited by 116 · see citing works

Early prostate cancer detected using expression of non‐functional cytolytic P2X7 receptors

Slater, M., Danieletto, S., Gidley-Baird, A. A., Teh, L. C., & Barden, J. A. (2004) · Histopathology · doi:10.1111/j.0309-0167.2004.01798.x · Cited by 116 · see citing works

Extracellular ATP Has Stimulatory Effects on the Expression and Release of IL-6 Via Purinergic Receptors in Normal Human Epidermal Keratinocytes

Inoue, K., Hosoi, J., & Denda, M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700526 · Cited by 114 · see citing works

Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer

Hofman, P. M., Cherfils‐Vicini, J., Bazin, M., Ilié, M., Juhel, T., Hébuterne, X., Gilson, É., Schmid‐Alliana, A., Boyer, O., Adriouch, S., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1778 · Cited by 110 · see citing works

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

Apolloni, S., Amadio, S., Montilli, C., Volonte, C., & D'Ambrosi, N. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt259 · Cited by 109 · see citing works

Signaling through Purinergic Receptors for ATP Induces Human Cutaneous Innate and Adaptive Th17 Responses: Implications in the Pathogenesis of Psoriasis

Killeen, M. E., Ferris, L. K., Kupetsky, E. A., Falo, L. D., & Mathers, A. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202045 · Cited by 109 · see citing works

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

Neves, A. R., Castelo-Branco, M. T. L., Figliuolo, V. R., Bernardazzi, C., Buongusto, F., Yoshimoto, A., Nanini, H. F., Coutinho, C. M. L. M., Carneiro, A. J. V., Coutinho-Silva, R., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000441201.10454.06 · Cited by 107 · see citing works

The purinergic 2X7 receptor participates in renal inflammation and injury induced by high‐fat diet: possible role of NLRP3 inflammasome activation

Solini, A., Menini, S., Rossi, C., Ricci, P. C., Santini, E., Fantauzzi, C. B., Iacobini, C., & Pugliese, G. (2013) · The Journal of Pathology · doi:10.1002/path.4237 · Cited by 107 · see citing works

Purinergic receptors as potential therapeutic targets in Alzheimer's disease

Woods, L. T., Ajit, D., Camden, J. M., Erb, L., & Weisman, G. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.031 · Cited by 106 · see citing works

Brilliant Blue G improves cognition in an animal model of Alzheimer’s disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons

Chen, X., Hu, J., Jiang, L., Xu, S., Zheng, B., Wang, C., Zhang, J., Wei, X., Chang, L. Y., & Wang, Q. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.036 · Cited by 105 · see citing works

Purinergic signaling in kidney disease

Menzies, R. I., Tam, F. W. K., Unwin, R. J., & Bailey, M. A. (2016) · Kidney International · doi:10.1016/j.kint.2016.08.029 · Cited by 105 · see citing works

Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation

Jiang, S., Zhang, Y., Zheng, J., Li, X., Yao, Y., Wu, Y., Song, S., Sun, P., Nan, J., & Lian, L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.040 · Cited by 104 · see citing works

A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma

Gilbert, S. M., Baird, A. G., Glazer, S., Barden, J. A., Glazer, A., Teh, L. C., & King, J. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15364 · Cited by 104 · see citing works

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior

Beamer, E. H., Gölöncsér, F., Horváth, G., Bekő, K., Otrokocsi, L., Koványi, B., & Sperlágh, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.019 · Cited by 103 · see citing works

Purinergic receptor P2X7: A novel target for anti-inflammatory therapy

Mehta, N., Kaur, M., Singh, M., Chand, S., Vyas, B., Silakari, P., Bahia, M. S., & Silakari, O. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.10.054 · Cited by 103 · see citing works

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

Lee, B. H., Hwang, D. M., Palaniyar, N., Grinstein, S., Philpott, D. J., & Hu, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035812 · Cited by 102 · see citing works

Targeting of the P2X7 receptor in pancreatic cancer and stellate cells

Giannuzzo, A., Saccomano, M., Napp, J., Ellegaard, M., Alves, F., & Novak, I. (2016) · International Journal of Cancer · doi:10.1002/ijc.30380 · Cited by 101 · see citing works

Purinergic Signalling: Pathophysiology and Therapeutic Potential

Burnstock, G. (2013) · The Keio Journal of Medicine · doi:10.2302/kjm.2013-0003-re · Cited by 100 · see citing works

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

Kasuya, G., Yamaura, T., Ma, X., Nakamura, R., Takemoto, M., Nagumo, H., Tanaka, E., Dohmae, N., Nakane, T., Yu, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00887-9 · Cited by 100 · see citing works

P2X7 Receptors Regulate NKT Cells in Autoimmune Hepatitis

Kawamura, H., Aswad, F., Minagawa, M., Govindarajan, S., & Dennert, G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2152 · Cited by 98 · see citing works

Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis

Amaral, E. P., Ribeiro, S. C. M., Lanes, V. R., Almeida, F. M., de Andrade, M. R. M., Bomfim, C. C. B., de Salles, É. M., Bortoluci, K. R., Coutinho‐Silva, R., Hirata, M. H., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004188 · Cited by 97 · see citing works

Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma

Giuliani, A. L., Colognesi, D., Ricco, T., Roncato, C., Capece, M., Amoroso, F., Wang, Q., Marchi, E. D., Gartland, A., Virgilio, F. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107224 · Cited by 97 · see citing works

Critical role of P2X7 receptors in the neuroinflammation and cognitive dysfunction after surgery

Zheng, B., Lai, R., Li, J., & Zuo, Z. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.005 · Cited by 97 · see citing works

Purinergic receptors in psychiatric disorders

Krügel, U. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.032 · Cited by 95 · see citing works

ATP Signaling in Brain: Release, Excitotoxicity and Potential Therapeutic Targets

Cisneros-Mejorado, A., Pérez‐Samartín, A., Gottlieb, M., & Matute, C. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0092-3 · Cited by 93 · see citing works

Purinergic signalling in the kidney in health and disease

Burnstock, G., Evans, L. C., & Bailey, M. A. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9400-5 · Cited by 92 · see citing works

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

Alves, L. A., Soares‐Bezerra, R. J., Faria, R. X., Ferreira, L., & Frutuoso, V. D. S. (2013) · Molecules · doi:10.3390/molecules180910953 · Cited by 92 · see citing works

P2X7 receptor antagonists: a patent review (2010–2015)

Park, J.-H., & Kim, Y. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1246538 · Cited by 92 · see citing works

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice

Metzger, M. W., Walser, S. M., Aprile-Garcia, F., Dedic, N., Chen, A., Holsboer, F., ARZT, E. S., Wurst, W., & Deussing, J. M. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9546-z · Cited by 92 · see citing works

P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice

Zhang, K., Liu, J., You, X., Kong, P., Song, Y., Cao, L., Yang, S. T., Wang, W., Fu, Q., & Ma, Z. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.043 · Cited by 90 · see citing works

Increased expression of the pro-apoptotic ATP-sensitive P2X7 receptor in experimental and human glomerulonephritis

Turner, C. M., Tam, F. W. K., Lai, P., Tarzi, R. M., Burnstock, G., Pusey, C. D., Cook, H. T., & Unwin, R. J. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl589 · Cited by 89 · see citing works

Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120

Allsopp, R. C., Dayl, S. A., Schmid, R., & Evans, R. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00732-5 · Cited by 87 · see citing works

Physiopathological Roles of P2X Receptors in the Central Nervous System

Burnstock, G. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867321666140706130415 · Cited by 86 · see citing works

Activation of P2X7-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice

Fu, W., McCormick, T., Qi, X., Luo, L., Zhou, L., Li, X., Wang, B.-C., Gibbons, H. E., Abdul‐Karim, F. W., & Gorodeski, G. I. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-114 · Cited by 85 · see citing works

Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells

Takai, E., Tsukimoto, M., Harada, H., & Kojima, S. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9411-x · Cited by 85 · see citing works

Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage

Ali, S. R., Timmer, A. M., Bilgrami, S., Park, E. J., Eckmann, L., Nizet, V., & Karin, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.015 · Cited by 84 · see citing works

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

Vergani, A., Fotino, C., D’Addio, F., Tezza, S., Podetta, M., Gatti, F., Chin, M., Bassi, R., Molano, R. D., Corradi, D., et al. (2013) · Diabetes · doi:10.2337/db12-0242 · Cited by 84 · see citing works

P2X7 Receptor Suppression Preserves Blood-Brain Barrier through Inhibiting RhoA Activation after Experimental Intracerebral Hemorrhage in Rats

Zhao, H., Zhang, X., Dai, Z., Feng, Y., Li, Q., Zhang, J. H., Liu, X., Chen, Y., & Feng, H. (2016) · Scientific Reports · doi:10.1038/srep23286 · Cited by 84 · see citing works

Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling

Wan, P., Liu, X., Xiong, Y., Ren, Y., Jiang, C., Lü, N., Guo, Y., & Bai, A. (2016) · Scientific Reports · doi:10.1038/srep19108 · Cited by 83 · see citing works

Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease

Wang, X., Xie, X., Luo, X., Shang, H., & He, Z. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6070 · Cited by 83 · see citing works

The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases

Coutinho-Silva, R., Morandini, A., & Savio, L. B. (2014) · Biomedical Journal · doi:10.4103/2319-4170.127803 · Cited by 81 · see citing works

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

Fischer, W., Franke, H., Krügel, U., Müller, H., Dinkel, K., Lord, B., Letavic, M. A., Henshall, D. C., & Engel, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156468 · Cited by 81 · see citing works

Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages

Graziano, F., Desdouits, M., Garzetti, L., Podini, P., Alfano, M., Rubartelli, A., Furlan, R., Benaroch, P., & Poli, G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500656112 · Cited by 77 · see citing works

Gain and Loss of Function of P2X7 Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain

Ursu, D., Ebert, P. J., Langron, E., Ruble, C., Munsie, L. M., Zou, W., Fijal, B. A., Qian, Y., McNearney, T. A., Mogg, A. J., et al. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-37 · Cited by 77 · see citing works

P2X7 receptor inhibition protects against ischemic acute kidney injury in mice

Yan, Y., Bai, J., Zhou, X., Tang, J., Jiang, C., Tolbert, E. M., Bayliss, G. P., Gong, R., Zhao, T. C., & Zhuang, S. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00245.2014 · Cited by 77 · see citing works

The evolution of P2X7 antagonists with a focus on CNS indications

Rech, J. C., Bhattacharya, A., Letavic, M. A., & Savall, B. M. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.06.048 · Cited by 77 · see citing works

Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

Xu, P., Xu, Y., Hu, B., Wang, J., Pan, R., Murugan, M., Wu, L., & Tang, Y. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.020 · Cited by 76 · see citing works

P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats

Ji, X., Naito, Y., Hirokawa, G., Weng, H., Hiura, Y., Takahashi, R., & Iwai, N. (2011) · Hypertension Research · doi:10.1038/hr.2011.153 · Cited by 76 · see citing works

P2X and P2Y purinoceptor expression in pancreas from streptozotocin-diabetic rats

Coutinho‐Silva, R., Parsons, M. E., Robson, T., Lincoln, J., & Burnstock, G. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00003-0 · Cited by 75 · see citing works

Blockade of P2X7 Receptors or Pannexin-1 Channels Similarly Attenuates Postischemic Damage

Cisneros-Mejorado, A., Gottlieb, M., Cavaliere, F., Magnus, T. U., Koch‐Nolte, F., Scemes, E., Pérez‐Samartín, A., & Matute, C. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.262 · Cited by 75 · see citing works

P2X7 receptor promotes intestinal inflammation in chemically induced colitis and triggers death of mucosal regulatory T cells

Figliuolo, V. R., Savio, L. E. B., Safya, H., Nanini, H. F., Bernardazzi, C., Abalo, A., de Souza, H. S. P., Kanellopoulos, J., Bobé, P., Coutinho, C. M. L. M., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.004 · Cited by 74 · see citing works

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

Gu, B. J., Field, J., Dutertre, S., Ou, A., Kilpatrick, T. J., Lechner‐Scott, J., Scott, R. J., Lea, R. A., Taylor, B. V., Stankovich, J. M., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv278 · Cited by 73 · see citing works

PI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions

Gómez‐Villafuertes, R., García-Huerta, P., Díaz‐Hernandéz, J. I., & Miras‐Portugal, M. T. (2015) · Scientific Reports · doi:10.1038/srep18417 · Cited by 72 · see citing works

P2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica

Monção-Ribeiro, L. C., Faffe, D. S., Santana, P. T., Vieira, F. S., da Graça, C. L. A. L., Marques-da-Silva, C., Machado, M. N., Caruso-Neves, C., Zin, W. A., Borojevic, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110185 · Cited by 71 · see citing works

P2 receptors, microglial cytokines and chemokines, and neuropathic pain

Tsuda, M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23816 · Cited by 71 · see citing works

Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD

Chang, M., Lu, J., Tian, Y., Chen, Y., Hung, C., Huang, Y.-H., Chen, Y., Wu, M.-S., Yang, C., & Cheng, Y. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010070728 · Cited by 70 · see citing works

Extracellular ATP induces cell death in human intestinal epithelial cells

de Souza, C. O., Santoro, G. F., Figliuolo, V. R., Nanini, H. F., de Souza, H. S. P., Castelo-Branco, M. T. L., Abalo, A., Paiva, M. M., Coutinho, C. M. L. M., & Coutinho‐Silva, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.013 · Cited by 69 · see citing works

Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis

Hu, H., Yang, B., Li, Y., Zhang, S., & Li, Z. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2770 · Cited by 69 · see citing works

Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival

Avendaño, B. C., Montero, T. D., Chávez, C. E., Rommy von Bernhardi, M., & Orellana, J. A. (2015) · Glia · doi:10.1002/glia.22877 · Cited by 67 · see citing works

Purinergic Signaling in Gut Inflammation: The Role of Connexins and Pannexins

Diezmos, E. F., Bertrand, P. P., & Liu, L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00311 · Cited by 67 · see citing works

Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling

Avanzato, D., Genova, T., Fiorio, A., Bernardini, M., Bianco, S., Bussolati, B., Mancardi, D., Giraudo, E., Maione, F., Cassoni, P., et al. (2016) · Scientific Reports · doi:10.1038/srep32602 · Cited by 67 · see citing works

Motor neuron dysfunction in a mouse model of ALS: Gender-dependent effect of P2X7 antagonism

Cervetto, C., Frattaroli, D., Maura, G., & Marcoli, M. (2013) · Toxicology · doi:10.1016/j.tox.2013.04.004 · Cited by 66 · see citing works

P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy

Sinadinos, A., Young, C., Al-khalidi, R. A. A., Teti, A. M., Kaliński, P., Mohamad, S., Floriot, L., Henry, T., Tozzi, G., Jiang, T., et al. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001888 · Cited by 65 · see citing works

A Critical Role for P2X7 Receptor–Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury

Mishra, A., Guo, Y., Zhang, L., More, S., Weng, T., Chintagari, N. R., Huang, C., Liang, Y., Pushparaj, S., Gou, D., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501041 · Cited by 65 · see citing works

Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation

Xie, Y., Williams, C. D., McGill, M. R., Lebofsky, M., Ramachandran, A., & Jaeschke, H. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs283 · Cited by 64 · see citing works

P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction

Savio, L. E. B., Andrade, M. G. J., de Andrade Mello, P., Santana, P. T., Moreira-Souza, A. C. A., Kolling, J., Longoni, A., Feldbrügge, L., Wu, Y., Wyse, A. T. S., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0168-9 · Cited by 64 · see citing works

The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide‐induced haemorrhagic cystitis in mice

Jp, M., Silva, R. B. M., Coutinho‐Silva, R., Takiya, C. M., Battastini, A., Morrone, F. B., & Campos, M. M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01535.x · Cited by 63 · see citing works

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

Antonioli, L., Giron, M. C., Colucci, R., Pellegrini, C., Sacco, D., Caputi, V., Orso, G., Tuccori, M., Scarpignato, C., Blandizzi, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116253 · Cited by 63 · see citing works

Lipopolysaccharide-induced lung injury: Role of P2X7 receptor

Monção-Ribeiro, L. C., Cagido, V. R., Lima-Murad, G., Santana, P. T., Riva, D. R., Borojević, R., Zin, W. A., Cavalcante, M. C. M., Riça, I. G., Brando-Lima, A. C., et al. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.09.015 · Cited by 62 · see citing works

P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes

Şeref-Ferlengez, Z., Maung, S., Schaffler, M. B., Spray, D. C., Suadicani, S. O., & Thi, M. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155107 · Cited by 60 · see citing works

Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells

Schneider, G., Glaser, T., Lameu, C., Abdelbaset‐Ismail, A., Sellers, Z. P., Moniuszko, M., Ulrich, H., & Ratajczak, M. Z. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0469-z · Cited by 59 · see citing works

Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis

Sadovnick, A. D., Gu, B. J., Traboulsee, A. L., Bernales, C. Q., Encarnacion, M. J., Yee, I. M. L., Criscuoli, M. G., Huang, X., Ou, A., Milligan, C. J., et al. (2017) · Human Mutation · doi:10.1002/humu.23218 · Cited by 58 · see citing works

Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons

da Silva, M. V., Marosti, A. R., Mendes, C. E., Palombit, K., & Castelucci, P. (2014) · Histochemistry and Cell Biology · doi:10.1007/s00418-014-1270-6 · Cited by 57 · see citing works

The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells

Murphy, N., Cowley, T. R., Richardson, J. C., Virley, D. J., Upton, N., Walter, D. S., & Lynch, M. A. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00531.x · Cited by 56 · see citing works

Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7

Hattori, F., Ohshima, Y., Seki, S., Tsukimoto, M., Sato, M., Takenouchi, T., Suzuki, A., Takai, E., Kitani, H., Harada, H., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.09.001 · Cited by 55 · see citing works

Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration

Ma, M., Ren, Q., Zhang, J.-C., & Hashimoto, K. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.1.31 · Cited by 55 · see citing works

Renal P2 receptors and hypertension

Menzies, R. I., Unwin, R. J., & Bailey, M. A. (2014) · Acta Physiologica · doi:10.1111/apha.12412 · Cited by 55 · see citing works

Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity

Amaral, S. S., de Oliveira, A. G., Marques, P. E., Quintão, J. L. D., Pires, D. A., Resende, R. R., de Sousa, B. R., Melgaço, J. G., Pinto, M. A., Russo, R. C., et al. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-10 · Cited by 55 · see citing works

Long noncoding NONRATT021972 siRNA normalized abnormal sympathetic activity mediated by the upregulation of P2X7 receptor in superior cervical ganglia after myocardial ischemia

Tu, G., Zou, L., Liu, S., Wu, B., Lv, Q., Wang, S., Xue, Y., Zhang, C., Yi, Z., Zhang, X., et al. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9518-3 · Cited by 55 · see citing works

Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells

Salvestrini, V., Orecchioni, S., Talarico, G., Reggiani, F., Mazzetti, C., Bertolini, F., Orioli, E., Adinolfi, E., Virgilio, F. D., Pezzi, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13927 · Cited by 55 · see citing works

Atypical P2X7receptor pharmacology in two human osteoblast‐like cell lines

Alqallaf, S. M., Evans, B., & Kidd, E. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00119.x · Cited by 54 · see citing works

Astrocytes mediate HIV‐1 Tat‐induced neuronal damage via ligand‐gated ion channel P2X7R

Tewari, M., Monika, Varghese, R. K., Menon, M. R., & Seth, P. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12953 · Cited by 54 · see citing works

The protective effect of resveratrol in the transmission of neuropathic pain mediated by the P2X7 receptor in the dorsal root ganglia

Xie, J., Liu, S., Wu, B., Li, G., Rao, S., Zou, L., Yi, Z., Zhang, C., Jia, T., Zhao, S., et al. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.006 · Cited by 54 · see citing works

Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition

Young, C., Chira, N., Róg, J., Al-khalidi, R. A. A., Bénard, M., Galas, L., Chan, P., Vaudry, D., Zabłocki, K., & Górecki, D. C. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx030 · Cited by 53 · see citing works

A novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus following traumatic brain injury in rats

Sun, L., Gao, J., Zhao, M., Cui, J., Li, Y., Yang, X., Jing, X., & Wu, Z. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.049 · Cited by 52 · see citing works

Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7

Hashimoto‐Hill, S., Friesen, L., Kim, M., & Kim, C. H. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.109 · Cited by 52 · see citing works

Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis

Gazzerro, E., Baldassari, S., Assereto, S., Fruscione, F., Pistorio, A., Panicucci, C., Volpi, S., Perruzza, L., Fiorillo, C., Minetti, C., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.08.010 · Cited by 51 · see citing works

Non-Synonymous Single Nucleotide Polymorphisms in the P2X Receptor Genes: Association with Diseases, Impact on Receptor Functions and Potential Use as Diagnosis Biomarkers

Caseley, E. A., Muench, S. P., Roger, S., Mao, H., Baldwin, S. A., & Jiang, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150813344 · Cited by 51 · see citing works

The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis

Santana, P. T., Benjamim, C. F., Martinez, C. G., Kurtenbach, E., Takiya, C. M., & Coutinho‐Silva, R. (2015) · Journal of Innate Immunity · doi:10.1159/000371388 · Cited by 51 · see citing works

Involvement of the P2X7 Purinergic Receptor in Inflammation: An Update of Antagonists Series Since 2009 and their Promising Therapeutic Potential

Baudelet, D., Lipka, E., Millet, R., & Ghinet, A. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666141212120926 · Cited by 51 · see citing works

Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium

Bergamin, L. S., Braganhol, E., Figueiró, F., Casali, É. A., Zanin, R. F., Sévigny, J., & Battastini, A. M. O. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25018 · Cited by 50 · see citing works

ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of β-amyloid peptide in hippocampal neurons

Sáez-Orellana, F., Godoy, P. A., Bastidas, C. Y., Silva-Grecchi, T., Guzmán, L., Aguayo, L. G., & Fuentealba, J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.005 · Cited by 50 · see citing works

Calcium Channels and Associated Receptors in Malignant Brain Tumor Therapy

Morrone, F. B., Gehring, M. P., & Nicoletti, N. F. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.103770 · Cited by 50 · see citing works

Purinergic receptors: new targets for the treatment of gout and fibrosis

Gicquel, T., Daré, B. L., Boichot, E., & Lagente, V. (2016) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12256 · Cited by 50 · see citing works

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1 G93A amyotrophic lateral sclerosis mice

Bartlett, R., Sluyter, V., Watson, D., Sluyter, R., & Yerbury, J. J. (2017) · PeerJ · doi:10.7717/peerj.3064 · Cited by 50 · see citing works

Extracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell death

Garg, A. D., Krysko, D. V., Vandenabeele, P., & Agostinis, P. (2016) · Cell Death and Disease · doi:10.1038/cddis.2015.411 · Cited by 49 · see citing works

P2X7 receptor as predictor gene for glioma radiosensitivity and median survival

Gehring, M. P., Kipper, F. C., Nicoletti, N. F., Sperotto, N. D. D. M., Zanin, R. F., Tamajusuku, A. S. K., Flores, D. G., Meurer, L., Roesler, R., Filho, A. B., et al. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.09.001 · Cited by 48 · see citing works

The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro

Agrawal, A., Buckley, K. M., Bowers, K. C., Furber, M., Gallagher, J. A., & Gartland, A. (2010) · Purinergic Signalling · doi:10.1007/s11302-010-9181-z · Cited by 48 · see citing works

Connexin‐purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation

Bhave, S. M., Gade, A. R., Kang, M., Hauser, K. F., Dewey, W. L., & Akbarali, H. I. (2017) · The FASEB Journal · doi:10.1096/fj.201601068r · Cited by 48 · see citing works

The role of P2X7 receptors in tissue fibrosis: a brief review

Gentile, D., Natale, M., Lazzerini, P. E., Capecchi, P. L., & Pasini, F. L. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9466-3 · Cited by 47 · see citing works

Role of the purinergic signaling in epilepsy

Cieślak, M., Wojtczak, A., & Komoszyński, M. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.09.018 · Cited by 47 · see citing works

Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection

Leyva-Grado, V. H., Ermler, M. E., Schotsaert, M., Gonzalez, M. G., Gillespie, V., Lim, J. K., & García-Sastre, A. (2017) · mBio · doi:10.1128/mbio.00229-17 · Cited by 47 · see citing works

Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice

Rodriguez-Alvarez, N., Jimenez-Mateos, E. M., Engel, T., Quinlan, S., Reschke, C. R., Conroy, R. M., Bhattacharya, A., Boylan, G. B., & Henshall, D. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.005 · Cited by 46 · see citing works

P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli

Greve, A., Skals, M., Fagerberg, S. K., Tonnus, W., Ellermann‐Eriksen, S., Evans, R. J., Linkermann, A., & Prætorius, H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00113 · Cited by 46 · see citing works

Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion

Park, J., Williams, D. R., Lee, J., Lee, S., Lee, J., Ko, H., Lee, G.-E., Kim, S., Lee, J. M., Abdelrahman, A., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01690 · Cited by 45 · see citing works

Microglial P2X7 receptor in the hypothalamic paraventricular nuclei contributes to sympathoexcitatory responses in acute myocardial infarction rat

Du, D., Jiang, M., Liu, M., Wang, J., Xia, C., Guan, R., Shen, L., Ji, Y., & Zhu, D. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.12.026 · Cited by 44 · see citing works

Medicinal Chemistry of P2X Receptors: Allosteric Modulators

Müller, C. E. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666141210155610 · Cited by 44 · see citing works

The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis

Portales‐Cervantes, L., Niño-Moreno, P., Salgado‐Bustamante, M., García-Hernández, M. H., Baranda-Candido, L., Reynaga-Hernández, E., Barajas‐López, C., González‐Amaro, R., & Portales‐Pérez, D. P. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.05.005 · Cited by 44 · see citing works

LncRNA uc.48 + siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats mediated by P2X7 receptor in SCG

Wu, B., Zhang, C., Zou, L., Ma, Y., Huang, K., Lv, Q., Zhang, X., Wang, S., Xue, Y., Yi, Z., et al. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.04.001 · Cited by 44 · see citing works

Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis

da Silva, M. V., Marosti, A. R., Mendes, C. E., Palombit, K., & Castelucci, P. (2017) · Acta Histochemica · doi:10.1016/j.acthis.2017.05.001 · Cited by 44 · see citing works

Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus

Rozmer, K., Gao, P., Araújo, M. G. L., Khan, M. T., Liu, J., Rong, W., Tang, Y., Franke, H., Krügel, U., Fernandes, M. J. D. S., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw178 · Cited by 43 · see citing works

Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury

Varley, I., Greeves, J. P., Sale, C., Friedman, E., Moran, D. S., Yanovich, R., Wilson, P. J., Gartland, A., Hughes, D. C., Stellingwerff, T., et al. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9495-6 · Cited by 42 · see citing works

P2X7 receptor-mediated analgesia in cancer-induced bone pain

Falk, S., Schwab, S., Frøsig-Jørgensen, M., Clausen, R. P., Dickenson, A. H., & Heegaard, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.011 · Cited by 41 · see citing works

Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis

Chandrashekaran, V., Das, S., Seth, R. K., Dattaroy, D., Alhasson, F. A., Michelotti, G. A., Nagarkatti, M., Nagarkatti, P. S., Diehl, A. M., & Chatterjee, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.009 · Cited by 40 · see citing works

The purinergic receptor P2X7 role in control of Dengue virus-2 infection and cytokine/chemokine production in infected human monocytes

Corrêa, G., Lindenberg, C. D. A., Fernandes-Santos, C., Gandini, M., de Paiva, F. P., Coutinho‐Silva, R., & Kubelka, C. F. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.02.003 · Cited by 40 · see citing works

miR-9 Mediates CALHM1-Activated ATP-P2X7R Signal in Painful Diabetic Neuropathy Rats

Liu, W., Ao, Q., Guo, Q., He, W., Peng, L., Jiang, J., & Hu, X. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9700-1 · Cited by 39 · see citing works

Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis

Corrêa, G., Lindenberg, C. D. A., Moreira-Souza, A. C. A., Savio, L. E. B., Takiya, C. M., Marques-da-Silva, C., Vommaro, R. C., & Coutinho‐Silva, R. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.12.007 · Cited by 39 · see citing works

P2X 7 -mediated chemoprevention of epithelial cancers

Gorodeski, G. I. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903277249 · Cited by 38 · see citing works

P2×7 Receptor in the Kidneys of Diabetic Rats Submitted to Aerobic Training or to N-Acetylcysteine Supplementation

Rodrigues, A. M., Bergamaschi, C. T., Fernandes, M. J. D. S., Paredes‐Gamero, E. J., Curi, M. V., Ferreira, A. T., Araújo, S., Punaro, G., Maciel, F. R., Nogueira, G. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097452 · Cited by 38 · see citing works

Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

Virgilio, F. D., & Giuliani, A. L. (2016) · Biomedical Journal · doi:10.1016/j.bj.2016.08.006 · Cited by 38 · see citing works

Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells

D’Alimonte, I., Nargi, E., Zuccarini, M., Lanuti, P., Iorio, P. D., Giuliani, P., Ricci‐Vitiani, L., D, R. P. M., Caciagli, F., & Ciccarelli, R. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9454-7 · Cited by 37 · see citing works

Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy

Sociali, G., Visigalli, D., Prukop, T., Cervellini, I., Mannino, E., Venturi, C. B., Bruzzone, S., Sereda, M. W., & Schenone, A. E. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.017 · Cited by 37 · see citing works

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control

Figliuolo, V. R., Chaves, S. P., Savio, L. E. B., Thorstenberg, M. L., de Salles, É. M., Takiya, C. M., Lima, M. R. D., Guedes, H. L. D. M., Rossi‐Bergmann, B., & Coutinho‐Silva, R. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9544-1 · Cited by 37 · see citing works

P2X7 receptor predicts postoperative cancer‐specific survival of patients with clear‐cell renal cell carcinoma

Liu, Z., Liu, Y., Xu, L., An, H., Chang, Y., Yang, Y., Zhang, W., & Xu, J. (2015) · Cancer Science · doi:10.1111/cas.12736 · Cited by 35 · see citing works

Role of P2X7 and P2Y 2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “ in vivo ” by P2X7 receptor

Miras‐Portugal, M. T., Díaz‐Hernandéz, J. I., Gómez‐Villafuertes, R., Dı́az-Hernández, M., Artalejo, A. R., & Gualix, J. (2015) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.02.005 · Cited by 33 · see citing works

Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation

Swartz, T. H., Dubyak, G., & Chen, B. K. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00585 · Cited by 33 · see citing works

The Dopamine D2 and Adenosine A2A Receptors: Past, Present and Future Trends for the Treatment of Parkinson’s Disease

Jörg, M., Scammells, P. J., & Capuano, B. (2014) · Current Medicinal Chemistry · doi:10.2174/1389200215666140217110716 · Cited by 32 · see citing works

P2X7 receptor knockout prevents streptozotocin-induced type 1 diabetes in mice

Vieira, F. S., Nanini, H. F., Takiya, C. M., & Coutinho‐Silva, R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.008 · Cited by 31 · see citing works

A Purinergic Trail for Metastases

Ferrari, D., Malavasi, F., & Antonioli, L. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.11.010 · Cited by 31 · see citing works

Physiopathological implications of P2X1and P2X7receptors in regulation of glomerular hemodynamics in angiotensin II-induced hypertension

Franco, M., Bautista‐Pérez, R., Cano-Martı́nez, A., Pacheco, U., Santamaría, J., del Valle‐Mondragón, L., Pérez-Méndez, O. A., & Navar, L. G. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00663.2016 · Cited by 31 · see citing works

P2X7 mRNA expression in non-small cell lung cancer: MicroRNA regulation and prognostic value

Boldrini, L., Giordano, M., Alì, G., Melfi, F. M. A., Romano, G., Lucchi, M., & Fontanini, G. (2014) · Oncology Letters · doi:10.3892/ol.2014.2620 · Cited by 30 · see citing works

The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?

Kvist, T., Schwarz, P., & Jørgensen, N. R. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/954530 · Cited by 29 · see citing works

Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X7 receptors

Zhang, J., Li, X., Gao, Y., Guo, G., Xu, C., Li, G., Liu, S., Huang, A., Tu, G., Peng, H., et al. (2012) · Burns · doi:10.1016/j.burns.2012.08.013 · Cited by 29 · see citing works

Role of P2Y12 Receptor in Thrombosis

Zhang, Y., Zhang, S., & Ding, Z. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_123 · Cited by 29 · see citing works

Purinergic signaling during Porphyromonas gingivalis infection

Almeida-da-Silva, C. L. C., Morandini, A. C., Ulrich, H., Ojcius, D. M., & Coutinho‐Silva, R. (2016) · Biomedical Journal · doi:10.1016/j.bj.2016.08.003 · Cited by 29 · see citing works

Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury

Nagahama, M., Seike, S., Shirai, H., Takagishi, T., Kobayashi, K., Takehara, M., & Sakùrai, J. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.08.011 · Cited by 28 · see citing works

The expression of P2X7receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas

Fang, J., Chen, X., Wang, S., Xie, T., Du, X., Liu, H., Wang, S., Li, X., Chen, J., Zhang, B., et al. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1016663 · Cited by 27 · see citing works

Structure–activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

Beswick, P., Billinton, A., Chambers, L. J., Dean, D. K., Fonfría, E., Gleave, R. J., Medhurst, S. J., Michel, A. D., Moses, A. P., Patel, S., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.05.107 · Cited by 27 · see citing works

Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: A preliminary study

Mrázek, F., Gallo, J., Stahelova, A., & Petřek, M. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.10.013 · Cited by 27 · see citing works

Human β Defensin-3 Increases CD86 Expression on Monocytes by Activating the ATP-Gated Channel P2X7

Lioi, A. B., Ferrari, B., Dubyak, G., Weinberg, A., & Sieg, S. F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401319 · Cited by 27 · see citing works

The impact of the P2X7 receptor antagonist A-804598 on neuroimmune and behavioral consequences of stress

Catanzaro, J. M., Hueston, C. M., Deak, M. M., & Deak, T. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000072 · Cited by 27 · see citing works

P2X7 receptors are a potential novel target for anti-glioma therapies

Monif, M., O'Brien, T. J., Drummond, K. J., Reid, C. A., Liubinas, S. V., & Williams, D. A. (2014) · Journal of Inflammation · doi:10.1186/s12950-014-0025-4 · Cited by 26 · see citing works

Localized inhibition of P2X7R at the spinal cord injury site improves neurogenic bladder dysfunction by decreasing urothelial P2X3R expression in rats

Muñoz, A., Yazdi, I. K., Tang, X., Rivera, C., Taghipour, N., Grossman, R. G., Boone, T. B., & Tasciotti, E. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.12.017 · Cited by 26 · see citing works

P2X7 Antagonists for CNS Indications: Recent Patent Disclosures

Pevarello, P., Bovolenta, S., Tarroni, P., Za, L., Severi, E., Torino, D., & Vitalone, R. (2017) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2016-0044 · Cited by 26 · see citing works

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function

Aprile-Garcia, F., Metzger, M. W., Páez-Pereda, M., Stadler, H., Acuña, M., Liberman, A. C., Senin, S. A., Gerez, J., Hoijman, E., Refojo, D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151862 · Cited by 25 · see citing works

Role of P2X Purinoceptor 7 in Neurogenic Pulmonary Edema after Subarachnoid Hemorrhage in Rats

Chen, S., Zhu, Z., Klebe, D. W., Bian, H., Krafft, P. R., Tang, J., Zhang, J., & Zhang, J. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089042 · Cited by 24 · see citing works

A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4+ T and macrophage infiltration and NADPH oxidase 2/4 expression in mice

Zempo, H., Sugita, Y., Ogawa, M., Watanabe, R., Suzuki, J., & Isobe, M. (2014) · Heart and Vessels · doi:10.1007/s00380-014-0527-2 · Cited by 24 · see citing works

P2×7 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression

Martinez, C. G., Zamith‐Miranda, D., da Silva, M. G., Ribeiro, K. C., Brandão, I. T., Silva, C. L., Diaz, B. L., Bellio, M., Persechini, P. M., & Kurtenbach, E. (2015) · Scientific Reports · doi:10.1038/srep16940 · Cited by 24 · see citing works

Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X7 receptor antagonist: a prospective genotyping approach

McHugh, S. M., Roman, S. A., Davis, B. G., Koch, A., Pickett, A. M., Richardson, J. C., Miller, S. R., Wetten, S., Cox, C. J., Karpe, F., et al. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04200.x · Cited by 23 · see citing works

Size and characteristics of the biomedical research workforce associated with U.S. National Institutes of Health extramural grants

Pool, L. R., Wagner, R. M., Scott, L. L., Roychowdhury, D., Berhane, R., Wu, C., Pearson, K., Sutton, J. A., & Schaffer, W. T. (2015) · The FASEB Journal · doi:10.1096/fj.14-264358 · Cited by 23 · see citing works

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

Virgilio, F. D., Sarti, A. C., Falzoni, S., Marchi, E. D., & Adinolfi, E. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0037-0 · Cited by 730 · see citing works

The Role of Inflammation in the Pathogenesis of Osteoarthritis

Chow, Y. Y., & Chin, K. (2020) · Mediators of Inflammation · doi:10.1155/2020/8293921 · Cited by 536 · see citing works

The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

Grams, R. J., Santos, W. L., Scorei, I. R., Abad-García, A., Rosenblum, C. A., Biţă, A., Cerecetto, H., Viñas, C., & Soriano-Ursua, M. A. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00663 · Cited by 389 · see citing works

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Cheng, R., Wu, Z., Li, M., Shao, M., & Hu, T. (2020) · International Journal of Oral Science · doi:10.1038/s41368-019-0068-8 · Cited by 304 · see citing works

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials

Miao, J., Ma, H., Yang, Y., Liao, Y., Lin, C., Zheng, J., Yu, M., & Lan, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1201982 · Cited by 293 · see citing works

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

McCarthy, A. E., Yoshioka, C., & Mansoor, S. (2019) · Cell · doi:10.1016/j.cell.2019.09.017 · Cited by 259 · see citing works

Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer’s disease

Thawkar, B. S., & Kaur, G. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.11.010 · Cited by 247 · see citing works

P2X7 Interactions and Signaling – Making Head or Tail of It

Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217 · see citing works

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

Sek, K., Mølck, C., Stewart, G. D., Kats, L. M., Darcy, P. K., & Beavis, P. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123837 · Cited by 204 · see citing works

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Eisinger, S., Sarhan, D., Boura, V. F., Ibarlucea-Benitez, I., Tyystjärvi, S., Oliynyk, G., Arsenian‐Henriksson, M., Lane, D. P., Wickström, S. L., Kiessling, R. W., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015343117 · Cited by 173 · see citing works

P2X7 Receptor Signaling in Stress and Depression

Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance

Wei, F., Wang, D., Wei, J., Tang, N., Tang, L. M., Xiong, F., Guo, C. J., Zhou, M., Li, X., Li, G., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03581-0 · Cited by 128 · see citing works

Mechanosensitive ion channels push cancer progression

Pethő, Z., Najder, K., Bulk, E., & Schwab, A. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.03.007 · Cited by 125 · see citing works

Animal models of pain: Diversity and benefits

Abboud, C., Duveau, A., Bouali‐Benazzouz, R., Massé, K. L., Mattar, J., Brochoire, L., Fossat, P., Boué‐Grabot, É., Hleihel, W., & Landry, M. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108997 · Cited by 112 · see citing works

High expression levels of pyrimidine metabolic rate–limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets

Wang, H., Wang, X., Xu, L., Zhang, J., & Cao, H. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09711-4 · Cited by 104 · see citing works

CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth

Azambuja, J. H., Gelsleichter, N. E., Beckenkamp, L. R., Iser, I. C., Fernandes, M. D. C., Figueiró, F., Battastini, A. M. O., Scholl, J. N., de Oliveira, F. H., Spanevello, R. M., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1240-4 · Cited by 96 · see citing works

P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

Young, C., & Górecki, D. C. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00248 · Cited by 95 · see citing works

The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications

Rotondo, J. C., Mazziotta, C., Lanzillotti, C., Stefani, C., Badiale, G., Campione, G., Martini, F., & Tognon, M. G. (2022) · Cancers · doi:10.3390/cancers14051116 · Cited by 94 · see citing works

The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis

Campagno, K. E., & Mitchell, C. H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.645244 · Cited by 90 · see citing works

Extracellular ATP and Adenosine in Cancer Pathogenesis and Treatment

Chiarella, A. M., Ryu, Y. K., Manji, G. A., & Rustgi, A. K. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.04.008 · Cited by 84 · see citing works

Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases

Ren, W.-J., Rubini, P., Tang, Y., Engel, T., & Illés, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010232 · Cited by 70 · see citing works

Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung Cancer

Qin, J., Zhang, X., Tan, B., Zhang, S., Yin, C., Xue, Q., Zhang, Z., Ren, H., Chen, J., Liu, M., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0123 · Cited by 80 · see citing works

Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors

Inoue, K., & Tsuda, M. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114309 · Cited by 78 · see citing works

Pathological ATPergic Signaling in Major Depression and Bipolar Disorder

Illés, P., Verkhratsky, A., & Tang, Y. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00331 · Cited by 77 · see citing works

Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure

Campagno, K. E., Lu, W., Jassim, A. H., Albalawi, F., Cenaj, A., Tso, H., Clark, S. P., Sripinun, P., Gómez, N. M., & Mitchell, C. H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02251-7 · Cited by 67 · see citing works

The role and pharmacological properties of the P2X7 receptor in neuropathic pain

Zhang, W., Zhu, J., & Liu, Z.-X. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.11.006 · Cited by 67 · see citing works

Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor

Martínez-Cuesta, M. Á., Blanch‐Ruiz, M. A., Ortega‐Luna, R., Sánchez‐López, A., & Álvarez, Á. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228454 · Cited by 62 · see citing works

The pharmacological and pharmacokinetic properties of esculin: A comprehensive review

Li, C., Li, J.-C., Lai, J., & Liu, Y. (2022) · Phytotherapy Research · doi:10.1002/ptr.7470 · Cited by 61 · see citing works

Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor

Guan, S., Shen, Y., Ge, H., Xiong, W., He, L., Liu, L., Yin, C., Wei, X., & Gao, Y. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00770 · Cited by 60 · see citing works

Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma

Zanoni, M., Sarti, A. C., Zamagni, A., Cortesi, M., Pignatta, S., Arienti, C., Tebaldi, M., Sarnelli, A., Romeo, A., Bartolini, D., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04526-0 · Cited by 58 · see citing works

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Price, G. W., Chadjichristos, C. E., Kavvadas, P., Tang, S. C. W., Yiu, W. H., Green, C. R., Potter, J. A., Siamantouras, E., Squires, P. E., & Hills, C. E. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00558-1 · Cited by 58 · see citing works

Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways

Ibrahim, S. S. A., & Huttunen, K. M. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00800-3 · Cited by 56 · see citing works

Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer

Drill, M., Jones, N. C., Hunn, M., O'Brien, T. J., & Monif, M. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09776-9 · Cited by 52 · see citing works

Astroglial and Microglial Purinergic P2X7 Receptor as a Major Contributor to Neuroinflammation during the Course of Multiple Sclerosis

Sidoryk‐Wȩgrzynowicz, M., & Strużyńska, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168404 · Cited by 51 · see citing works

P2X7 receptor in inflammation and pain

Hu, S.-Q., Hu, J., Zou, F.-L., Liu, J., Luo, H., Hu, D.-X., Wu, L., & Zhang, W. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.006 · Cited by 50 · see citing works

Oxidative Imbalance as a Crucial Factor in Inflammatory Lung Diseases: Could Antioxidant Treatment Constitute a New Therapeutic Strategy?

Victoni, T., Barreto, E., Lagente, V., & Carvalho, V. F. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6646923 · Cited by 54 · see citing works

The progress and prospects of targeting the adenosine pathway in cancer immunotherapy

Yang, Y., Zhu, L., Xu, Y., Liang, L., Liu, L.-Z., Chen, X., Li, H., & Liu, H. (2025) · Biomarker Research · doi:10.1186/s40364-025-00784-0 · Cited by 50 · see citing works

P2X7R promotes angiogenesis and tumour‐associated macrophage recruitment by regulating the NF‐κB signalling pathway in colorectal cancer cells

Yang, C., Shi, S., Su, Y., Tong, J., & Li, L. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15708 · Cited by 50 · see citing works

Role of the P2X7 receptor in the pathogenesis of type 2 diabetes and its microvascular complications

Solini, A., & Novak, I. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.02.009 · Cited by 48 · see citing works

The Role of the NLRP3 Inflammasome in Mediating Glomerular and Tubular Injury in Diabetic Nephropathy

Williams, B. M., Cliff, C. L., Lee, K., Squires, P. E., & Hills, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.907504 · Cited by 43 · see citing works

Novel biologics targeting the P2X7 ion channel.

Koch-Nolte, F., Eichhoff, A., Pinto-Espinoza, C., Schwarz, N., Schäfer, T., Menzel, S., Haag, F., Demeules, M., Gondé, H., & Adriouch, S. (2019) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2019.03.001 · Cited by 44 · see citing works

P2X7R antagonists in chronic stress-based depression models: a review

von Mücke-Heim, I.-A., Ries, C., Urbina-Treviño, L., & Deussing, J. M. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01306-3 · Cited by 46 · see citing works

Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases

Li, Y., Chen, J., Bolinger, A. A., Chen, H., Liu, Z., Cong, Y., Brasier, A. R., Pinchuk, I. V., Tian, B., & Zhou, J. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab190 · Cited by 45 · see citing works

High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity

da Silva, G. B., Manica, D., da Silva, A. P., Kosvoski, G. C., Hanauer, M. C., Assmann, C. E., Simões, J. L. B., Pillat, M. M., de Lara, J. D., Marafon, F., et al. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02185-4 · Cited by 44 · see citing works

P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3

Feng, W., Yang, X. Q., Wang, L., Wang, R., Yang, F., Wang, H., Liu, X., Ren, Q., Zhang, Y., Zhu, X., et al. (2020) · Haematologica · doi:10.3324/haematol.2019.243360 · Cited by 44 · see citing works

P2X7 receptor antagonism inhibits tumour growth in human high-grade gliomas

Kan, L. K., Seneviratne, S. O., Drummond, K. J., Williams, D. A., O'Brien, T. J., & Monif, M. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09705-2 · Cited by 46 · see citing works

P2X7 receptor: a critical regulator and potential target for breast cancer

Zhu, X., Li, Q., Song, W., Peng, X., & Zhao, R. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02041-x · Cited by 43 · see citing works

The Role of ATP Receptors in Pain Signaling

Inoue, K. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03516-6 · Cited by 42 · see citing works

The P2X7 Receptor Is Shed Into Circulation: Correlation With C-Reactive Protein Levels

Giuliani, A. L., Berchan, M., Sanz, J. M., Passaro, A., Pizzicotti, S., Vultaggio-Poma, V., Sarti, A. C., & Virgilio, F. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00793 · Cited by 42 · see citing works

Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology

Oken, A. C., Krishnamurthy, I., Savage, J. C., Lisi, N. E., Godsey, M., & Mansoor, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.925880 · Cited by 41 · see citing works

P2X receptors in cancer growth and progression

Virgilio, F. D., Vultaggio-Poma, V., & Sarti, A. C. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114350 · Cited by 41 · see citing works

Purinergic signaling and tumor microenvironment in cervical Cancer

Pfaffenzeller, M. S., Franciosi, M. L. M., & Cardoso, A. M. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09693-3 · Cited by 39 · see citing works

P2 Purinergic Signaling in the Distal Lung in Health and Disease

Wirsching, E., Fauler, M., Fois, G., & Frick, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144973 · Cited by 40 · see citing works

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

Kozak, M., Dąbrowska‐Żamojcin, E., Mazurek−Mochol, M., & Pawlik, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124045 · Cited by 38 · see citing works

The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome

Bernardazzi, C., Castelo-Branco, M. T. L., Pêgo, B., Ribeiro, B. E., Rosas, S. L. B., Santana, P. T., Machado, J. C., Leal, C. V., Thompson, F. L., Coutinho‐Silva, R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094616 · Cited by 38 · see citing works

Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment

Scarpellino, G., Genova, T., & Munaron, L. (2019) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892814666190116122256 · Cited by 36 · see citing works

The role of microglia and P2X7 receptors in gliomas

Kan, L. K., Williams, D. J., Drummond, K. J., O'Brien, T. J., & Monif, M. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.04.010 · Cited by 35 · see citing works

The P2X7 purinergic receptor: a potential therapeutic target for lung cancer

Li, Q., Zhu, X., Song, W., Peng, X., & Zhao, R. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03379-4 · Cited by 36 · see citing works

To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?

Stokes, L., Bidula, S. M., Bibič, L., & Allum, E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00627 · Cited by 35 · see citing works

Possible role of purinergic signaling in COVID-19

Franciosi, M. L. M., Lima, M. D. M., Schetinger, M. R. C., & Cardoso, A. M. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04130-4 · Cited by 35 · see citing works

FTY720 in CNS injuries: Molecular mechanisms and therapeutic potential

Zhang, L., & Wang, H. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.08.013 · Cited by 34 · see citing works

Parthenolide, bioactive compound of Chrysanthemum parthenium L., ameliorates fibrogenesis and inflammation in hepatic fibrosis via regulating the crosstalk of TLR4 and STAT3 signaling pathway

Cui, Z., Wang, G., Zhang, J., Song, J., Jiang, Y., Dou, J., Lian, L., Nan, J., & Wu, Y. (2021) · Phytotherapy Research · doi:10.1002/ptr.7214 · Cited by 34 · see citing works

Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration

Ernest James Phillips, T., & Maguire, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652593 · Cited by 33 · see citing works

Loss of P2X7 receptor function dampens whole body energy expenditure and fatty acid oxidation

Giacovazzo, G., Apolloni, S., & Coccurello, R. (2018) · Purinergic Signalling · doi:10.1007/s11302-018-9610-y · Cited by 32 · see citing works

PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus

Liu, X., Xie, Z., Li, S., He, J., Cao, S., & Xiao, Z. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59032 · Cited by 33 · see citing works

Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy

Zhang, W. (2021) · Purinergic Signalling · doi:10.1007/s11302-020-09761-8 · Cited by 31 · see citing works

Implication of lncRNA MSTRG.81401 in Hippocampal Pyroptosis Induced by P2X7 Receptor in Type 2 Diabetic Rats with Neuropathic Pain Combined with Depression

Zhan, T., Tang, S., Du, J., Liu, J., Yu, B., Yang, Y., Xie, Y., Qiu, Y., Li, G., & Gao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021186 · Cited by 30 · see citing works

P2RX7 at the Host-Pathogen Interface of Infectious Diseases

Soare, A., Freeman, T. L., Min, A. K., Malik, H. S., Osota, E. O., & Swartz, T. H. (2021) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00055-20 · Cited by 25 · see citing works

Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor

Rabelo, I. L. A., Arnaud-Sampaio, V. F., Adinolfi, E., Ulrich, H., & Lameu, C. (2021) · Cells · doi:10.3390/cells10071782 · Cited by 30 · see citing works

A promising independent prognostic biomarker in colorectal cancer: P2X7 receptor.

Çalık, İ., Çalık, M., Turken, G., & Özercan, İ. H. (2020) · PubMed Central · Cited by 29 · see citing works

P2X7 receptor/NLRP3 inflammasome complex and α‐synuclein in peripheral blood mononuclear cells: a prospective study in neo‐diagnosed, treatment‐naïve Parkinson’s disease

Solini, A., Rossi, C., Santini, E., Giuntini, M., Raggi, F., Parolini, F., Biancalana, E., Prete, E. D., Bonuccelli, U., & Ceravolo, R. (2021) · European Journal of Neurology · doi:10.1111/ene.14918 · Cited by 29 · see citing works

P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction

Khalafalla, M. G., Woods, L. T., Jasmer, K. J., Forti, K. M., Camden, J. M., Jensen, J. L., Limesand, K. H., Galtung, H. K., & Weisman, G. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00222 · Cited by 28 · see citing works

Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS‐CoV‐2

dos Anjos, F., Simões, J. L. B., Assmann, C. E., Carvalho, F. B., & Bagatini, M. D. (2020) · Journal of Immunology Research · doi:10.1155/2020/8632048 · Cited by 29 · see citing works

Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star?

Schmidt, S., Isaak, A., & Junker, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021374 · Cited by 28 · see citing works

P2X7 purinoceptor as a therapeutic target in muscular dystrophies

Górecki, D. C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.02.003 · Cited by 28 · see citing works

Purinergic Calcium Signals in Tumor-Derived Endothelium

Scarpellino, G., Genova, T., Avanzato, D., Bernardini, M., Bianco, S., Petrillo, S., Tolosano, E., Vieira, J. R. D. A., Bussolati, B., Fiorio, A., et al. (2019) · Cancers · doi:10.3390/cancers11060766 · Cited by 28 · see citing works

High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket

Oken, A. C., Lisi, N. E., Krishnamurthy, I., McCarthy, A. E., Godsey, M., Glasfeld, A., & Mansoor, S. (2024) · Nature Communications · doi:10.1038/s41467-024-50771-6 · Cited by 27 · see citing works

The P2X7 receptor in activated microglia promotes depression- and anxiety-like behaviors in lithium -pilocarpine induced epileptic rats

Sun, H. J., Xin, Y., Wu, J., ShuQin, Z., GuiLian, Z., Wu, H., Zhen, G., HongWei, R., & Yongnan, L. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104773 · Cited by 27 · see citing works

A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention

Strassheim, D., Karoor, V., Stenmark, K. R., Verin, A. D., & Gerasimovskaya, E. V. (2018) · Vessel Plus · doi:10.20517/2574-1209.2018.44 · Cited by 26 · see citing works

Ca2+ as a therapeutic target in cancer

Gross, S., Mallu, P., Joshi, H., Schultz, B. M., Go, C. K., & Soboloff, J. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.05.003 · Cited by 28 · see citing works

Activation of the P2X 7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats

Li, P., Zhang, Q., Xiao, Z., Yu, S., Yan, Y., & Qin, Y. (2018) · Molecular Pain · doi:10.1177/1744806918803039 · Cited by 26 · see citing works

The Role of NMDA Receptors in the Effect of Purinergic P2X7 Receptor on Spontaneous Seizure Activity in WAG/Rij Rats With Genetic Absence Epilepsy

Doǧan, E., Aygün, H., Arslan, G., Rzayev, E., Avcı, B., Ayyıldız, M., & Ağar, E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00414 · Cited by 26 · see citing works

Nitrogen-containing bisphosphonates and lipopolysaccharide mutually augment inflammation via adenosine triphosphate (ATP)-mediated and interleukin 1β (IL-1β)-mediated production of neutrophil extracellular traps (NETs)

Bando, K., Kuroishi, T., Tada, H., Oizumi, T., Tanaka, Y., Takahashi, T., Mizoguchi, I., Sugawara, S., & Endo, Y. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4384 · Cited by 24 · see citing works

The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

Wang, K., Sun, M., Juan, Z., Zhang, J., Sun, Y., Wang, G., Wang, C., Li, Y., Kong, W., Fan, L., et al. (2022) · Behavioural Neurology · doi:10.1155/2022/3777351 · Cited by 24 · see citing works

Purinergic Signaling in Pancreas—From Physiology to Therapeutic Strategies in Pancreatic Cancer

Novak, I., Yu, H., Magni, L., & Deshar, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228781 · Cited by 24 · see citing works

Photobiomodulation inhibits inflammation in the temporomandibular joint of rats

Pereira, E. D. S. B. M., Basting, R. T., Abdalla, H. B., Garcez, A. S., Napimoga, M. H., & Clemente‐Napimoga, J. T. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112281 · Cited by 24 · see citing works

P2X 7 receptors exhibit at least three modes of allosteric antagonism

Oken, A. C., Ditter, I. A., Lisi, N. E., Krishnamurthy, I., Godsey, M., & Mansoor, S. (2024) · Science Advances · doi:10.1126/sciadv.ado5084 · Cited by 23 · see citing works

eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases

Panicucci, C., Raffaghello, L., Bruzzone, S., Baratto, S., Principi, E., Minetti, C., Gazzerro, E., & Bruno, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175963 · Cited by 24 · see citing works

P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization

Sheng, G., Gao, Y., Ding, Q., Zhang, R., Wang, T., Jing, S., Zhao, H., Ma, T., Wu, H. K., & Yang, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03985-z · Cited by 24 · see citing works

P2X7R as an independent prognostic indicator in gastric cancer

Çalık, İ., Çalık, M., Sarıkaya, B., Özercan, İ. H., Arslan, R., Artaş, G., & Dağlı, A. F. (2020) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2020.4620 · Cited by 23 · see citing works

Persistent Activation of the P2X7 Receptor Underlies Chronic Inflammation and Carcinogenic Changes in the Intestine

Santana, P. T., de Lima, I. S., Souza, K. C. D. S. E., Barbosa, P. H. S., & de Souza, H. S. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010874 · Cited by 23 · see citing works

Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer’s Disease

Tamburini, B., Badami, G. D., Manna, M. P. L., Azgomi, M. S., Caccamo, N., & Dieli, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511922 · Cited by 22 · see citing works

P2X7 Receptor: an Emerging Target in Alzheimer’s Disease

Huang, Q., Ying, J., Yu, W., Dong, Y., Xiong, H., Zhang, Y., Liu, J., Wang, X., & Hua, F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03699-9 · Cited by 22 · see citing works

Arylboronic acids inhibit P2X7 receptor function and the acute inflammatory response

Faria, R. X., Hiller, N. D. J., Salles, J. P., Resende, J. A. L. C., Diogo, R. T., von Ranke, N. L., Bello, M. L., Rodrigues, C. R., Castro, H. C., & Martins, D. D. L. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09802-x · Cited by 22 · see citing works

Radioligands targeting purinergic P2X7 receptor

Zheng, Q. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127169 · Cited by 22 · see citing works

Central nervous system‐infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling

Bijelić, D. D., Milicevic, K. D., Lazarević, M. N., Miljković, D. M., Pristov, J. B., Savić, D. Z., Petković, B. B., Anđjus, P. R., Momčilović, M. B., & Nikolic, L. M. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24699 · Cited by 22 · see citing works

Targeting NLRP3 inflammasome with curcumin: mechanisms and therapeutic promise in chronic inflammation

Pandey, S. N., Babu, M. A., Goyal, K., Menon, S. V., Ray, S., Kaur, M., Sharma, S., Rana, M., Rekha, A., Ali, H., et al. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01926-4 · Cited by 21 · see citing works

P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones

Martins, D. D. L., Borges, A. A., Silva, N. A. D. A. E., Faria, J. V., Hoelz, L. V. B., de Souza, H. V. C. M., Bello, M. L., Boechat, N., Ferreira, V. F., & Faria, R. X. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104278 · Cited by 20 · see citing works

Soybean lectin induces autophagy through P2RX7 dependent activation of NF-κB-ROS pathway to kill intracellular mycobacteria

Mishra, A., Behura, A., Kumar, A., Ghosh, A., Naik, L., Mawatwal, S., Mohanty, S. S., Mishra, A., Saha, S., Bhutia, S. K., et al. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129806 · Cited by 20 · see citing works

Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model

Apolloni, S., Fabbrizio, P., Amadio, S., Napoli, G., Freschi, M., Sironi, F. M., Pevarello, P., Tarroni, P., Liberati, C., Bendotti, C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910649 · Cited by 21 · see citing works

The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications

Rotondo, J. C., Mazziotta, C., Lanzillotti, C., Stefani, C., Badiale, G., Campione, G., Martini, F., & Tognon, M. G. (2022) · Cancers · doi:10.3390/cancers14051116 · Cited by 94 · see citing works

Physiological roles and therapeutic potential of the purinergic P2X7 receptor

Dunker, C., Gross, S., Vinnenberg, L., Prinz, A., Koch, O., & Junker, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00063-7

[Effect of P2X7 receptor on inflammatory diseases and its mechanism].

Xu, H., & Liang, S. (2013) · PubMed · Cited by 7 · see citing works

Editorial: Advancements in P2X7 antagonists: from mechanistic insights to therapeutic applications

Ferreira, N. C. D. S., Bezerra, R. J. S., & Bisaggio, R. D. C. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1912316

The P2X 7 purinergic receptor: from physiology to neurological disorders

Skaper, S. D., Debetto, P., & Giusti, P. (2009) · The FASEB Journal · doi:10.1096/fj.09-138883 · Cited by 336 · see citing works