The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer
Open accessAbstract
Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in various cellular and physiological processes such as in gene regulation, chromatin dynamics, cell differentiation, development etc. NcRNAs are dysregulated in a variety of human disorders including cancers, neurological disorders, and immunological disorders. The mechanisms through which ncRNAs regulate various biological processes and human diseases still remain elusive. HOX antisense intergenic RNA (HOTAIR) is a recently discovered long non-coding RNA (lncRNA) that plays critical role in gene regulation and chromatin dynamics, appears to be misregulated in a variety of cancers. HOTAIR interacts with key epigenetic regulators such as histone methyltransferase PRC2 and histone demethylase LSD1 and regulates gene silencing. Here, we have reviewed recent advancements in understanding the functions and regulation of HOTAIR and its association with cancer and other diseases.
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Cites
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
The Polycomb complex PRC2 and its mark in life
Margueron, R., & Reinberg, D. (2011) · Nature · doi:10.1038/nature09784 · Cited by 3,347
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins
Guttman, M., Russell, P., Ingolia, N. T., Weissman, J. S., & Lander, E. S. (2013) · Cell · doi:10.1016/j.cell.2013.06.009 · Cited by 745
ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology
Lam, Y. C., Bowman, A. B., Jafar-Nejad, P., Lim, J., Richman, R., Fryer, J. D., Hyun, E. D., Duvick, L. A., Orr, H. T., Botas, J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.038 · Cited by 326
Expanding functional diversity of the coactivators
Lonard, D. M., & O'Malley, B. W. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.01.001 · Cited by 172
Cited by
Bian, Z., Jin, L., Zhang, J., Yin, Y., Quan, C., Hu, Y., Feng, Y., Liu, H., Fei, B., Mao, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep23892 · Cited by 363
Gene Insertion Into Genomic Safe Harbors for Human Gene Therapy
Papapetrou, E. P., & Schambach, A. (2016) · Molecular Therapy · doi:10.1038/mt.2016.38 · Cited by 238
Chang, C. Y.-Y., Tseng, C.-C., Lai, M.-T., Chiang, A.-J., Lo, L.-C., Chen, C.-M., Yen, M.-J., Sun, L., Yang, L., Hwang, T., et al. (2021) · PLOS ONE · doi:10.1371/journal.pone.0248168 · Cited by 20
“Since oncogenic lncRNAs like HOTAIR can interact with many miRNAs as decoys or sponges to establish competing endogenous RNA (ceRNA) networks for malignant transformation [12,16], whether HOTAIR forms a complex with mir196a2 to promote endometriosis progression is worthy of further investigation.”
Background
Metadata
- Authors
- Bhan, A., & Mandal, S. S.
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 1856
- Issue
- 1
- Pages
- 151-164
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W964275744
- Cited by
- 456
- References
- 8
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- green
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