The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Chemical exposure-response relationship between air pollutants and reactive oxygen species in the human respiratory tract
Open accessAbstract
Air pollution can cause oxidative stress and adverse health effects such as asthma and other respiratory diseases, but the underlying chemical processes are not well characterized. Here we present chemical exposure-response relations between ambient concentrations of air pollutants and the production rates and concentrations of reactive oxygen species (ROS) in the epithelial lining fluid (ELF) of the human respiratory tract. In highly polluted environments, fine particulate matter (PM2.5) containing redox-active transition metals, quinones, and secondary organic aerosols can increase ROS concentrations in the ELF to levels characteristic for respiratory diseases. Ambient ozone readily saturates the ELF and can enhance oxidative stress by depleting antioxidants and surfactants. Chemical exposure-response relations provide a quantitative basis for assessing the relative importance of specific air pollutants in different regions of the world, showing that aerosol-induced epithelial ROS levels in polluted megacity air can be several orders of magnitude higher than in pristine rainforest air.
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Health Effects of Fine Particulate Air Pollution: Lines that Connect
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Atmospheric composition change – global and regional air quality
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Self-citationRedox activity of airborne particulate matter at different sites in the Los Angeles Basin
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Air Pollution and Cardiovascular Disease
Rajagopalan, S., Al-Kindi, S. G., & Brook, R. D. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.07.099 · Cited by 1,299
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Metadata
- Authors
- Lakey, P. S. J., Berkemeier, T., Tong, H., Arangio, A. M., Lucas, K., Pöschl, U., & Shiraiwa, M.
- Venue
- Scientific Reports
- Published
- 2016-09-08
- Volume
- 6
- Issue
- 1
- Pages
- 32916-32916
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2514973363
- Cited by
- 365
- References
- 40
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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