Cited by 2,504Redox biology and oxidative stressAntioxidant Activity and Oxidative StressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Reconciling the chemistry and biology of reactive oxygen species

Winterbourn, Christine C·2008·Nature Chemical Biology

Abstract

There is a vast literature on the generation and effects of reactive oxygen species in biological systems, both in relation to damage they cause and their involvement in cell regulatory and signaling pathways. The biological chemistry of different oxidants is becoming well understood, but it is often unclear how this translates into cellular mechanisms where redox changes have been demonstrated. This review addresses this gap. It examines how target selectivity and antioxidant effectiveness vary for different oxidants. Kinetic considerations of reactivity are used to assess likely targets in cells and how reactions might be influenced by restricted diffusion and compartmentalization. It also highlights areas where greater understanding is required on the fate of oxidants generated by cellular NADPH oxidases and on the identification of oxidant sensors in cell signaling.

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Crossref · 10.1038/nchembio.85

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Authors
Winterbourn, C. C.
Affiliations
University of Otago (NZ)
Corresponding author
Winterbourn, Christine C
Venue
Nature Chemical Biology
Published
2008-04-17
Volume
4
Issue
5
Pages
278-286
ISSN
  • 1552-4450 (ISSN-L)
  • 1552-4469
OpenAlex
W1991952977
Cited by
2,504
References
108
Citations by year
2026: 113 · 2025: 136 · 2024: 133 · 2023: 167 · 2022: 182 · 2021: 189 · 2020: 190 · 2019: 182 · 2018: 179 · 2017: 152 · 2016: 167 · 2015: 127 · 2014: 126 · 2013: 136 · 2012: 101
FWCI
5.66
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Chemical Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
reactive oxygen species, antioxidant effectiveness, redox signaling, NADPH oxidase, restricted diffusion, compartmentalization, oxidative damage, signal transduction
MeSH terms
Enzymes, Kinetics, Mitochondria, NADP, Oxidation-Reduction, Reactive Oxygen Species, Oxidative Stress

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