Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury
Open accessAbstract
Acute kidney injury (AKI) is a rapid loss of kidney function characterized by damage to renal tubular cells driven by mitochondrial dysregulation and oxidative stress. Here, we used a murine caecal ligation and puncture (CLP) model of sepsis-induced AKI to study the role of sirtuin 3 (SIRT3), a NAD+ dependent deacetylase critical for the maintenance of mitochondrial viability, in AKI-related renal tubular cell damage and explored the underlying mechanisms. CLP induced alterations in kidney function and morphology were associated with SIRT3 downregulation, and SIRT3 deletion exacerbated CLP-induced kidney dysfunction, renal tubular cell injury and apoptosis, mitochondrial alterations, and ROS production in a knockout mouse model. SIRT3 deletion increased the CLP-induced upregulation of the NLRP3 inflammasome and apoptosis-associated speck-like protein, resulting in the activation of oxidative stress, increased production of the proinflammatory cytokines interleukin (IL)-1β and IL-18, and the enhancement of apoptosis, and these effects were reversed by antioxidant NAC. Our results suggest that SIRT3 plays a protective role against mitochondrial damage in the kidney by attenuating ROS production, inhibiting the NRLP3 inflammasome, attenuating oxidative stress, and downregulating IL-1β and IL-18.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SIRT3 can directly bind and deacetylate SOD2, leading to increased SOD2 activity and subsequently exerting significant effects on mitochondrial reactive oxygen species homeostasis and NLRP3 inflammasome activation.
“More importantly, SIRT3 can directly bind and deacetylate SOD2, leading to increased SOD2 activity and subsequently exerting significant effects on mtROS homeostasis and NLRP3 inflammasome activation.18, 19, 20”
From Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway (2017) · cites this paper as [18]
Zhao and colleagues demonstrated a protective role of SIRT3 against mitochondrial damage in kidney through activating SOD2 and decreasing ROS production, subsequently inhibiting NLRP3 inflammasome and downregulating IL-1β and IL-18.
“Recently, Zhao and colleagues18 demonstrated a protective role of SIRT3 against mitochondrial damage in the kidney through activating SOD2 and decreasing ROS production, subsequently inhibiting the NRLP3 inflammasome and downregulating IL‐1β and IL‐18.”
From Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway (2017) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works
Hospital-acquired renal insufficiency
Nash, K., Hafeez, A., & Hou, S. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.32766 · Cited by 1,955 · see citing works
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-07 · Cited by 1,216 · see citing works
Acetylation: a regulatory modification to rival phosphorylation?
Kouzarides, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1176 · Cited by 1,155 · see citing works
Pathophysiology of Acute Kidney Injury
Basile, D. P., Anderson, M. D., & Sutton, T. A. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110041 · Cited by 1,115 · see citing works
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works
Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction
Chen, C., Gao, J., Liu, M., Li, S., Xuan, X., Zhang, X., Zhang, X.-Y., Wei, Y., Zhen, C., Jin, J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479536 · Cited by 782 · see citing works
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
Vilaysane, A., Chun, J., Seamone, M. E., Wang, W., Chin, R., Hirota, S., Li, Y., Clark, S. A., Tschopp, J., Trpkov, K., et al. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010020143 · Cited by 587 · see citing works
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
Chen, Y., Zhang, J., Lin, Y., Lei, Q., Guan, K., Zhao, S., & Xiong, Y. (2011) · The EMBO Reports · doi:10.1038/embor.2011.65 · Cited by 572 · see citing works
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
North, B. J., & Verdin, E. M. (2004) · Genome biology · doi:10.1186/gb-2004-5-5-224 · Cited by 568 · see citing works
Sundaresan, N. R., Samant, S. A., Pillai, V. B., Rajamohan, S. B., & Gupta, M. P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00426-08 · Cited by 542 · see citing works
Mediators of Inflammation in Acute Kidney Injury
Akçay, A., Nguyen, Q., & Edelstein, C. L. (2009) · Mediators of Inflammation · doi:10.1155/2009/137072 · Cited by 523 · see citing works
Markers of renal function tests.
Gowda, S., Desai, P. B., Kulkarni, S. S., Hull, V. V., Math, A. A. K., & Vernekar, S. N. (2010) · Europe PMC (PubMed Central) · Cited by 486 · see citing works
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14023834 · Cited by 457 · see citing works
SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage.
Tseng, A. H., Shieh, S., & Wang, D. (2013) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2013.05.002 · Cited by 445 · see citing works
Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology
Zhan, M., Brooks, C. R., Liu, F., Sun, L., & Dong, Z. (2013) · Kidney International · doi:10.1038/ki.2012.441 · Cited by 396 · see citing works
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury.
Morigi, M., Perico, L., Rota, C., Longaretti, L., Conti, S., Rottoli, D., Novelli, R., Remuzzi, G., & Benigni, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77632 · Cited by 388 · see citing works
Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity
Finley, L. W. S., Haas, W., Desquiret‐Dumas, V., Wallace, D. C., Procaccio, V., Gygi, S. P., & Haigis, M. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023295 · Cited by 364 · see citing works
The Inflammasomes in Kidney Disease
Anders, H., & Muruve, D. A. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080798 · Cited by 349 · see citing works
North American Journal of Medical Sciences
(2010) · North American Journal of Medical Sciences · doi:10.4297/najms · Cited by 307 · see citing works
Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer
Chen, Y., Fu, L., Wen, X., Wang, X. Y., Liu, J., Cheng, Y., & Huang, J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.14 · Cited by 231 · see citing works
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
Kitada, M., Kume, S., Takeda‐Watanabe, A., Kanasaki, K., & Koya, D. (2012) · Clinical Science · doi:10.1042/cs20120190 · Cited by 209 · see citing works
Cheung, K. G., Cole, L., Xiang, B., Chen, K., Ma, X., Myal, Y., Hatch, G. M., Tong, Q., & Dolinsky, V. W. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.607960 · Cited by 175 · see citing works
Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer
Kumar, S., & Lombard, D. B. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6213 · Cited by 158 · see citing works
p53-Induced Growth Arrest Is Regulated by the Mitochondrial SirT3 Deacetylase
Li, S., Banck, M. S., Mujtaba, S., Zhou, M.-M., Sugrue, M. M., & Walsh, M. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010486 · Cited by 153 · see citing works
SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells
Koyama, T., Kume, S., Koya, D., Araki, S., Isshiki, K., Chin‒Kanasaki, M., Sugimoto, T., Haneda, M., Sugaya, T., Kashiwagi, A., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.028 · Cited by 142 · see citing works
Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation
Lombard, D. B., Tishkoff, D. X., & Bao, J. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_8 · Cited by 124 · see citing works
Shinomol, G. K., & ., M. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.03.002 · Cited by 83 · see citing works
Mitochondrial Homeostasis in Acute Organ Failure
Stallons, L. J., Funk, J. A., & Schnellmann, R. G. (2013) · Current Pathobiology Reports · doi:10.1007/s40139-013-0023-x · Cited by 76 · see citing works
Beta‐arrestin 2 negatively regulates sepsis‐induced inflammation
Fan, H., Bitto, A., Zingarelli, B., Luttrell, L. M., Borg, K. T., Halushka, P. V., & Cook, J. A. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03185.x · Cited by 66 · see citing works
Cellular localization of NLRP3 inflammasome
Wang, Y., Yang, C., Mao, K., Chen, S., Meng, G., & Sun, B. (2013) · Protein & Cell · doi:10.1007/s13238-013-2113-2 · Cited by 56 · see citing works
Mitochondrial sirtuins and metabolic homeostasis
Pirinen, E., Sasso, G. L., & Auwerx, J. H. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.05.001 · Cited by 56 · see citing works
Sirtuin 3 in acute kidney injury
Perico, L., Remuzzi, G., & Benigni, A. (2015) · Oncotarget · doi:10.18632/oncotarget.4794 · Cited by 5 · see citing works
[Practical methods of biological exploration of cortisol secretion].
Boyer, J. (1972) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Xie, N., Zhang, L., Gao, W. Q., Huang, C., Huber, P., Zhou, X., Li, C. L., Shen, G., & Zou, B. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00311-7 · Cited by 1,076 · see citing works
Self-citationThe sirtuin family in health and disease
Wu, Q., Zhang, T., Chen, H., Yu, X., Lv, J.-L., Liu, Y., Liu, Y., Zheng, G., Zhao, J.-Q., Wei, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01257-8 · Cited by 891 · see citing works
Chen, M., Zhu, X., Ran, L., Lang, H., Yi, L., & Mi, M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006347 · Cited by 600 · see citing works
NAD+ homeostasis in renal health and disease
Ralto, K. M., Rhee, E. P., & Parikh, S. M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0216-6 · Cited by 288 · see citing works
The NLRP3 Inflammasome and Its Role in Sepsis Development
Danielski, L. G., Giustina, A. D., Bonfante, S., Barichello, T., & Petronilho, F. C. (2019) · Inflammation · doi:10.1007/s10753-019-01124-9 · Cited by 237 · see citing works
The Pathophysiology of Sepsis-Associated AKI
Kuwabara, S., Goggins, E. S., & Okusa, M. D. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00850122 · Cited by 232 · see citing works
Liu, Y., & Dai, M. (2020) · Mediators of Inflammation · doi:10.1155/2020/4634172 · Cited by 231 · see citing works
Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives
Hu, D., Prabhakaran, H. S., Zhang, Y.-Y., Luo, G., He, W., & Liou, Y. (2024) · Critical Care · doi:10.1186/s13054-024-05069-w · Cited by 204 · see citing works
SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy
Zhao, W., Zhang, L., Chen, R., Lu, H., Sui, M., Zhu, Y., & Zeng, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01526 · Cited by 156 · see citing works
Self-citationSirt3 modulates fatty acid oxidation and attenuates cisplatin‐induced AKI in mice
Li, M., Li, C., Ye, Z., Huang, J., Li, Y., Lai, W., Peng, H., & Lou, T. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15148 · Cited by 155 · see citing works
SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury
Kurundkar, D., Kurundkar, A., Bone, N. B., Becker, E., Liu, W., Chacko, B. K., Darley-Usmar, V. M., Zmijewski, J. W., & Thannickal, V. J. (2019) · JCI Insight · doi:10.1172/jci.insight.120722 · Cited by 149 · see citing works
Silwal, P., Kim, J. K., Kim, Y. J., & Jo, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01649 · Cited by 131 · see citing works
Traba, J., Geiger, S. S., Osei, M. A., Han, K., Ra, O. H., Siegel, R. M., Gius, D. R., & Sack, M. N. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.791715 · Cited by 119 · see citing works
Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways
Xiang, H., Zhu, F., Xu, Z., & Xiong, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00106 · Cited by 94 · see citing works
Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α
Clark, A. J., & Parikh, S. M. (2020) · Kidney International · doi:10.1016/j.kint.2020.09.037 · Cited by 93 · see citing works
Chen, K., Feng, L., Hu, W., Chen, J., Wang, X., Wang, L., & He, Y. (2019) · The FASEB Journal · doi:10.1096/fj.201801749rrr · Cited by 85 · see citing works
Hu, Q., Ren, J., Ren, H., Wu, J., Wu, X., Liu, S., Wang, G., Gu, G., Guo, K., & Li, J. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8074936 · Cited by 82 · see citing works
The miR-15a-5p-XIST-CUL3 regulatory axis is important for sepsis-induced acute kidney injury
Xu, G., Mo, L., Wu, C., Shen, X., Dong, H., Yu, L., Pan, P., & Pan, K. (2019) · Renal Failure · doi:10.1080/0886022x.2019.1669460 · Cited by 71 · see citing works
Involvement of Inflammasome Components in Kidney Disease
Aranda‐Rivera, A. K., Srivastava, A., Cruz‐Gregorio, A., Pedraza‐Chaverrí, J., Mulay, S. R., & Scholze, A. (2022) · Antioxidants · doi:10.3390/antiox11020246 · Cited by 71 · see citing works
The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases
Jiang, H., Gong, T., & Zhou, R. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.11.003 · Cited by 71 · see citing works
Sirtuins at the Service of Healthy Longevity
Watroba, M., & Szukiewicz, D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.724506 · Cited by 64 · see citing works
Peerapanyasut, W., Kobroob, A., Palee, S., Chattipakorn, N., & Wongmekiat, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020267 · Cited by 64 · see citing works
Wu, J., Deng, Z., Sun, M., Zhang, W., Yang, Y., Zeng, Z., Wu, J., Zhang, Q., Liu, Y., Chen, Z., et al. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0332-8 · Cited by 62 · see citing works
Jian, Y., Yang, Y., Cheng, L., Yang, X., Liu, H., Li, W., Wan, Y., & Yang, D. (2022) · Cell Proliferation · doi:10.1111/cpr.13362 · Cited by 60 · see citing works
Sirtuins and Immuno-Metabolism of Sepsis
Wang, X., Buechler, N. L., Woodruff, A. G., Long, D. L., Zabalawi, M., Yoza, B. K., McCall, C. E., & Vachharajani, V. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092738 · Cited by 60 · see citing works
Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling
Kim, J. K., Jin, H. S., Suh, H., & Jo, E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.23 · Cited by 53 · see citing works
Sirtuins: Research advances on the therapeutic role in acute kidney injury
Huang, C., Jiang, S., Gao, S., Wang, Y., Cai, X.-T., Fang, J., Yan, T., Wan, C. C., & Cai, Y. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154122 · Cited by 51 · see citing works
Xu, Y., Zhang, S., Rong, J., Lin, Y., Du, L., Wáng, Y., & Zhang, Z. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104887 · Cited by 51 · see citing works
Sirtuins in kidney health and disease
Perico, L., Remuzzi, G., & Benigni, A. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00806-4 · Cited by 52 · see citing works
Targeting Mitochondria and Metabolism in Acute Kidney Injury
Li, Y., Hepokoski, M., Gu, W., Simonson, T. S., & Singh, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173991 · Cited by 47 · see citing works
Protective effects of Croton hookeri on streptozotocin-induced diabetic nephropathy
Kundu, A. B., Dey, P. K., Sarkar, P., Karmakar, S., Tae, I. H., Kim, K. S., Park, J. H., Lee, S. H., Lee, B. M., Renthlei, L., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110873 · Cited by 48 · see citing works
Zhao, W., Sui, M., Chen, R., Lu, H., Zhu, Y., Zhang, L., & Zeng, L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120005 · Cited by 45 · see citing works
Self-citationLumpuy‐Castillo, J., Amador‐Martínez, I., Díaz-Rojas, M., Lorenzo, Ó., Pedraza-Chaverrí, J., Sánchez‐Lozada, L. G., & Aparicio‐Trejo, O. E. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103340 · Cited by 44 · see citing works
Sun, F., Si, Y., Bao, H., Xu, Y., Pan, X., Zeng, L., & Jing, L. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0476-2 · Cited by 43 · see citing works
Self-citationPeerapanyasut, W., Kobroob, A., Palee, S., Chattipakorn, N., & Wongmekiat, O. (2019) · IUBMB Life · doi:10.1002/iub.2175 · Cited by 42 · see citing works
The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome
Traba, J., & Sack, M. N. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2431-7 · Cited by 37 · see citing works
Platelets at the crossroads of thrombosis, inflammation and haemolysis
Vogel, S., & Thein, S. L. (2018) · British Journal of Haematology · doi:10.1111/bjh.15117 · Cited by 37 · see citing works
Heinonen, T., Ciarlo, E., Roy, D. L., & Roger, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02341 · Cited by 36 · see citing works
Zheng, K., Bai, J., Li, N., Li, M., Sun, H., Zhang, W., Ge, G., Liang, X., Tao, H., Xue, Y., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.039 · Cited by 36 · see citing works
Metabolic mechanisms orchestrated by Sirtuin family to modulate inflammatory responses
Li, X., Li, Y., Hao, Q., Jin, J., & Wang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1448535 · Cited by 35 · see citing works
Chronic kidney disease attenuates the plasma metabolome response to insulin
Roshanravan, B., Zelnick, L. R., Djucovic, D., Gu, H., Alvarez, J. A., Ziegler, T. R., Gamboa, J. L., Utzschneider, K. M., Kestenbaum, B. R., Himmelfarb, J., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122219 · Cited by 33 · see citing works
Raheem, A. K., Abu-Raghif, A. R., Abbas, A. H., Ridha‐Salman, H., & Oubaid, E. N. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10442-2 · Cited by 32 · see citing works
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells
Haschler, T. N., Horsley, H., Bałys, M., Anderson, G. W., Taanman, J., Unwin, R. J., & Norman, J. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-94185-6 · Cited by 32 · see citing works
Sirtuins: potential therapeutic targets for regulating acute inflammatory response?
Vachharajani, V., & McCall, C. E. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1743268 · Cited by 32 · see citing works
Sirtuin 3 in renal diseases and aging: From mechanisms to potential therapies
Xuan, P., Ni, H., Kuang, B., Wang, Z., Hou, S., Gu, S., & Gong, N. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107261 · Cited by 30 · see citing works
The Mitochondrion: A Promising Target for Kidney Disease
Tanrıöver, C., Çöpür, S., Uçku, D., Cakir, A. B., Hasbal, N. B., Soler, M. J., & Kanbay, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020570 · Cited by 30 · see citing works
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
Ciarlo, E., Heinonen, T., Lugrin, J., Acha‐Orbea, H., Roy, D. L., Auwerx, J. H., & Roger, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-04263-x · Cited by 28 · see citing works
Liu, X., Liu, H., Lu, X., & Zhao, S. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108654 · Cited by 28 · see citing works
Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats
Kundu, A., Richa, S., Dey, P., Kim, K. S., Son, J. Y., Kim, H. R., Lee, S.-Y., Lee, B.-H., Lee, K. Y., Kacew, S., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114899 · Cited by 27 · see citing works
Chen, Y.-H., Fu, Y., & Wu, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020147 · Cited by 27 · see citing works
Effects of Dapagliflozin on Experimental Sepsis Model in Rats
Kingir, Z. B. (2018) · Turkish Journal of Trauma and Emergency Surgery · doi:10.5505/tjtes.2018.82826 · Cited by 25 · see citing works
Bayer, J., Vaghela, R., Drechsler, S., Osuchowski, M. F., Erben, R. G., & Andrukhova, O. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251317 · Cited by 24 · see citing works
Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation
Mayorov, V., Uchakin, P., Amarnath, V., Panov, A. V., Bridges, C. C., Uzhachenko, R. V., Zackert, B., Moore, C. S., Davies, S. S., Dikalova, A., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101300 · Cited by 25 · see citing works
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3
Cheng, Z., Lv, D., Luo, M., Wang, R., Guo, Y., Yang, X., Huang, L., Li, X., Li, C., Shang, F., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174186 · Cited by 23 · see citing works
Fan, H., Le, J., Sun, M., & Zhu, J. (2021) · PubMed Central · doi:10.22038/ijbms.2021.54905.12312 · Cited by 22 · see citing works
Saadat, Y. R., Khatibi, S. M. H., Ardalan, M., Barzegari, A., & Vahed, S. Z. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30084 · Cited by 22 · see citing works
Zhang, Y., Ning, B., Xu, Z., Xu, L., Zhou, L., Ge, Y., & Jia, R. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6428498 · Cited by 21 · see citing works
Kundu, A. B., Gali, S., Sharma, S., Park, J. H., Kyung, S. Y., Kacew, S., Kim, I. S., Lee, K. Y., & Kim, H. S. (2022) · Antioxidants · doi:10.3390/antiox11091812 · Cited by 22 · see citing works
Histone Modifications in Acute Kidney Injury
Wang, J., Shen, F., Liu, F., & Zhuang, S. (2022) · Kidney Diseases · doi:10.1159/000527799 · Cited by 21 · see citing works
Emerging Evidence concerning the Role of Sirtuins in Sepsis
Li, L., Chen, Z., Fu, W., Cai, S., & Zeng, Z. (2018) · Critical Care Research and Practice · doi:10.1155/2018/5489571 · Cited by 21 · see citing works
Richardson, K. K., Adam, G. O., Ling, W., Warren, A. D., Marques-Carvalho, A., Thostenson, J. D., Krager, K. J., Aykin‐Burns, N., Byrum, S. D., Almeida, M., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102012 · Cited by 21 · see citing works
Dey, P. K., Kundu, A. B., Lee, H. E., Kar, B., Vishal, V., Dash, S., Kim, I. S., Bhakta, T., & Kim, H. S. (2022) · Molecules · doi:10.3390/molecules27154985 · Cited by 20 · see citing works
The Significance of NAD+ Biosynthesis Alterations in Acute Kidney Injury
Clark, A. J., Saadé, M. C., & Parikh, S. M. (2022) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2022.10.013 · Cited by 20 · see citing works
Xiong, J., & Zhou, Q. (2023) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12676 · Cited by 19 · see citing works
The protective mechanism of SIRT3 and potential therapy in acute kidney injury
Yuan, J., Zhao, J., Qin, Y., Zhang, Y., Wang, A., Ma, R., Han, M., Hui, Y., Guo, S., Ning, X., et al. (2023) · QJM · doi:10.1093/qjmed/hcad152 · Cited by 19 · see citing works
The role and therapeutic potential of SIRTs in sepsis
You, J., Li, Y., & Chong, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1394925 · Cited by 18 · see citing works
NADPH oxidase inhibitor, diphenyleneiodonium prevents necroptosis in HK-2 cells
Dong, W., Li, Z., Chen, Y., Zhang, L., Ye, Z., Liang, H., Li, R., Xu, L., Zhang, B., Liu, S., et al. (2017) · Biomedical Reports · doi:10.3892/br.2017.948 · Cited by 18 · see citing works
Self-citationSirtuins play critical and diverse roles in acute kidney injury
Peasley, K., Chiba, T., Goetzman, E. S., & Sims‐Lucas, S. (2021) · Pediatric Nephrology · doi:10.1007/s00467-020-04866-z · Cited by 18 · see citing works
Yuan, Y., Li, X., Chu, Y., Ye, G., Yang, L., & Dong, Z. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.632398 · Cited by 18 · see citing works
Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways
Anugraha, G., Roychowdhury, S., & Vachharajani, V. (2021) · Antioxidants · doi:10.3390/antiox11010003 · Cited by 17 · see citing works
mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses
Lund, N. C., Kayode, Y. I., McReynolds, M. R., Clemmer, D. C., Hudson, H., Clerc, I., Hong, H., Brenchley, J. M., Bass, J. T., D’Aquila, R. T., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03804-z · Cited by 16 · see citing works
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3
Yang, X., Li, X., Luo, M., Li, C., Huang, L., Li, X., Huang, B., Shen, J., Luo, S., & Yan, J. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00580-y · Cited by 16 · see citing works
The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury
Zhou, X. C., Chen, H., Shi, Y., Ma, X., Zhuang, S., & Liu, N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.695237 · Cited by 16 · see citing works
The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
LoBianco, F. V., Krager, K. J., Carter, G. S., Alam, S., Yuan, Y., Lavoie, É. G., Dranoff, J. A., & Aykin‐Burns, N. (2020) · Antioxidants · doi:10.3390/antiox9050409 · Cited by 16 · see citing works
P27 Protects Cardiomyocytes from Sepsis via Activation of Autophagy and Inhibition of Apoptosis
Zhao, X., Qi, H., Zhou, J., Xu, S., & Gao, Y. (2018) · Medical Science Monitor · doi:10.12659/msm.912750 · Cited by 15 · see citing works
The Effect of PGC-1alpha-SIRT3 Pathway Activation on Pseudomonas aeruginosa Infection
Maurice, N. M., Bedi, B., Yuan, Z., Lin, K.-C., Goldberg, J. B., Hart, C. M., Bailey, K. L., & Sadikot, R. T. (2022) · Pathogens · doi:10.3390/pathogens11020116 · Cited by 13 · see citing works
MicroRNA‐16‐5p exacerbates sepsis by upregulating aerobic glycolysis via SIRT3‐SDHA axis
He, Y., Huang, B., Yang, Y., Song, W., Fan, Y., Zhang, L., & Liu, G. (2022) · Cell Biology International · doi:10.1002/cbin.11908 · Cited by 12 · see citing works
Self-citationDietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice
Lee, D., Kim, Y.-R., Js, K., Kim, D.-G., Kim, S., Kim, S., Jang, K., Lee, J.-D., & Yang, C. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01231-4 · Cited by 12 · see citing works
Sirtuins, Healthspan, and Longevity in Mammals
Giblin, W., & Lombard, D. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00003-4 · Cited by 12 · see citing works
Role of oxidative stress in sepsis: Mechanisms, pathways, and therapeutic strategies
Yang, X., Wen, R., Yang, N., Gao, Y., & Zhang, T. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101452 · Cited by 13 · see citing works
The Role of Mitochondrial Dysfunction in Sepsis-Associated Acute Kidney Injury: A Narrative Review
Liu, J., Zheng, J., Xu, Y., & Jiang, Y. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s553838 · Cited by 11 · see citing works
Hutton, H., Alikhan, M. A., & Kitching, A. R. (2018) · Experientia supplementum · doi:10.1007/978-3-319-89390-7_8 · Cited by 11 · see citing works
Mitochondrial Sirt3 serves as a biomarker for sepsis diagnosis and mortality prediction
Liu, J., Zhou, G., Chen, R., Tong, Z., Zhang, H., Wang, X., & Liu, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-14365-w · Cited by 11 · see citing works
Li, Y., Ren, S., & Zhou, S. (2025) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2025.104963 · Cited by 10 · see citing works
Role of sirtuins in sepsis and sepsis-induced organ dysfunction: A review
Yang, X., Wen, R., Yang, N., & Zhang, T. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134853 · Cited by 9 · see citing works
Exploring Sirtuins: New Frontiers in Managing Heart Failure with Preserved Ejection Fraction
Lü, Y., Li, Y., Xie, Y., Bu, J., Yuan, R., & Zhang, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147740 · Cited by 8 · see citing works
Tungalag, T., Yoo, Y.-J., Tae, H., & Yang, D. K. (2022) · Antioxidants · doi:10.3390/antiox11030443 · Cited by 8 · see citing works
Wang, S., Liu, G., Jia, T., Wang, C., Lu, X., Tian, L., Yang, Q., & Zhu, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.848491 · Cited by 7 · see citing works
Labiner, H. E., Sas, K. M., Hoying, J., Sepeda, J. A., Wolf, N., Perez, E. C., Sas, A., & Sims, C. A. (2023) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000004212 · Cited by 7 · see citing works
Yang, S., Wu, C., Li, S., Zhao, S., & Fan, C. (2025) · Biomolecules · doi:10.3390/biom15101445 · Cited by 6 · see citing works
Resolvin D4 mitigates lipopolysaccharide-induced lung injury in mice
Inomata, R., Tsubouchi, H., Takao, T., Kurokawa, M., Yanagi, S., Sakai, K., & Miyazaki, T. (2024) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2024.102652 · Cited by 6 · see citing works
The Role of Sirt3 in Kidney Health and Disease
Azzouz, R. S., & Yan, L. (2025) · Pharmaceuticals · doi:10.3390/ph18111668 · Cited by 5 · see citing works
Fan, H., Le, J., Sun, M., & Zhu, J. (2024) · PubMed Central · doi:10.22038/ijbms.2024.72882.15853 · Cited by 5 · see citing works
Sirt3 Deletion Increases Inflammation and Mortality in Polymicrobial Sepsis
Labiner, H. E., Sas, K. M., Baur, J. A., & Sims, C. A. (2023) · Surgical Infections · doi:10.1089/sur.2023.161 · Cited by 5 · see citing works
Gali, S., Kundu, A. B., Sharma, S., Ahn, M.-Y., Puia, Z., Kumar, V., Kim, I. S., Kwak, J. H., Palit, P., & Kim, H. S. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2394586 · Cited by 5 · see citing works
Sun, C., Xiong, H., & Guo, T. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01619-9 · Cited by 5 · see citing works
Gu, H., Xu, L., Yu, X., Xiang, J., Shan, Y., & Ye, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-18938-3 · Cited by 4 · see citing works
Sun, S., Liu, S., Ruan, S., Zhou, H., Cui, X., Lu, N., Hong, L., & Lu, M. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117465 · Cited by 3 · see citing works
Targeting the NAD + -SIRT3 axis to mitigate metabolic memory in diabetic kidney disease
Zhang, Y., Wang, Y., Qiao, Y., Liu, L. S., Zhao, H., Jin, Q., Peng, L., & Li, P. (2026) · Renal Failure · doi:10.1080/0886022x.2026.2648912 · Cited by 3 · see citing works
Sirtuins, healthspan, and longevity in mammals
Kumar, S., Giblin, W., & Lombard, D. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00005-6 · Cited by 2 · see citing works
- Authors
- Zhao, W.-Y., Zhang, L., Sui, M.-X., Zhu, Y.-H., & Zeng, L.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Zeng, Li
- Venue
- Scientific Reports
- Published
- 2016-09-13
- Volume
- 6
- Issue
- 1
- Pages
- 33201-33201
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5020492
- OpenAlex
- W2519715909
- Cited by
- 114
- References
- 39
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 15 · 2023: 7 · 2022: 17 · 2021: 17 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 6 · 2016: 1 · 2015: 1
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81470979, 81370854, 81270830)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Keywords
- SIRT3, sepsis-associated acute kidney injury, cecal ligation and puncture, mitochondrial dysfunction, oxidative stress, reactive oxygen species, NLRP3 inflammasome, apoptosis, IL-1β, IL-18, N-acetylcysteine, antioxidant defense
- MeSH terms
- Animals, Disease Models, Animal, Kidney Tubules, Proximal, Male, Mice, Inbred C57BL, Mitochondria, Cytokines, Apoptosis, Reactive Oxygen Species, Mice, Knockout, Sepsis, RNA Interference, Sirtuin 3, Mice, 129 Strain, Acute Kidney Injury, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
