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Cited by 61Heart Rate Variability and Autonomic ControlMental Health Research TopicsNeuroscience of respiration and sleep

Resting-state high-frequency heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls

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Quintana, Daniel S., Elstad, Maja, Kaufmann, Tobias, Brandt, Christine L., Haatveit, Beathe, Haram, Marit, Nerhus, Mari, Westlye, Lars T. +1 more·2016·Scientific Reports
DOI 10.1038/srep37212PMC PMC5112550
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Abstract

Heart rate variability (HRV) has become central to biobehavioral models of self-regulation and interpersonal interaction. While research on healthy populations suggests changes in respiratory frequency do not affect short-term HRV, thus negating the need to include respiratory frequency as a HRV covariate, the nature of the relationship between these two variables in psychiatric illness is poorly understood. Therefore, the aim of this study was to investigate the association between HRV and respiratory frequency in a sample of individuals with severe psychiatric illness (n = 55) and a healthy control comparison group (n = 149). While there was no significant correlation between HF-HRV and respiration in the control group, we observed a significant negative correlation in the psychiatric illness group, with a 94.1% probability that these two relationships are different. Thus, we provide preliminary evidence suggesting that HF-HRV is related to respiratory frequency in severe mental illness, but not in healthy controls, suggesting that HRV research in this population may need to account for respiratory frequency. Future work is required to better understand the complex relationship between respiration and HRV in other clinical samples with psychiatric diseases.

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Authors
Quintana, D. S., Elstad, M., Kaufmann, T., Brandt, C. L., Haatveit, B., Haram, M., Nerhus, M., Westlye, L. T., & Andreassen, O. A.
Affiliations
  • Oslo University Hospital (NO)
  • University of Oslo (NO)
Corresponding author
Quintana, Daniel S.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-11-17
Volume
6
Issue
1
Pages
37212-37212
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep37212
PMC
PMC5112550
OpenAlex
W2551490154
Cited by
61
References
12
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 4 · 2015: 1
FWCI
4.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
heart rate variability, respiratory rate, high-frequency HRV, severe mental illness, mental illness, self-regulation, healthy controls
MeSH terms
Adult, Mental Disorders, Female, Heart Rate, Humans, Male, Rest, Severity of Illness Index, Respiratory Rate

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