Taking Systems Medicine to Heart
Open accessAbstract
Systems medicine is a holistic approach to deciphering the complexity of human physiology in health and disease. In essence, a living body is constituted of networks of dynamically interacting units (molecules, cells, organs, etc) that underlie its collective functions. Declining resilience because of aging and other chronic environmental exposures drives the system to transition from a health state to a disease state; these transitions, triggered by acute perturbations or chronic disturbance, manifest as qualitative shifts in the interactions and dynamics of the disease-perturbed networks. Understanding health-to-disease transitions poses a high-dimensional nonlinear reconstruction problem that requires deep understanding of biology and innovation in study design, technology, and data analysis. With a focus on the principles of systems medicine, this Review discusses approaches for deciphering this biological complexity from a novel perspective, namely, understanding how disease-perturbed networks function; their study provides insights into fundamental disease mechanisms. The immediate goals for systems medicine are to identify early transitions to cardiovascular (and other chronic) diseases and to accelerate the translation of new preventive, diagnostic, or therapeutic targets into clinical practice, a critical step in the development of personalized, predictive, preventive, and participatory (P4) medicine.
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According to the concepts of complex systems science, the human body is a self-organizing complex adaptive system (CAS), namely, a "network of networks".
“According to the concepts of complex systems science, the human body is a self-organizing complex adaptive system (CAS), namely, a “network of networks”.82”
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- Authors
- Trachana, K., Bargaje, R., Glusman, G., Price, N. D., Huang, S., & Hood, L. E.
- Affiliations
- Institute for Systems Biology (US)
- University of Calgary (CA)
- Venue
- Circulation Research
- Published
- 2018-04-27
- Volume
- 122
- Issue
- 9
- Pages
- 1276-1289
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC5926821
- OpenAlex
- W2801985397
- Cited by
- 41
- References
- 121
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 11 · 2018: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM109964, P50GM076547)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- systems medicine, cardiovascular disease, chronic disease, aging, biological networks, nonlinear reconstruction, disease mechanisms, P4 medicine, personalized medicine, preventive medicine, translational research
- MeSH terms
- Industrial Development, Cardiovascular Diseases, Chronic Disease, Diagnostic Techniques, Cardiovascular, Environmental Exposure, Forecasting, Humans, Models, Cardiovascular, Systems Analysis, Biomarkers, Disease Progression, Genomics, Early Diagnosis, Genome-Wide Association Study, Translational Research, Biomedical, Precision Medicine, In Vitro Techniques
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