Body composition and bone mineral status in patients with Turner syndrome
Open accessAbstract
Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body composition and decreased bone mineral status parameters in patients with TS. This study included 24 girls with TS, in which 13 girls exhibited X0 karyotype and 11 had mosaicism. Quantitative ultrasound (QUS) assessed the bone mineral status of the calcaneus, including bone mineral density (BMD), amplitude-dependent speed of sound (AD-SOS), broadband ultrasound attenuation (BUA) and InBody 770 assessed body composition. Pearson's test was performed to correlate measured parameters with patient age. The body composition and bone mineral status parameters were not significantly influenced by patient karyotype. There was a correlation between patient age and AD-SOS (r = -0.61, P = 0.002) and BUA (r = 0.50, P = 0.013) but not BMD (r = -0.19, P = 0.379). In conclusion, there was no effect of karyotype on body composition or body mineral status. Bone mineral status, as evidenced by changes in AD-SOS and BUA, alters with age regardless of karyotype. The developmental trajectory demonstrated in the current study warrants further validation in a longitudinal study.
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Karyotype per se is not predictive of BMD.
“Although karyotype per se737 is not predictive of BMD, the “dose effect” of the SHOX gene is associated with thinning of cortical bone and increased bone geometry at the distal radius.351,738,739”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [737]
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- Authors
- Shi, K., Liu, L., He, Y.-J., Li, D., Yuan, L.-X., Lash, G. E., & Li, L.
- Affiliations
- Guangzhou Women and Children Medical Center (CN)
- Corresponding author
- Lash, Gendie E.
- Li, Li
- Venue
- Scientific Reports
- Published
- 2016-11-30
- Volume
- 6
- Issue
- 1
- Pages
- 38026-38026
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5128814
- OpenAlex
- W2558927646
- Cited by
- 18
- References
- 29
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 2
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Hologic
- Baoji University of Arts And Sciences
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- Turner syndrome, body composition, bone mineral status, bone mineral density, quantitative ultrasound, amplitude-dependent speed of sound, broadband ultrasound attenuation, mosaicism, age-related changes, fracture risk
- MeSH terms
- Adolescent, Adult, Body Composition, Child, Female, Humans, Mosaicism, Turner Syndrome, Bone Density
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