Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease
Open accessAbstract
Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is difficult to construct because of the complex characteristics of neuroimaging data. To address this problem, we present a longitudinal measurement of MCI brain images and a hierarchical classification method for AD prediction. Longitudinal images obtained from individuals with MCI were investigated to acquire important information on the longitudinal changes, which can be used to classify MCI subjects as either MCI conversion (MCIc) or MCI non-conversion (MCInc) individuals. Moreover, a hierarchical framework was introduced to the classifier to manage high feature dimensionality issues and incorporate spatial information for improving the prediction accuracy. The proposed method was evaluated using 131 patients with MCI (70 MCIc and 61 MCInc) based on MRI scans taken at different time points. Results showed that the proposed method achieved 79.4% accuracy for the classification of MCIc versus MCInc, thereby demonstrating very promising performance for AD prediction.
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Longitudinal-data classifiers outperform cross-sectional-data classifiers in classification performance.
“Informed by pattern classification studies which have demonstrated that pattern classifiers built on longitudinal data could achieve better classification performance than those built on cross-sectional data”
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Cites
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- Authors
- Huang, M., Yang, W., Feng, Q., Chen, W., Initiative, T. A. D. N., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R., Dolen, S., Schneider, L. S., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B. M., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J. L., Lord, J. L., Mason, S. S., Albers, C. S., Knopman, D., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L. S., Bell, K. L., Ances, B., Morris, J. C., Carroll, M., Creech, M. L., Franklin, E., Mintun, M. A., Schneider, S., Oliver, A., Marson, D., Griffith, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Love, M. N., Grossman, H., Mitsis, E., Shah, R. C., deToledo-Morrell, L., Duara, R., Varon, D., Greig, M. T., Roberts, P., Albert, M., Onyike, C., D’Agostino, D., Kielb, S., Galvin, J. E., Cerbone, B., Michel, C. A., Pogorelec, D. M., Rusinek, H., de Leon, M. J., Glodzik, L., De Santi, S., Doraiswamy, P. M., Petrella, J. R., Borges-Neto, S., Wong, T. Z., Coleman, E., Smith, C. D., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Mulnard, R. A., Thai, G., Mc-Adams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Swerdlow, R. H., Brooks, W. M., Apostolova, L., Tingus, K., Woo, E., Silverman, D. H. S., Lu, P. H., Bartzokis, G., Graff-Radford, N. R., Parfitt, F., Kendall, T., Johnson, H., Farlow, M. R., Hake, A. M., Matthews, B. R., Brosch, J. R., Herring, S., Hunt, C., van Dyck, C. H., Carson, R. E., MacAvoy, M. G., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Hsiung, G.-Y. R., Feldman, H., Mudge, B., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Mesulam, M. M., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C.-K., Johnson, N., Sadowsky, C., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M. N., Belden, C. M., Jacobson, S. A., Sirrel, S. A., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Obisesan, T. O., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., DeCarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T.-Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C. M., Potkin, S. G., Preda, A., Nguyen, D., Tariot, P., Burke, A., Trncic, N., Fleisher, A., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Adeli, A., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Flashman, L. A., Seltzer, M., Hynes, M. L., Santulli, R. B., Sink, K. M., Gordineer, L., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Raj, B. A., & Fargher, K.
- Affiliations
- Southern Medical University (CN)
- University of California, San Francisco (US)
- Mayo Clinic (US)
- University of Pennsylvania (US)
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Washington University in St. Louis (US)
- Oregon Health & Science University (US)
- University of California San Diego (US)
- University of Michigan (US)
- Baylor College of Medicine (US)
- Columbia University Irving Medical Center (US)
- University of Alabama at Birmingham (US)
- Icahn School of Medicine at Mount Sinai (US)
- Rush University Medical Center (US)
- Johns Hopkins University (US)
- New York University (US)
- Duke Medical Center (US)
- University of Kentucky (US)
- University of Rochester Medicine (US)
- University of California, Irvine (US)
- The University of Texas Southwestern Medical Center (US)
- Emory University (US)
- University of Kansas (US)
- University of California, Los Angeles (US)
- Mayo Clinic in Florida (US)
- Indiana University (US)
- Yale University (US)
- Jewish General Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Cleveland Clinic (US)
- Northwestern University (US)
- Palm Beach Neurology (US)
- Georgetown University Medical Center (US)
- Stanford University (US)
- Banner Sun Health Research Institute (US)
- Boston University (US)
- Howard University (US)
- Case Western Reserve University (US)
- University of California, Davis (US)
- Banner Alzheimer’s Institute (US)
- Dent Neurologic Institute (US)
- The Ohio State University (US)
- Albany Medical College (US)
- Hartford Hospital (US)
- Dartmouth–Hitchcock Medical Center (US)
- Wake Forest University Health Sciences (US)
- Rhode Island Hospital (US)
- Butler Hospital (US)
- Medical University of South Carolina (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Cornell University (US)
- University of South Florida (US)
- Corresponding author
- Feng, Qianjin
- ORCID
- Huang, Meiyan
- Yang, Wei
- Feng, Qianjin
- Chen, Wufan
- Weiner, Michael W.
- Aisen, Paul
- Petersen, Ronald
- Jack, Clifford R.
- Jagust, William
- Toga, Arthur W.
- Beckett, Laurel
- Green, Robert C.
- Saykin, Andrew J.
- Shaw, Leslie M.
- Kaye, Jeffrey
- Quinn, Joseph
- Silbert, Lisa
- Schneider, Lon S.
- Heidebrink, Judith L.
- Lord, Joanne L.
- Knopman, David
- Johnson, Kris
- Stern, Yaakov
- Honig, Lawrence S.
- Bell, Karen L.
- Ances, Beau
- Carroll, Maria
- Franklin, Erin
- Oliver, Angela
- Marson, Daniel
- Clark, David
- Geldmacher, David
- Roberson, Erik
- Love, Marissa Natelson
- Shah, Raj C.
- Duara, Ranjan
- Albert, Marilyn
- Onyike, Chiadi
- D’Agostino, Daniel
- Kielb, Stephanie
- Galvin, James E.
- Cerbone, Brittany
- Rusinek, Henry
- Glodzik, Lidia
- Doraiswamy, P. Murali
- Petrella, Jeffrey R.
- Wong, Terence Z.
- Smith, Charles D.
- Hardy, Peter
- Sinha, Partha
- Porsteinsson, Anton P.
- Ismail, M. Saleem
- Thai, Gaby
- Womack, Kyle
- Quiceno, Mary
- Levey, Allan I.
- Lah, James J.
- Burns, Jeffrey M.
- Swerdlow, Russell H.
- Brooks, William M.
- Apostolova, Liana
- Silverman, Daniel H. S.
- Lu, Po H.
- Johnson, Heather
- Farlow, Martin R.
- Hake, Ann Marie
- Brosch, Jared R.
- Carson, Richard E.
- Chertkow, Howard
- Bergman, Howard
- Black, Sandra
- Stefanovic, Bojana
- Hsiung, Ging-Yuek Robin
- Feldman, Howard
- Finger, Elizabeth
- Bernick, Charles
- Bonakdarpour, Borna
- Kerwin, Diana
- Johnson, Nancy
- Turner, Raymond Scott
- Sperling, Reisa A.
- Johnson, Keith A.
- Marshall, Gad
- Yesavage, Jerome
- Taylor, Joy L.
- Lane, Barton
- Rosen, Allyson
- Sabbagh, Marwan N.
- Belden, Christine M.
- Jacobson, Sandra A.
- Kowall, Neil
- Killiany, Ronald
- Budson, Andrew E.
- Norbash, Alexander
- Obisesan, Thomas O.
- Lerner, Alan
- Tatsuoka, Curtis
- Maillard, Pauline
- Olichney, John
- DeCarli, Charles
- Carmichael, Owen
- Johnson, Sterling
- Asthana, Sanjay
- Carlsson, Cynthia M.
- Potkin, Steven G.
- Preda, Adrian
- Nguyen, Dana
- Tariot, Pierre
- Burke, Anna
- Scharre, Douglas W.
- Kataki, Maria
- Pearlson, Godfrey D.
- Flashman, Laura A.
- Hynes, Mary L.
- Santulli, Robert B.
- Sink, Kaycee M.
- Williamson, Jeff D.
- Garg, Pradeep
- Ott, Brian R.
- Tremont, Geoffrey
- Salloway, Stephen
- Correia, Stephen
- Miller, Bruce L.
- Perry, David
- Mintzer, Jacobo
- Bachman, David
- Pomara, Nunzio
- Relkin, Norman
- Ravdin, Lisa
- Venue
- Scientific Reports
- Published
- 2017-01-12
- Volume
- 7
- Issue
- 1
- Pages
- 39880-39880
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5227696
- OpenAlex
- W2575828404
- Cited by
- 55
- References
- 4
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 9 · 2017: 4
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- UKnowledge (University of Kentucky) (submittedVersion, cc-by)
- Scholarship@Western (Western University) (submittedVersion)
- Funders
- Foundation for the National Institutes of Health (U01AG024904, Grant U01 AG024904, AG024904)
- Alzheimer's Association (U01 AG024904)
- Bristol-Myers Squibb (U01 AG024904, AG024904)
- Eli Lilly and Company (U01 AG024904, AG024904)
- AstraZeneca
- GlaxoSmithKline
- Novartis
- University of Southern California (U01 AG024904)
- F. Hoffmann-La Roche (AG024904, U01 AG024904)
- Medpace (U01 AG024904)
- Synarc (U01 AG024904)
- Alzheimer's Disease Neuroimaging Initiative (U01AG024904, AG024904)
- Northern California Institute for Research and Education (U01 AG024904)
- National Natural Science Foundation of China (U15012561016942, 31371009, U01 AG024904, 81601562, 2015B010131011)
- Elan (U01 AG024904)
- Eisai (U01 AG024904, AG024904)
- National Institutes of Health (3u01ag024904-10s2, U01-AG024904, Grant U01 AG024904, AG024904)
- Genentech (AG024904, U01 AG024904)
- University of California, San Diego
- Science and Technology Planning Project of Guangdong Province (2015B010131011)
- National Institute on Aging (U01-AG-024904, P30AG010129, AG 024904, P50AG005142)
- National Institute of Biomedical Imaging and Bioengineering (U01 AG024904, AG024904)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- Alzheimer's disease prediction, mild cognitive impairment, MCI conversion, longitudinal brain MRI, hierarchical classification, dimensionality reduction, geospatial data, early diagnosis, neuroimaging
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Sensitivity and Specificity, Disease Progression, Early Diagnosis, Neuroimaging, Cognitive Dysfunction
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