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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Open accessAbstract
GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.
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Metadata
- Authors
- Lo, M. K., Jordan, R., Arvey, A., Sudhamsu, J., Shrivastava-Ranjan, P., Hotard, A. L., Flint, M., McMullan, L. K., Siegel, D., Clarke, M. O., Mackman, R. L., Hui, H. C., Perron, M., Ray, A. S., Cihlar, T., Nichol, S. T., & Spiropoulou, C. F.
- Venue
- Scientific Reports
- Published
- 2017-03-06
- Volume
- 7
- Issue
- 1
- Pages
- 43395-43395
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2593309919
- Cited by
- 513
- References
- 26
- FWCI
- 40.72
- Type
- journal article
- Language
- en
- Open access
- gold
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