Drug repositioning: Progress and challenges in drug discovery for various diseases

Hua, Yi; Dai, Xiaowen; Xu, Yuan; Xing, Guomeng; Liu, Haichun; Lu, Tao; Chen, Yadong; Zhang, Yanmin

doi:10.1016/j.ejmech.2022.114239

Cited by 233Computational Drug Discovery MethodsPharmaceutical Economics and PolicyHistorical Medical Research and Treatments

Drug repositioning: Progress and challenges in drug discovery for various diseases

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Hua, Yi, Dai, Xiaowen, Xu, Yuan, Xing, Guomeng, Liu, Haichun, Lu, Tao, Chen, Yadong, Zhang, Yanmin·2022·European Journal of Medicinal Chemistry

DOI 10.1016/j.ejmech.2022.114239PMC PMC8883737

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Abstract

Compared with traditional de novo drug discovery, drug repurposing has become an attractive drug discovery strategy due to its low-cost and high efficiency. Through a comprehensive analysis of the candidates that have been identified with drug repositioning potentials, it is found that although some drugs do not show obvious advantages in the original indications, they may exert more obvious effects in other diseases. In addition, some drugs have a synergistic effect to exert better clinical efficacy if used in combination. Particularly, it has been confirmed that drug repositioning has benefits and values on the current public health emergency such as the COVID-19 pandemic, which proved the great potential of drug repositioning. In this review, we systematically reviewed a series of representative drugs that have been repositioned for different diseases and illustrated successful cases in each disease. Especially, the mechanism of action for the representative drugs in new indications were explicitly explored for each disease, we hope this review can provide important insights for follow-up research.

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The conventional pathway for novel drug discovery, development, and regulatory approval can span approximately 15 years, rendering it inadequate to address immediate clinical demands posed by resistant Candida infections.
“Yet, the conventional pathway for novel drug discovery, development, and regulatory approval can span approximately 15 years, rendering it inadequate to address the immediate and growing clinical demands posed by resistant Candida infections [14, 15].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [14]
The Introduction (page unavailable) estimates that developing a new drug takes 12–17 years, supporting the approximately 15-year figure. The Antimicrobial repositioning section (page unavailable) says new treatments are urgently needed for antimicrobial resistance, but it does not specifically establish that the conventional pathway is inadequate for the immediate clinical demands of resistant Candida infections. (LLM, conf=0.84)
Experimental — accuracy not yet measured
The drug development process can take approximately 12-17 years.
“Completing these stages can take approximately 12–17 years [14].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [14]

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1 Contemporary trends in drug repurposing: Identifying new targets for existing drugs
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DRUG REPURPOSING IN THE ERA OF ARTIFICIAL INTELLIGENCE: FROM MOLECULAR INSIGHTS TO CLINICAL TRANSLATION
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Authors: Hua, Y., Dai, X., Xu, Y., Xing, G., Liu, H., Lu, T., Chen, Y., & Zhang, Y.
Affiliations: China Pharmaceutical University (CN)
Corresponding author: Chen, Yadong
Zhang, Yanmin
ORCID: Dai, Xiaowen
Xu, Yuan
Liu, Haichun
Chen, Yadong
Zhang, Yanmin
Venue: European Journal of Medicinal Chemistry
Publisher: Elsevier BV
Published: 2022-04
Volume: 234
Pages: 114239
ISSN: 0223-5234 (ISSN-L)
DOI: 10.1016/j.ejmech.2022.114239
PMC: PMC8883737
OpenAlex: W4220885170
Cited by: 232
References: 249
Citations by year: 2026: 35 · 2025: 77 · 2024: 80 · 2023: 31 · 2022: 9
FWCI: 4.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: European Journal of Medicinal Chemistry (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China
Topics: Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
Keywords: drug repurposing, drug discovery, drug synergy, combination therapy, COVID-19 pandemic, mechanism of action
MeSH terms: COVID-19 Drug Treatment, Humans, Drug Discovery, Drug Repositioning, Pandemics

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