A Potential Mechanism Underlying Atypical Antipsychotics-Induced Lipid Disturbances
Open accessAbstract
Previous findings suggested that a four-protein complex, including sterol-regulatory element-binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), insulin-induced gene (INSIG) and progesterone receptor membrane component 1 (PGRMC1), within the endoplasmic reticulum appears to be an important regulator responsible for atypical antipsychotic drug (AAPD)-induced lipid disturbances. In the present study, effects of typical antipsychotic drug and AAPDs as well as treatment outcome of steroid antagonist mifepristone (MIF) on the PGRMC1/INSIG/SCAP/SREBP pathway were investigated in rat liver using real-time quantitative polymerase chain reaction (qPCR) and western blot analysis. In addition, serum triacylglycerol, total cholesterol, free fatty acids and various hormones including progesterone, corticosterone and insulin were measured simultaneously. Following treatment with clozapine or risperidone, both lipogenesis and cholesterogenesis were enhanced via inhibition of PGRMC1/INSIG-2 and activation of SCAP/SREBP expressions. Such metabolic disturbances, however, were not demonstrated in rats treated with aripiprazole (ARI) or haloperidol (HAL). Moreover, the add-on treatment of MIF was effective in reversing the AAPD-induced lipid disturbances by upregulating the expression of PGRMC1/INSIG-2 and subsequent downregulation of SCAP/SREBP. Taken together, our findings suggest that disturbances in lipid metabolism can occur at an early stage of AAPD treatment before the presence of weight gain. Such metabolic defects can be modified by an add-on treatment of steroid antagonist MIF enhancing the PGRMC1 pathway. Thus, it is likely that PGRMC1/INSIG-2 signaling may be a therapeutic target for AAPD-induced weight gain.
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Additional treatment with mifepristone effectively reversed the lipid abnormalities induced by atypical antipsychotics.
“Moreover, additional treatment with mifepristone effectively reversed the lipid abnormalities induced by atypical antipsychotics [137].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [137]
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Dose translation from animal to human studies revisited.
Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9574lsf · Cited by 6,524 · see citing works
Protein Sensors for Membrane Sterols
Goldstein, J. L., DeBose‐Boyd, R. A., & Brown, M. S. (2006) · Cell · doi:10.1016/j.cell.2005.12.022 · Cited by 1,685 · see citing works
‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease
Chan, C. S., Guzmán, J. N., Ilijić, E., Mercer, J. N., Rick, C., Tkatch, T., Meredith, G. E., & Surmeier, D. J. (2007) · Nature · doi:10.1038/nature05865 · Cited by 905 · see citing works
The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements.
Buchanan, R., Kreyenbuhl, J., Kelly, D., Noel, J. M., Boggs, D., Fischer, B., Himelhoch, S., Fang, B., Peterson, E., Aquino, P. R., et al. (2010) · Schizophrenia bulletin · doi:10.1093/schbul/sbp116 · Cited by 844 · see citing works
Seckl, J. R., & Walker, B. R. (2001) · Endocrinology · doi:10.1210/endo.142.4.8114 · Cited by 714 · see citing works
Metabolic syndrome in people with schizophrenia: a review
DE HERT, M., SCHREURS, V., VANCAMPFORT, D., & VAN WINKEL, R. (2009) · World Psychiatry · doi:10.1002/j.2051-5545.2009.tb00199.x · Cited by 634 · see citing works
Peuskens, J. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.166.6.712 · Cited by 551 · see citing works
Suchanek, M., Radzikowska, A., & Thiele, C. (2005) · Nature Methods · doi:10.1038/nmeth752 · Cited by 487 · see citing works
Metabolic side effects of antipsychotic drug treatment – pharmacological mechanisms
Reynolds, G. P., & Kirk, S. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.010 · Cited by 400 · see citing works
Kim, S. F., Huang, A. S., Snowman, A. M., Teuscher, C., & Snyder, S. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611417104 · Cited by 394 · see citing works
Hulver, M. W., Berggren, J. R., Carper, M. J., Miyazaki, M., Ntambi, J. M., Hoffman, E. P., Thyfault, J. P., Stevens, R., Dohm, G. L., Houmard, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.002 · Cited by 384 · see citing works
Moon, Y.-A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L., & Horton, J. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.017 · Cited by 320 · see citing works
Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
Yabe, D., Komuro, R., Liang, G., Goldstein, J. L., & Brown, M. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0130116100 · Cited by 293 · see citing works
Meyer, C., Schmid, R., Scriba, P. C., & Wehling, M. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0726u.x · Cited by 284 · see citing works
Hummon, A. B., Lim, S. R., Difilippantonio, M. J., & Ried, T. (2007) · BioTechniques · doi:10.2144/000112401 · Cited by 260 · see citing works
Binder, M. D., Schreurs, V., Sweers, K., Eyck, D. V., Hanssens, L., Šinko, S., Wampers, M., Scheen, A. J., Peuskens, J., & van Winkel, R. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.028 · Cited by 247 · see citing works
Rohe, H. J., Ahmed, I., Twist, K. E., & Craven, R. J. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.006 · Cited by 213 · see citing works
Fleischhacker, W. W., Heikkinen, M. E., Olié, J., Landsberg, W., Dewaele, P., McQuade, R. D., Loze, J.-Y., Hennicken, D., & Kerselaers, W. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000490 · Cited by 198 · see citing works
Krebs, C. J., Jarvis, E. D., Chan, J. S. W., Lydon, J. P., Ogawa, S., & Pfaff, D. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12816 · Cited by 195 · see citing works
The 5-HT2C receptor and antipsychoticinduced weight gain – mechanisms and genetics
Reynolds, G. P., Hill, M., & Kirk, S. L. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066040 · Cited by 159 · see citing works
Fernø, J., Raeder, M. B., Vik‐Mo, A. O., Skrede, S., Glambek, M., Tronstad, K. J., Breilid, H., Løvlie, R., Berge, R. K., Stansberg, C. T., et al. (2005) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500323 · Cited by 152 · see citing works
Tissue Production of Cortisol by 11β‐Hydroxysteroid Dehydrogenase Type 1 and Metabolic Disease
Walker, B. R., & Andrew, R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.012 · Cited by 148 · see citing works
Pouzet, B., Mow, T. J., Kreilgaard, M., & Velschow, S. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00042-x · Cited by 141 · see citing works
Baptista, T., Parada, M. A., & Hernandez, L. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90340-6 · Cited by 130 · see citing works
Insulin-induced gene: A new regulator in lipid metabolism
Dong, X., & Tang, S.-Q. (2010) · Peptides · doi:10.1016/j.peptides.2010.07.020 · Cited by 122 · see citing works
An animal model of antipsychotic-induced weight gain
Arjona, A. A. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.040 · Cited by 118 · see citing works
Progesterone receptor membrane component 1—Many tasks for a versatile protein
Lösel, R., Besong, D., Peluso, J. J., & Wehling, M. (2007) · Steroids · doi:10.1016/j.steroids.2007.12.017 · Cited by 115 · see citing works
Takaishi, K., Duplomb, L., Wang, M.-Y., Li, J., & Unger, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401715101 · Cited by 110 · see citing works
Fernø, J., Vik‐Mo, A. O., Jassim, G., Håvik, B., Berge, K., Skrede, S., Gudbrandsen, O. A., Waage, J. E. R., Lunder, N., Mørk, S. J., et al. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1370-x · Cited by 104 · see citing works
Hellard, S. L., Theisen, F., Haberhausen, M., Raeder, M. B., Fernø, J., Gebhardt, S., Hinney, A., Remschmidt, H., Krieg, J. C., Mehler‐Wex, C., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002133 · Cited by 102 · see citing works
Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats
Langley‐Evans, S. C., & York, D. A. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.259.3.r539 · Cited by 94 · see citing works
Polymeropoulos, M. H., Licamele, L., Volpi, S., Mack, K., Mitkus, S. N., Carstea, E. D., Getoor, L. C., Thompson, A. D., & Lavedan, C. N. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.025 · Cited by 83 · see citing works
Studies on modulation of feeding behavior by atypical antipsychotics in female mice
Kaur, G., & Kulkarni, S. K. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00266-4 · Cited by 81 · see citing works
Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat
Jassim, G., Skrede, S., Vazquez, M. J., Wergedal, H., Vik‐Mo, A. O., Lunder, N., Diéguez, C., Vidal‐Puig, A., Berge, R. K., López, M., et al. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2397-y · Cited by 76 · see citing works
Risperidone: Efficacy and Safety
Umbricht, D., & Kane, J. M. (1995) · Schizophrenia Bulletin · doi:10.1093/schbul/21.4.593 · Cited by 73 · see citing works
Lauressergues, E., Staels, B., Valeille, K., Majd, Z., Hum, D. W., Duriez, P., & Cussac, D. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0499-4 · Cited by 72 · see citing works
Boyda, H. N., Tse, L., Procyshyn, R. M., Wong, D., Wu, T. K. Y., Pang, C. C. Y., & Barr, A. M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.024 · Cited by 69 · see citing works
Vik‐Mo, A. O., Birkenaes, A. B., Fernø, J., Jónsdóttir, H., Andreassen, O. A., & Steen, V. M. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008468 · Cited by 68 · see citing works
Tulipano, G., Rizzetti, M. C., Bianchi, I., Fanzani, A., Spano, P., & Cocchi, D. (2007) · Neuroendocrinology · doi:10.1159/000100981 · Cited by 61 · see citing works
Liou, Y.-J., Bai, Y. M., Lin, E., Chen, J.-Y., Chen, T.-T., Hong, C.-J., & Tsai, S.-J. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.74 · Cited by 60 · see citing works
Effects of long-term administration of clozapine on body weight and food intake in rats
Baptista, T., Mata, A., Teneud, L., Quijada, M. D., Han, H., & Hernández, L. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90084-7 · Cited by 55 · see citing works
Mifepristone treatment of olanzapine-induced weight gain in healthy men
Gross, C., Blasey, C., Roe, R., Allen, K., Block, T. S., & Belanoff, J. (2009) · Advances in Therapy · doi:10.1007/s12325-009-0070-1 · Cited by 48 · see citing works
Gross, C., Blasey, C. M., Roe, R. L., & Belanoff, J. K. (2010) · Obesity · doi:10.1038/oby.2010.51 · Cited by 47 · see citing works
Mace, S., & Taylor, D. M. (2009) · CNS Drugs · doi:10.2165/11310820-000000000-00000 · Cited by 39 · see citing works
Lauressergues, E., Martin, F., Helleboid‐Chapman, A., Bouchaert, E., Cussac, D., Bordet, R., Hum, D. W., Luc, G., Majd, Z., Staels, B., et al. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0597-3 · Cited by 38 · see citing works
Beebe, K. D., Block, T. S., DeBattista, C., Blasey, C. M., & Belanoff, J. K. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.039 · Cited by 35 · see citing works
Walker, A. K., & Näär, A. M. (2012) · Clinical Lipidology · doi:10.2217/clp.11.67 · Cited by 25 · see citing works
Chan, H., & Mitchell, P. B. (2012) · Side effects of drugs annual · doi:10.1016/b978-0-444-59499-0.00002-7 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology
Shimano, H., & Sato, R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.91 · Cited by 1,174 · see citing works
Atypical Antipsychotics and Metabolic Syndrome: From Molecular Mechanisms to Clinical Differences
Carli, M., Kolachalam, S., Longoni, B., Pintaudi, A. M., Baldini, M., Aringhieri, S., Fasciani, I., Annibale, P., Maggio, R., & Scarselli, M. (2021) · Pharmaceuticals · doi:10.3390/ph14030238 · Cited by 252 · see citing works
SREBP-1c and lipogenesis in the liver: an update
Ferré, P., Phan, F., & Foufelle, F. (2021) · Biochemical Journal · doi:10.1042/bcj20210071 · Cited by 168 · see citing works
Classics in Chemical Neuroscience: Aripiprazole
Casey, A. B., & Canal, C. E. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00087 · Cited by 114 · see citing works
Ryu, C. S., Klein, K., & Zanger, U. M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00159 · Cited by 108 · see citing works
The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology
Cahill, M. A., Jazayeri, J. A., Catalano, S. M., Toyokuni, S., Kovačević, Ž., & Richardson, D. R. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.07.004 · Cited by 107 · see citing works
Olanzapine-induced lipid disturbances: A potential mechanism through the gut microbiota-brain axis
Zhu, Z., Gu, Y., Zeng, C., Yang, M., Yu, H., Chen, H., Zhang, B., & Cai, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.897926 · Cited by 79 · see citing works
Xu, H., & Zhuang, X. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s208061 · Cited by 77 · see citing works
Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands
Cahill, M. A., & Medlock, A. E. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.12.020 · Cited by 68 · see citing works
Liu, Z., Cui, C., Xu, P., Dang, R., Cai, H., Liao, D., Yang, M., Feng, Q., Yan, X., & Jiang, P. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00558 · Cited by 63 · see citing works
Ma, X., Zhao, T., Yan, H., Guo, K., Liu, Z., Wei, L., Lü, W., Qiu, C., & Jiang, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03762-0 · Cited by 59 · see citing works
Lizama, B. N., Kahle, J. S., Catalano, S. M., Caggiano, A. O., Grundman, M., & Hamby, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076251 · Cited by 51 · see citing works
Liu, X., Wu, Z., Lian, J., Hu, C., Huang, X., & Deng, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-02884-w · Cited by 48 · see citing works
Association between Serum Lipids and Antipsychotic Response in Schizophrenia
Kim, D. D., Barr, A. M., Fredrikson, D. H., Honer, W. G., & Procyshyn, R. M. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190228113348 · Cited by 46 · see citing works
Lee, S. R., Kwon, S. W., Kaya, P., Lee, Y. H., Lee, J. G., Kim, G., Lee, G., Baek, I., & Hong, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-34148-6 · Cited by 42 · see citing works
Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
Karpale, M., Hukkanen, J., & Hakkola, J. (2022) · Cells · doi:10.3390/cells11030313 · Cited by 40 · see citing works
Gjerde, P. B., Dieset, I., Simonsen, C., Hoseth, E. Z., Iversen, T., Lagerberg, T. V., Lyngstad, S. H., Mørch, R. H., Skrede, S., Andreassen, O. A., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.042 · Cited by 40 · see citing works
Cai, H., Jiang, P., Tan, Q. Y., Dang, R., Tang, M., Xue, Y., DENG, Y., Zhang, B., Fang, P., Xu, P., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.94 · Cited by 39 · see citing works
Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
Zorkina, Y., Ushakova, V., Ochneva, A., Tsurina, A., Abramova, O., Savenkova, V., Goncharova, A., Alekseenko, I., Morozova, I., Riabinina, D., et al. (2024) · Metabolites · doi:10.3390/metabo14020080 · Cited by 36 · see citing works
Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis
Mantere, O., Trontti, K., García‐González, J., Balcells, I., Saarnio, S., Mäntylä, T. J. S., Lindgren, M., Kieseppä, T., Raij, T. T., Honkanen, J. K., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.11.008 · Cited by 31 · see citing works
Cahill, M. A., & Neubauer, H. J. (2021) · Cancers · doi:10.3390/cancers13030512 · Cited by 27 · see citing works
Metabolic effects of atypical antipsychotics: Molecular targets
Fonseca, M., Carmo, F., & Martel, F. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13347 · Cited by 26 · see citing works
Delacrétaz, A., Vandenberghe, F., Gholam‐Rezaee, M., Saigí-Morgui, N., Glatard, A., Thonney, J., Solida-Tozzi, A., Kolly, S., Gallo, S. F., Baumann, P., et al. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.10.002 · Cited by 25 · see citing works
Chen, C.-C., Hsu, L., Huang, K., Goto, S., Chen, C., & Nakano, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-11323-9 · Cited by 24 · see citing works
Corigliano, V., Comparelli, A., Mancinelli, I., Montalbani, B., Lamis, D. A., Carolis, A. D., Erbuto, D., Girardi, P., & Pompili, M. (2018) · Schizophrenia Research and Treatment · doi:10.1155/2018/4834135 · Cited by 23 · see citing works
Li, N., Cao, T., Wu, X., Tang, M., Xiang, D., & Cai, H. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01669 · Cited by 22 · see citing works
Horská, K., Kučerová, J., Dražanová, E., Karpíšek, M., Demlová, R., Kašpárek, T., & Kotolová, H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.003 · Cited by 20 · see citing works
Access to the CNS: Biomarker Strategies for Dopaminergic Treatments
van den Brink, W. J., Palić, S., Köhler, I., & de Lange, E. C. M. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2333-x · Cited by 17 · see citing works
Horská, K., Kotolová, H., Karpíšek, M., Babinská, Z., Hammer, T., Procházka, J. H., Štark, T., Micale, V., & Kučerová, J. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115214 · Cited by 17 · see citing works
Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review
Burghardt, K. J., Kajy, M., Ward, K. M., & Burghardt, P. R. (2023) · Biomedicines · doi:10.3390/biomedicines11123295 · Cited by 16 · see citing works
Cao, T., Tang, M., Jiang, P., Zhang, B., Wu, X., Chen, Q., Zeng, C., Li, N., Zhang, S., & Cai, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.612083 · Cited by 16 · see citing works
Prajapat, S. K., Mishra, L., Khera, S., Owusu, S. D., Ahuja, K., Sharma, P., Choudhary, E., Chhabra, S., Kumar, N., Singh, R., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-023-00014-w · Cited by 15 · see citing works
Šagud, M., Vlatković, S., Štrac, D. Š., Sviben, M., Živković, M., Vilibić, M., Vuksan‐Ćusa, B., Mihaljević-Peleš, A., & Pivac, N. (2018) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2018.02.002 · Cited by 15 · see citing works
Luo, C., Wang, X., Mao, X., Huang, H., Liu, Y., Zhao, J., Zhou, H., Liu, Z., & Li, X. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05524-w · Cited by 14 · see citing works
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling
Cao, T., Qian, C., Zhang, B., Wu, X., Zeng, C., Zhang, S., & Cai, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.727371 · Cited by 14 · see citing works
Depot risperidone-induced adverse metabolic alterations in female rats
Horská, K., Kučerová, J., Karpíšek, M., Suchý, P., Opatřilová, R., & Kotolová, H. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117691466 · Cited by 14 · see citing works
GLP-1 agonists: superior for mind and body in antipsychotic-treated patients?
Horská, K., Kučerová, J., & Skrede, S. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.06.005 · Cited by 13 · see citing works
Akyol, Ö., Chowdhury, I., Akyol, H. R., Tessier, K., Vural, H., & Akyol, S. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109821 · Cited by 13 · see citing works
Li, Y., Su, R., Xu, S., Huang, Q., & Xu, H. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s145069 · Cited by 13 · see citing works
Delacrétaz, A., Santos, P. L., Saigí-Morgui, N., Vandenberghe, F., Glatard, A., Gholam‐Rezaee, M., von Gunten, A., Conus, P., & Eap, C. B. (2017) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000313 · Cited by 13 · see citing works
Biswas, M., Vanwong, N., & Sukasem, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1285967 · Cited by 12 · see citing works
Predicting therapeutic and side effects from drug binding affinities to human proteome structures
Sawada, R., Sakajiri, Y., Shibata, T., & Yamanishi, Y. (2024) · iScience · doi:10.1016/j.isci.2024.110032 · Cited by 11 · see citing works
Fan, L., You, Y., Fan, Y., Shen, C., & Xue, Y. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s305200 · Cited by 12 · see citing works
Cao, T., Zhang, S., Chen, Q., Zeng, C., Wang, L., Jiao, S., Chen, H., Zhang, B., & Cai, H. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.07.027 · Cited by 11 · see citing works
Zhu, Z., Cao, T., Chen, H., Zhang, B., Lin, C., & Cai, H. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113757 · Cited by 11 · see citing works
Sylvester, E., Yi, W., Han, M., & Deng, C. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173064 · Cited by 11 · see citing works
Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins
Cahill, M. A. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2711317 · Cited by 9 · see citing works
Wang, L., Chen, Q., Ma, R., Zhang, B., Yang, P., Cao, T., Jiao, S., Chen, H., Lin, C., & Cai, H. (2023) · Toxicology · doi:10.1016/j.tox.2023.153515 · Cited by 9 · see citing works
Atypical antipsychotic drugs cause abnormal glucose and lipid metabolism independent of weight gain
Yang, Y., & Wu, R. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-01965-6 · Cited by 10 · see citing works
Quo vadis PGRMC? Grand-Scale Biology in Human Health and Disease
Cahill, M. A. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2711318 · Cited by 8 · see citing works
Jo, S.-L., Baek, I., Ko, J., Kwun, H., Shin, H., & Hong, E. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00206.2022 · Cited by 8 · see citing works
Cataldi, M., Citro, V., Resnati, C., Manco, F., & Tarantino, G. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01669-y · Cited by 8 · see citing works
Tamarit, D., Teakel, S. L., Marama, M., Aragão, D., Gerdes, S., Forwood, J. K., Ettema, T. J. G., & Cahill, M. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.17.468889 · Cited by 6 · see citing works
da Silva, F. N., Zimath, P. L., do Amaral, T. A., Martins, J. R. N., & Rafacho, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121660 · Cited by 6 · see citing works
Vanwong, N., Sukasem, C., Unaharassamee, W., Jiratjintana, N., Nakorn, C. N., Hongkaew, Y., & Puangpetch, A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11100943 · Cited by 6 · see citing works
Soares, M. A., da Costa, A. L. A., Silva, N. L. C., Martins, A. F., Matias, D. O., de Araújo, O. M. O., Lopes, R. T., Takiya, C. M., Miranda, A. L. P., Miranda‐Alves, L., et al. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13090 · Cited by 6 · see citing works
Hulvershorn, L., Parkhurst, S., Jones, S., Dauss, K., & Adams, C. (2017) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2017.0040 · Cited by 6 · see citing works
Bába, L.-I., Kolcsár, M., Kun, I. Z., Ulakcsai, Z., Bagaméry, F., Szökő, É., Tábi, T., & Gáll, Z. (2019) · Medicina · doi:10.3390/medicina55050160 · Cited by 6 · see citing works
Chen, H., Cao, T., Lin, C., Jiao, S., He, Y., Zhu, Z., Guo, Q., Wu, R., Cai, H., & Zhang, B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1550015 · Cited by 5 · see citing works
Chen, C.-C., Nakano, T., Hsu, L.-W., Chu, C. Y., & Huang, K. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s345046 · Cited by 5 · see citing works
Galal, A., El-Bakly, W. M., El-Kilany, S. S., Ali, A. A., & El-Demerdash, E. (2021) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000656 · Cited by 4 · see citing works
Śmierciak, N., Krzyściak, W., Szwajca, M., Bryll, A., Popiela, T. J., Karcz, P., & Pilecki, M. W. (2021) · Psychiatria Polska · doi:10.12740/pp/119021 · Cited by 4 · see citing works
Lipid Disturbances in Adolescents Treated With Second-Generation Antipsychotics
Delacrétaz, A., Vandenberghe, F., Glatard, A., Dubath, C., Levier, A., Gholam‐Rezaee, M., Holzer, L., Ambresin, A., Conus, P., & Eap, C. B. (2019) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.18m12414 · Cited by 5 · see citing works
Clinical and molecular implications of antipsychotics in MASLD
Gonzalez-Peña, C., Uribe, M., & Chávez-Tapia, N. C. (2025) · Annals of Hepatology · doi:10.1016/j.aohep.2025.102158 · Cited by 3 · see citing works
Zeng, C., Chen, H., Cao, T., Wang, L., Jiao, S., Lin, C., Zhang, B., & Cai, H. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114490 · Cited by 3 · see citing works
He, Y., Wang, L., Cao, T., Jiao, S., Chen, H., Lin, C., Guo, Q., He, F., & Cai, H. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117091 · Cited by 3 · see citing works
Bába, L.-I., Gáll, Z., Kolcsár, M., Pap, Z., Varga, Z. V., Kovács, B., Beatrix, H., & Kun, I.-Z. (2020) · Scientia Pharmaceutica · doi:10.3390/scipharm88040050 · Cited by 3 · see citing works
Cao, T., Wang, L., Jiao, S., Chen, H., Lin, C., Zhang, B., & Cai, H. (2023) · Neuropsychobiology · doi:10.1159/000533148 · Cited by 3 · see citing works
Prajapat, S. K., Mishra, L., Khera, S., Owusu, S. D., Ahuja, K., Sharma, P., Singh, R., Mahajan, D., Banerjee, A. K., Motiani, R. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.05.535645 · Cited by 3 · see citing works
Partyka, A., Górecka, K., Gdula‐Argasińska, J., Wilczyńska-Zawal, N., Jastrzębska‐Więsek, M., & Wesołowska, A. (2023) · Pharmaceuticals · doi:10.3390/ph16020154 · Cited by 2 · see citing works
Dang, R., Wang, J., Tang, M., Han, W., & Jiang, P. (2023) · Advanced Biology · doi:10.1002/adbi.202300228 · Cited by 2 · see citing works
Lin, C., Zhang, S., Yang, P., Zhang, B., Guo, W., Wu, R., Liu, Y., Wang, J., Wu, H., & Cai, H. (2024) · Schizophrenia · doi:10.1038/s41537-024-00473-1 · Cited by 2 · see citing works
Delacrétaz, A., Sadler, M. C., Gamma, F., Preisig, M., Richard-Lepouriel, H., von Gunten, A., Conus, P., Plessen, K. J., Kutalik, Z., & Eap, C. B. (2024) · BJPsych Open · doi:10.1192/bjo.2024.757 · Cited by 2 · see citing works
The Biopsychosocial Model Advanced by Evolutionary Theory
Hunt, A., John‐Smith, P. S., & Abed, R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781911623625.004 · Cited by 2 · see citing works
Ma, Q., Yang, F., Ma, B., Jing, W., Liu, J., Guo, M., Li, J., Wang, Z., & Liu, M. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043259 · Cited by 1 · see citing works
Atypical Antipsychotics‐Induced Glucose and Lipid Metabolism Disorders and Therapeutic Intervention
Xia, A., Jin, Q., Ke, S., Li, H., & Wang, J. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.70036 · Cited by 1 · see citing works
Severe Hypercholesterolemia Caused by Mesalazine Which Is a Key Drug of Ulcerative Colitis
Anno, T., Murakami, K., Nakanishi, S., Wada, J., Kaku, K., Kaneto, H., & Kamei, S. (2025) · Internal Medicine · doi:10.2169/internalmedicine.6599-25 · Cited by 1 · see citing works
Clinical Practice Guideline on the Pharmacological Management of Antipsychotic-Related Dyslipidemia
Carolan, A., Hynes-Ryan, C., Bourke, R., Columb, D., Cullen, W., de Ferranti, S. D., Harrington, S. M., Kelleher, I., Kennedy, C., Khoury, M., et al. (2026) · Schizophrenia Bulletin · doi:10.1093/schbul/sbag086 · Cited by 1 · see citing works
Guo, Z., Zhang, Z. M., Li, L., Zhang, M., Huang, S., Li, Z., & Shang, D. (2025) · Current Neuropharmacology · doi:10.2174/1570159x23666241016090634 · Cited by 1 · see citing works
Rogalski, J. K., Gawlik-Kotelnicka, O., & Tomczak, T. (2024) · Current Problems of Psychiatry · doi:10.12923/2353-8627/2024-0021
Yi, W., Lian, J., & Deng, C. (2026) · Recent Progress in Nutrition · doi:10.21926/rpn.2603013
Altered Lipid Landscapes Provide a Molecular Perspective on Schizophrenia
Roychaudhuri, R. (2025) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20250016
Research Progress on the Regulation of Schizophrenia-Related Signaling Pathways by LncRNA
那, 千. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.161191
Liao, X., Zheng, L., Li, H., Lu, X., Mao, X., Sun, Y., Qiao, D., Zhang, Y., Yuan, N., Li, C., et al. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07912-6
Adam, T. J., Højlund, M., Pillinger, T., McCutcheon, R. A., Siskind, D. J., DelBello, M. P., Welge, J. A., Taipale, H. T., Tiihonen, J., Chang, W. C., et al. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00721-6
Westacott, L. J., Dec, K., Gruszczyńska, H., Joyce, C., Mitchell, S., Hall, J., & Harwood, A. J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1929742
- Authors
- Cai, H. L., Tan, Q. Y., Jiang, P., Dang, R. L., Xue, Y., Tang, M. M., Xu, P., Deng, Y., Li, H. D., & Yao, J. K.
- Affiliations
- Central South University (CN)
- Guilin Medical University (CN)
- University of Pittsburgh (US)
- Corresponding author
- Li, H D
- Yao, J K
- Venue
- Translational Psychiatry
- Published
- 2015-10-20
- Volume
- 5
- Issue
- 10
- Pages
- e661-e661
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC4930135
- OpenAlex
- W2198099582
- Cited by
- 86
- References
- 49
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 7 · 2021: 14 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 15 · 2016: 1
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Office of Research and Development
- National Natural Science Foundation of China (NSFC81401113)
- VA Pittsburgh Healthcare System
- Specialized Research Fund for the Doctoral Program of Higher Education of China
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- atypical antipsychotics, PGRMC1, INSIG2, SREBP, SCAP, endoplasmic reticulum, mifepristone, clozapine, risperidone, aripiprazole, haloperidol, lipogenesis, cholesterogenesis, lipid metabolism, antipsychotic-induced weight gain
- MeSH terms
- Animals, Cholesterol, Clozapine, Corticosterone, Disease Models, Animal, Fatty Acids, Nonesterified, Insulin, Liver, Male, Progesterone, Antipsychotic Agents, Triglycerides, Blotting, Western, Signal Transduction, Polymerase Chain Reaction, Rats, Sprague-Dawley, Risperidone, Lipogenesis, Lipid Metabolism, Rats
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