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Cited by 93Chemical Reaction MechanismsPhotochemistry and Electron Transfer StudiesProtein Structure and Dynamics

Quantum Tunnelling in Enzyme-Catalysed Reactions

·2009·Royal Society of Chemistry eBooks
DOI 10.1039/9781847559975
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Abstract

In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.

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  • Recent theoretical and experimental developments have highlighted potential roles for quantum-mechanical tunnelling in enzyme-catalysed multiple-hydrogen transfer, and there has been a focus on depicting hydrogen transfer within a quantum-mechanical formalism.

    “Transition-state theory has been used as the basis of explanations of enzyme catalysis, but recent theoretical and experimental developments have highlighted potential roles for quantum-mechanical tunnelling in enzyme-catalysed multiple-hydrogen transfer, and there has been a focus on depicting hydrogen transfer within a quantum-mechanical formalism [87].”

    From The future of quantum biology (2018) · cites this paper as [87]

  • Enzymes often rely on the coupling of electrons and protons to control charge transport and catalysis.

    “Enzymes often rely on the coupling of electrons and protons to control charge transport and catalysis [87].”

    From The future of quantum biology (2018) · cites this paper as [87]

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Venue
Royal Society of Chemistry eBooks
Publisher
The Royal Society of Chemistry
Published
2009-03-27
DOI
10.1039/9781847559975
OpenAlex
W2154547861
Cited by
93
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 11
FWCI
3.41
Type
book
Language
en
Open access
closed
Locations
  • Royal Society of Chemistry eBooks (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords
quantum tunneling, enzyme catalysis, hydrogen tunneling, proton transfer, electron transfer, hydride transfer, proton-coupled electron transfer, Marcus theory, electron transfer in proteins, enzyme kinetics

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