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LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition
Abstract
A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.
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Cited by
The current landscape of nucleic acid therapeutics
Kulkarni, J. A., Witzigmann, D., Thomson, S. B., Chen, S., Leavitt, B. R., Cullis, P. R., & van der Meel, R. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00898-0 · Cited by 1,371
The chemical evolution of oligonucleotide therapies of clinical utility
Khvorova, A., & Watts, J. K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3765 · Cited by 1,216
LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA
Vester, B., & Wengel, J. (2004) · Biochemistry · doi:10.1021/bi0485732 · Cited by 727
Self-citationPotent and nontoxic antisense oligonucleotides containing locked nucleic acids
Wahlestedt, C., Salmi, P., Good, L., Kela, J., Johnsson, T., Hökfelt, T., Broberger, C., Porreca, F., Lai, J., Ren, K., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5633 · Cited by 520
Self-citationStein, C. A., Hansen, J. B., Lai, J., Wu, S., Voskresenskiy, A., H⊘g, A., Worm, J., Hedtjärn, M., Souleimanian, N., Miller, P., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp841 · Cited by 360
Metadata
- Authors
- Singh, S. K., Koshkin, A. A., Wengel, J., & Nielsen, P.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 1998
- Issue
- 4
- Pages
- 455-456
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2108185026
- Cited by
- 768
- References
- 0
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition. https://app.cochat.ai/papers/10.1039/a708608c
- The paper
- Singh, S. K., Koshkin, A. A., Wengel, J., & Nielsen, P. (1998). LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition. Chemical Communications. https://doi.org/10.1039/a708608c
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
