The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Fluorinated amino acids in protein design and engineering
Abstract
Selective incorporation of unnatural amino acids into proteins is a powerful tool for illuminating the principles of protein design. In particular, fluorinated amino acids have recently emerged as valuable building blocks for designing hyperstable protein folds, as well as directing highly specific protein-protein interactions. We review the collagen mimetic and coiled coil peptide systems that exemplify generalizable paradigms for future design. The unique electronic and phase properties of fluorocarbons are discussed, and protein synthesis using unnatural amino acids is briefly reviewed.
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Cites
Expanding the Genetic Code of Escherichia coli
Wang, L., Brock, A., Herberich, B., & Schultz, P. G. (2001) · Science · doi:10.1126/science.1060077 · Cited by 1,499
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
Harbury, P. B., Zhang, T., Kim, P. S., & Alber, T. (1993) · Science · doi:10.1126/science.8248779 · Cited by 1,490
Facile Catalyst Separation Without Water: Fluorous Biphase Hydroformylation of Olefins
Horváth, I. T., & Rábai, J. (1994) · Science · doi:10.1126/science.266.5182.72 · Cited by 1,416
Coiled coils: new structures and new functions
LUPAS, A. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10052-9 · Cited by 1,183
Synthesis of Native Proteins by Chemical Ligation
Dawson, P. E., & Kent, S. B. H. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.923 · Cited by 1,082
Yan, L. Z., & Dawson, P. E. (2001) · Journal of the American Chemical Society · doi:10.1021/ja003265m · Cited by 661
Code for collagen's stability deciphered
Holmgren, S. K., Taylor, K. M., Bretscher, L. E., & Raines, R. T. (1998) · Nature · doi:10.1038/33573 · Cited by 498
Studer, A., Hadida, S., Ferritto, R., Kim, S.-Y., Jeger, P., Wipf, P., & Curran, D. P. (1997) · Science · doi:10.1126/science.275.5301.823 · Cited by 470
Conformational Stability of Collagen Relies on a Stereoelectronic Effect
Bretscher, L. E., Jenkins, C. L., Taylor, K. M., DeRider, M. L., & Raines, R. T. (2001) · Journal of the American Chemical Society · doi:10.1021/ja005542v · Cited by 461
DeRider, M. L., Wilkens, S. J., Waddell, M. J., Bretscher, L. E., Weinhold, F., Raines, R. T., & Markley, J. L. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0166904 · Cited by 349
Insights on the conformational stability of collagen
(2002) · Natural Product Reports · doi:10.1039/a903001h · Cited by 224
Structure of the β-Amyloid(10-35) Fibril
Burkoth, T. S., Benzinger, T. L. S., Urban, V., Morgan, D. M., Gregory, D. M., Thiyagarajan, P., Botto, R. E., Meredith, S. C., & Lynn, D. G. (2000) · Journal of the American Chemical Society · doi:10.1021/ja000645z · Cited by 224
Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability
Tang, Y., Ghirlanda, G., Petka, W. A., Nakajima, T., DeGrado, W. F., & Tirrell, D. A. (2001) · Angewandte Chemie International Edition · Cited by 198
Programmed Self-Sorting of Coiled Coils with Leucine and Hexafluoroleucine Cores
Bilgiçer, B., Xing, X., & Kumar, K. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016767o · Cited by 169
Self-citationTang, Y., & Tirrell, D. A. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016652k · Cited by 169
A Coiled Coil with a Fluorous Core
Bilgiçer, B., Fichera, A., & Kumar, K. (2001) · Journal of the American Chemical Society · doi:10.1021/ja002961j · Cited by 164
Self-citationStabilization of Coiled-Coil Peptide Domains by Introduction of Trifluoroleucine
Tang, Y., Ghirlanda, G., Vaidehi, N., Kua, J., Mainz, D. T., Goddard, W. A., DeGrado, W. F., & Tirrell, D. A. (2001) · Biochemistry · doi:10.1021/bi0022588 · Cited by 164
Datta, D., Wang, P., Carrico, I. S., Mayo, S. L., & Tirrell, D. A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0177096 · Cited by 139
Magliery, T. J., Anderson, J. C., & Schultz, P. G. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4518 · Cited by 131
Salgado, J., Grage, S. L., Kondejewski, L. H., Hodges, R. S., McElhaney, R. N., & Ulrich, A. S. (2001) · Journal of Biomolecular NMR · doi:10.1023/a:1012946026231 · Cited by 123
Adding l -3-(2-Naphthyl)alanine to the Genetic Code of E. coli
Wang, L., Brock, A., & Schultz, P. G. (2002) · Journal of the American Chemical Society · doi:10.1021/ja012307j · Cited by 111
Synthesis and thermodynamic characterization of self-sorting coiled coils
Bilgiçer, B., & Kumar, K. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00260-0 · Cited by 76
Self-citationGregory, D. M., Benzinger, T. L. S., Burkoth, T. S., Miller-Auer, H., Lynn, D. G., Meredith, S. C., & Botto, R. E. (1998) · Solid State Nuclear Magnetic Resonance · doi:10.1016/s0926-2040(98)00086-1 · Cited by 75
Five-base codons for incorporation of nonnatural amino acids into proteins.
Hohsaka, T., Ashizuka, Y., Murakami, H., & Sisido, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.17.3646 · Cited by 75
Malkar, N. B., Lauer‐Fields, J. L., Borgia, J. A., & Fields, G. (2002) · Biochemistry · doi:10.1021/bi012071w · Cited by 49
Side Chain Accessibility and Dynamics in the Molten Globule State of α-Lactalbumin: A19F-NMR Study
Bai, P., Luo, L., & Peng, Z. (1999) · Biochemistry · doi:10.1021/bi992056f · Cited by 38
Incorporation of Noncoded Amino Acids by In Vitro Protein Biosynthesis
Gilmore, M. A., Steward, L. E., & Chamberlin, A. (1999) · Topics in current chemistry · doi:10.1007/3-540-48990-8_3 · Cited by 24
Cited by
Fluorine in Medicinal Chemistry and Chemical Biology
(2009) · Wiley eBooks · doi:10.1002/9781444312096 · Cited by 1,731
The Design of Coiled-Coil Structures and Assemblies
Woolfson, D. N. (2005) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(05)70004-8 · Cited by 585
Protein Design: Toward Functional Metalloenzymes
Yu, F., Cangelosi, V. M., Zastrow, M. L., Tegoni, M., Plegaria, J. S., Tebo, A. G., Mocny, C. S., Ruckthong, L., Qayyum, H., & Pecoraro, V. L. (2014) · Chemical Reviews · doi:10.1021/cr400458x · Cited by 441
Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J. L., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallée, M. R. J., Phanumartwiwath, A., et al. (2016) · Science · doi:10.1126/science.aag1465 · Cited by 317
Metadata
- Authors
- Yoder, N. C., & Kumar, K.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2002-09-13
- Volume
- 31
- Issue
- 6
- Pages
- 335-341
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2330772790
- Cited by
- 317
- References
- 27
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
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