The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
Abstract
Radicals push proteins beyond genes: Chemically modifying proteins after their translation can expand their structural and functional roles (see the Perspective by Hofmann and Bode). Two related methods describe how to exploit free radical chemistry to form carbon-carbon bonds between amino acid residues and a selected functional group. Wright et al. added a wide range of functional groups to proteins containing dehydroalanine precursors, with borohydride mediating the radical chemistry. Yang et al. employed a similar approach, using zinc in combination with copper ions. Together, these results will be useful for introducing functionalities and labels to a wide range of proteins. Science , this issue pp. 597 and 623 ; see also p. 553
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Residue-Specific Peptide Modification: A Chemist’s Guide
deGruyter, J. N., Malins, L. R., & Baran, P. S. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00536 · Cited by 573
Contemporary approaches to site-selective protein modification
Hoyt, E. A., Cal, P. M. S. D., Oliveira, B. L., & Bernardes, G. J. L. (2019) · Nature Reviews Chemistry · doi:10.1038/s41570-019-0079-1 · Cited by 537
Self-citationRedox-based reagents for chemoselective methionine bioconjugation
Lin, S., Yang, X., Jia, S., Weeks, A. M., Hornsby, M., Lee, P. S., Nichiporuk, R. V., Iavarone, A. T., Wells, J. A., Toste, F. D., et al. (2017) · Science · doi:10.1126/science.aal3316 · Cited by 513
Tamura, T., & Hamachi, I. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11747 · Cited by 339
Chemical and Biochemical Perspectives of Protein Lysine Methylation
Luo, M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00008 · Cited by 284
Metadata
- Authors
- Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J. L., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallée, M. R. J., Phanumartwiwath, A., Coleman, O. D., Thézénas, M.-L., Khan, M., Galan, S. R. G., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D. W., Mohammed, S., & Davis, B. G.
- Venue
- Science
- Published
- 2016-11-04
- Volume
- 354
- Issue
- 6312
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2523580724
- Cited by
- 317
- References
- 84
- FWCI
- 15.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J. L., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallée, M. R. J., Phanumartwiwath, A., Coleman, O. D., Thézénas, M.-L., Khan, M., Galan, S. R. G., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., . . . Davis, B. G. (2016). Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity. Science. https://doi.org/10.1126/science.aag1465
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