The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Microenvironment design considerations for cellular scale studies
Abstract
In vivo cellular microenvironments are not well-mimicked in present in vitro cell culture systems. Microtechnology, and microfluidics in particular, provides the tools to create in vivo-like cellular microenvironments in vitro. Features of in vitro cellular microenvironments are discussed and compared to macroscale cell culture environments; the concept of an effective culture volume (ECV) is introduced to facilitate the comparison. Current research using microtechnology to investigate in vitro cellular microenvironments is presented and areas where more research is needed in characterizing the in vitro microenvironment are outlined.
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Cites
Purcell, E. M. (1977) · American Journal of Physics · doi:10.1119/1.10903 · Cited by 4,360
Cited by
Biological implications of polydimethylsiloxane-based microfluidic cell culture
Regehr, K. J., Domenech, M., Koepsel, J. T., Carver, K. C., Ellison-Zelski, S. J., Murphy, W. L., Schuler, L. A., Alarid, E. T., & Beebe, D. J. (2009) · Lab on a Chip · doi:10.1039/b903043c · Cited by 719
Self-citationFundamentals of microfluidic cell culture in controlled microenvironments
Young, E. W. K., & Beebe, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b909900j · Cited by 615
Self-citationContinuous perfusion microfluidic cell culture array for high‐throughput cell‐based assays
Hung, P. J., Lee, P. J., Sabounchi, P., Lin, R., & Lee, L. P. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20289 · Cited by 522
Engineered Microenvironments for Controlled Stem Cell Differentiation
Burdick, J. A., & Vunjak-Novakovic, G. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0131 · Cited by 485
Microfluidics technology for manipulation and analysis of biological cells
Yi, C., Li, C.-W., Ji, S., & Yang, M. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2005.12.037 · Cited by 478
Metadata
- Authors
- Walker, G. M., Zeringue, H. C., & Beebe, D. J.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2004
- Volume
- 4
- Issue
- 2
- Pages
- 91
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2017656225
- Cited by
- 388
- References
- 1
- FWCI
- 19.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
