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Cucurbitacins and cucurbitane glycosides: structures and biological activities
Abstract
The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity. Structurally, they are characterized by the tetracyclic cucurbitane nucleus skeleton, namely, 19-(10-->9beta)-abeo-10alpha-lanost-5-ene (also known as 9beta-methyl-19-norlanosta-5-ene), with a variety of oxygen substitutions at different positions. According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered.
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Citations
Cites
Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells
Duncan, K. L. K., Duncan, M. D., Alley, M. C., & Sausville, E. A. (1996) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00557-6 · Cited by 151
Cited by
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
Schust, J., Sperl, B., Hollis, A., Mayer, T. U., & Berg, T. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.018 · Cited by 1,105
Biosynthesis, regulation, and domestication of bitterness in cucumber
Shang, Y., Ma, Y., Zhou, Y., Zhang, H., Duan, L., Chen, H., Zeng, J., Zhou, Q., Wang, S., Gu, W., et al. (2014) · Science · doi:10.1126/science.1259215 · Cited by 490
Cucurbitacin I Induces Protective Autophagy in Glioblastoma in Vitro and in Vivo
Yuan, G., Yan, S.-F., Xue, H., Zhang, P., Sun, J.-T., & Li, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.528760 · Cited by 90
Pest Control Agents from Natural Products
Ujváry, I. (2010) · Hayes' Handbook of Pesticide Toxicology · doi:10.1016/b978-0-12-374367-1.00003-3 · Cited by 81
The natural product cucurbitacin E inhibits depolymerization of actin filaments
Sörensen, P. M., Iacob, R. E., Fritzsche, M., Engen, J. R., Brieher, W. M., Charras, G., & Eggert, U. S. (2012) · ACS Chemical Biology · doi:10.1021/cb300254s · Cited by 61
Metadata
- Authors
- Chen, J. C., Chiu, M. H., Nie, R. L., Cordell, G. A., & Qiu, S. X.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2005
- Volume
- 22
- Issue
- 3
- Pages
- 386
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2142869757
- Cited by
- 635
- References
- 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, J. C., Chiu, M. H., Nie, R. L., Cordell, G. A., & Qiu, S. X. (2005). Cucurbitacins and cucurbitane glycosides: structures and biological activities. Natural Product Reports. https://doi.org/10.1039/b418841c
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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