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Cucurbitacin I Induces Protective Autophagy in Glioblastoma in Vitro and in Vivo

Yuan, Guang, Yan, Shao-Feng, Xue, Hao, Zhang, Ping, Sun, Jin-Tang, Li, Gang·2014·Journal of Biological Chemistry
DOI 10.1074/jbc.m113.528760
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  • Inhibition of the JAK/STAT3 pathway by cucurbitacin I (JSI124) largely rescues p-STAT3 activation and M1 polarization upon miR-9-5p mimic treatment.

    “Moreover, inhibition of the JAK/STAT3 pathway by cucurbitacin I (JSI124) [38] largely rescued p-STAT3 activation and M1 polarization upon miR-9-5p mimic treatment (Fig. 5e, f, Additional file 1: Fig. S5e, f).”

    From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [38]

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  1. [1]1. Kim, D.J. ∙ Chan, K.S. ∙ Sano, S. ... Signal transducer and activator of transcription 3 (STAT3) in epithelial carcinogenesis Mol. Carcinog. 2007; 46:725-731 Crossref Scopus (100) PubMed Google Scholar
  2. [2]2. Chan, K.S. ∙ Sano, S. ∙ Kataoka, K. ... Forced expression of a constitutively active form of STAT3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis Oncogene. 2008; 27:1087-1094 Crossref Scopus (93) PubMed Google Scholar
  3. [3]3. Ling, X. ∙ Arlinghaus, R.B. Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice Cancer Res. 2005; 65:2532-2536 Crossref Scopus (194) PubMed Google Scholar
  4. [4]4. Li, Y. ∙ Du, H. ∙ Qin, Y. ... Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung Cancer Res. 2007; 67:8494-8503 Crossref Scopus (124) PubMed Google Scholar
  5. [5]5. Garner, J.M. ∙ Fan, M. ∙ Yang, C.H. ... Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway J. Biol. Chem. 2013; 288:26167-26176 Full Text Full Text (PDF) Scopus (152) PubMed Google Scholar
  6. [6]6. Zhao, W. ∙ Jaganathan, S. ∙ Turkson, J. A cell-permeable STAT3 SH2 domain mimetic inhibits STAT3 activation and induces antitumor cell effects in vitro J. Biol. Chem. 2010; 285:35855-35865 Full Text Full Text (PDF) Scopus (56) PubMed Google Scholar
  7. [7]7. Turkson, J. ∙ Zhang, S. ∙ Mora, L.B. ... A novel platinum compound inhibits constitutive STAT3 signaling and induces cell cycle arrest and apoptosis of malignant cells J. Biol. Chem. 2005; 280:32979-32988 Full Text Full Text (PDF) Scopus (163) PubMed Google Scholar
  8. [8]8. Redell, M.S. ∙ Ruiz, M.J. ∙ Alonzo, T.A. ... STAT3 signaling in acute myeloid leukemia. Ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule STAT3 inhibitor Blood. 2011; 117:5701-5709 Crossref Scopus (192) PubMed Google Scholar
  9. [9]9. Blaskovich, M.A. ∙ Sun, J. ∙ Cantor, A. ... Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice Cancer Res. 2003; 63:1270-1279 PubMed Google Scholar
  10. [10]10. Jing, N. ∙ Tweardy, D.J. Targeting STAT3 in cancer therapy Anticancer Drugs. 2005; 16:601-607 Crossref Scopus (255) PubMed Google Scholar
  11. [11]11. Molavi, O. ∙ Ma, Z. ∙ Hamdy, S. ... Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model Immunol. Cell Biol. 2008; 86:506-514 Crossref Scopus (38) PubMed Google Scholar
  12. [12]12. Chen, J.C. ∙ Chiu, M.H. ∙ Nie, R.L. ... Cucurbitacins and cucurbitane glycosides. Structures and biological activities Nat. Prod. Rep. 2005; 22:386-399 Crossref Scopus (514) PubMed Google Scholar
  13. [13]13. Louis, D.N. ∙ Ohgaki, H. ∙ Wiestler, O.D. ... The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol. 2007; 114:97-109 Crossref Scopus (8709) PubMed Google Scholar
  14. [14]14. Van Meir, E.G. ∙ Hadjipanayis, C.G. ∙ Norden, A.D. ... Exciting new advances in neuro-oncology. The avenue to a cure for malignant glioma CA-Cancer J. Clin. 2010; 60:166-193 Crossref Scopus (1204) PubMed Google Scholar
  15. [15]15. Peñuelas, S. ∙ Anido, J. ∙ Prieto-Sánchez, R.M. ... TGF-β increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma Cancer Cell. 2009; 15:315-327 Full Text Full Text (PDF) Scopus (457) PubMed Google Scholar
  16. [16]16. Wang, H. ∙ Lathia, J.D. ∙ Wu, Q. ... Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth Stem Cells. 2009; 27:2393-2404 Crossref Scopus (276) PubMed Google Scholar
  17. [17]17. Cao, Y. ∙ Lathia, J.D. ∙ Eyler, C.E. ... Erythropoietin receptor signaling through STAT3 is required for glioma stem cell maintenance Genes Cancer. 2010; 1:50-61 Crossref Scopus (70) PubMed Google Scholar
  18. [18]18. Carro, M.S. ∙ Lim, W.K. ∙ Alvarez, M.J. ... The transcriptional network for mesenchymal transformation of brain tumours Nature. 2010; 463:318-325 Crossref Scopus (978) PubMed Google Scholar
  19. [19]19. Yang, Z. ∙ Klionsky, D.J. Eaten alive. A history of macroautophagy Nat. Cell Biol. 2010; 12:814-822 Crossref Scopus (1802) PubMed Google Scholar
  20. [20]20. Rubinsztein, D.C. ∙ Gestwicki, J.E. ∙ Murphy, L.O. ... Potential therapeutic applications of autophagy Nat. Rev. Drug Dis. 2007; 6:304-312 Crossref Scopus (925) PubMed Google Scholar
  21. [21]21. Lum, J.J. ∙ Bauer, D.E. ∙ Kong, M. ... Growth factor regulation of autophagy and cell survival in the absence of apoptosis Cell. 2005; 120:237-248 Full Text Full Text (PDF) Scopus (1310) PubMed Google Scholar
  22. [22]22. Degenhardt, K. ∙ Mathew, R. ∙ Beaudoin, B. ... Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Cancer Cell. 2006; 10:51-64 Full Text Full Text (PDF) Scopus (1709) PubMed Google Scholar
  23. [23]23. Kim, K.W. ∙ Mutter, R.W. ∙ Cao, C. ... Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling J. Biol. Chem. 2006; 281:36883-36890 Full Text Full Text (PDF) Scopus (169) PubMed Google Scholar
  24. [24]24. Apel, A. ∙ Herr, I. ∙ Schwarz, H. ... Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy Cancer Res. 2008; 68:1485-1494 Crossref Scopus (462) PubMed Google Scholar
  25. [25]25. Qadir, M.A. ∙ Kwok, B. ∙ Dragowska, W.H. ... Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization Breast Cancer Res. Treat. 2008; 112:389-403 Crossref Scopus (205) PubMed Google Scholar
  26. [27]27. Livesey, K.M. ∙ Tang, D. ∙ Zeh, H.J. ... Autophagy inhibition in combination cancer treatment Curr. Opin. Investig. Drugs. 2009; 10:1269-1279 PubMed Google Scholar
  27. [28]28. Maycotte, P. ∙ Thorburn, A. Autophagy and cancer therapy Cancer Biol. Ther. 2011; 11:127-137 Crossref Scopus (159) PubMed Google Scholar
  28. [29]29. Chen, N. ∙ Karantza, V. Autophagy as a therapeutic target in cancer Cancer Biol. Ther. 2011; 11:157-168 Crossref Scopus (269) PubMed Google Scholar
  29. [30]30. Ogier-Denis, E. ∙ Codogno, P. Autophagy. A barrier or an adaptive response to cancer Biochim. Biophys. Acta. 2003; 1603:113-128 PubMed Google Scholar
  30. [31]31. Gozuacik, D. ∙ Kimchi, A. Autophagy as a cell death and tumor suppressor mechanism Oncogene. 2004; 23:2891-2906 Crossref Scopus (1304) PubMed Google Scholar
  31. [33]33. Yang, Z. ∙ Klionsky, D.J. An overview of the molecular mechanism of autophagy Curr. Top. Microbiol. Immunol. 2009; 335:1-32 Crossref Scopus (665) PubMed Google Scholar
  32. [34]34. Roca, H. ∙ Varsos, Z. ∙ Pienta, K.J. CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation J. Biol. Chem. 2008; 283:25057-25073 Full Text Full Text (PDF) Scopus (149) PubMed Google Scholar
  33. [35]35. He, C. ∙ Klionsky, D.J. Regulation mechanisms and signaling pathways of autophagy Annu. Rev. Genet. 2009; 43:67-93 Crossref Scopus (3029) PubMed Google Scholar
  34. [36]36. Meley, D. ∙ Bauvy, C. ∙ Houben-Weerts, J.H. ... AMP-activated protein kinase and the regulation of autophagic proteolysis J. Biol. Chem. 2006; 281:34870-34879 Full Text Full Text (PDF) Scopus (405) PubMed Google Scholar
  35. [37]37. Park, J.H. ∙ Darvin, P. ∙ Lim, E.J. ... Hwanggeumchal sorghum induces cell cycle arrest, and suppresses tumor growth and metastasis through Jak2/STAT pathways in breast cancer xenografts PloS ONE. 2012; 7:e40531 Crossref Scopus (68) PubMed Google Scholar
  36. [38]38. Kandala, P.K. ∙ Srivastava, S.K. Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3) BMC Med. 2012; 10:9 Crossref Scopus (48) PubMed Google Scholar
  37. [39]39. Anglesio, M.S. ∙ George, J. ∙ Kulbe, H. ..., Australian Ovarian Cancer Study Group IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer Clin. Cancer Res. 2011; 17:2538-2548 Crossref Scopus (205) PubMed Google Scholar
  38. [40]40. Horiguchi, A. ∙ Asano, T. ∙ Kuroda, K. ... STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma Br. J. Cancer. 2010; 102:1592-1599 Crossref Scopus (105) PubMed Google Scholar
  39. [41]41. Reischl, S. ∙ Li, L. ∙ Walkinshaw, G. ... Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke PloS ONE. 2014; 9:e84767 Crossref Scopus (85) PubMed Google Scholar
  40. [43]43. Carmeliet, P. ∙ Dor, Y. ∙ Herbert, J.M. ... Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis Nature. 1998; 394:485-490 Crossref Scopus (2294) PubMed Google Scholar
  41. [44]44. Wei, Y. ∙ Pattingre, S. ∙ Sinha, S. ... JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy Mol. Cell. 2008; 30:678-688 Full Text Full Text (PDF) Scopus (1126) PubMed Google Scholar
  42. [45]45. Pattingre, S. ∙ Tassa, A. ∙ Qu, X. ... Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy Cell. 2005; 122:927-939 Full Text Full Text (PDF) Scopus (3094) PubMed Google Scholar
  43. [46]46. Meijer, A.J. ∙ Codogno, P. Autophagy. Regulation and role in disease Crit. Rev. Clin. Lab. Sci. 2009; 46:210-240 Crossref Scopus (173) PubMed Google Scholar
  44. [47]47. Maiuri, M.C. ∙ Zalckvar, E. ∙ Kimchi, A. ... Self-eating and self-killing. Crosstalk between autophagy and apoptosis Nat. Rev. Mol. Cell Biol. 2007; 8:741-752 Crossref Scopus (3119) PubMed Google Scholar
  45. [48]48. Stechishin, O.D. ∙ Luchman, H.A. ∙ Ruan, Y. ... On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells Neuro-oncology. 2013; 15:198-207 Crossref Scopus (89) PubMed Google Scholar
  46. [49]49. Banerjee, S. ∙ Byrd, J.N. ∙ Gianino, S.M. ... The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo Cancer Res. 2010; 70:1356-1366 Crossref Scopus (59) PubMed Google Scholar
  47. [50]50. Su, Y. ∙ Li, G. ∙ Zhang, X. ... JSI-124 inhibits glioblastoma multiforme cell proliferation through G2/M cell cycle arrest and apoptosis augment Cancer Biol. Ther. 2008; 7:1243-1249 Crossref Scopus (76) PubMed Google Scholar
  48. [51]51. Marino, M.L. ∙ Pellegrini, P. ∙ Di Lernia, G. ... Autophagy is a protective mechanism for human melanoma cells under acidic stress J. Biol. Chem. 2012; 287:30664-30676 Full Text Full Text (PDF) Scopus (150) PubMed Google Scholar
  49. [52]52. Wullschleger, S. ∙ Loewith, R. ∙ Hall, M.N. TOR signaling in growth and metabolism Cell. 2006; 124:471-484 Full Text Full Text (PDF) Scopus (4948) PubMed Google Scholar
  50. [53]53. Zhang, H. ∙ Bosch-Marce, M. ∙ Shimoda, L.A. ... Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia J. Biol. Chem. 2008; 283:10892-10903 Full Text Full Text (PDF) Scopus (1385) PubMed Google Scholar
  51. [54]54. Shintani, T. ∙ Klionsky, D.J. Autophagy in health and disease. A double-edged sword Science. 2004; 306:990-995 Crossref Scopus (2292) PubMed Google Scholar
  52. [56]56. Takeuchi, H. ∙ Kondo, Y. ∙ Fujiwara, K. ... Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors Cancer Res. 2005; 65:3336-3346 Crossref Scopus (488) PubMed Google Scholar
  53. [57]57. Bommareddy, A. ∙ Hahm, E.R. ∙ Xiao, D. ... Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells Cancer Res. 2009; 69:3704-3712 Crossref Scopus (144) PubMed Google Scholar
  54. [58]58. Yu, H.C. ∙ Lin, C.S. ∙ Tai, W.T. ... Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation J. Biol. Chem. 2013; 288:18249-18259 Full Text Full Text (PDF) Scopus (86) PubMed Google Scholar
  55. [59]59. Kim, R.H. ∙ Coates, J.M. ∙ Bowles, T.L. ... Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis Cancer Res. 2009; 69:700-708 Crossref Scopus (257) PubMed Google Scholar
  56. [60]60. Sy, L.K. ∙ Yan, S.C. ∙ Lok, C.N. ... Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells Cancer Res. 2008; 68:10229-10237 Crossref Scopus (133) PubMed Google Scholar
  57. [61]61. Huang, S. ∙ Yang, Z.J. ∙ Yu, C. ... Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1 J. Biol. Chem. 2011; 286:40002-40012 Full Text Full Text (PDF) Scopus (69) PubMed Google Scholar
  58. [62]62. Sotelo, J. ∙ Briceño, E. ∙ López-González, M.A. Adding chloroquine to conventional treatment for glioblastoma multiforme. A randomized, double-blind, placebo-controlled trial Ann. Intern. Med. 2006; 144:337-343 Crossref Scopus (430) PubMed Google Scholar Figures (7) Article metrics Related Articles Advertisement Hide CaptionDownloadSee figure in Article Toggle Thumbstrip FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 Download .PPT Home Access for Developing Countries Articles Papers in Press Current Volume Archive Editorials JBC Reviews Meeting Reports Thematic Series Virtual Issues Classics Reflections Editors' Picks JBC Communications eLetters Tabor Awards For Authors Information for Authors About Open Access Permissions Submit manuscript Submission Help Contact Us Contact Information Journal Info About the Journal Early Career Reviewers Editorial Board Image Gallery New Content Alerts All Topics Bioenergetics Cell Biology Computational Biology Developmental Biology DNA and Chromosomes Enzymology Gene Regulation Genomics and Proteomics Glycobiology and Extracellular Matrices Immunology Lipids Membrane Biology Metabolism

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Authors
Yuan, G., Yan, S.-F., Xue, H., Zhang, P., Sun, J.-T., & Li, G.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2014-04
Volume
289
Issue
15
Pages
10607-10619
ISSN
0021-9258
DOI
10.1074/jbc.m113.528760
Cited by
80
References
4
Language
en
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