The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Biosynthesis, regulation, and domestication of bitterness in cucumber
Open accessAbstract
Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the plant and have also been shown to have antitumor properties. With genomics and biochemistry, we identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps. We discovered transcription factors Bl ( Bitter leaf ) and Bt ( Bitter fruit ) that regulate this pathway in leaves and fruits, respectively. Traces in genomic signatures indicated that selection imposed on Bt during domestication led to derivation of nonbitter cucurbits from their bitter ancestors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
High-level semi-synthetic production of the potent antimalarial artemisinin
Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature · doi:10.1038/nature12051 · Cited by 2,060
The genome of the cucumber,Cucumis sativus L
Huang, S., Li, R., Zhang, Z., Li, L., Gu, X., Fan, W., Lucas, W. J., Wang, X., Xie, B., Ni, P., et al. (2009) · Nature Genetics · doi:10.1038/ng.475 · Cited by 1,490
Self-citationThe Arabidopsis Basic/Helix-Loop-Helix Transcription Factor Family[W]
Toledo-Ortiz, G., Huq, E., & Quail, P. H. (2003) · The Plant Cell · doi:10.1105/tpc.013839 · Cited by 1,328
Cucurbitacins and cucurbitane glycosides: structures and biological activities
Chen, J. C., Chiu, M. H., Nie, R. L., Cordell, G. A., & Qiu, S. X. (2005) · Natural Product Reports · doi:10.1039/b418841c · Cited by 635
Blaskovich, M. A., Sun, J., Cantor, A. B., Turkson, J., Jove, R., & Sebti, S. M. (2003) · PubMed · Cited by 561
Qi, J., Liu, X., Shen, D., Miao, H., Xie, B., Li, X., Zeng, P., Wang, S., Shang, Y., Gu, X., et al. (2013) · Nature Genetics · doi:10.1038/ng.2801 · Cited by 517
Self-citationMetabolic Diversification—Independent Assembly of Operon-Like Gene Clusters in Different Plants
Field, B., & Osbourn, A. E. (2008) · Science · doi:10.1126/science.1154990 · Cited by 424
Mining the Biodiversity of Plants: A Revolution in the Making
De Luca, V., Salim, V., Atsumi, S. M., & Yu, F. (2012) · Science · doi:10.1126/science.1217410 · Cited by 337
Genomic Signatures of Specialized Metabolism in Plants
Chae, L., Kim, T., Nilo-Poyanco, R., & Rhee, S. Y. (2014) · Science · doi:10.1126/science.1252076 · Cited by 308
Metadata
- Authors
- Shang, Y., Ma, Y., Zhou, Y., Zhang, H., Duan, L., Chen, H., Zeng, J., Zhou, Q., Wang, S., Gu, W., Liu, M., Ren, J., Gu, X., Zhang, S., Wang, Y., Yasukawa, K., Bouwmeester, H. J., Qi, X., Zhang, Z., Lucas, W. J., & Huang, S.
- Venue
- Science
- Published
- 2014-11-28
- Volume
- 346
- Issue
- 6213
- Pages
- 1084-1088
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059041677
- Cited by
- 490
- References
- 19
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Biosynthesis, regulation, and domestication of bitterness in cucumber. https://app.cochat.ai/papers/10.1126/science.1259215
- The paper
- Shang, Y., Ma, Y., Zhou, Y., Zhang, H., Duan, L., Chen, H., Zeng, J., Zhou, Q., Wang, S., Gu, W., Liu, M., Ren, J., Gu, X., Zhang, S., Wang, Y., Yasukawa, K., Bouwmeester, H. J., Qi, X., Zhang, Z., . . . Huang, S. (2014). Biosynthesis, regulation, and domestication of bitterness in cucumber. Science. https://doi.org/10.1126/science.1259215
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
