The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Saxitoxin, a toxic marine natural product that targets a multitude of receptors
Abstract
Saxitoxin (STX) was discovered early last century and can contaminate seafood and drinking water, and over time has become an invaluable research tool and an internationally regulated chemical weapon. Among natural products, toxins obtain a unique reputation from their high affinity and selectivity for their target pharmacological receptor, which for STX has long been considered to only be the voltage gated sodium channel. In recent times however, STX has been discovered to also bind to calcium and potassium channels, neuronal nitric oxide synthase, STX metabolizing enzymes and two circulatory fluid proteins, namely a transferrin-like family of proteins and a unique protein found in the blood of pufferfish.
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Cites
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Cited by
Neurotoxic Alkaloids: Saxitoxin and Its Analogs
Wiese, M., D’Agostino, P. M., Mihali, T. K., Moffitt, M. C., & Neilan, B. A. (2010) · Marine Drugs · doi:10.3390/md8072185 · Cited by 769
Blunt, J. W., Copp, B. R., Hu, W.-P., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2008) · Natural Product Reports · doi:10.1039/b701534h · Cited by 365
A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis
Di Gioia, D., Bozzi Cionci, N., Baffoni, L., Amoruso, A., Pane, M., Mogna, L., Gaggìa, F., Lucenti, M. A., Bersano, E., Cantello, R., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01607-9 · Cited by 151
Metadata
- Authors
- Llewellyn, L. E.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 23
- Issue
- 2
- Pages
- 200
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2152589735
- Cited by
- 403
- References
- 141
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
