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Automated oligosaccharide synthesis
Abstract
Peptides and oligonucleotides are prepared by automated synthesizers that can be operated by non-specialists. Carbohydrates have been hard to assemble, but the increasing awareness of the biological importance of this class of complex repeating biopolymers has prompted efforts to accelerate their synthesis. This tutorial review defines the state of the art of automated solid phase oligosaccharide synthesis and identifies areas in need of further innovation. Application of the automated synthesis method to prepare a malaria vaccine candidate is briefly highlighted.
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Cited by
Carbohydrate vaccines: developing sweet solutions to sticky situations?
Astronomo, R. D., & Burton, D. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3012 · Cited by 629
“One-Pot” Protection, Glycosylation, and Protection–Glycosylation Strategies of Carbohydrates
Kulkarni, S. S., Wang, C.-C., Sabbavarapu, N. M., Podilapu, A. R., Liao, P.-H., & Hung, S.-C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00036 · Cited by 351
Enzymes in the Synthesis of Glycoconjugates
Schmaltz, R. M., Hanson, S. R., & Wong, C.-H. (2011) · Chemical Reviews · doi:10.1021/cr200113w · Cited by 283
Polysaccharide matrices used in 3D in vitro cell culture systems
Diekjürgen, D., & Grainger, D. W. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.020 · Cited by 125
Synthesis of a TLR4 Agonist‐Carbohydrate Antigen Conjugate As A Self‐Adjuvanting Cancer Vaccine
Lewicky, J. D., Ulanova, M., & Jiang, Z. (2016) · ChemistrySelect · doi:10.1002/slct.201600230 · Cited by 20
Metadata
- Authors
- Seeberger, P. H.
- Venue
- Chem. Soc. Rev.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 37
- Issue
- 1
- Pages
- 19-28
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W4249230231
- Cited by
- 290
- References
- 0
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
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