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Critical particle size for fractionation by deterministic lateral displacement
Abstract
The fractionation of small particles in a liquid based on their size in a micropost array by deterministic lateral displacement was recently demonstrated with unprecedented resolution (L. R. Huang, E. C. Cox, R. H. Austin and J. C. Sturm, Science, 2004, 304, 987-990, ). In this paper, we present a model of how the critical particle size for fractionation depends on the micropost geometry, depending specifically on the gap between posts, the offset of posts in one row with respect to another, and whether the fluid is driven by hydrodynamics or by electroosmosis. In general the critical particle diameter is much smaller than the gap, which prevents clogging. The model is supported by data with particles from 2.3 to 22 microm.
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Cited by
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Gossett, D. R., Weaver, W. M., Mach, A. J., Hur, S. C., Tse, H. T. K., Lee, W., Amini, H., & Di Carlo, D. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3721-9 · Cited by 930
Continuous flow separations in microfluidic devices
Pamme, N. (2007) · Lab on a Chip · doi:10.1039/b712784g · Cited by 770
Inertial microfluidics for continuous particle separation in spiral microchannels
Kuntaegowdanahalli, S. S., Bhagat, A. A. S., Kumar, G., & Papautsky, I. (2009) · Lab on a Chip · doi:10.1039/b908271a · Cited by 708
Continuous particle separation in spiral microchannels using dean flows and differential migration
Bhagat, A. A. S., Kuntaegowdanahalli, S. S., & Papautsky, I. (2008) · Lab on a Chip · doi:10.1039/b807107a · Cited by 656
Deterministic hydrodynamics: Taking blood apart
Davis, J. A., Inglis, D. W., Morton, K. J., Lawrence, D. A., Huang, L. R., Chou, S. Y., Sturm, J. C., & Austin, R. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605967103 · Cited by 622
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Metadata
- Authors
- Inglis, D. W., Davis, J. A., Austin, R. H., & Sturm, J. C.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 6
- Issue
- 5
- Pages
- 655
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W1975214851
- Cited by
- 421
- References
- 0
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
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