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Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis
Abstract
The ability to separate living cells is an essential aspect of cell research. Magnetic cell separation methods are among some of the most efficient methods for bulk cell separation. With the development of microfluidic platforms within the biotechnology sector, the design of miniaturised magnetic cell sorters is desirable. Here, we report the continuous sorting of cells loaded with magnetic nanoparticles in a microfluidic magnetic separation device. Cells were passed through a microfluidic chamber and were deflected from the direction of flow by means of a magnetic field. Two types of cells were studied, mouse macrophages and human ovarian cancer cells (HeLa cells). The deflection was dependent on the magnetic moment and size of the cells as well as on the applied flow rate. The experimentally observed deflection matched well with calculations. Furthermore, the separation of magnetic and non-magnetic cells was demonstrated using the same microfluidic device.
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Cited by
Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications
Mark, D., Haeberle, S., Roth, G., von Stetten, F., & Zengerle, R. (2010) · Chemical Society Reviews · doi:10.1039/b820557b · Cited by 1,647
Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy
Krishnan, K. M. (2010) · IEEE Transactions on Magnetics · doi:10.1109/tmag.2010.2046907 · Cited by 819
Continuous flow separations in microfluidic devices
Pamme, N. (2007) · Lab on a Chip · doi:10.1039/b712784g · Cited by 770
Self-citationMicrofluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Xu, H., Aguilar, Z. P., Yang, L., Kuang, M., Duan, H., Xiong, Y., Wei, H., & Wang, A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.076 · Cited by 381
Metadata
- Authors
- Pamme, N., & Wilhelm, C.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 6
- Issue
- 8
- Pages
- 974
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W1986429246
- Cited by
- 497
- References
- 0
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- closed
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