The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The growing applications of click chemistry
Abstract
Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
The growing impact of click chemistry on drug discovery
Kolb, H. C., & Sharpless, K. B. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02933-7 · Cited by 3,148
Agard, N. J., Prescher, J. A., & Bertozzi, C. R. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044996f · Cited by 3,017
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
Wang, Q., Chan, T. R., Hilgraf, R., Fokin, V. V., Sharpless, K. B., & Finn, M. G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja021381e · Cited by 1,641
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis
Chan, T. R., Hilgraf, R., Sharpless, K. B., & Fokin, V. V. (2004) · Organic Letters · doi:10.1021/ol0493094 · Cited by 1,531
Prescher, J. A., & Bertozzi, C. R. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0605-13 · Cited by 1,456
CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective
Bock, V. D., Hiemstra, H., & van Maarseveen, J. H. (2006) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200500483 · Cited by 1,452
Wu, P., Feldman, A. K., Nugent, A. K., Hawker, C. J., Scheel, A., Voit, B., Pyun, J., Fréchet, J. M. J., Sharpless, K. B., & Fokin, V. V. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200454078 · Cited by 1,167
Speers, A. E., Adam, G. C., & Cravatt, B. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034490h · Cited by 955
Profiling Enzyme Activities In Vivo Using Click Chemistry Methods
Speers, A. E., & Cravatt, B. F. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.03.012 · Cited by 774
Lewis, W. G., Green, L. G., Grynszpan, F., Radić, Z., Carlier, P. R., Taylor, P., Finn, M. G., & Sharpless, K. B. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020315)41:6<1053::aid-anie1053>3.0.co;2-4 · Cited by 744
An Efficient Route to Well-Defined Macrocyclic Polymers via “Click” Cyclization
Laurent, B. A., & Grayson, S. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0585836 · Cited by 700
Ladmiral, V., Mantovani, G., Clarkson, G. J., Cauet, S., Irwin, J. L., & Haddleton, D. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058364k · Cited by 586
Dendronized Linear Polymers via “Click Chemistry”
Helms, B., Mynar, J. L., Hawker, C. J., & Fréchet, J. M. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044744e · Cited by 580
Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry
Whiting, M., Muldoon, J., Lin, Y., Silverman, S. M., Lindstrom, W., Olson, A. J., Kolb, H. C., Finn, M. G., Sharpless, K. B., Elder, J. H., et al. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200502161 · Cited by 516
Gierlich, J., Burley, G. A., Gramlich, P. M. E., Hammond, D. M., & Carell, T. (2006) · Organic Letters · doi:10.1021/ol0610946 · Cited by 492
Multivalent, bifunctional dendrimers prepared by click chemistry
Wu, P., Malkoch, M., Hunt, J. N., Vestberg, R., Kaltgrad, E., Finn, M. G., Fokin, V. V., Sharpless, K. B., & Hawker, C. J. (2005) · Chemical Communications · doi:10.1039/b512021g · Cited by 449
Li, H., Cheng, F., Duft, A. M., & Adronov, A. (2005) · Journal of the American Chemical Society · doi:10.1021/ja054958b · Cited by 432
A Potent and Highly Selective Inhibitor of Human α-1,3-Fucosyltransferase via Click Chemistry
Lee, L. V., Mitchell, M. L., Huang, S.-J., Fokin, V. V., Sharpless, K. B., & Wong, C.-H. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0302836 · Cited by 432
Díaz, D. D., Punna, S., Holzer, P., McPherson, A. K., Sharpless, K. B., Fokin, V. V., & Finn, M. G. (2004) · Journal of Polymer Science Part A: Polymer Chemistry · doi:10.1002/pola.20330 · Cited by 424
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
Manetsch, R., Krasiński, A., Radić, Z., Raushel, J., Taylor, P., Sharpless, K. B., & Kolb, H. C. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046382g · Cited by 423
Aucagne, V., Hänni, K. D., Leigh, D. A., Lusby, P. J., & Walker, D. B. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056903f · Cited by 394
Sun, X.-L., Stabler, C. L., Cazalis, C. S., & Chaikof, E. L. (2006) · Bioconjugate Chemistry · doi:10.1021/bc0502311 · Cited by 353
Gupta, S. S., Kuzelka, J., Singh, P., Lewis, W. G., Manchester, M., & Finn, M. G. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050147l · Cited by 303
Whittaker, M. R., Urbani, C. N., & Monteiro, M. J. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0645990 · Cited by 258
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
Mocharla, V. P., Colasson, B., Lee, L. V., Röper, S., Sharpless, K. B., Wong, C., & Kolb, H. C. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461580 · Cited by 242
Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry
Moorhouse, A. D., Santos, A. M., Gunaratnam, M., Moore, M., Neidle, S., & Moses, J. E. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0661919 · Cited by 228
Self-citationAzide–Alkyne Coupling: A Powerful Reaction for Bioconjugate Chemistry
Breinbauer, R., & Köhn, M. (2003) · ChemBioChem · doi:10.1002/cbic.200300705 · Cited by 215
“Click” Chemistry by Microcontact Printing
Rozkiewicz, D. I., Jańczewski, D., Verboom, W., Ravoo, B. J., & Reinhoudt, D. N. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601090 · Cited by 197
Efficient Synthesis of Water-Soluble Calixarenes Using Click Chemistry
Ryu, E.-H., & Zhao, Y. (2005) · Organic Letters · doi:10.1021/ol047468h · Cited by 185
In situ click chemistry: a powerful means for lead discovery
Sharpless, K. B., & Manetsch, R. (2006) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.1.6.525 · Cited by 181
Integrated Microfluidics for Parallel Screening of an In Situ Click Chemistry Library
Wang, J., Sui, G., Mocharla, V. P., Lin, R. J., Phelps, M. E., Kolb, H. C., & Tseng, H. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601677 · Cited by 159
“Clickphine”: A Novel and Highly Versatile P,N Ligand Class via Click Chemistry
Detz, R. J., Heras, S. A., Gelder, R. D., van Leeuwen, P. W. N. M., Hiemstra, H. C., Reek, J. N. H., & van Maarseveen, J. H. (2006) · Organic Letters · doi:10.1021/ol061015q · Cited by 152
Rostovtsev, V. V., Green, L. G., Fokin, V. V., & Sharpless, K. B. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4
Kolb (2001) · doi:10.1002/1521-3773(20010601)40:11<2004::aid-anie2004>3.0.co;2-5
Cited by
Thiol-ene “click” reactions and recent applications in polymer and materials synthesis
Lowe, A. B. (2010) · Polym. Chem. · doi:10.1039/b9py00216b · Cited by 1,563
Chanda, A., & Fokin, V. V. (2009) · Chemical Reviews · doi:10.1021/cr800448q · Cited by 1,534
Hydrogels in a historical perspective: From simple networks to smart materials
Buwalda, S. J., Boere, K. W. M., Dijkstra, P. J., Feijen, J., Vermonden, T., & Hennink, W. E. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.052 · Cited by 994
Triazoles and tetrazoles: Prime ligands to generate remarkable coordination materials
Aromí, G., Barrios, L. A., Roubeau, O., & Gamez, P. (2011) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2010.10.038 · Cited by 989
Self-healing gels based on constitutional dynamic chemistry and their potential applications
Wei, Z., Yang, J. H., Zhou, J., Xu, F., Zrínyi, M., Dussault, P. H., Osada, Y., & Chen, Y. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00219a · Cited by 896
Metadata
- Authors
- Moses, J. E., & Moorhouse, A. D.
- Venue
- Chem. Soc. Rev.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 36
- Issue
- 8
- Pages
- 1249-1262
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2137577190
- Cited by
- 2,367
- References
- 35
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.