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Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems
Abstract
Recent advancements in controlling the surface properties and particle morphology of the structurally defined mesoporous silica materials with high surface area (>700 m(2) g(-1)) and pore volume (>1 cm(3) g(-1)) have significantly enhanced their biocompatibility. Various methods have been developed for the functionalization of both the internal pore and exterior particle surfaces of these silicates with a tunable pore diameter ranging from 2 to 30 nm and a narrow pore size distribution. Herein, we review the recent research progress on the design of functional mesoporous silica materials for stimuli-responsive controlled release delivery of pharmaceutical drugs, genes, and other chemicals. Furthermore, the recent breakthroughs in utilizing these nanoscale porous materials as sensors for selective detections of various neurotransmitters and biological molecules are summarized.
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Citations
Cited by
Mesoporous materials and electrochemistry
Walcarius, A. (2013) · Chemical Society Reviews · doi:10.1039/c2cs35322a · Cited by 623
He, Q., Zhang, J., Shi, J., Zhu, Z., Zhang, L., Bu, W., Guo, L., & Chen, Y. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.046 · Cited by 502
Liang, C., Xu, L., Song, G., & Liu, Z. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00458j · Cited by 435
Tunable Redox-Responsive Hybrid Nanogated Ensembles
Liu, R., Zhao, X., Wu, T., & Feng, P. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8060886 · Cited by 391
Yuan, L., Tang, Q., Yang, D., Zhang, J. Z., Zhang, F., & Hu, J. (2011) · The Journal of Physical Chemistry C · doi:10.1021/jp201053d · Cited by 328
Metadata
- Authors
- Trewyn, B. G., Giri, S., Slowing, I. I., & Lin, V. S.-Y.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Issue
- 31
- Pages
- 3236
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2155385159
- Cited by
- 583
- References
- 0
- FWCI
- 23.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trewyn, B. G., Giri, S., Slowing, I. I., & Lin, V. S.-Y. (2007). Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems. Chemical Communications. https://doi.org/10.1039/b701744h
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