The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Preparation of pH-Responsive Mesoporous Silica Nanoparticles and Their Application in Controlled Drug Delivery
Abstract
Poly(acrylic acid) grafted mesoporous silica nanoparticles (PAA-MSNs) were prepared by a facile graft-onto strategy, i.e., the amidation between PAA homopolymer and amino group functionalized MSNs. The resultant PAA-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 150 nm, and the graft amount of PAA evaluated by thermogravimetric analysis (TGA) was about 12 wt %. Due to the covalent graft of hydrophilic and pH-responsive PAA, the PAA-MSNs could be well dispersed in aqueous solution, which is favorable to be utilized as drug carriers to construct a pH-responsive controlled drug delivery system. N 2 adsorption–desorption isotherm results demonstrated that doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of PAA-MSNs through the electrostatic interaction. The loading content and the entrapment efficiency of DOX could reach up to 48% and 95%, respectively. The drug release rate of DOX@PAA-MSN was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that PAA-MSNs were highly biocompatible and suitable to use as drug carriers. The drug-loaded DOX@PAA-MSNs were distinctly cytotoxic to HeLa cells, due to the sustained release of drug, and showed higher clinical effects than free DOX. These results imply that the PAA-MSNs are promising platforms to construct pH-responsive controlled drug delivery systems for cancer therapy.
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pH ‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents
Karimi, M., Eslami, M., Sahandi‐Zangabad, P., Mirab, F., Farajisafiloo, N., Shafaei, Z., Ghosh, D., Bozorgomid, M., Dashkhaneh, F., & Hamblin, M. R. (2016) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1389 · Cited by 327
Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment
Martínez-Carmona, M., Lozano, D., Colilla, M., & Vallet-Regí, M. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.11.007 · Cited by 220
Drug releasing nanoplatforms activated by alternating magnetic fields
Mertz, D., Sandre, O., & Bégin-Colin, S. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.02.025 · Cited by 119
Kundu, M., Chatterjee, S., Ghosh, N., Manna, P., Das, J., & Sil, P. C. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111239 · Cited by 89
Chen, T., Wu, W., Xiao, H., Chen, Y., Chen, M., & Li, J. (2016) · ACS Macro Letters · doi:10.1021/acsmacrolett.5b00765 · Cited by 87
Metadata
- Authors
- Yuan, L., Tang, Q., Yang, D., Zhang, J. Z., Zhang, F., & Hu, J.
- Venue
- The Journal of Physical Chemistry C
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-05-04
- Volume
- 115
- Issue
- 20
- Pages
- 9926-9932
- ISSN
- 1932-7447 (ISSN-L)
- 1932-7455
- OpenAlex
- W2320325931
- Cited by
- 328
- References
- 36
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- closed
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