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Review of applications of high-field asymmetric waveform ion mobility spectrometry (FAIMS) and differential mobility spectrometry (DMS)
Abstract
High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) and Differential Mobility Spectrometry (DMS) harness differences in ion mobility in low and high electric fields to achieve a gas-phase separation of ions at atmospheric pressure. This separation is orthogonal to either chromatographic or mass spectrometric separation, thereby increasing the selectivity and specificity of analysis. The orthogonality of separation, which in some cases may obviate chromatographic separation, can be used to differentiate isomers, to reduce background, to resolve isobaric species, and to improve signal-to-noise ratios by selective ion transmission. This review will focus on the applications of these techniques to the separation of various classes of analytes, including chemical weapons, explosives, biologically active molecules, pharmaceuticals and pollutants. These papers cover the period up to January 2007.
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Citations
Cited by
Ion mobility–mass spectrometry
Kanu, A. B., Dwivedi, P., Tam, M., Matz, L., & Hill, H. H. (2008) · Journal of Mass Spectrometry · doi:10.1002/jms.1383 · Cited by 1,154
Ion Mobility Spectrometry: Fundamental Concepts, Instrumentation, Applications, and the Road Ahead
Dodds, J. N., & Baker, E. S. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02288-2 · Cited by 574
Review on ion mobility spectrometry. Part 1: current instrumentation
Cumeras, R., Figueras, E., Davis, C. E., Baumbach, J. I., & Gràcia, I. (2015) · The Analyst · doi:10.1039/c4an01100g · Cited by 459
Lapthorn, C., Pullen, F., & Chowdhry, B. Z. (2013) · Mass Spectrometry Reviews · doi:10.1002/mas.21349 · Cited by 398
Ion Mobility Spectrometry and Its Applications in Detection of Chemical Warfare Agents
Mäkinen, M. A., Anttalainen, O. A., & Sillanpää, M. E. T. (2010) · Analytical Chemistry · doi:10.1021/ac100931n · Cited by 294
Metadata
- Authors
- Kolakowski, B. M., & Mester, Z.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 132
- Issue
- 9
- Pages
- 842
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W2163546899
- Cited by
- 351
- References
- 0
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kolakowski, B. M., & Mester, Z. (2007). Review of applications of high-field asymmetric waveform ion mobility spectrometry (FAIMS) and differential mobility spectrometry (DMS). The Analyst. https://doi.org/10.1039/b706039d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
