The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications
Abstract
This tutorial review discusses a new class of colloidal metal nanoparticles that is able to enhance the efficiencies of surface-enhanced Raman scattering (SERS) by as much as 10(14)-10(15) fold. This enormous enhancement allows spectroscopic detection and identification of single molecules located on the nanoparticle surface or at the junction of two particles under ambient conditions. Considerable progress has been made in understanding the enhancement mechanisms, including definitive evidence for the single-molecule origin of fluctuating SERS signals. For applications, SERS nanoparticle tags have been developed based on the use of embedded reporter molecules and a silica or polymer encapsulation layer. The SERS nanoparticle tags are capable of providing detailed spectroscopic information and are much brighter than semiconductor quantum dots in the near-infrared spectral window. These properties have raised new opportunities for multiplexed molecular diagnosis and in vivo Raman spectroscopy and imaging.
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Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Self-citation
Cited by
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Sub-nanometre sized metal clusters: from synthetic challenges to the unique property discoveries
Lu, Y., & Chen, W. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15325d · Cited by 1,152
Seh, Z. W., Liu, S., Low, M., Zhang, S., Liu, Z., Mlayah, A., & Han, M. (2012) · Advanced Materials · doi:10.1002/adma.201104241 · Cited by 855
Qiao, X., Su, B., Liu, C., Song, Q., Luo, D., Mo, G., & Wang, T. (2018) · Advanced Materials · doi:10.1002/adma.201702275 · Cited by 469
Guerrini, L., & Graham, D. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35118h · Cited by 441
Metadata
- Authors
- Qian, X.-M., & Nie, S. M.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 37
- Issue
- 5
- Pages
- 912
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2091588319
- Cited by
- 1,105
- References
- 3
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
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