Cited by 469Gold and Silver Nanoparticles Synthesis and ApplicationsSpectroscopy Techniques in Biomedical and Chemical ResearchGas Sensing Nanomaterials and Sensors

Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure

Qiao, Xuezhi, Su, Bensheng, Liu, Cong, Song, Qian, Luo, Dan, Mo, Guang, Wang, Tie·2018·Advanced Materials

Abstract

Surface enhanced Raman scattering (SERS) is a trace detection technique that extends even to single molecule detection. Its potential application to the noninvasive recognition of lung malignancies by detecting volatile organic compounds (VOCs) that serve as biomarkers would be a breakthrough in early cancer diagnostics. This application, however, is currently limited by two main factors: (1) most VOC biomarkers exhibit only weak Raman scattering; and (2) the high mobility of gaseous molecules results in a low adsorptivity on solid substrates. To enhance the adsorption of gaseous molecules, a ZIF‐8 layer is coated onto a self‐assembly of gold superparticles (GSPs) in order to slow the flow rate of gaseous biomarkers and depress the exponential decay of the electromagnetic field around the GSP surfaces. Gaseous aldehydes that are released as a result of tumor‐specific tissue composition and metabolism, thereby acting as indicators of lung cancer, are guided onto SERS‐active GSPs substrates through a ZIF‐8 channel. Through a Schiff base reaction with 4‐aminothiophenol pregrafted onto gold GSPs, gaseous aldehydes are captured with a 10 ppb limit of detection, demonstrating tremendous prospects for in vitro diagnoses of early stage lung cancer.

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Crossref · 10.1002/adma.201702275

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Authors
Qiao, X., Su, B., Liu, C., Song, Q., Luo, D., Mo, G., & Wang, T.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Beijing University of Chemical Technology (CN)
Corresponding author
Wang, Tie
Venue
Advanced Materials
Publisher
Wiley
Published
2017-12-11
Volume
30
Issue
5
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2771902832
Cited by
469
References
50
Citations by year
2026: 44 · 2025: 67 · 2024: 66 · 2023: 66 · 2022: 64 · 2021: 69 · 2020: 47 · 2019: 32 · 2018: 13
FWCI
8.56
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (21422507, 21635002, 21321003)
Topics
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Gas Sensing Nanomaterials and Sensors
Keywords
surface-enhanced Raman scattering, lung cancer, volatile organic compounds, gas sensing, ZIF-8, metal-organic frameworks, aldehyde detection, 4-aminothiophenol, Schiff base, early cancer detection, non-invasive diagnosis
MeSH terms
Gold, Spectrum Analysis, Raman, Biomarkers, Tumor, Nanotechnology, Metal Nanoparticles

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