The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery
Abstract
We have recently achieved efficient cytosolic delivery by using pH-sensitive poly(2-(methacryloyloxy)ethylphosphorylcholine)-co-poly(2-(diisopropylamino)ethylmethacrylate) (PMPC-PDPA) diblock copolymers that self-assemble to form vesicles, known as polymersomes, in aqueous solution. It is particularly noteworthy that these diblock copolymers form stable polymersomes at physiological pH but rapidly dissociate below pH 6 to give molecularly-dissolved copolymer chains (unimers). These PMPC-PDPA polymersomes are used to encapsulate nucleic acids for efficient intracellular delivery. Confocal laser scanning microscopy and fluorescence flow cytometry are used to quantify cellular uptake and to study the kinetics of this process. Finally, we examine how PMPC-PDPA polymersomes affect the viability of primary human cells (human dermal fibroblasts (HDF)), paying particular regard to whether inflammatory responses are triggered.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Parameters influencing the stealthiness of colloidal drug delivery systems
Vonarbourg, A., Passirani, C., Saulnier, P., & Benoit, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.039 · Cited by 740
Polymer vesicles in vivo: correlations with PEG molecular weight
Photos, P. J., Bacakova, L., Discher, B., Bates, F. S., & Discher, D. E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00201-3 · Cited by 527
Biodegradable nanoparticles for cytosolic delivery of therapeutics
VASIR, J., & LABHASETWAR, V (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.003 · Cited by 526
Cited by
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Self-citationCanton, I., & Battaglia, G. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15309b · Cited by 936
Self-citationAdvances and challenges in smart and functional polymer vesicles
Du, J., & O'Reilly, R. K. (2009) · Soft Matter · doi:10.1039/b905635a · Cited by 572
Self-citationStimuli-Responsive Polymers and Their Applications in Nanomedicine
Cabane, E., Zhang, X., Langowska, K., Palivan, C. G., & Meier, W. (2012) · Biointerphases · doi:10.1007/s13758-011-0009-3 · Cited by 468
Stimuli‐Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery
Onaca, O., Enea, R., Hughes, D. W., & Meier, W. (2009) · Macromolecular Bioscience · doi:10.1002/mabi.200800248 · Cited by 465
Metadata
- Authors
- Lomas, H., Massignani, M., Abdullah, K. A., Canton, I., Lo Presti, C., MacNeil, S., Du, J., Blanazs, A., Madsen, J., Armes, S. P., Lewis, A. L., & Battaglia, G.
- Venue
- Faraday Discussions
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 139
- Pages
- 143
- ISSN
- 1359-6640 (ISSN-L)
- 1364-5498
- OpenAlex
- W2052569796
- Cited by
- 164
- References
- 3
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery. https://app.cochat.ai/papers/10.1039/b717431d
- The paper
- Lomas, H., Massignani, M., Abdullah, K. A., Canton, I., Lo Presti, C., MacNeil, S., Du, J., Blanazs, A., Madsen, J., Armes, S. P., Lewis, A. L., & Battaglia, G. (2008). Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery. Faraday Discussions. https://doi.org/10.1039/b717431d
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
