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Stimuli-Responsive Polymers and Their Applications in Nanomedicine
Open accessAbstract
This review focuses on smart nano-materials built of stimuli-responsive (SR) polymers and will discuss their numerous applications in the biomedical field. The authors will first provide an overview of different stimuli and their corresponding, responsive polymers. By introducing myriad functionalities, SR polymers present a wide range of possibilities in the design of stimuli-responsive devices, making use of virtually all types of polymer constructs, from self-assembled structures (micelles, vesicles) to surfaces (polymer brushes, films) as described in the second section of the review. In the last section of this review the authors report on some of the most promising applications of stimuli-responsive polymers in nanomedicine. In particular, we will discuss applications pertaining to diagnosis, where SR polymers are used to construct sensors capable of selective recognition and quantification of analytes and physical variables, as well as imaging devices. We will also highlight some examples of responsive systems used for therapeutic applications, including smart drug delivery systems (micelles, vesicles, dendrimers …) and surfaces for regenerative medicine.
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Cites
Polymers for Drug Delivery Systems
Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A. (2010) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-073009-100847 · Cited by 1,608
Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095838 · Cited by 844
Biologically erodable microspheres as potential oral drug delivery systems
Mathiowitz, E., Jacob, J. S., Jong, Y. S., Carino, G. P., Chickering, D. E., Chaturvedi, P., Santos, C. A., Vijayaraghavan, K., Montgomery, S., Bassett, M., et al. (1997) · Nature · doi:10.1038/386410a0 · Cited by 823
Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
Ryu, J. H., Lee, Y., Kong, W. H., Kim, T. G., Park, T. G., & Lee, H. (2011) · Biomacromolecules · doi:10.1021/bm200464x · Cited by 677
Cited by
Soft Actuators for Small-Scale Robotics
Hines, L., Petersen, K., Lum, G. Z., & Sitti, M. (2017) · Advanced Materials · doi:10.1002/adma.201603483 · Cited by 1,337
Döring, A., Birnbaum, W., & Kuckling, D. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60031a · Cited by 391
Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
Wei, D., Sun, Y., Zhu, H., & Fu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.3c06019 · Cited by 303
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156
“The stimulus types, administering the arrangement of stimuli-responsive nanomicelles, which is mandatory to act on the micelles to exert such required stimulus-outcome as physical, chemical, or biological [130].”
BackgroundpH-Responsive PDMS- b -PDMAEMA Micelles for Intracellular Anticancer Drug Delivery
Car, A., Baumann, P., Duskey, J. T., Chami, M., Bruns, N., & Meier, W. (2014) · Biomacromolecules · doi:10.1021/bm500919z · Cited by 113
Self-citation
Metadata
- Authors
- Cabane, E., Zhang, X., Langowska, K., Palivan, C. G., & Meier, W.
- Venue
- Biointerphases
- Publisher
- American Vacuum Society
- Published
- 2012-02-11
- Volume
- 7
- Issue
- 1
- Pages
- 9-9
- ISSN
- 1559-4106 (ISSN-L)
- 1934-8630
- OpenAlex
- W2038802821
- Cited by
- 468
- References
- 4
- FWCI
- 13.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
