Biodegradable nanoparticles for cytosolic delivery of therapeutics
Open accessAbstract
Many therapeutics require efficient cytosolic delivery either because the receptors for those drugs are located in the cytosol or their site of action is an intracellular organelle that requires transport through the cytosolic compartment. To achieve efficient cytosolic delivery of therapeutics, different nanomaterials have been developed that consider the diverse physicochemical nature of therapeutics (macromolecule to small molecule; water soluble to water insoluble) and various membrane associated and intracellular barriers that these systems need to overcome to efficiently deliver and retain therapeutics in the cytoplasmic compartment. Our interest is in investigating PLGA and PLA-based nanoparticles for intracellular delivery of drugs and genes. The present review discusses the various aspects of our studies and emphasizes the need for understanding of the molecular mechanisms of intracellular trafficking of nanoparticles in order to develop an efficient cytosolic delivery system.
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High-molecular-weight PLA has been used to produce non-dismantling surgical sutures and low-molecular-weight PLA as a slow-release drug-packaging agent.
“High-molecular-weight PLA has been used to produce non-dismantling surgical sutures and low-molecular-weight PLA as a slow-release drug-packaging agent [51].”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [51]
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- Authors
- VASIR, J., & LABHASETWAR, V
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- LABHASETWAR, V
- ORCID
- LABHASETWAR, V
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2007-08-10
- Volume
- 59
- Issue
- 8
- Pages
- 718-728
- ISSN
- 0169-409X (ISSN-L)
- PMC
- PMC2002520
- OpenAlex
- W2032965857
- Cited by
- 526
- References
- 77
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 29 · 2023: 25 · 2022: 20 · 2021: 24 · 2020: 28 · 2019: 29 · 2018: 33 · 2017: 22 · 2016: 35 · 2015: 28 · 2014: 43 · 2013: 41 · 2012: 27
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R21 MH67525, R21MH067525)
- National Cancer Institute (CA121751, R21CA121751)
- National Institute of Biomedical Imaging and Bioengineering (R01EB003975)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- biodegradable nanoparticles, cytosolic drug delivery, intracellular delivery, PLGA nanoparticles, intracellular trafficking, gene delivery
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Biocompatible Materials, Biological Transport, Biotransformation, Chemistry, Pharmaceutical, Cytosol, Delayed-Action Preparations, Drug Carriers, Particle Size, Polyesters, Polyethylene Glycols, Polyglycolic Acid, Polymers, Drug Design, Lactic Acid, Absorbable Implants, Nanoparticles
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