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A primer on ankyrin repeat function in TRP channels and beyond
Open accessAbstract
Transient receptor potential (TRP) channels are rapidly gaining attention as important receptors and transducers of diverse sensory and environmental cues. Recent progress in the field has provided new insights into the structure and function of the ankyrin repeat motifs present in the N-terminal cytosolic domain of many TRP channels. The topics addressed in this Highlight include the structural features of canonical ankyrin repeats, new clues into the functions these repeats perform in cells, and how this information can be applied to develop further experiments on TRP channels and other proteins containing ankyrin repeats.
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Cites
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Cited by
Dennis, E. A., Cao, J., Hsu, Y.-H., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,203
The vanilloid transient receptor potential channel TRPV4: From structure to disease
Everaerts, W., Nilius, B., & Owsianik, G. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2009.10.002 · Cited by 347
Discovery Through the Computational Microscope
Lee, E. H., Hsin, J., Sotomayor, M., Comellas, G., & Schulten, K. (2009) · Structure · doi:10.1016/j.str.2009.09.001 · Cited by 334
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients
Marchi, M., Salvi, E., Andelic, M., Mehmeti, E., D'Amato, I., Cazzato, D., Chiappori, F., Lombardi, R., Cartelli, D., Devigili, G., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002905 · Cited by 29
Metadata
- Authors
- Gaudet, R.
- Venue
- Molecular BioSystems
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03-26
- Volume
- 4
- Issue
- 5
- Pages
- 372-379
- ISSN
- 1742-2051 (ISSN-L)
- 1742-206X
- OpenAlex
- W2039884257
- Cited by
- 198
- References
- 1
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
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