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A portable surface-enhanced Raman scattering sensor integrated with a lab-on-a-chip for field analysis
Abstract
An integrated real-time sensing system that uses a portable Raman spectrometer and a micropillar array chip has been developed for field analysis. The problem of poor detection sensitivity, caused by miniaturization in the portable Raman spectrometer, was overcome by using the surface-enhanced Raman scattering (SERS) technique. The problem of poor reproducibility in the SERS detection, caused by different particle sizes and inhomogeneous degrees of aggregation, was also overcome by using continuous flow and homogeneous mixing between the analytes and nanocolloidal silver in a micropillar array microfluidic chip. Two hazardous materials, dipicolinic acid and malachite green, were quantitatively analysed using our integrated portable Raman sensor system. The observed limit of detection was estimated to be 200 ppb and 500 ppb, respectively. Our proposed analytical method, using a micropillar array PDMS chip and a portable SERS system, offers a rapid and reproducible trace detection capability for hazardous materials in the field.
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Wood, B. R., Heraud, P., Stojkovic, S., Morrison, D., Beardall, J., & McNaughton, D. (2005) · Analytical Chemistry · doi:10.1021/ac050281z · Cited by 135
Cited by
Surface-enhanced Raman spectroscopy (SERS): progress and trends
Cialla, D., März, A., Böhme, R., Theil, F., Weber, K., Schmitt, M., & Popp, J. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5631-x · Cited by 931
Recent progress in SERS biosensing
Bantz, K. C., Meyer, A. F., Wittenberg, N. J., Im, H., Kurtuluş, Ö., Lee, S. H., Lindquist, N. C., Oh, S.-H., & Haynes, C. L. (2011) · Physical Chemistry Chemical Physics · doi:10.1039/c0cp01841d · Cited by 620
Surface-Enhanced Raman Spectroscopy (SERS) for Environmental Analyses
Halvorson, R. A., & Vikesland, P. J. (2010) · Environmental Science & Technology · doi:10.1021/es101228z · Cited by 484
Latest Developments in Micro Total Analysis Systems
Arora, A., Simone, G., Salieb-Beugelaar, G. B., Kim, J. T., & Manz, A. (2010) · Analytical Chemistry · doi:10.1021/ac100969k · Cited by 421
Plasmonic colorimetric and SERS sensors for environmental analysis
Wei, H., Hossein Abtahi, S. M., & Vikesland, P. J. (2015) · Environmental Science: Nano · doi:10.1039/c4en00211c · Cited by 285
Metadata
- Authors
- Quang, L. X., Lim, C., Seong, G. H., Choo, J., Do, K. J., & Yoo, S.-K.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 8
- Issue
- 12
- Pages
- 2214
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2073708689
- Cited by
- 158
- References
- 1
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Quang, L. X., Lim, C., Seong, G. H., Choo, J., Do, K. J., & Yoo, S.-K. (2008). A portable surface-enhanced Raman scattering sensor integrated with a lab-on-a-chip for field analysis. Lab on a Chip. https://doi.org/10.1039/b808835g
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