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Lessons learned from the contamination of heparin
Open accessAbstract
Heparin is unique as one of the oldest drugs currently still in widespread clinical use as an anticoagulant, a natural product, one of the first biopolymeric drugs, and one of the few carbohydrate drugs. Recently, certain batches of heparin have been associated with anaphylactoid-type reactions, some leading to hypotension and death. These reactions were traced to contamination with a semi-synthetic oversulfated chondroitin sulfate (OSCS). This Highlight reviews the heparin contamination crisis, its resolution, and the lessons learned. Pharmaceutical scientists now must consider dozens of natural and synthetic heparinoids as potential heparin contaminants. Effective assays, which can detect both known and unknown contaminants, are required to monitor the quality of heparin. Safer and better-regulated processes are needed for heparin production.
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Cites
Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate
Esko, J. D., & Selleck, S. B. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135458 · Cited by 1,495
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Lu, G., Crihfield, C. L., Gattu, S., Veltri, L. M., & Holland, L. A. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00669 · Cited by 174
Direct oral anticoagulants: analysis of worldwide use and popularity using Google trends
Lippi, G., Mattiuzzi, C., Cervellin, G., & Favaloro, E. J. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.06.65 · Cited by 91
Glycoengineering in CHO cells: advances in systems biology
Tejwani, V., Andersen, M. R., Nam, J. H., & Sharfstein, S. T. (2018) · Biotechnology Journal · doi:10.1002/biot.201700234 · Cited by 70
Debele, T. A., Mekuria, S. L., & Tsai, H.-C. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.01.103 · Cited by 36
Shi, J., Wu, Y., Tong, B., Zhi, J., & Dong, Y. (2014) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2014.03.004 · Cited by 29
Metadata
- Authors
- Liu, H., Zhang, Z., & Linhardt, R. J.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 26
- Issue
- 3
- Pages
- 313
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2151178558
- Cited by
- 396
- References
- 1
- FWCI
- 27.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, H., Zhang, Z., & Linhardt, R. J. (2009). Lessons learned from the contamination of heparin. Natural Product Reports. https://doi.org/10.1039/b819896a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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