Capillary Electrophoresis Separations of Glycans

Lu, Grace; Crihfield, Cassandra L.; Gattu, Srikanth; Veltri, Lindsay M.; Holland, Lisa A.

doi:10.1021/acs.chemrev.7b00669

Cited by 174Glycosylation and Glycoproteins ResearchMicrofluidic and Capillary Electrophoresis ApplicationsCarbohydrate Chemistry and Synthesis

Capillary Electrophoresis Separations of Glycans

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Lu, Grace, Crihfield, Cassandra L., Gattu, Srikanth, Veltri, Lindsay M., Holland, Lisa A.·2018·Chemical Reviews

DOI 10.1021/acs.chemrev.7b00669PMC PMC6135675

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Abstract

Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses since 2014. The method provides high resolution capable of separating carbohydrates by charge-to-size ratio. Principle applications are heavily focused on N-glycans, which are highly relevant to biological therapeutics and biomarker research. Advances in techniques used for N-glycan structural identification include migration time indexing and exoglycosidase and lectin profiling, as well as mass spectrometry. Capillary electrophoresis methods have been developed that are capable of separating glycans with the same monosaccharide sequence but different positional isomers, as well as determining whether monosaccharides composing a glycan are alpha or beta linked. Significant applications of capillary electrophoresis to the analyses of N-glycans in biomarker discovery and biological therapeutics are emphasized with a brief discussion included on carbohydrate analyses of glycosaminoglycans and mono-, di-, and oligosaccharides relevant to food and plant products. Innovative, emerging techniques in the field are highlighted and the future direction of the technology is projected based on the significant contributions of capillary electrophoresis to glycoscience from 2014 to the present as discussed in this review.

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Glycosylation is an important and common PTM, but its detailed characterization is challenging because of heterogeneity in localization and forms.
“Glycosylation is an important and common PTM in biological systems, but its detailed characterization is challenging because of its heterogeneity in localization and forms76–79.”
From Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research (2019) · cites this paper as [78]
CZE is the most commonly used CE technique in proteomics research.
“While many CE-based techniques have been reported for the analysis of proteins and peptides, CZE is the most commonly used in proteomics research10,64–66.”
From Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research (2019) · cites this paper as [65]
tITP requires optimization of both electrolyte concentrations and loading volume for efficient stacking of target analytes.
“tITP requires an optimization of both electrolyte concentrations and loading volume to enable efficient stacking of the target analytes13,27,65,120–122.”
From Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research (2019) · cites this paper as [65]

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Essentials of glycobiology
Wiederschain, G. Y. (2009) · Biochemistry (Moscow) · doi:10.1134/s0006297909090156 · Cited by 4,089 · see citing works
Glycans in cancer and inflammation — potential for therapeutics and diagnostics
Dube, D. H., & Bertozzi, C. R. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1751 · Cited by 1,600 · see citing works
The sweet and sour of cancer: glycans as novel therapeutic targets
Fuster, M. M., & Esko, J. D. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1649 · Cited by 1,389 · see citing works
The therapeutic monoclonal antibody market
Ecker, D. M., Jones, S. D., & Levine, H. L. (2014) · mAbs · doi:10.4161/19420862.2015.989042 · Cited by 1,292 · see citing works
Capillary Zone Electrophoresis
Jorgenson, J. W., & Lukacs, K. D. (1983) · Science · doi:10.1126/science.6623076 · Cited by 1,289 · see citing works
Handbook of Capillary Electrophoresis
(1998) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826079808001954 · Cited by 1,072 · see citing works
Glycoprotein glycosylation and cancer progression
Dennis, J. W. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00167-1 · Cited by 652 · see citing works
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
Guerrini, M., Beccati, D., Shriver, Z. H., Naggi, A., Viswanathan, K., Bisio, A., Capila, I., Lansing, J. C., Guglieri, S., Fraser, B. A., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1407 · Cited by 631 · see citing works
High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human Populations
Pučić‐Baković, M., Knežević, A., Vidič, J., Adamczyk, B., Novokmet, M., Polašek, O., Gornik, O., Goreta, S. Š., Wormald, M. R., Redžić, I., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010090 · Cited by 521 · see citing works
Glycans as cancer biomarkers
Adamczyk, B., Tharmalingam, T., & Rudd, P. M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.12.001 · Cited by 481 · see citing works
Glycan labeling strategies and their use in identification and quantification
Ruhaak, L. R., Zauner, G., Hühn, C., Bruggink, C., Deelder, A. M., & Wuhrer, M. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3532-z · Cited by 481 · see citing works
Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: A critical review
Maverakis, E. M., Kim, K., Shimoda, M., Gershwin, M. E., Patel, F., Wilken, R., Raychaudhuri, S. P., Ruhaak, L. R., & Lebrilla, C. B. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.12.002 · Cited by 456 · see citing works
Biological Function of Fucosylation in Cancer Biology
Miyoshi, E., Moriwaki, K., & Nakagawa, T. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvn011 · Cited by 396 · see citing works
Lessons learned from the contamination of heparin
Liu, H., Zhang, Z., & Linhardt, R. J. (2009) · Natural Product Reports · doi:10.1039/b819896a · Cited by 396 · see citing works
High-Mannose Glycans are Elevated during Breast Cancer Progression
Leoz, M. L. A. D., Young, L. J. T., An, H. J., Kronewitter, S. R., Kim, J., Miyamoto, S., Borowsky, A. D., Chew, H. K., & Lebrilla, C. B. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.002717 · Cited by 320 · see citing works
High-sensitivity Analytical Approaches for the Structural Characterization of Glycoproteins
Alley, W. R., Mann, B. F., & Novotný, M. V. (2013) · Chemical Reviews · doi:10.1021/cr3003714 · Cited by 307 · see citing works
Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein Biopharmaceuticals
Fekete, S., Guillarme, D., Sandra, P. J. F., & Sandra, K. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04561 · Cited by 258 · see citing works
Exploring extraction/dissolution procedures for analysis of starch chain-length distributions
Wu, A. C., Li, E., & Gilbert, R. G. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.08.001 · Cited by 245 · see citing works
Essentials of carbohydrate chemistry and biochemistry
(2003) · Choice Reviews Online · doi:10.5860/choice.41-0944 · Cited by 233 · see citing works
Characterization of 9-Aminopyrene-1,4,6-trisulfonate Derivatized Sugars by Capillary Electrophoresis with Laser-Induced Fluorescence Detection
Evangelista, R. A., Liu, M., & Chen, F.-T. A. (1995) · Analytical Chemistry · doi:10.1021/ac00109a051 · Cited by 207 · see citing works
Oxidative release of natural glycans for functional glycomics
Song, X., Ju, H., Lasanajak, Y., Kudelka, M. R., Smith, D. F., & Cummings, R. D. (2016) · Nature Methods · doi:10.1038/nmeth.3861 · Cited by 191 · see citing works
Glycan Analysis by Ion Mobility–Mass Spectrometry
Hofmann, J., & Pagel, K. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701309 · Cited by 181 · see citing works
Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 1: Separation-based methods
Reusch, D., Haberger, M., Maier, B., Maier, M., Kloseck, R., Zimmermann, B., Hook, M., Szabó, Z., Tep, S., Wegstein, J., et al. (2014) · mAbs · doi:10.4161/19420862.2014.986000 · Cited by 169 · see citing works
Comparative Performance of Four Methods for High-throughput Glycosylation Analysis of Immunoglobulin G in Genetic and Epidemiological Research
Huffman, J. E., Pučić‐Baković, M., Klarić, L., Hennig, R., Selman, M. H. J., Vučković, F., Novokmet, M., Krištić, J., Borowiak, M., Muth, T., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.037465 · Cited by 169 · see citing works
High Capacity Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry: Coupling a Porous Sheathless Interface with Transient-Isotachophoresis
Busnel, J., Schoenmaker, B., Ramautar, R., Carrasco‐Pancorbo, A., Ratnayake, C. K., Feitelson, J. S., Chapman, J. D., Deelder, A. M., & Mayboroda, O. A. (2010) · Analytical Chemistry · doi:10.1021/ac102159d · Cited by 165 · see citing works
Characterization of isomeric glycan structures by LC‐MS/MS
Veillon, L. J., Huang, Y., Peng, W., Dong, X., Cho, B. G., & Mechref, Y. S. (2017) · Electrophoresis · doi:10.1002/elps.201700042 · Cited by 163 · see citing works
Stability of N-glycan profiles in human plasma
Gornik, O., Wagner, J., Pučić‐Baković, M., Knezevic, A., Redžić, I., & Lauc, G. (2009) · Glycobiology · doi:10.1093/glycob/cwp134 · Cited by 160 · see citing works
Enzymes for N-Glycan Branching and Their Genetic and Nongenetic Regulation in Cancer
Kizuka, Y., & Taniguchi, N. (2016) · Biomolecules · doi:10.3390/biom6020025 · Cited by 156 · see citing works
Altered Glycosylation in Tumours Focused to Cancer Diagnosis
Peracaula, R., Barrabés, S., Sarrats, A., Rudd, P. M., & Llorens, R. (2008) · Disease Markers · doi:10.1155/2008/797629 · Cited by 155 · see citing works
Analysis of Mono- and Oligosaccharide Isomers Derivatized with 9-Aminopyrene-1,4,6-trisulfonate by Capillary Electrophoresis with Laser-Induced Fluorescence
Chen, F. T. A., & Evangelista, R. A. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1474 · Cited by 153 · see citing works
Glycosylation Changes in Brain Cancer
Veillon, L. J., Fakih, C., Abou‐El‐Hassan, H., Kobeissy, F. H., & Mechref, Y. S. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00271 · Cited by 141 · see citing works
Integrated Microfluidic Capillary Electrophoresis-Electrospray Ionization Devices with Online MS Detection for the Separation and Characterization of Intact Monoclonal Antibody Variants
Redman, E. A., Batz, N. G., Mellors, J. S., & Ramsey, J. M. (2015) · Analytical Chemistry · doi:10.1021/ac503964j · Cited by 136 · see citing works
New frontiers for mass spectrometry based upon structures for lossless ion manipulations
Ibrahim, Y., Hamid, A. M., Deng, L., Garimella, S., Webb, I., Baker, E. S., & Smith, R. D. (2017) · The Analyst · doi:10.1039/c7an00031f · Cited by 136 · see citing works
Relationships between protein content, starch molecular structure and grain size in barley
Yu, W., Tan, X., Zou, W., Hu, Z., Fox, G. P., Gidley, M. J., & Gilbert, R. G. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.08.078 · Cited by 136 · see citing works
N -glycan and Alzheimer's disease
Kizuka, Y., Kitazume, S., & Taniguchi, N. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.04.012 · Cited by 132 · see citing works
Glycomic and glycoproteomic analysis of glycoproteins—a tutorial
Shajahan, A., Heiß, C., Ishihara, M., & Azadi, P. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0406-7 · Cited by 132 · see citing works
Recent Advances in the Analysis of Complex Glycoproteins
Gaunitz, S., Nagy, G., Pohl, N. L. B., & Novotný, M. V. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04343 · Cited by 130 · see citing works
Carbonyl-Reactive Tandem Mass Tags for the Proteome-Wide Quantification of N-Linked Glycans
Hahne, H., Neubert, P., Kuhn, K., Etienne, C. L., Bomgarden, R. D., Rogers, J. C., & Küster, B. (2012) · Analytical Chemistry · doi:10.1021/ac300197c · Cited by 124 · see citing works
The sugar code: Why glycans are so important
Gabius, H. (2017) · Biosystems · doi:10.1016/j.biosystems.2017.07.003 · Cited by 124 · see citing works
Recent advances in capillary electrophoresis separation of monosaccharides, oligosaccharides, and polysaccharides
Mantovani, V., Galeotti, F., Maccari, F., & Volpi, N. (2017) · Electrophoresis · doi:10.1002/elps.201700290 · Cited by 122 · see citing works
Analysis of monosaccharide composition by capillary electrophoresis
Guttman, A. (1997) · Journal of Chromatography A · doi:10.1016/s0021-9673(96)00750-9 · Cited by 121 · see citing works
Serum N-glycan profile shift during human ageing
Vanhooren, V., Dewaele, S., Libert, C., Engelborghs, S., Deyn, P. P. D., Toussaint, O., Debacq‐Chainiaux, F., Poulain, M., Glupczynski, Y., Franceschi, C., et al. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.009 · Cited by 120 · see citing works
Rapid Magnetic Bead Based Sample Preparation for Automated and High Throughput N-Glycan Analysis of Therapeutic Antibodies
Váradi, C., Lew, C., & Guttman, A. (2014) · Analytical Chemistry · doi:10.1021/ac501573g · Cited by 120 · see citing works
Microfluidic Capillary Electrophoresis–Mass Spectrometry for Analysis of Monosaccharides, Oligosaccharides, and Glycopeptides
Khatri, K., Klein, J., Haserick, J. R., Leon, D. R., Costello, C. E., McComb, M. E., & Zaia, J. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00875 · Cited by 119 · see citing works
Reversed-phase separation methods for glycan analysis
Vreeker, G. C. M., & Wuhrer, M. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-0073-0 · Cited by 119 · see citing works
High Throughput Quantitative Glycomics and Glycoform-focused Proteomics of Murine Dermis and Epidermis
Uematsu, R., Furukawa, J., Nakagawa, H., Shinohara, Y., Deguchi, K., Monde, K., & Nishimura, S. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500203-mcp200 · Cited by 117 · see citing works
Characterization of Intact Antibody Drug Conjugate Variants Using Microfluidic Capillary Electrophoresis–Mass Spectrometry
Redman, E. A., Mellors, J. S., Starkey, J. A., & Ramsey, J. M. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b03866 · Cited by 113 · see citing works
A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis
Mahan, A. E., Tedesco, J., Dionne, K., Baruah, K., Cheng, H. D., Jager, P. L. D., Barouch, D. H., Suscovich, T. J., Ackerman, M. E., Crispin, M., et al. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.12.004 · Cited by 108 · see citing works
Effects of pectin on molecular structural changes in starch during digestion
Bai, Y., Wu, P., Wang, K., Li, C., Li, E., & Gilbert, R. G. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2017.01.021 · Cited by 105 · see citing works
Decreased Core-Fucosylation Contributes to Malignancy in Gastric Cancer
Zhao, Y., Xu, X., Fang, M., Wang, H., You, Q., Yi, C., Ji, J., Gu, X., Zhou, P., Cheng, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094536 · Cited by 101 · see citing works
Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometry
Lageveen‐Kammeijer, G. S. M., Jansen, B. C., Köhler, I., Heemskerk, A. A. M., Mayboroda, O. A., Hensbergen, P. J., Schappler, J., & Wuhrer, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-03838-y · Cited by 101 · see citing works
Separation of 1‐aminopyrene‐3,6,8‐trisulfonate‐labeled asparagine‐linked fetuin glycans by capillary gel electrophoresis
Guttman, A., Chen, F. A., & Evangelista, R. A. (1996) · Electrophoresis · doi:10.1002/elps.1150170221 · Cited by 98 · see citing works
Improved sample preparation method for glycan analysis of glycoproteins by CE‐LIF and CE‐MS
Szabó, Z., Guttman, A., Rejtar, T., & Karger, B. L. (2010) · Electrophoresis · doi:10.1002/elps.201000037 · Cited by 97 · see citing works
Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry for Quantitative Analysis of Glycans Labeled with Multiplex Carbonyl-Reactive Tandem Mass Tags
Zhong, X., Chen, Z., Snovida, S., Liu, Y., Rogers, J. C., & Li, L. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01835 · Cited by 92 · see citing works
High Resolution CZE-MS Quantitative Characterization of Intact Biopharmaceutical Proteins: Proteoforms of Interferon-β1
Bush, D. R., Zang, L., Belov, A. M., Ivanov, A. R., & Karger, B. L. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b03218 · Cited by 92 · see citing works
Glycan characterization of biopharmaceuticals: Updates and perspectives
Planinc, A., Bones, J., Dejaegher, B., Antwerpen, P. V., & Delporte, C. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.03.049 · Cited by 91 · see citing works
Glycomics and glycoproteomics focused on aging and age-related diseases — Glycans as a potential biomarker for physiological alterations
Miura, Y., & Endo, T. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.01.013 · Cited by 88 · see citing works
Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications
Geissner, A., & Seeberger, P. H. (2016) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071015-041641 · Cited by 85 · see citing works
Microheterogeneity of Recombinant Antibodies: Analytics and Functional Impact
Beyer, B., Schuster, M., Jungbauer, A., & Lingg, N. (2017) · Biotechnology Journal · doi:10.1002/biot.201700476 · Cited by 81 · see citing works
Glycoform Separation and Characterization of Cetuximab Variants by Middle-up Off-Line Capillary Zone Electrophoresis-UV/Electrospray Ionization-MS
Biacchi, M., Gahoual, R., Saïd, N., Beck, A., Leize‐Wagner, E., & François, Y. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00928 · Cited by 79 · see citing works
Capillary Electrophoresis in Pharmaceutical Analysis
Holland, L., Chetwyn, N. P., Perkins, M. D., & Lunte, S. M. (1997) · Pharmaceutical Research · doi:10.1023/a:1012018709641 · Cited by 76 · see citing works
Self-citation
Towards personalized diagnostics via longitudinal study of the human plasma N-glycome
Hennig, R., Cajic, S., Borowiak, M., Hoffmann, M., Kottler, R., Reichl, U., & Rapp, E. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.03.035 · Cited by 76 · see citing works
Engineering the Pichia pastoris N-Glycosylation Pathway Using the GlycoSwitch Technology
Laukens, B., Wachter, C. D., & Callewaert, N. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2760-9_8 · Cited by 71 · see citing works
Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry
Gahoual, R., Biacchi, M., Chicher, J., Kühn, L., Hammann, P., Beck, A., Leize‐Wagner, E., & François, Y. (2014) · mAbs · doi:10.4161/mabs.36305 · Cited by 68 · see citing works
Comparison of separation techniques for the elucidation of IgG N-glycans pooled from healthy mammalian species
Adamczyk, B., Tharmalingam, T., Schomberg, M., Szekrényes, Á., Kelly, R. M., Karlsson, N. G., Guttman, A., & Rudd, P. M. (2014) · Carbohydrate Research · doi:10.1016/j.carres.2014.01.018 · Cited by 64 · see citing works
Glycosylation of monoclonal antibody products: Current status and future prospects
Batra, J., & Rathore, A. S. (2016) · Biotechnology Progress · doi:10.1002/btpr.2366 · Cited by 64 · see citing works
Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering
Yu, X., Marshall, M. J. E., Cragg, M. S., & Crispin, M. (2017) · BioDrugs · doi:10.1007/s40259-017-0223-8 · Cited by 63 · see citing works
High-throughput glycosylation analysis of therapeutic immunoglobulin G by capillary gel electrophoresis using a DNA analyzer
Reusch, D., Haberger, M., Kailich, T., Heidenreich, A.-K., Kampe, M., Bulau, P., & Wuhrer, M. (2013) · mAbs · doi:10.4161/mabs.26712 · Cited by 61 · see citing works
Capillary Electrophoresis–Mass Spectrometry for the Analysis of Heparin Oligosaccharides and Low Molecular Weight Heparin
Sun, X., Lin, L., Liu, X., Zhang, F., Chi, L., Xia, Q., & Linhardt, R. J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04405 · Cited by 58 · see citing works
Capillary electrophoresis–mass spectrometry for direct structural identification of serum N-glycans
Snyder, C. M., Zhou, X., Karty, J. A., Fonslow, B. R., Novotny, M. V., & Jacobson, S. C. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.09.009 · Cited by 58 · see citing works
Increased α1-3 fucosylation of α-1-acid glycoprotein (AGP) in pancreatic cancer
Balmaña, M., Giménez, E., Puerta, A., Llop, E., Figueras, J., Fort, E., Sanz‐Nebot, V., de Bolós, C., Rizzi, A. M., Barrabés, S., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.11.006 · Cited by 54 · see citing works
Simple Capillary Electrophoresis–Mass Spectrometry Method for Complex Glycan Analysis Using a Flow-Through Microvial Interface
Jayo, R. G., Thaysen-Andersen, M., Lindenburg, P. W., Haselberg, R., Hankemeier, T., Ramautar, R., & Chen, D. D. Y. (2014) · Analytical Chemistry · doi:10.1021/ac5010212 · Cited by 54 · see citing works
Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG)
Thiesler, C. T., Cajic, S., Hoffmann, D., Thiel, C., van Diepen, L., Hennig, R., Sgodda, M., Weiβmann, R., Reichl, U., Steinemann, D., et al. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.054122 · Cited by 53 · see citing works
Complementary Glycomic Analyses of Sera Derived from Colorectal Cancer Patients by MALDI-TOF-MS and Microchip Electrophoresis
Snyder, C. M., Alley, W. R., Campos, M. I., Svoboda, M., Goetz, J. A., Vasseur, J. A., Jacobson, S. C., & Novotný, M. V. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02310 · Cited by 52 · see citing works
Rapid N -glycan release from glycoproteins using immobilized PNGase F microcolumns
Szigeti, M., Bondar, J., Gjerde, D. T., Keresztessy, Z., Szekrényes, Á., & Guttman, A. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.02.006 · Cited by 51 · see citing works
Analysis of monoclonal antibody by a novel CE‐UV/MALDI‐MS interface
Biacchi, M., Bhajun, R., Saïd, N., Beck, A., François, Y., & Leize‐Wagner, E. (2014) · Electrophoresis · doi:10.1002/elps.201400276 · Cited by 49 · see citing works
Analysis of heparin oligosaccharides by capillary electrophoresis–negative-ion electrospray ionization mass spectrometry
Lin, L., Liu, X., Zhang, F., Chi, L., Amster, I. J., Leach, F. E., Xia, Q., & Linhardt, R. J. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9662-1 · Cited by 49 · see citing works
Structural Characterization of Serum N-Glycans by Methylamidation, Fluorescent Labeling, and Analysis by Microchip Electrophoresis
Mitra, I., Snyder, C. M., Zhou, X., Campos, M. I., Alley, W. R., Novotný, M. V., & Jacobson, S. C. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00882 · Cited by 48 · see citing works
Automated N-Glycosylation Sequencing Of Biopharmaceuticals By Capillary Electrophoresis
Szigeti, M., & Guttman, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11493-6 · Cited by 47 · see citing works
Liquid phase separation methods for N-glycosylation analysis of glycoproteins of biomedical and biopharmaceutical interest. A critical review
Hajba, L., Csánky, E., & Guttman, A. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.08.035 · Cited by 45 · see citing works
Influence of molecular configuration and conformation on the electromigration of oligosaccharides in narrow bore capillaries
Mittermayr, S., & Guttman, A. (2012) · Electrophoresis · doi:10.1002/elps.201100681 · Cited by 44 · see citing works
Multi-Site N-glycan mapping study 1: Capillary electrophoresis – laser induced fluorescence
Szekrényes, Á., Park, S. S., Santos, M., Lew, C., Jones, A. W., Haxo, T., Kimzey, M. J., Pourkaveh, S., Szabó, Z., Sosic, Z., et al. (2015) · mAbs · doi:10.1080/19420862.2015.1107687 · Cited by 44 · see citing works
Triple-Internal Standard Based Glycan Structural Assignment Method for Capillary Electrophoresis Analysis of Carbohydrates
Járvás, G., Szigeti, M., Chapman, J., & Guttman, A. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b03596 · Cited by 44 · see citing works
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Huang, C., Liu, Y., Wu, H., Sun, D., & Li, Y. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0302-1 · Cited by 44 · see citing works
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Szigeti, M., Lew, C., Roby, K., & Guttman, A. (2015) · SLAS TECHNOLOGY · doi:10.1177/2211068215608767 · Cited by 43 · see citing works
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Redman, E. A., Ramos‐Payán, M., Mellors, J. S., & Ramsey, J. M. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00622 · Cited by 41 · see citing works
Capillary electrophoresis method for the simultaneous determination of carbohydrates and proline in honey samples
Domínguez, M. A., Jacksén, J., Emmer, Å., & Centurión, M. E. (2016) · Microchemical Journal · doi:10.1016/j.microc.2016.05.017 · Cited by 41 · see citing works
Exoglycosidase matrix-mediated sequencing of a complex glycan pool by capillary electrophoresis
Guttman, A., & Ulfelder, K. J. (1997) · Journal of Chromatography A · doi:10.1016/s0021-9673(97)00724-3 · Cited by 40 · see citing works
Quantitative twoplex glycan analysis using 12C6 and 13C6 stable isotope 2-aminobenzoic acid labelling and capillary electrophoresis mass spectrometry
Váradi, C., Mittermayr, S., Millán-Martín, S., & Bones, J. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9935-8 · Cited by 40 · see citing works
Recent advances on separation and characterization of human milk oligosaccharides
Mantovani, V., Galeotti, F., Maccari, F., & Volpi, N. (2016) · Electrophoresis · doi:10.1002/elps.201500477 · Cited by 39 · see citing works
Capillary electrophoresis for total glycosaminoglycan analysis
Uçaktürk, E., Cai, C., Li, L., Li, G., Zhang, F., & Linhardt, R. J. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-7859-8 · Cited by 38 · see citing works
New insight into chondroitin and heparosan-like capsular polysaccharide synthesis by profiling of the nucleotide sugar precursors
Restaino, O. F., di Lauro, I., Nuzzo, R. D., ROSA, M. D., & Schiraldi, C. (2017) · Bioscience Reports · doi:10.1042/bsr20160548 · Cited by 38 · see citing works
Microscale Measurements of Michaelis–Menten Constants of Neuraminidase with Nanogel Capillary Electrophoresis for the Determination of the Sialic Acid Linkage
Gattu, S., Crihfield, C. L., & Holland, L. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04074 · Cited by 37 · see citing works
Self-citation
Glyco-Engineering of Human IgG-Fc to Modulate Biologic Activities
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Acute‐phase glycoprotein N‐glycome of ovarian cancer patients analyzed by CE‐LIF
Weiz, S., Wieczorek, M., Schwedler, C., Kaup, M., Braicu, E. I., Sehouli, J., Tauber, R., & Blanchard, V. (2016) · Electrophoresis · doi:10.1002/elps.201500518 · Cited by 34 · see citing works
Capillary electrophoresis of urinary prostate glycoproteins assists in the diagnosis of prostate cancer
Vermassen, T., Praet, C. V., Vanderschaeghe, D., Maenhout, T. M., Lumen, N., Callewaert, N., Hoebeke, P. B., Belle, S. V., Rottey, S., & Delanghe, J. (2013) · Electrophoresis · doi:10.1002/elps.201300332 · Cited by 32 · see citing works
Identification of 34 N-glycan isomers in human serum by capillary electrophoresis coupled with laser-induced fluorescence allows improving glycan biomarker discovery
Schwedler, C., Kaup, M., Weiz, S., Hoppe, M., Braicu, E. I., Sehouli, J., Hoppe, B., Tauber, R., Berger, M., & Blanchard, V. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8168-y · Cited by 32 · see citing works
Effect of the Quantity and Linkage Position of Mannose(α1,2) Residues in Capillary Gel Electrophoresis of High-Mannose-Type Oligosaccharides
Guttman, A., & Herrick, S. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0118 · Cited by 31 · see citing works
Capillary electrophoresis separation of oligosaccharides: I. Effect of operational variables
Guttman, A., Cooke, N., & Starr, C. M. (1994) · Electrophoresis · doi:10.1002/elps.11501501217 · Cited by 31 · see citing works
Structural features of glycan recognition among viral pathogens
Shanker, S., Hu, L., Ramani, S., Atmar, R. L., Estes, M. K., & Prasad, B. V. V. (2017) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2017.05.007 · Cited by 31 · see citing works
Analysis of amino acids, proteins, carbohydrates and lipids in food by capillary electromigration methods: a review
de Oliveira, M. A. L., Porto, B. L. S., Bastos, C. D. A., Sabarense, C. M., Vaz, F. A. S., Neves, L. N. D. O., Duarte, L. M., Campos, N. D. S., Chellini, P. R., da Silva, P. H. F., et al. (2016) · Analytical Methods · doi:10.1039/c5ay02736e · Cited by 30 · see citing works
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Qirong, K., Xu, J., Wang, K., Zhou, S., & Liu, X. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.08.023 · Cited by 30 · see citing works
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Toutounji, M. R., van Leeuwen, M. P., Oliver, J. D., Shrestha, A. K., Castignolles, P., & Gaborieau, M. (2015) · Carbohydrate Research · doi:10.1016/j.carres.2015.03.008 · Cited by 29 · see citing works
GUcal: An integrated application for capillary electrophoresis based glycan analysis
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Quantitative Assessment of Sialo‐Glycoproteins and N‐Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells
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A capillary electrophoresis system with dual capacitively coupled contactless conductivity detection and electrospray ionization tandem mass spectrometry
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In‐line SPE ‐ CE using a fritless bead string design— A pplication for the analysis of organic sulfonates including inline SPE ‐ CE ‐ MS for APTS ‐labeled glycans
Jooß, K., Sommer, J., Bunz, S., & Neusüß, C. (2013) · Electrophoresis · doi:10.1002/elps.201300388 · Cited by 25 · see citing works
Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand
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Effect of Separation Temperature on Structure Specific Glycan Migration in Capillary Electrophoresis
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The N-glycan profile of placental membrane glycoproteins alters during gestation and aging
Robajac, D., Masnikosa, R., Vanhooren, V., Libert, C., Miković, Ž., & Nedić, O. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.010 · Cited by 22 · see citing works
Sialic acid methylation refines capillary electrophoresis laser‐induced fluorescence analyses of immunoglobulin G N‐glycans of ovarian cancer patients
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Plug-plug kinetic capillary electrophoresis for in-capillary exoglycosidase digestion as a profiling tool for the analysis of glycoprotein glycans
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Multiplexing N‐glycan analysis by DNA analyzer
Feng, H., Li, P., Rui, G., Stray, J. E., Khan, S. H., Chen, S.-M., & Li, S. F. Y. (2017) · Electrophoresis · doi:10.1002/elps.201600404 · Cited by 22 · see citing works
Serum N-Glycans: A New Diagnostic Biomarker for Light Chain Multiple Myeloma
Chen, J., Fang, M., Zhao, Y., Yi, C., Ji, J., Cheng, C., Wang, M., Gu, X., Sun, Q.-S., Chen, X., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127022 · Cited by 20 · see citing works
glyXalign: High‐throughput migration time alignment preprocessing of electrophoretic data retrieved via multiplexed capillary gel electrophoresis with laser‐induced fluorescence detection‐based glycoprofiling
Behne, A., Muth, T., Borowiak, M., Reichl, U., & Rapp, E. (2013) · Electrophoresis · doi:10.1002/elps.201200696 · Cited by 20 · see citing works
High-Resolution Glycan Analysis by Temperature Gradient Capillary Electrophoresis
Szigeti, M., & Guttman, A. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00016 · Cited by 20 · see citing works
Development of a rapid method for simultaneous separation of hyaluronic acid, chondroitin sulfate, dermatan sulfate and heparin by capillary electrophoresis
Zhao, T., Song, X., Tan, X., Xu, L., Yu, M., Wang, S., Liu, X., & Wang, F. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.01.016 · Cited by 19 · see citing works
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Kovács, Z., Szarka, M., Szigeti, M., & Guttman, A. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.06.002 · Cited by 19 · see citing works
Synthetic plant glycans.
Pfrengle, F. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.09.010 · Cited by 19 · see citing works
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Kinoshita, M., & Kakehi, K. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1292-6_12 · Cited by 18 · see citing works
Filariasis asymptomatically infected donors have lower levels of disialylated IgG compared to endemic normals
O’Regan, N. L., Steinfelder, S., Schwedler, C., Rao, G. B., Srikantam, A., Blanchard, V., & Hartmann, S. (2014) · Parasite Immunology · doi:10.1111/pim.12137 · Cited by 17 · see citing works
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N‐Glycosylation analysis of formalin fixed paraffin embedded samples by capillary electrophoresis
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Lu, Y., Hu, Y., Wang, T., Yang, X., & Zhao, Y. (2017) · CyTA - Journal of Food · doi:10.1080/19476337.2017.1308970 · Cited by 15 · see citing works
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Capillary Zone Electrophoresis Method for a Highly Glycosylated and Sialylated Recombinant Protein: Development, Characterization and Application for Process Development
Zhang, L., Lawson, K., Yeung, B., & Wypych, J. (2014) · Analytical Chemistry · doi:10.1021/ac504187v · Cited by 14 · see citing works
Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma
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Chain Length Distribution of Amylopectin and Physicochemical Properties of Starch in Myanmar Rice Cultivars
Mar, N. N., Umemoto, T., Abdulah, S. N. A., & Mahmood, M. (2014) · International Journal of Food Properties · doi:10.1080/10942912.2013.822884 · Cited by 13 · see citing works
A novel condition for capillary electrophoretic analysis of reductively aminated saccharides without removal of excess reagents
Yodoshi, M., Ikeda, N., Yamaguchi, N., Nagata, M., Nishida, N., Kakehi, K., Hayakawa, T., & Suzuki, S. (2013) · Electrophoresis · doi:10.1002/elps.201200612 · Cited by 13 · see citing works
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Self-citation
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Molecular glycopathology by capillary electrophoresis: Analysis of the N‐glycome of formalin‐fixed paraffin‐embedded mouse tissue samples
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Sample Preparation for N-Glycosylation Analysis of Therapeutic Monoclonal Antibodies by Electrophoresis
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A rapid and highly sensitive microchip electrophoresis of mono- and mucin-type oligosaccharides labeled with 7-amino-4-methylcoumarin
Yamamoto, S., Nagai, E., Asada, Y., Kinoshita, M., & Suzuki, S. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8363-x · Cited by 10 · see citing works
Total and single species of uronic acid-bearing glycosaminoglycans in urine of newborns of 2–3 days of age for early diagnosis application
Maccari, F., Galeotti, F., Zampini, L., Padella, L., Tomanin, R., Concolino, D., Fiumara, A., Galeazzi, T., Coppa, G. V., Gabrielli, O., et al. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.10.012 · Cited by 10 · see citing works
High throughput human plasma N-glycan analysis using DNA analyzer and multivariate analysis for biomarker discovery
Feng, H.-T., Lim, S. Y., Laserna, A. K. C., Li, P., Yin, X., Simsek, E., Khan, S. H., Chen, S.-M., & Li, S. F. Y. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.09.003 · Cited by 10 · see citing works
Glycosaminoglycans : chemistry and biology
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Comparative Studies ofN-Glycans and Glycosaminoglycans Present in SIRC (Statens Seruminstitut Rabbit Cornea) Cells and Corneal Epithelial Cells from Rabbit Eyes
Iwatsuka, K., Iwamoto, H., Kinoshita, M., Inada, K., Yasueda, S.-I., & Kakehi, K. (2014) · Current Eye Research · doi:10.3109/02713683.2013.863940 · Cited by 9 · see citing works
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Moreno, D., Berli, F., Bottini, R., Píccoli, P., & Silva, M. F. (2017) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2017.07.010 · Cited by 8 · see citing works

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Danyluk H. J.; Shum L. K.; Zandberg W. F. In Protein-Carbohydrate Interactions: Methods and Protocols; Abbott D. W., Lammerts van Bueren A., Eds.; Humana Press: New York, NY, 2017, 1588, 223− 236.

Sorted by citations

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Background
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Resolving Isomeric Structures of Native Glycans by Nanoflow Porous Graphitized Carbon Chromatography–Mass Spectrometry
She, Y., Tam, R. Y., Li, X., Rosu‐Myles, M., & Sauvé, S. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02951 · Cited by 46 · see citing works
Highly sensitive SERS detection and photocatalytic degradation of 4-aminothiophenol by a cost-effective cobalt metal–organic framework-based sandwich-like sheet
Shi, C., Qin, L., Wu, S., Kang, S., & Li, X. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129970 · Cited by 44 · see citing works
Targeted ginkgo kernel biomass precursor using eco-friendly synthesis of efficient carbon quantum dots for detection of trace nitrite ions and cell imaging
Zhang, Q., Tian, F., Zhou, Q., Zhang, C., Tang, S., Jiang, L., & Du, S. (2022) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2022.109442 · Cited by 44 · see citing works
High-Sensitivity Glycan Profiling of Blood-Derived Immunoglobulin G, Plasma, and Extracellular Vesicle Isolates with Capillary Zone Electrophoresis-Mass Spectrometry
Marie, A., Ray, S., Lu, S., Jones, J. C., Ghiran, I. C., & Ivanov, A. R. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03102 · Cited by 43 · see citing works
Sweet systems: technologies for glycomic analysis and their integration into systems biology
Chen, S., Qin, R., & Mahal, L. K. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1908953 · Cited by 42 · see citing works
“A recent review of CE technology is given in (Lu et al. 2018).”
Background
Profiling the N -Glycan Composition of IgG with Lectins and Capillary Nanogel Electrophoresis
Lu, G., & Holland, L. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03725 · Cited by 39 · see citing works
Self-citation
Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them
Kremsreiter, S. M., Kroell, A.-S. H., Weinberger, K., & Boehm, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910577 · Cited by 39 · see citing works
Highly-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples
Marie, A., Ray, S., & Ivanov, A. R. (2023) · Nature Communications · doi:10.1038/s41467-023-37365-4 · Cited by 36 · see citing works
Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate
Zhang, F., He, P., Rodrigues, A. L., Jeske, W. P., Tandon, R., Bates, J. T., Bierdeman, M. A., Fareed, J., Dordick, J. S., & Linhardt, R. J. (2022) · Pharmaceuticals · doi:10.3390/ph15020258 · Cited by 37 · see citing works
“These interactions play vital roles in pathological processes/diseases such as inflammation, angiogenesis, cancer, neurodegenerative diseases, and infectious diseases [15,16].”
Background
Specific Analysis of α-2,3-Sialylated N-Glycan Linkage Isomers by Microchip Capillary Electrophoresis–Mass Spectrometry
Cheng, M., Shu, H., Ye, P., Feng, X., Yan, G., Zhang, L., Yao, J. H., Bao, H., & Lu, H. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00064 · Cited by 35 · see citing works
Native N-glycome profiling of single cells and ng-level blood isolates using label-free capillary electrophoresis-mass spectrometry
Marie, A., Gao, Y., & Ivanov, A. R. (2024) · Nature Communications · doi:10.1038/s41467-024-47772-w · Cited by 34 · see citing works
Recent progress in the molecular imaging of therapeutic monoclonal antibodies
He, K., Zeng, S., & Qian, L. (2020) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2020.07.006 · Cited by 33 · see citing works
Modular instrumentation for capillary electrophoresis with laser induced fluorescence detection using plug-and-play microfluidic, electrophoretic and optic modules
Liénard--Mayor, T., Furter, J. S., Taverna, M., Pham, H. V., Hauser, P. C., & Mai, T. D. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.08.025 · Cited by 30 · see citing works
Mass spectrometry-based qualitative and quantitative N-glycomics: An update of 2017–2018
Xiao, K., Han, Y., Yang, H., Lu, H., & Tian, Z. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.10.007 · Cited by 29 · see citing works
Omics‐Enhanced Nanomedicine for Cancer Therapy
Qi, L., Li, Z., Liu, J., & Chen, X. S. (2024) · Advanced Materials · doi:10.1002/adma.202409102 · Cited by 30 · see citing works
Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers
Kobeissy, F. H., Kobaisi, A., Peng, W., Barsa, C., Goli, M., Sibahi, A., Hayek, S. E., Abdelhady, S., Haidar, M. A., Sabra, M., et al. (2022) · Cells · doi:10.3390/cells11030581 · Cited by 28 · see citing works
Continuous CTC separation through a DEP ‐based contraction–expansion inertial microfluidic channel
Islam, M. S., & Chen, X. (2023) · Biotechnology Progress · doi:10.1002/btpr.3341 · Cited by 28 · see citing works
Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2017–2018
Harvey, D. J. (2021) · Mass Spectrometry Reviews · doi:10.1002/mas.21721 · Cited by 27 · see citing works
Associations between the serum levels of PFOS/PFOA and IgG N-glycosylation in adult or children
Liu, J., Liu, S., Huang, Z., Fu, Y., Fei, J., Liu, X., & He, Z. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114285 · Cited by 26 · see citing works
A quantitative method for polysaccharides based on endo-enzymatic released specific oligosaccharides: A case of Lentinus edodes
Deng, Y., Chen, L.-X., Zhu, B., Zhao, J., & Li, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.048 · Cited by 24 · see citing works
Labeling strategies for analysis of oligosaccharides and glycans by capillary electrophoresis
Smolkova, D., Čmelík, R., & Lavická, J. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117068 · Cited by 24 · see citing works
Translating N‐Glycan Analytical Applications into Clinical Strategies for Ovarian Cancer
Briggs, M. T., Condina, M. R., Klingler‐Hoffmann, M., Arentz, G., Everest‐Dass, A., Kaur, G., Oehler, M. K., Packer, N. H., & Hoffmann, P. (2018) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201800099 · Cited by 24 · see citing works
Fast Discrimination of Sialylated N-Glycan Linkage Isomers with One-Step Derivatization by Microfluidic Capillary Electrophoresis–Mass Spectrometry
Cheng, M., Shu, H., Yang, M., Yan, G., Zhang, L., Wang, L., Wang, W., & Lu, H. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04760 · Cited by 23 · see citing works
Quantification of the α2–6 Sialic Acid Linkage in Branched N-Glycan Structures with Capillary Nanogel Electrophoresis
Bwanali, L., Crihfield, C. L., Newton, E. O., Zeger, V. R., Gattu, S., & Holland, L. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04787 · Cited by 23 · see citing works
Self-citation
Analyzing glycans cleaved from a biotherapeutic protein using ultrahigh-resolution ion mobility spectrometry together with cryogenic ion spectroscopy
Yalovenko, N., Yatsyna, V., Bansal, P., Abikhodr, A. H., & Rizzo, T. R. (2020) · The Analyst · doi:10.1039/d0an01206h · Cited by 22 · see citing works
High sensitivity capillary electrophoresis with fluorescent detection for glycan mapping
Liénard--Mayor, T., Yang, B., Tran, N. T., Bruneel, A., Guttman, A., Taverna, M., & Mai, T. D. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2021.462593 · Cited by 22 · see citing works
Liquid chromatography and capillary electrophoresis in glycomic and glycoproteomic analysis
Molnárová, K., Čokrtová, K., Tomnikova, A., Krizek, T., & Kozlík, P. (2022) · Monatshefte für Chemie - Chemical Monthly · doi:10.1007/s00706-022-02938-4 · Cited by 22 · see citing works
Ultrasensitive electrochemiluminescent aptasensor for trace detection of kanamycin based-on novel semi-sandwich gadolinium phthalocyanine complex and dysprosium metal-organic framework
Duan, X., Zhang, N., Li, Z., Zhang, L., Sun, F., Zhou, Z., Liu, H., Guo, Y., Sun, X., Jiang, J., et al. (2022) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2022.11.016 · Cited by 21 · see citing works
Eu3+ functionalized metal-organic framework as a colorimetric and luminescence dual-mode sensor for efficient detection of carcinoid tumor biomarker in urine
Ren, H., Wang, J., Li, X., Liu, L., Yin, J., Zhang, L., Hao, H., & Fan, L. (2025) · Journal of Rare Earths · doi:10.1016/j.jre.2025.12.025 · Cited by 20 · see citing works
Multi-cationic aminopyrene-based labeling tags for oligosaccharide analysis by capillary electrophoresis-mass spectrometry
Křenková, J., Lišková, M., Čmelík, R., Vigh, G., & Foret, F. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.10.032 · Cited by 19 · see citing works
Negatively Charged Yellow‐Emitting 1‐Aminopyrene Dyes for Reductive Amination and Fluorescence Detection of Glycans
Savicheva, E. A., Mitronova, G. Y., Thomas, L., Böhm, M. J., Seikowski, J., Belov, V. N., & Hell, S. W. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201908063 · Cited by 19 · see citing works
High-Throughput Multiplexed Infrared Spectroscopy of Ion Mobility-Separated Species Using Hadamard Transform
Yatsyna, V., Abikhodr, A. H., Faleh, A. B., Warnke, S., & Rizzo, T. R. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04843 · Cited by 18 · see citing works
Enhanced electrophoretic separation of proteins by tethered SiO 2 nanoparticles in an SDS-polyacrylamide gel network
Sajjadi, S. H., Ahmadzadeh, H., & Goharshadi, E. K. (2019) · The Analyst · doi:10.1039/c9an01759c · Cited by 18 · see citing works
On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry
Zhang, H., Shi, X., Liu, Y., Wang, B., Xu, M. J., Welham, N. V., & Li, L. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-03894-y · Cited by 17 · see citing works
Chromatographic Methods for Separation and Identification of Bioactive Compounds
de Souza, A. L. C., Pires, A. D. R., Moraes, C. A. F., de Matos, C. H. C., dos Santos, K. I. P., Silva, R. C. E., Acuña, S. P. C., & Araújo, S. D. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-35205-8_6 · Cited by 17 · see citing works
Current status and future prospects for ion-mobility mass spectrometry in the biopharmaceutical industry
Skeene, K., Khatri, K., Soloviev, Z., & Lapthorn, C. (2021) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2021.140697 · Cited by 17 · see citing works
Progresses and Prospects on Glucosinolate Detection in Cruciferous Plants
Li, X. L., Wen, D., He, Y., Liu, Y., Han, F., Su, J., Lai, S., Zhuang, M., Gao, F. X., & Li, Z. (2024) · Foods · doi:10.3390/foods13244141 · Cited by 16 · see citing works
Recent Strategies for Using Monolithic Materials in Glycoprotein and Glycopeptide Analysis
Alla, A. J., & Stine, K. J. (2022) · Separations · doi:10.3390/separations9020044 · Cited by 16 · see citing works
“The produced glycans, glycopeptides, or deglycosylated peptides then undergo separation by high-performance CE or nano-LC and are then detected using MS [9].”
Method
Heat dissipation in slab gel electrophoresis: The effect of embedded TiO2 nanoparticles on the thermal profiles
Sajjadi, S. H., Goharshadi, E. K., & Ahmadzadeh, H. (2019) · Journal of Chromatography B · doi:10.1016/j.jchromb.2019.04.030 · Cited by 16 · see citing works
A fluorescent aptasensor for kanamycin detection in milk, seafood and water samples using DNA-AgNCs and exonuclease I-assisted recycling amplification strategy
Xu, D., Shan, L., Guo, B., Wang, J., Huang, Q., Wang, S., Li, F., Wu, S., Wang, W., & Chen, J. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.143291 · Cited by 15 · see citing works
Machine Learning Based Analysis of Human Serum N-glycome Alterations to Follow up Lung Tumor Surgery
Mészáros, B., Járvás, G., Kun, R., Szabó, M., Csánky, E., Abonyi, J., & Guttman, A. (2020) · Cancers · doi:10.3390/cancers12123700 · Cited by 15 · see citing works
“Capillary electrophoresis separation has several advantages compared to LC, such as short separation times, high e ﬃ ciency, ultra-low sample volume requirement (in the range of femtoliter and nanoliter injected) and minimal bu ﬀ er usage, just to list the most important ones [15].”
Background
Negatively Charged Red-Emitting Acridine Dyes for Facile Reductive Amination, Separation, and Fluorescent Detection of Glycans
Fomin, M. A., Seikowski, J., Belov, V. N., & Hell, S. W. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05863 · Cited by 15 · see citing works
Capillary (Gel) Electrophoresis-Based Methods for Immunoglobulin (G) Glycosylation Analysis
Cajic, S., Hennig, R., Burock, R., & Rapp, E. (2021) · Experientia supplementum · doi:10.1007/978-3-030-76912-3_4 · Cited by 15 · see citing works
Characterization of glycan isomers using magnetic carbon nanoparticles as a MALDI co-matrix
Banazadeh, A., Nieman, R., Goli, M., Peng, W., Hussein, A., Bursal, E., Lischka, H., & Mechref, Y. S. (2019) · RSC Advances · doi:10.1039/c9ra02337b · Cited by 15 · see citing works
Fluorescence Assisted Capillary Electrophoresis of Glycans Enabled by the Negatively Charged Auxochromes in 1‐Aminopyrenes
Savicheva, E. A., Seikowski, J., Kast, J. I., Grünig, C. R., Belov, V. N., & Hell, S. W. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202013187 · Cited by 15 · see citing works
Quality evaluation of Codonopsis Radix and processed products based on the analysis of monosaccharides and oligosaccharides by liquid chromatography coupled with charged aerosol detector
Xie, Q., Tian, H., Huan, X., Cao, L., Wang, Y., Cheng, X. M., Ning, C., Hu, F., & Wang, C. (2021) · Phytochemical Analysis · doi:10.1002/pca.3085 · Cited by 13 · see citing works
High‐performance capillary electrophoresis to determine intact keratan sulfate and hyaluronic acid in animal origin chondroitin sulfate samples and food supplements
Restaino, O. F., ROSA, M. D., & Schiraldi, C. (2020) · Electrophoresis · doi:10.1002/elps.202000028 · Cited by 13 · see citing works
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans
Morticelli, L., Rossdam, C., Cajic, S., Böthig, D., Magdei, M., Tuladhar, S. R., Petersen, B., Fischer, K., Rapp, E., Korossis, S., et al. (2023) · Xenotransplantation · doi:10.1111/xen.12804 · Cited by 13 · see citing works
Bromine‐Promoted Glycosidation of Conformationally Superarmed Thioglycosides
Panza, M., Civera, M., Yasomanee, J. P., Belvisi, L., & Demchenko, A. V. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201901969 · Cited by 13 · see citing works
Analysis of Sugars in Honey Samples by Capillary Zone Electrophoresis Using Fluorescence Detection
Andrási, M., Gyémánt, G., Sajtos, Z., & Nagy, C. (2023) · Separations · doi:10.3390/separations10030150 · Cited by 12 · see citing works
Extraction and chemical characterization of novel water-soluble polysaccharides from two palm species and their antioxidant and antitumor activities
Dawood, D. H., Elmongy, M. S., Negm, A., & Taher, M. A. (2020) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2020.1773126 · Cited by 12 · see citing works
Chemical Synthesis of Human Milk Oligosaccharides: para‐Lacto‐N‐hexaose and para‐Lacto‐N‐neohexaose
Singh, Y., Escopy, S., Shadrick, M. L., Bandara, M. D., Stine, K. J., & Demchenko, A. V. (2023) · Chemistry - A European Journal · doi:10.1002/chem.202302288 · Cited by 12 · see citing works
Distinguishing the glycan isomers 2,3-sialyllactose and 2,6-sialyllactose by voltammetry after modification with osmium(VI) complexes
Trefulka, M., Černocká, H., Fojt, L., Paleček, E., & Ostatná, V. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.03.060 · Cited by 12 · see citing works
Highly sensitive two-dimensional profiling of N-linked glycans by hydrophilic interaction liquid chromatography and dual stacking capillary gel electrophoresis
Miki, T., Yamamoto, S., Liu, C., Torikai, K., Kinoshita, M., Matsumori, N., & Kawai, T. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342990 · Cited by 11 · see citing works
Research Progress on Saccharide Molecule Detection Based on Nanopores
Yin, B., Xie, W., Fang, S., He, S., Ma, W., Liang, L., Yin, Y., Zhou, D., Wang, Z., & Wang, D. (2024) · Sensors · doi:10.3390/s24165442 · Cited by 11 · see citing works
“Serving as the foundational units for the construction of oligosaccharides and polysaccharides, monosaccharides adhere to the empirical formula (C x (H 2 O) n ) [12].”
Background
Effective Separation of Human Milk Glycosides using Carbon Dioxide Supercritical Fluid Chromatography
Liou, S., Fang, J., Lin, H., Tsai, T., Huang, H., Liang, C., Yang, C., Wei, G., & Yu, C. (2021) · Chemistry - An Asian Journal · doi:10.1002/asia.202001404 · Cited by 11 · see citing works
Recent advances in N-glycan biomarker discovery among human diseases
Wang, Y., Liu, Y., Liu, S., Cheng, L., & Liu, X. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024101 · Cited by 10 · see citing works
Gels in Microscale Electrophoresis
Holland, L., & Casto-Boggess, L. D. (2023) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-091522-080207 · Cited by 10 · see citing works
Self-citation
Harnessing aptamers for the biosensing of cell surface glycans – A review
Liu, S., Zhao, F., Xu, K., Cao, M., Sohail, M., Li, B., & Zhang, X. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.342044 · Cited by 10 · see citing works
Developments and applications of separation and microfluidics methods coupled to electrospray mass spectrometry in glycomics of nervous system gangliosides
Sârbu, M., Ică, R., & Zamfir, A. D. (2020) · Electrophoresis · doi:10.1002/elps.202000236 · Cited by 10 · see citing works
Characterization of multi‐cationic aminopyrene‐based tag for oligosaccharide labeling by capillary electrophoresis with laser‐induced fluorescence detection
Křenková, J., Duša, F., & Čmelík, R. (2021) · Electrophoresis · doi:10.1002/elps.202100012 · Cited by 10 · see citing works
Lab-in-droplet: From glycan sample treatment toward diagnostic screening of congenital disorders of glycosylation
Liénard--Mayor, T., Bricteux, C., Bendali, A., Tran, N. T., Bruneel, A., Taverna, M., & Mai, T. D. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.340150 · Cited by 10 · see citing works
Magnetic carbon nanocomposites as a MALDI co-matrix enhancing MS-based glycomics
Banazadeh, A., Williamson, S. D., Zabet, M., Hussien, A. A., & Mechref, Y. S. (2018) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-1345-7 · Cited by 10 · see citing works
Recent advances in microscale separation techniques for glycome analysis
Liu, C., Otsuka, K., & Kawai, T. (2024) · Journal of Separation Science · doi:10.1002/jssc.202400170 · Cited by 9 · see citing works
Proteomic and Glyco(proteo)mic tools in the profiling of cardiac progenitors and pluripotent stem cell derived cardiomyocytes: Accelerating translation into therapy
Sebastião, M. J., Marcos-Silva, L., Gomes‐Alves, P., & Alves, P. M. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107755 · Cited by 9 · see citing works
Recent applications of the derivatization techniques in capillary electrophoresis
Gotti, R., Pasquini, B., Orlandini, S., & Furlanetto, S. (2023) · Journal of Pharmaceutical and Biomedical Analysis Open · doi:10.1016/j.jpbao.2023.100003 · Cited by 9 · see citing works
Quantitative comparison of the N-glycosylation of therapeutic glycoproteins using the Glycosimilarity Index. A tutorial
Szekrényes, Á., Szigeti, M., Dvořáková, V., Járvás, G., & Guttman, A. (2020) · Trends in Analytical Chemistry (TrAC) · doi:10.1016/j.trac.2019.115728 · Cited by 9 · see citing works
LC-MS/MS in glycomics and glycoproteomics analyses
Goli, M., Yu, A., Cho, B. G., Gautam, S., Wang, J., Reyes, C. D. G., Jiang, P., Peng, W., & Mechref, Y. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821447-3.00005-6 · Cited by 9 · see citing works
Capillary electrophoresis - A bibliometric analysis
Palmblad, M., van Eck, N. J., & Bergquist, J. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116899 · Cited by 9 · see citing works
“The powerful hyphenation of capillary electrophoresis with mass spectrometry has been reviewed by Stolz et al. [3], as has the applications of this hyphenated technique in proteomics [4], metab-olomics [5] and glycomics [6].”
Expanding the capillary electrophoresis-based glucose unit database of the GUcal app
Járvás, G., Szigeti, M., Campbell, M. P., & Guttman, A. (2019) · Glycobiology · doi:10.1093/glycob/cwz102 · Cited by 9 · see citing works
“Currently, the necessary sample preparation methods and liquid chromatography and capillary electrophoresis (CE)-based separation workflows are well developed, but the related bioinformatics tools are not adequately addressed, especially not for CE (Lu et al. 2018; Shubhakar et al. 2015; Walsh et al. 2016).”
Background
The minimum information required for a glycomics experiment (MIRAGE): reporting guidelines for capillary electrophoresis
Lageveen‐Kammeijer, G. S. M., Rapp, E., Chang, D. K., Rudd, P. M., Kettner, C., & Zaia, J. (2022) · Glycobiology · doi:10.1093/glycob/cwac021 · Cited by 8 · see citing works
Capillary Zone Electrophoresis of 8-Aminopyrene-1,3,6-trisulfonic Acid Labeled Carbohydrates with Online Electrokinetic Sample Cleanup
Farsang, R., Hogyor, K., Járvás, G., & Guttman, A. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03714 · Cited by 8 · see citing works
The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses
Wormwood, K. L., Deng, L., Hamid, A. M., DeBord, D., & Maxon, L. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-15950-4_17 · Cited by 8 · see citing works
A Tapered Capillary-Based Contactless Atmospheric Pressure Ionization Mass Spectrometry for On-Line Preconcentration and Separation of Small Organics
Chen, Y.-C., Krishnamurthy, A., Chen, S. H., & Chen, S. H. (2021) · Separations · doi:10.3390/separations8080111 · Cited by 8 · see citing works
Hitting the sweet spot with capillary electrophoresis: advances in N-glycomics and glycoproteomics
Makrydaki, E., Kotidis, P., Polizzi, K. M., & Kontoravdi, C. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.07.013 · Cited by 8 · see citing works
In capillary labeling and online electrophoretic separation of N‐glycans from glycoproteins
Yang, B., Mai, T. D., Tran, N. T., & Taverna, M. (2022) · Journal of Separation Science · doi:10.1002/jssc.202200340 · Cited by 8 · see citing works
N-Glycan Isomer Differentiation by Zero Flow Capillary Electrophoresis Coupled to Mass Spectrometry
Wagt, S., de Haan, N., Wang, W., Zhang, T., Wuhrer, M., & Lageveen‐Kammeijer, G. S. M. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c02840 · Cited by 8 · see citing works
New insights into phytochemicals via protein glycosylation focused on aging and diabetes
Chen, Y., Lu, S., Shan, S., Wu, W., He, X., Farag, M. A., Chen, W., & Zhao, C. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156673 · Cited by 7 · see citing works
A mass spectrometry-based glycotope-centric cellular glycomics is the more fruitful way forward to see the forest for the trees
Khoo, K. (2021) · Biochemical Society Transactions · doi:10.1042/bst20190861 · Cited by 7 · see citing works
Purification free N-glycan analysis by capillary zone electrophoresis: Hunt for the lost glycans
Farsang, R., Járvás, G., & Guttman, A. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115812 · Cited by 7 · see citing works

Unraveling the Glyco-Puzzle: Glycan Structure Identification by Capillary Electrophoresis
Mittermayr, S., Bones, J., & Guttman, A. (2013) · Analytical Chemistry · doi:10.1021/ac4006099 · Cited by 61 · see citing works
Capillary Electrophoresis
Holland, L., & Bennett, C. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819475-1.00029-8
Self-citation
Capillary electrophoresis for the analysis of glycosaminoglycans and glycosaminoglycan‐derived oligosaccharides
Mao, W., Thanawiroon, C., & Linhardt, R. J. (2002) · Biomedical Chromatography · doi:10.1002/bmc.153 · Cited by 81 · see citing works
Hitting the sweet spot with capillary electrophoresis: advances in N-glycomics and glycoproteomics
Makrydaki, E., Kotidis, P., Polizzi, K. M., & Kontoravdi, C. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.07.013 · Cited by 8 · see citing works
Capillary Electrophoresis-Based N-Glycosylation Analysis in the Biomedical and Biopharmaceutical Fields
Kun, R., Jona, E., & Guttman, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-77252-9_7 · Cited by 5 · see citing works

Authors: Lu, G., Crihfield, C. L., Gattu, S., Veltri, L. M., & Holland, L. A.
Affiliations: West Virginia University (US)
Corresponding author: Holland, Lisa A.
ORCID: Lu, Grace
Holland, Lisa A.
Venue: Chemical Reviews
Publisher: American Chemical Society (ACS)
Published: 2018-03-12
Volume: 118
Issue: 17
Pages: 7867-7885
ISSN: 0009-2665 (ISSN-L)
1520-6890
DOI: 10.1021/acs.chemrev.7b00669
PMC: PMC6135675
OpenAlex: W2790011125
Cited by: 174
References: 148
Citations by year: 2026: 15 · 2025: 14 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 31 · 2020: 25 · 2019: 17 · 2018: 9
FWCI: 2.01
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
pubs.acs.org/page/policy/authorchoice_termsofuse.html (vor)
Locations: Chemical Reviews (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM114330)
Division of Graduate Education (DGE-1144676)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
Keywords: capillary electrophoresis, glycans, N-glycans, carbohydrate analysis, regioisomers, biomarker discovery, biologic therapy, glycosaminoglycans, oligosaccharides, dietary carbohydrates, glycoscience
MeSH terms: Carbohydrate Conformation, Monosaccharides, Oligosaccharides, Polysaccharides, Pyrenes, Staining and Labeling, Electrophoresis, Capillary, High-Throughput Screening Assays

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Capillary Electrophoresis Separations of Glycans

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