Direct oral anticoagulants: analysis of worldwide use and popularity using Google trends
Open accessAbstract
Background: Four direct oral anticoagulants (DOACs) have been approved for clinical use by many medicines regulatory agencies around the world. Due to increasing use of these drugs in routine practice, we planned an original study to investigate their worldwide diffusion using a popular Web-search engine. Methods: Two electronic searches were performed using Google Trends, the former using the keywords “warfarin” AND “heparin” AND “fondaparinux”, and the latter using the keywords “warfarin” AND “dabigatran” AND “rivaroxaban” AND “apixaban” AND “edoxaban”, both using the search criterion “prescription drug”. No language restriction was applied, and the searches were carried out from the first date available in Google Trends (January 1st, 2004) to present time (June 1st, 2017). Results: The median Google Trends score of warfarin (i.e., 86) was consistently higher than that of heparin (54; P<0.001), fondaparinux (6; P<0.001), dabigatran (11; P<0.001), rivaroxaban (5; P<0.001), apixaban (1; P<0.001) and edoxaban (1; P<0.001). Specific analysis of the trends shows that the score of warfarin exhibits a highly significant decrease over time (r=−0.40; P<0.001), whilst that of heparin has remained virtually unchanged (r=0.12; P=0.127), and that of fondaparinux has marginally increased (r=0.16; P=0.038). As regards DOACs, the scores of these drugs significantly increased during the search period (dabigatran, r=0.79; rivaroxaban, r=0.99; apixaban, r=0.98; edoxaban, r=0.78; all P<0.001). When the analysis was limited to the past five years, the dabigatran score significantly decreased (r=−0.57; P<0.001), whereas that of the other DOACs exhibited an even sharper increase. Most Google searches for DOACs were performed in North America, central-eastern Europe and Australia. Conclusions: The results of our analysis suggest that the popularity of DOACs is constantly increasing around the world, whereas that of warfarin has exhibited a constant and inexorable decline.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lead-in anticoagulation with heparin products adds complexity to the treatment regimen and is one reason why dabigatran or edoxaban is less often prescribed than apixaban and rivaroxaban.
“Lead-in anticoagulation with heparin products adds complexity to the treatment regimen and is 1 reason why dabigatran or edoxaban is less often prescribed than apixaban and rivaroxaban. 2”
From Systematic review and meta-analysis of the efficacy and safety of apixaban compared to rivaroxaban in acute VTE in the real world (2019) · cites this paper as [2]
The discussion reports a recent decrease in dabigatran use alongside increased prescribing of factor Xa inhibitors, and the sales table lists lower 2015 sales for dabigatran and edoxaban than for apixaban and rivaroxaban. But the paper does not say that dabigatran or edoxaban requires heparin lead-in treatment, or that regimen complexity explains prescribing differences (discussion and Conclusions table; page not provided). (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The use of google trends in health care research: a systematic review
Nuti, S. V., Wayda, B., Ranasinghe, I., Wang, S., Dreyer, R. P., Chen, S. I., & Murugiah, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109583 · Cited by 1,086 · see citing works
National trends in ambulatory oral anticoagulant use
Barnes, G. D., Lucas, E., Alexander, G. C., & Goldberger, Z. D. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.05.044 · Cited by 598 · see citing works
Lessons learned from the contamination of heparin
Liu, H., Zhang, Z., & Linhardt, R. J. (2009) · Natural Product Reports · doi:10.1039/b819896a · Cited by 396 · see citing works
Is Google Trends a reliable tool for digital epidemiology? Insights from different clinical settings
Cervellin, G., Comelli, I., & Lippi, G. (2017) · Journal of Epidemiology and Global Health · doi:10.1016/j.jegh.2017.06.001 · Cited by 331 · see citing works
Self-citationHarrington, A. R., Armstrong, E. P., Nolan, P. E., & Malone, D. C. (2013) · Stroke · doi:10.1161/strokeaha.111.000402 · Cited by 259 · see citing works
Trends in the prescription of novel oral anticoagulants in UK primary care
Loo, S. Y., Dell’Aniello, S., Huiart, L., & Renoux, C. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13299 · Cited by 241 · see citing works
Gadsbøll, K., Stærk, L., Fosbøl, E. L., Sindet‐Pedersen, C., Gundlund, A., Lip, G. Y. H., Gislason, G., & Olesen, J. B. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw658 · Cited by 182 · see citing works
Olesen, J. B., Sørensen, R., Hansen, M. L., Lamberts, M., Weeke, P. E., Mikkelsen, A. P., Køber, L., Gislason, G., Torp-Pedersen, C. T., & Fosbøl, E. L. (2014) · EP Europace · doi:10.1093/europace/euu225 · Cited by 164 · see citing works
Trends in Prescribing Oral Anticoagulants in Canada, 2008–2014
Weitz, J. I., Semchuk, W., Turpie, A. G. G., Fisher, W. D., Kong, C., Ciaccia, A., & Cairns, J. A. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.09.008 · Cited by 145 · see citing works
Can Google Trends search queries contribute to risk diversification?
Krištoufek, L. (2013) · Scientific Reports · doi:10.1038/srep02713 · Cited by 126 · see citing works
Lippi, G., & Favaloro, E. J. (2014) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-0767 · Cited by 113 · see citing works
Self-citationThe evolution of anticoagulant therapy.
Franchini, M., Liumbruno, G. M., Bonfanti, C., & Lippi, G. (2016) · PubMed Central · doi:10.2450/2015.0096-15 · Cited by 98 · see citing works
Self-citationChang, S., Dong, J., Ma, C., Du, X., Wu, J., Tang, R., Xia, S., Guo, X., Yu, R., Long, D., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.012988 · Cited by 97 · see citing works
Warfarin Versus Novel Oral Anticoagulants
Wadhera, R. K., Russell, C. E., & Piazza, G. (2014) · Circulation · doi:10.1161/circulationaha.114.010426 · Cited by 63 · see citing works
The new oral anticoagulants and the future of haemostasis laboratory testing
Favaloro, E. J., & Lippi, G. (2012) · Biochemia Medica · doi:10.11613/bm.2012.035 · Cited by 57 · see citing works
Self-citationFavaloro, E. J., Pasalic, L., Curnow, J. L., & Lippi, G. (2017) · Current Drug Metabolism · doi:10.2174/1389200218666170417124035 · Cited by 52 · see citing works
Self-citationKomen, J. J., Forslund, T., Hjemdahl, P., Andersen, M. T., & Wettermark, B. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13150 · Cited by 45 · see citing works
Favaloro, E. J., Pasalic, L., & Lippi, G. (2017) · Pathology · doi:10.1016/j.pathol.2017.04.011 · Cited by 36 · see citing works
Self-citationTrends in oral anticoagulant use in Qatar: a 5-year experience
Elewa, H. F., Al-Haddad, A. A. K., Al-Rawi, S., Nounou, A., Mahmoud, H. A. A., & Singh, R. (2017) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-017-1474-4 · Cited by 31 · see citing works
Simmering, J. E., Polgreen, L. A., & Polgreen, P. M. (2014) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2014.01.003 · Cited by 26 · see citing works
Facchinetti, R., Deguidi, G., Pitoni, F., Ricci, G., & Lippi, G. (2017) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000634 · Cited by 17 · see citing works
Self-citationLinking Annual Prescription Volume of Antidepressants to Corresponding Web Search Query Data
Gahr, M., Uzelac, Ž., Zeiss, R., Connemann, B. J., Lang, D., & Schönfeldt‐Lecuona, C. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000397 · Cited by 16 · see citing works
Laboratory monitoring of direct oral anticoagulants (DOACs)—The perfect storm?
Lippi, G., & Favaloro, E. J. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.01.03 · Cited by 15 · see citing works
Self-citationNational Utilization and Forecasting of Ototopical Antibiotics
Crowson, M. G., Schulz, K. A., & Tucci, D. L. (2016) · Otology & Neurotology · doi:10.1097/mao.0000000000001115 · Cited by 14 · see citing works
Quality and Safety Issues of Direct Oral Anticoagulants in the Emergency Department
Benatti, M., Bonfanti, L., Lippi, G., & Cervellin, G. (2015) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0035-1549090 · Cited by 11 · see citing works
Self-citationCaterina, R. D., Renda, G., Sangiuolo, R., Attena, E., Lecce, L. D., & Romeo, F. (2014) · Giornale italiano di cardiologia · doi:10.1714/1424.15779 · Cited by 10 · see citing works
Trends in Oral Anticoagulant use in Qatar: A 5-Year Experience
Elewa, H. F., Al-Haddad, A. A. K., Al-Rawi, S., Nounou, A., & Mahmoud, H. (2016) · Value in Health · doi:10.1016/j.jval.2016.03.137 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Renda G, Patti G, Sangiuolo R, et al. Management of thromboembolic risk in patients with atrial fibrillation in Italy: follow-up data from the PREFER in AF European Registry. G Ital Cardiol (Rome) 2016;17:922-31.
Cited by
Sorted by citations
Kershaw, G., Mohammed, S., Lippi, G., & Favaloro, E. (2019) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1677018 · Cited by 96 · see citing works
Self-citationFactor XI inhibitors: cardiovascular perspectives
Caterina, R. D., Prisco, D., & Eikelboom, J. W. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac464 · Cited by 73 · see citing works
Aryal, M. R., Gosain, R., Donato, A., Yu, H., Katel, A., Bhandari, Y., Dhital, R., & Kouides, P. A. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000572 · Cited by 62 · see citing works
Poon, M. T. C., Rea, C. J., Kolias, A. G., Brennan, P. M., Afshari, F. T., Ahmed, A. I., Alli, S. D., Al-Mahfoudh, R., Bal, J. S., Belli, A., et al. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.6080 · Cited by 64 · see citing works
Current and Emerging Direct Oral Anticoagulants: State-of-the-Art
Lippi, G., Gosselin, R. C., & Favaloro, E. J. (2019) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0039-1692703 · Cited by 56 · see citing works
Self-citationMilling, T. J., & Pollack, C. V. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.05.086 · Cited by 52 · see citing works
Laboratory hemostasis: from biology to the bench
Lippi, G., & Favaloro, E. J. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1205 · Cited by 48 · see citing works
Self-citationRadadiya, D. K., Devani, K., Brahmbhatt, B. S., & Reddy, C. M. (2021) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002035 · Cited by 45 · see citing works
Non-bleeding Adverse Events with the Use of Direct Oral Anticoagulants: A Sequence Symmetry Analysis
Maura, G., Billionnet, C., Coste, J., Weill, A., Neumann, A., & Pariente, A. (2018) · Drug Safety · doi:10.1007/s40264-018-0668-9 · Cited by 34 · see citing works
Favaloro, E. J. (2018) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1667342 · Cited by 35 · see citing works
Self-citationCao, D., Amabile, N., Chiarito, M., Lee, V. T., Angiolillo, D. J., Capodanno, D., Bhatt, D. L., Mack, M. J., Storey, R. F., Schmoeckel, M., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad119 · Cited by 31 · see citing works
Atzemian, N., Kareli, D., Ragia, G., & Manolopoulos, V. G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1244098 · Cited by 30 · see citing works
Optimizing warfarin dosing for patients with atrial fibrillation using machine learning
Petch, J., Nelson, W., Wu, M., Ghassemi, M., Benz, A. P., Fatemi, M., Di, S., Carnicelli, A., Granger, C. B., Giugliano, R. P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-55110-9 · Cited by 27 · see citing works
Periprocedural Bridging in Patients with Venous Thromboembolism: A Systematic Review
Baumgartner, C., de Kouchkovsky, I., Whitaker, E. M., & Fang, M. C. (2019) · The American Journal of Medicine · doi:10.1016/j.amjmed.2019.01.004 · Cited by 24 · see citing works
Recent Advances in Mainstream Hemostasis Diagnostics and Coagulation Testing
Favaloro, E. J., & Lippi, G. (2019) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1676579 · Cited by 23 · see citing works
Self-citationMahroum, N., Bragazzi, N. L., Brigo, F., Waknin, R., Sharif, Κ., Mahagna, H., Amital, H., & Watad, . (2018) · Health Informatics Journal · doi:10.1177/1460458218766573 · Cited by 23 · see citing works
Is Digital Epidemiology the Future of Clinical Epidemiology?
Lippi, G., Mattiuzzi, C., & Cervellin, G. (2019) · Journal of Epidemiology and Global Health · doi:10.2991/jegh.k.190314.003 · Cited by 22 · see citing works
Self-citationYan, V. K. C., Li, H., Wei, L., Knapp, M. R. J., Wong, I. C. K., & Chan, E. W. (2023) · Drugs · doi:10.1007/s40265-023-01837-0 · Cited by 22 · see citing works
Evaluation of DOAC Filter, a New Device to Remove Direct Oral Anticoagulants from Plasma Samples
Sevenet, P., Cucini, V., Hervé, T., Depasse, F., Carlo, A., Contant, G., & Mathieu, O. (2020) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.13267 · Cited by 21 · see citing works
Impact of anticoagulation and antiplatelet drugs on surgery rates and mortality in trauma patients
Bläsius, F., Laubach, M., Andruszkow, H., Lübke, C., Lichte, P., Lefering, R. L., Hildebrand, F., & Horst, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-94675-7 · Cited by 21 · see citing works
Zhao, J., Wang, H., Li, X., Hu, Y., Yan, V. K. C., Wong, C. K. H., Guo, Y., Cheung, M. K. H., Lip, G. Y. H., Siu, C., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003730 · Cited by 19 · see citing works
Holmes, B., Strzelecki, A., Springer, S., & Zieger, M. (2022) · Environmental Conservation · doi:10.1017/s037689292200011x · Cited by 19 · see citing works
Is digital epidemiology reliable?—insight from updated cancer statistics
Lippi, G., & Cervellin, G. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2018.11.55 · Cited by 19 · see citing works
Self-citationLabaki, M., & Kock, M. D. (2022) · Clinical Case Reports · doi:10.1002/ccr3.6462 · Cited by 18 · see citing works
Barriers and facilitators to optimal oral anticoagulant management: a scoping review
Wang, M., Holbrook, A. M., Lee, M., Liu, J., Leenus, A., Chen, N., Mbuagbaw, L. C. E., & Thabane, L. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02056-0 · Cited by 18 · see citing works
Marcelino, G., Hemett, O. M., & Descombes, É. (2020) · Case Reports in Nephrology · doi:10.1155/2020/6940183 · Cited by 18 · see citing works
Treatment and Outcomes of Acute Pulmonary Embolism and Deep Venous Thrombosis: The CVRN VTE Study
Fang, M. C., Fan, D., Sung, S. H., Witt, D. M., Schmelzer, J. R., Williams, M. S., Yale, S. H., Baumgartner, C., & Go, A. S. (2019) · The American Journal of Medicine · doi:10.1016/j.amjmed.2019.05.040 · Cited by 17 · see citing works
Maura, G., Bardou, M., Billionnet, C., Weill, A., Drouin, J., & Neumann, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68304-8 · Cited by 16 · see citing works
Thrombotic complications with interruption of direct oral anticoagulants in dermatologic surgery
Siscos, S. M., Neill, B. C., Singh, A. H., & Hocker, T. L. H. (2020) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.10.008 · Cited by 14 · see citing works
Hiller, S., Qi, J., Leavitt, D., Frontera, J. R., Jafri, S. M., Hollingsworth, J. M., Dauw, C. A., & Ghani, K. R. (2020) · The Journal of Urology · doi:10.1097/ju.0000000000001416 · Cited by 14 · see citing works
Andexanet alfa for the reversal of factor Xa inhibitors
Favresse, J., Hardy, M. J., van Dievoet, M., Sennesael, A., Douxfils, J., Samama, C. M., Vornicu, O., Dincq, A.-S., Lessire, S., & Mullier, F. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1599355 · Cited by 13 · see citing works
Ågren, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-92204-0 · Cited by 12 · see citing works
Alrowily, A., Aloudah, N. M., Jalal, Z., Abutaleb, M., & Paudyal, V. (2022) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-022-01448-x · Cited by 12 · see citing works
Zhang, C., Wang, J., Yang, Y. J., Ma, E.-L., Lin, H., Liu, B.-L., & Gu, Z.-C. (2022) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296221132551 · Cited by 12 · see citing works
Aarnio, E., Huupponen, R., Martikainen, J. E., & Korhonen, M. J. (2019) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2019.06.012 · Cited by 12 · see citing works
Kampouraki, E., Abohelaika, S., Avery, P. J., Biss, T. T., Murphy, P., Wynne, H., & Kamali, F. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02326-x · Cited by 12 · see citing works
Hemorrhage risk of direct oral anticoagulants in real-world venous thromboembolism patients
Jin, M. C., Sussman, E. S., Feng, A. Y., Han, S. S., Skirboll, S. L., Berube, C., & Ratliff, J. K. (2021) · Thrombosis Research · doi:10.1016/j.thromres.2021.06.015 · Cited by 12 · see citing works
Munk, L., van Essen, T., van der Hoeven, C., Nolte, P. A., & Becker, M. L. (2023) · Patient Safety in Surgery · doi:10.1186/s13037-023-00357-w · Cited by 11 · see citing works
Anti‐factor IIa (FIIa) heparin assay for patients on direct factor Xa (FXa) inhibitors
Stuart, M., Johnson, L. L., Hanigan, S., Pipe, S. W., & Li, S. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14806 · Cited by 10 · see citing works
Impact of oral anticoagulants on 30-day readmission: a study from a single academic centre
Bhattarai, M., Hudali, T. H., ROBINSON, R. L., Al‐Akchar, M., Vogler, C. N., & Chami, Y. G. (2018) · BMJ Evidence-Based Medicine · doi:10.1136/bmjebm-2018-111026 · Cited by 10 · see citing works
Frydman, G. H., Ellett, F. E., Cott, E. M. V., Hayden, D., Majmudar, M. D., Vanderburg, C. R., Dalzell, H., Padmanabhan, D. L., Davis, N., Jorgensen, J. A., et al. (2019) · Critical Care Explorations · doi:10.1097/cce.0000000000000024 · Cited by 10 · see citing works
Updates in periprocedural management of direct oral anticoagulants
Tao, J. Z., & Oprea, A. D. (2020) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000873 · Cited by 10 · see citing works
Freeman, S. C., Heath, M. S., Neill, B. C., Morris, C., Lucero, O. M., Yu, W., Bar, A., & Leitenberger, J. J. (2023) · Dermatologic Surgery · doi:10.1097/dss.0000000000003931 · Cited by 9 · see citing works
Lim, M. S., Hayes, R., Sharma, A., Kitiponchai, T., Mohamed, M., & McRae, S. J. (2022) · Pathology · doi:10.1016/j.pathol.2022.01.004 · Cited by 9 · see citing works
Gong, X., He, Q., Yan, J., Chen, J., Chen, X., Huang, M., Li, J., & Chen, P. (2021) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13538 · Cited by 8 · see citing works
Wang, M., Swinton, M. E., Troyan, S., Ho, J. M.-W., Siegal, D. M., Mbuagbaw, L. C. E., Thabane, L., & Holbrook, A. M. (2022) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.13665 · Cited by 8 · see citing works
A Review on the New and Old Anticoagulants
Myers, K., & Lyden, A. (2019) · Orthopaedic Nursing · doi:10.1097/nor.0000000000000517 · Cited by 8 · see citing works
Bonsu, K. O., Young, S. W., Lee, T. A., Nguyen, H. V., & Chitsike, R. S. (2022) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-022-03418-8 · Cited by 7 · see citing works
Use of Direct Oral Anticoagulants in People Living with HIV: A Single-Center Experience
Cattaneo, D., Formenti, T., Gidaro, A., Merlo, A., & Gervasoni, C. (2020) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1718398 · Cited by 7 · see citing works
Veettil, S. K., Harris, J., Syeed, M. S., Thakkinstian, A., Chaikledkaew, U., Witt, D. M., & Chaiyakunapruk, N. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.06.004 · Cited by 7 · see citing works
Aseri, Z. A. A., AlGahtani, F. H., Bakheet, M. F., Al-Jedai, A. H., & Almubrik, S. A. (2023) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/10742484231202655 · Cited by 7 · see citing works
Fabbro, M., Dunn, S. A., Rodriguez‐Blanco, Y. F., & Jain, P. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2018.07.023 · Cited by 7 · see citing works
Ziakas, P. D., & Mylonakis, E. E. (2020) · Medicine · doi:10.1097/md.0000000000020005 · Cited by 7 · see citing works
Kuybu, O., Javalkar, V., Amireh, A. O., Kaur, A., Kelley, R. E., Cuellar, H., & Sharma, P. K. (2020) · Journal of NeuroInterventional Surgery · doi:10.1136/neurintsurg-2020-015903 · Cited by 7 · see citing works
Qian, Y., Zhang, J., Li, J., & Weng, Z. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259199 · Cited by 6 · see citing works
Evidence for Andexanet Alpha in Reversing Intracerebral Hemorrhage due to Factor Xa Inhibitors?
Armahizer, M. J., & Badjatia, N. (2021) · Stroke · doi:10.1161/strokeaha.120.031825 · Cited by 6 · see citing works
Reversing anticoagulation in the hemorrhaging patient
Treml, B., Oswald, E., & Schenk, B. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000697 · Cited by 4 · see citing works
Ferreira, R. M., Pinheiro, Í. D. C., & Rocha, J. (2020) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20190768 · Cited by 5 · see citing works
Advances in management of nonvariceal upper gastrointestinal bleeding
Holzwanger, E. A., Mahmoud, M., & Wassef, W. Y. (2018) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000487 · Cited by 5 · see citing works
Trends of popularity of cardiac biomarkers: Insights from Google Trends
Lippi, G., Mattiuzzi, C., & Cervellin, G. (2018) · Emergency Care Journal · doi:10.4081/ecj.2018.7769 · Cited by 4 · see citing works
Self-citationLänger, F. P., Favaloro, E. J., & Lippi, G. (2019) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0039-3402478 · Cited by 4 · see citing works
Self-citationLetter to the Editor: 10-Year Evolution in Worldwide Usage of Anticoagulant Drugs
Lippi, G., Mattiuzzi, C., & Favaloro, E. J. (2022) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0042-1756702 · Cited by 4 · see citing works
Self-citationThe new era of anticoagulation: factor XI and XII inhibitors
Prisco, D., Mattioli, I., Caterina, R. D., & Bettiol, A. (2023) · Bleeding Thrombosis and Vascular Biology · doi:10.4081/btvb.2023.76 · Cited by 3 · see citing works
Kurdi, A. B., Albutti, A., Darweesh, O., M-Amen, K., Baker, K., Karwi, H., & Godman, B. (2025) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2025.2473613 · Cited by 3 · see citing works
Kotnis-Gąska, A., Trawińska, A., Broniatowska, E., Konieczyńska, M., Undas, A., & Wypasek, E. (2025) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-025-03159-2 · Cited by 2 · see citing works
Oral Anticoagulant Therapy in the Arab World
Abdeladim, S., Harras, M. E., Bensahi, I., Elouarradi, A., & Sabry, M. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-36811-1_194 · Cited by 2 · see citing works
Lim, M. S., & Mohamed, M. (2024) · Internal Medicine Journal · doi:10.1111/imj.16329 · Cited by 2 · see citing works
Bai, H., Wang, J., Nie, X., Li, H., Ma, L., Han, X., & Peng, L. (2025) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2025.2461203 · Cited by 2 · see citing works
Mahmoudpour, S. H., Valerio, L., Douxfils, J., Mahan, C. E., Jankowski, M., Quitzau, K., Konstantinides, S., & Barco, S. (2020) · Hämostaseologie · doi:10.1055/a-1120-4064 · Cited by 2 · see citing works
Ali, M. D., Ahmad, A., Banu, N., Patel, M., Ghosn, S. A., & Eltrafi, Z. (2020) · Journal of Pharmaceutical Health Services Research · doi:10.1111/jphs.12382 · Cited by 2 · see citing works
Thakur, N., Patel, K. A., Hall, I., Duggal, Y. N., & Cui, S. (2023) · Data · doi:10.3390/data8110163 · Cited by 2 · see citing works
Gavrilova, A., Zolovs, M., Šmits, D., Ņikitina, A., Latkovskis, G., & Urtāne, I. (2024) · Healthcare · doi:10.3390/healthcare12100975 · Cited by 1 · see citing works
The Military Separated Me; You Cannot Connect Me
Kinch, A. K., & Lyon, J. S. (2024) · Journal of Veterans Studies · doi:10.21061/jvs.v10i1.561 · Cited by 1 · see citing works
Scannell, M., Burton, E., & Kearney, P. M. (2024) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.70011 · Cited by 1 · see citing works
Attention-deficit hyperactivity disorder drug search trends: a Scandinavian perspective
Zoltek, M., & Ågren, R. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2025.20 · Cited by 1 · see citing works
Spontaneous Splenic Ruptures: A Contemporary Systematic Review
Pastak, M., Saar, S., Lipping, E., & Talving, P. (2026) · Journal of Surgical Research · doi:10.1016/j.jss.2025.12.029 · Cited by 1 · see citing works
Meearsa, C., Wongvipaporn, C., Nachom, C., Singhapeerakul, S., Chumworathayi, P., & Uchaipichat, V. (2018) · Srinagarind Medical Journal-ศรีนครินทร์เวชสาร · Cited by 1 · see citing works
Trends in use of Direct Oral Anticoagulants and Warfarin in Atrial Fibrillation Patients
Musnelina, L., Handayani, F., Vo, T. H., & Pontoan, J. (2023) · JURNAL ILMU KEFARMASIAN INDONESIA · doi:10.35814/jifi.v21i2.1475 · Cited by 1 · see citing works
Hospital consumption of direct oral anticoagulants in regions of the Russian Federation in 2017–2022
Matveev, A. V., Владимирович, Г. С., Koryanova, K. N., & Sychev, D. A. (2024) · Pharmacy & Pharmacology · doi:10.19163/2307-9266-2023-11-6-461-470 · Cited by 1 · see citing works
Давидович, И. М., Скопецкая, С. А., Неаполитанская, Т. Э., & Леонидович, Ж. С. (2018) · Kazan medical journal · doi:10.17816/kmj2018-887
Świeczkowski, D., Zdanowski, S., Merks, P., & Jaguszewski, M. J. (2019) · Farmacja Polska · doi:10.32383/farmpol/115156
Oral Anticoagulant Therapy in the Arab World
Abdeladim, S., Harras, M. E., Bensahi, I., Elouarradi, A., & Sabry, M. A. (2021) · Springer eBooks · doi:10.1007/978-3-319-74365-3_194-1
Chan, K. S., Go, K. T. S., Teo, L. T., & Goh, S. S. N. (2023) · PubMed Central
Nitirahardjo, C., Morgan, E., Lawler, B. C., Aimone, E., Tregub, A., Puri, A., Ontiveros, J., Carlyle, R. C., Majumder, M. S., & Piontkivska, H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4871612
Kitchen, M., Bryant, M., Brown, P., Woolley, A. M., & Kitchen, S. (2024) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.14369
Decreasing Trends of Traumatic Brain Injury Despite a Surge in Anticoagulant Use in the Elderly
Rafieezadeh, A., Zangbar, B., Rodriguez, G., Kirsch, J. M., Samson, D., Shnaydman, I., Jose, A. M., & Prabhakaran, K. (2024) · Journal of Surgical Research · doi:10.1016/j.jss.2024.09.078
Baharoglu, M. I. (2025) · doi:10.1007/978-90-368-3059-1_16
Munk, L., van Essen, T., van der Hoeven, C., Pa, N., & Becker, M. L. (2024) · Figshare · doi:10.6084/m9.figshare.26583810
Lal, A., Tekin, A., Gonçalves, G. L. B., Portner, E. R., & Park, J. G. (2026) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-026-03376-3
Postoperative Management of Direct Oral Anticoagulants After Elective Spine Surgery
Rizkallah, M., Melhem, E., Moreau, P. E., Wolff, S., & Riouallon, G. (2026) · Clinical Spine Surgery A Spine Publication · doi:10.1097/bsd.0000000000002169
- Authors
- Lippi, G., Mattiuzzi, C., Cervellin, G., & Favaloro, E. J.
- Affiliations
- University of Verona (IT)
- Provincia Autonoma di Trento (IT)
- University of Parma (IT)
- Westmead Hospital (AU)
- Corresponding author
- Lippi, Giuseppe
- Venue
- Annals of Translational Medicine
- Publisher
- AME Publishing Company
- Published
- 2017-08
- Volume
- 5
- Issue
- 16
- Pages
- 322-322
- ISSN
- 2305-5839 (ISSN-L)
- 2305-5847
- PMC
- PMC5566735
- OpenAlex
- W2739421744
- Cited by
- 91
- References
- 28
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 10 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 14 · 2018: 13
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Translational Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- Charles Sturt University Research Output (CRO) (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Epidemiology › Data-Driven Disease Surveillance
- Keywords
- direct oral anticoagulants, drug diffusion, Google Trends, web search trends, warfarin, heparin, fondaparinux, dabigatran, rivaroxaban, apixaban, edoxaban, anticoagulant prescribing, North America, Europe, Australia, South America, Asia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
